Section Review Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis: Glucocorticosteroids, old and new: Biological function and use in the treatment of asthma

References to Primarv Literature

• ALEXANDER HL, PADDOCK R: Bronchial asthma: re-sponse to pilocarpine and epinephrine. Arch. Int. Med. (1921) 27:184–191.
   Google Scholar
• WEISS S, ROBB GP: The systemic effects of histamine inman. Arch. Int. Med. (1932) 49:360–396.
   Google Scholar
• AZZAWI M, BRADLEY B, JEFFERY PK, FREW AJ, WARDLAWAJ, KNOWLES G, ASSOUFI B, COLLINS JV, DURHAM S, KAY AB: Identification of activated T-lymphocytes and cosi-nophils in bronchial biopsies in stable atopic asthma. Am. Rev. Respir. Dis. (1990) 142:1407–1413.
   PubMed Web of Science ®Google Scholar
• DJUKANOVIC R, WILSON JW, BRITTEN KM, WILSON SJ,WALLS AF, ROCHE WE, HOWARTH PH, HOLGATE ST: Quantitation of mast cells and eosinophils in the bron-chial mucosa of symptomatic atopic asthmatics and healthy control subjects using immunocytochemistry. Am. Rev. Respir. Dis. (1990) 142:863–871.
   PubMed Web of Science ®Google Scholar
• ROBINSON D, HAMID Q, BENTLEY A, YING ST, KAY AB,DURHAM SR: Activation of CD4+ T-cells, increased TH2 type cytokine mRNA expression, and eosinophil re-cruitment in bronchoalveolar lavage after allergen in-halation challenge in patients with atopic asthma. J. Allergy Ctn. Immunol. (1993) 92:313–324.
   PubMed Web of Science ®Google Scholar
• RICHARDS IM, CHIN JE, LEACH ILL: Glucocorticoids. In:Airways Smooth Muscle: Neurotransmitters, Amines, Lipid Mediators, and Signal Trarzsduction. Raebum D and Giem-bycz MA (Eds.), Birkhauser Verlag, Basel (1995):325–348.
   Google Scholar
• PARNHAM MJ: Outlook for emerging asthma therapies. In: Spectrum: Therapy Markets and Emerging Technologies. Pamham MJ, Waltham MA (Eds.), Decision Resources, Inc. (1995):81–1–81–18.
   Google Scholar
• MELLIS CM, PEAT JK, WOOLCOCK AJ: The cost of asthma. Can it be reduced? PharrnacoEconomics (1993) 3:205–219.
   Google Scholar
• JONES DG: The eosinophiL J. Comp. Path. (1993) 108:317–335.
   PubMed Web of Science ®Google Scholar
• VENGE P, HAKANSSON L: Current understanding of therole of the eosinophil in asthma. Clin. Exp. Allergy (1991) 21:31–37.
   PubMed Web of Science ®Google Scholar
• FRIGAS E, GLEICII GJ: The eosinophil and the patho-physiology of asthma. J. Allergy. Clin. Immunol. (1986) 77:527–537.
   PubMed Web of Science ®Google Scholar
• FRIGAS E, LOEGERING DA, GLEICH GJ: Cytotoxic effectsof the guinea pig eosinophil major basic protein on tracheal epithelium. Lab. Invest. (1980) 42:35–43.
   PubMed Web of Science ®Google Scholar
• FLAVAHAN NA, SLIFMAN NR, GLEICH GJ, VAN HOUTTE PM: Human eosinophil major basic protein causes hy-perreactivity of respiratory smooth muscle. Am. Rev. Respir. Dis. (1988) 138:685–688.
   PubMed Web of Science ®Google Scholar
• STREK ME, WHITE SR, HSIUE TR, KULP GVP, WILLIAMS FS, LEFF AR: Effect of mode of activation of human eosino-phi's on tracheal smooth muscle contractions in guinea pigs. Am. J. Physiol. (1993) 264:L475–L481.
   PubMed Web of Science ®Google Scholar
• F1LLEY WV, HOLLEY ICE, KEPHART GM, GLEICH GJ: Iden-tification by irnmunofluorescence of eosinophil major basic protein in lung tissues of patients with bronchial asthma. Lancet (1982) 2:11–16.
   PubMed Web of Science ®Google Scholar
• LEE T, LENIHAN DJ, MALONE B, RODDY LL, WASSERMANSI: Increased biosynthesis of platelet-activating factor In activated human eosinophils. J. Biol. Chem. (1984) 259:5526–5530.
   PubMed Web of Science ®Google Scholar
• WELLER PF, LEE CW, FOSTER DW, COREY EJ, AUSTEN KF,LEWIS RA: Generation and metabolism of 5-liporry-genase pathway leukotrienes by human eosinophils: predominant production of leukotriene C4. Proc. Nat, Acad. Sci. USA (1983) 80:7626–7630.
   PubMed Web of Science ®Google Scholar
• JORG A, HENDERSON WR, MURPHY RC, KLEBANOFF SJ:Leukotriene generation by eosinophils. J. Exp. Med. (1982) 155:390–402.
   PubMed Web of Science ®Google Scholar
• HOLGATE ST, WILSON JR, HOWARTH PH: New insights into airway inflammation by endobronchial biopsy. Am, Rev, Respir. Dis. (1992) 145:S2–S6.
   PubMed Web of Science ®Google Scholar
• CORRIGAN CJ, KAY AB: Role of T-lymphocytes and lymphokines. Br. Med. Bull. (1992) 48:72–84.
   PubMed Web of Science ®Google Scholar
• CORRIGAN CJ, KAY AB: T-cells and eosinophiLs in the pathogenisis of asthma. Immunol. Today (1992) 13:501–507.
   PubMedGoogle Scholar
• BENTLEY AM, MENZ G, STORZ CHR, ROBINSON DS, BRADLEY B, JEFFERY PK, DURHAM SR, KAY AB: Identifi-cation of T-lymphocytes, macrophages, and activated eosinophiLs in the bronchial mucosa in intrinsic asthma. Relationship to symptoms and bronchial re-sponsiveness. Am. Rev. Respir. Dis. (1992) 146:500–506.
   PubMed Web of Science ®Google Scholar
• DEL PRE, IE GF, DE CARLI M, D'ELIOS MM, MAESTRELLI P,FtICCI M, FABBRI L, ROMAGNANI S: Allergen exposure induces the activation and allergen-specific TH2 cells in the airway mucosa of patients with allergic respira-tory disorders. Eur. J. Immunol. (1993) 23:1445–1449.
   PubMedGoogle Scholar
• WILSON JW, DJUKANOVIC R, HOWARTH PR, HOLGATE ST:Lymphocyte activation in bronchoalveolar lavage and peripheral blood in atopic asthma. Am, Rev. Respir. Dis, (1992) 145:958–960.
   PubMed Web of Science ®Google Scholar
• WALKER C, KAEGI MK, BRAUN P, BLASER K: Activated T-cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease se-verity.]. Allergy Clin. Immunol. (1991) 88:935–942.
   PubMed Web of Science ®Google Scholar
• WALKER C, VIRCHOW JC, BRUIJNZEEL PLB, BLASER K: T-cell subsets and their soluble products regulate cosi-nophilia in allergic and nonallergic asthma. J. Immunol. (1991) 146:1829–1835.
   PubMed Web of Science ®Google Scholar
• GERBLICH AA, CAMPBELL AE, SCHUYLER MR: Changes inT-lymphocyte subpopulations after antigenic bronchial provocation in asthmatics. New Engl. J. Med. (1984) 310:1349–1352.
   PubMed Web of Science ®Google Scholar
• MOSMANN TR, CHERWINSIU H, BOND MW, GRIEDLIN MA,COFFMAN RI.: Two types of murine helper T-cell clone. I. Definition according to profiles of tymphokine activi-ties and secreted proteins. J. Immunol. (1986) 136:2348–2357.
   Google Scholar
• ROMAGNANI 5: Induction of Till and TH2 responses: a key role for the 'natural' immune response? Immunol. Today (1992) 13:379–381.
   Google Scholar
• FONG TAT, MOSMANN TR: The role of IFN-gamma in delayed type hypersensitivity mediated by Till clones. J. Immunol. (1989) 143:2887–2893.
   PubMed Web of Science ®Google Scholar
• ROBINSON DS, HAMID Q, YING S, TSICOPOULOS A, BARICANS J, BENTLEY AM, CORRIGAN C, DURHAM SR, KAY AB: Predominant TH2-like bronchoalveolar T-lympho-cyte population in atopic asthma. New Engl.J. Med. (1992) 326:298–304.
   PubMed Web of Science ®Google Scholar
• ROBINSON DS, YING S. BENTLEY AM, MENG Q, NORTH J,DURHAM SR, KAY AB, HAMID Q: Relationship among numbers of bronchoalveolar lavage cells expressing messenger ribonucleic acid for cytokines, asthma symptoms, and airway methacholine responsiveness in atopic asthma. J. Allergy Clin. Immunol. (1993) 92:397–403.
   PubMed Web of Science ®Google Scholar
• WIERRNGA EA, SNOEK M, DE GROOT C, CHRETTEN I, BOS JD, JANSEN HM, KAPSENBERG ML: Evidence for compart-mentalization of functional subsets of CD4 T-lympho-cytes in atopic patients. J. Immunol. (1990) 144:4651–4656.
   PubMed Web of Science ®Google Scholar
• KAPSENBERG ML, WIERENGA EA, BOS JD, JANSEN HM: Functional subsets of allergen-reactive human CD4* T-cells. Immunol. Today (1991) 12:392–395.
   PubMedGoogle Scholar
• PARRONCHI P, DE CARLI M, MANETIT R, SIMONELLI C, PICCINNI M-P, MACCHIA D, MAGGI E, DEL PRETE G, RICCI M, ROMAGNANI S: Abberant interleukin (11)-4 and 11-5 production in vitro by CD4. helper T-cells from atopic subjects. Eur. J. Immunol. (1992) 22:1615–1620.
   PubMed Web of Science ®Google Scholar
• HAMID Q, AZZAWI M, YING S, MOQBEL R, WARDLAW AJ, CORRIGAN CJ, BRADLEY B, DURHAM SR, COLLINS JV, JEFFREY PK: Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma. J. Clin. Invest. (1991) 87:1541–1546.
   PubMed Web of Science ®Google Scholar
• CLUTTERBUCK EJ, HIRST EMA, SANDERSON g: Inter-leukin 5(11,5) regulates the production of eosinophils In human bone marrow cultures: comparison with11-1, 11-3,11-6, and GMCSF. Blood (1988) 73:1504–1512.
   Web of Science ®Google Scholar
• LOPEZ AF, SANDERSON CJ, GAMBLE JR, CAMPBELL HD,YOUNG ID, VADAS MA: Recombinant human inter-leukin-5 is a selective activator of human eosinophil function. J. Exp. Med. (1988) 167:219–224.
   PubMed Web of Science ®Google Scholar
• WALSH GM, HARTNELL A, WARDLAW AJ, KURIHARA K,SANDERSON CJ, KAY AB: IL-5 enhances the adhesion of human eosinophils, but not neutrophils, in a leukocyte integrin (CD11/18) dependent manner. Immunology (1990) 71:258–265.
   PubMed Web of Science ®Google Scholar
• OWEN WF, ROTHENBURG ME, SILBERSTEIN DS, GASSONJC, STEVENS RL, AUSTEN KY, SOBERMAN RJ: Regulation of human eosinophil viability, density and function by granulocyte/macrophage colony-stimulating factor in the presence of 3T3 fibroblasts. J. Exp. Med. (1987) 166:129–141.
   PubMed Web of Science ®Google Scholar
• ROTHENBURG ME, OWEN WF, SILBERSTEIN DS: Humaneosinophils have prolonged survival, enhanced func-tional properties and become hypodense when ex-posed to human interleukin-3. j (Tin. Invest. (1988) 81:1986–1992.
   PubMed Web of Science ®Google Scholar
• DEL PRETE GF, MAGGI E, PARRONCHI P: 11-4 is an essential co-factor for the IgE synthesis induced by human T-cell clones and their supernatents. J. Immunol. (1988) 140:4651–4656.
   Google Scholar
• CORRIGAN CJ, BROWN PH, BARNES NC, SZEFLER SJ, TSAIJJ, FREW AJ, KAY AB: Glucocorticoid resistance in chronic asthma: ghwocorticoid pharmacokinetics, glu-cocorticoid receptor characteristics, and inhibition of peripheral blood T-lymphocyte proliferation by g,luco-corticoids in vitro. Am. Rev. Respir. Dis. (1991) 144:1016–1025–
   Google Scholar
• ROBINSON D, HAMID Q, YING 5, BENTLEY A, ASSOUFI B,DURHAM S, KAY AB: Prednisolone treatment in asthma Is associated with modulation of bronchoalveolar lay-age cell I1-4, 11-5, and IFN-gamma cytokine gene expres-sion. Am. Rev. Respir. Dis. (1993) 148:401–406.
   PubMed Web of Science ®Google Scholar
• FLINT KC, LELTNG KBP, HUDSPITH BN, BROSTOFF J, PEARCE FL, JOHNSON NM: Bronchoalveolar mast cells In extrinsic asthma: a mechanism for the initiation of antigen-specific bronchoconstriction. Br. Med. J. Clin. Res. (1985) 291:923–926.
   PubMed Web of Science ®Google Scholar
• FLINT KC, LEUNG KB, HUDSPITH BN, BROSTOFF J, JOHNSON NM: Bronchoalveolar mast cells in intrinsic asthma. din. Sci. (1986) 70\(Suppl. 13):46.
   Google Scholar
• KIRBY JG, HARGREAVE FE, GLEICH GJ, O'BYRNE PM:Bronchoalveolar cell profiles of asthmatic and non-asthmatic subjects. Am. Rev. Respir. Dis. (1987) 135:A474.
   Google Scholar
• LAITINEN LA, HEINO M, KARJALAINEN J, YLIKOSKI J, LAITTNEN A: Inflammation of bronchial epithelium and oral steroid treatment in patients with asthma at early stages of the disease. Am. Rev. Respir. Dir. (1987) 135:A474.
   Google Scholar
• HOWARTH PH, DURHAM SR, LEE TH, KAY AB, CHURCHMK, HOLGATE ST: Influence of albuterol, cromolyn sodium and ipratroprium bromide on the airway and circulating mediator responses to allergen bronchial provocation in asthma. Am. Rev. Respir. Dis. (1985) 132:986–992.
   PubMed Web of Science ®Google Scholar
• METZGER WJ, ZAVALA D, RICHERSON HB, MOSELEY P,IWAMOTA P, MONICK M, SJOERDSMA K, HLJNNINGHAKE GW: Local allergen challenge and bronchoalveolar lay-age of allergic asthma lungs. Description of the model and local airway inflammation. Am. Rev. Respir. Dis. (1987) 135:433–440.
   PubMed Web of Science ®Google Scholar
• HOLGATE ST, EMANUEL MB, HOWARTH PH: Asternizoleand other Hl-antihistamine drug treatment of asthma. J. Allergy Clin. Immunol. (1985) 76:375–382.
   PubMed Web of Science ®Google Scholar
• RAFFERTY P, BEASLEY R, HOLGATE ST: The contribution of histamine to bronchoconstriction provoked by in-haled allergen and adenosine-5'-monophosphate in atopic asthma. Am. Rev. Respir. Dig. (1987) 136:369–373.
   PubMed Web of Science ®Google Scholar
• CRUZEN H, RAFFERTY P, HOLGATE ST: Effects of a cydo-oxygenase inhibitor, flurbiprofen, and an H1 histamine receptor antagonist, terfenadine, alone and in combi-nation on allergen induced immediate bronchocon-striction in man. Thorax (1987) 42:946–952.
   PubMed Web of Science ®Google Scholar
• GORDON JR, BURD PR, GALLI SJ: Mast cells as a source of multifunctional cytokines. Immunol. Today (1990) 11:458–464.
   PubMedGoogle Scholar
• GORDON JR, GALLI SJ: Release of both preformed and newly synthesised tumour necrosis factor-a (TNF-a)/Cachectin by mouse mast cells stimulated via the FceRl. A mechanism for the sustained action of mast cell-derived TNF-a during IgE-dependent biological re-sponses. J. Exp. Med. (1991) 174:103–107.
   Google Scholar
• BRADDING P, FEATHER IH, HOWARTH PH, MUELLER R, ROBERTS JA, BRITTEN K, BEWS JP, HUNT TC, OKAYAMA Y, HEUSSER CH: Interleukin-4 is loc117,-d to and re-leased by human mast cells. J. Exp. Med. (1992) 176:1381–1386.
   PubMed Web of Science ®Google Scholar
• GAUCHAT JF, HENCHOZ S, MAZZEI G, AUBRY JP, BRUN-NER T, BLASEY H, LIFE P, TALABOT D, FLORES-ROMO L, THOMPSON J: Induction of human IgE synthesis in B-cells by mast cells and basophils. Nature (1993) 365:340–313.
   PubMed Web of Science ®Google Scholar
• HOGG JC: Is asthma an epithelial disease? Am. Rev. Respir. Ms. (1984) 129:207–208.
   PubMed Web of Science ®Google Scholar
• FLAVAHAN NA, AARHUS LL, RIMELE TJ, VANHOUTE PM: Respiratory epithelium inhibits bronchial smooth mus-de. J. Appl. Phystol. (1985) 58:834–838.
   PubMed Web of Science ®Google Scholar
• BARNES PJ, CUSS FM, PALMER JB: The effect of airway epithelium on smooth muscle contractibility in bovine trachea. Br. J. Pharm. (1985) 86:685–691.
   PubMed Web of Science ®Google Scholar
• BELLINI A, YOSHIMURA H, VITTORI E, MARINI M, MAT-TOLI S: Respiratory pathophysiologic responses. Bron-chial epithelial cells of patients with asthma release chemoattractant factors for T-lymphocytes. J. Allergy Clin. Immunol. (1993) 92:412–424.
   Google Scholar
• BIGBY TO, GOETZL EJ, HOLTZMANN MJ: Canine trachealepithelial cells generate leukotriene B4 in response to calcium ionophore. Clin. Res. (1985) 33:76A.
   Google Scholar
• HUNTER JA, FINKBEINER WE, NADEL JA, GOETZL Ej, HOLTZMANN MJ: Predominant generation of 15-lipoxy-genase metabolites of arachidonic add by epithelial cells from human trachea. Clin. Res. (1985) 33:78A.
   Google Scholar
• MARINI M, SCIACCA F, MEZZETI M, MANTOVANI A, MAT-TOLI S: ruip induces the expression of 11-8 gene and protein in normal human bronchial epithelial cells in vitro. J. Allergy Clin. Immunol. (1992) 89:211.
   Web of Science ®Google Scholar
• MARINI M, VITTORI E, HOLLEMBORG J, mATrou s: Ex-pression of the potent inflammatory cytokines, granu-locyte-macrophage colony-stimulating factor and interleukin-6 and interleukin-8, in bronchial epithelial cells of patients with asthma. J. Allergy din. Immunol (1992) 89:1001–1009.
   PubMed Web of Science ®Google Scholar
• CROMWELL O, HAMID Q, CORRIGAN C, BARKANS J, MENG Q, COLLINS P, KAY AB: Expression and generation of interleultin-8, IL-6, and granulocyte-macrophage col-ony-stimulating factor by bronchial epithelial cells and enhancement by IL-1 3 and tumour necrosis factor-a. Immunology (1992) 77:330–337.
   PubMed Web of Science ®Google Scholar
• METCALF D: The granulocyte-macrophage colony-stimulating factors. Science (1985) 229:16–22.
   PubMed Web of Science ®Google Scholar
• BURKE LA, HALLSWORTH MP, LrFCHFIELD TM, DAVIDSON R, LEE T11: Identification of the major activity derived from cultured human peripheral blood mononuclear cells, which enhances eosinophil viability, as granulo-cyte-macrophage colony-stimulating factor (GM-CSF). J. Allergy Clin. Immunol. (1991) 88:226–235.
   PubMed Web of Science ®Google Scholar
• HOWELL CJ, PUJOL JL, CREA AEG, DAVIDSON R, GEARING AYH, GODARD PH, LEE TH: Identification of an alveolar macrophage-derived activity in bronchial asthma which enhances leukotriene C4 generation by human eosinophils stimulated by ionophore (A23187) as granulocyte-macrophage colony-stimulating factor (GM-CSF). Am. Rev. Respir. Dis. (1989) 140:1340–1347.
   PubMed Web of Science ®Google Scholar
• TAI PC, SPRY CJ: The effects of recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 on the secretory capacity of human blood eosinophils. Clin. Exp. Immunol. (1990) 80:426–434.
   PubMed Web of Science ®Google Scholar
• SOUSA AR, POSTON RN, LANE SJ, NAKHOSTEEN JA, LEE TH : Detection of GM-CSF in asthmatic bronchial epithe-lium and decrease by inhaled corticosteroids. Am, Rev. Respir. Dis. (1993) 147:1557–1561.
   PubMed Web of Science ®Google Scholar
• BROWN PH, CROMPTON GK, GREENING AP: Proinflammatory cytokines in acute asthma. Lancet (1991) 338:590–593.
   PubMed Web of Science ®Google Scholar
• LEE TH, LANE SJ: The role of macrophages in the mechanisms of airway inflammation in asthma. Am. Rev. Respir. Dis. (1992) 145:827–830.
   PubMedGoogle Scholar
• FULLER RW: Macrophages. Br. Med. Bull. (1992) 48:65–71.
   PubMed Web of Science ®Google Scholar
• LEE T: Interactions between alveolar macrophages, monocytes, and granulocytes: implications for airway Inflammation. Am. Rev. Respir. Dis. (1987) 135:S14–S17.
   PubMed Web of Science ®Google Scholar
• UNANUE ER, ALLEN PM: The basis for the immunoregu-latory role of macrophages and other accessory cells. Science (1987) 236:551–557.
   PubMed Web of Science ®Google Scholar
• SPIELBERG HL: Structure and function of Fc receptorsfor IgE on lymphocytes, monocytes, and marrophages. Adv. Immunol. (1984) 35:61–68.
   PubMedGoogle Scholar
• JOSEPH M, TONNEL AB, CAPRON A, VOISIN C: Enzyme release and superoxide anion production by human alveolar macrophages stimulated with immunoglobu-lin E. Ctn. Exp. Immunol. (1986) 65:416–426.
   PubMedGoogle Scholar
• DESSAINT JP, TORPIER G, CAPRON M, BASIN H, CAPRON H: Cytophilic binding of IgE to the macrophage. Cell Immunol. (1979) 46:12–23.
   PubMed Web of Science ®Google Scholar
• MELEWICZ FM, ZEIGLER RS, MELLON MH, O'CONNOR RD, SPEIGELBERG HL: Increased peripheral blood mono-cytes with Fc receptors for IgE in patients with severe allergic disorders. J. Immunol. (1981) 126:1592–1595.
   PubMed Web of Science ®Google Scholar
• MELEWICZ FM, KLINE LE, COHEN AB: Characterization of IgE receptors for IgE on human alveolar macro-phages. Clin. Exp. Immunol. (1982) 49:364–370.
   PubMed Web of Science ®Google Scholar
• KAY AB, YING S, VARNEY V, GAGA M, DURHAM SR, MOQBEL R, WARDLAW AJ, HAMID Q: Messenger RNA expression of the cytokine gene duster, interleukin-3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cuta-neous reactions in atopic subjects. J. Exp. Med. (1991) 173:775–778.
   PubMed Web of Science ®Google Scholar
• BACH MK, BRASHLER JR, HAMMARSTROM S, SAMUELSSON B: Identification of leukotriene C-1 as a major compo-nent of slow reacting substance from rat mononuclear cells. J. Immunol. (1980), 125:115–117.
   PubMed Web of Science ®Google Scholar
• ARNOUX B, DUVAL D, BENVENISTE J: Release of platelet activating factor (PAF-acether) from alveolar macro-phages by the calcium ionophore A23187 and phago-cytosis. Eur. J. Clin. Invest. (1980) 10:437–441.
   PubMed Web of Science ®Google Scholar
• MARTINET Y, ROM WM, GROTENDORST GR: Exaggerated spontaneous release of platelet-derived growth factor from patients with idiopathic pulmonary fibrosis. New Eng. J. Med. (1978) 317:202–209.
   Google Scholar
• BEUTLER B, CERAMI A: Cachectin: more than a tumournecrosis factor. Neu) Eng. J. Med. (1987) 316:379–385.
   PubMed Web of Science ®Google Scholar
• HOLT PG, MCMENAMIN C, SCHON-HEGRAD MA, STRICK-LAND D, NELSON D, WILKES L, BILYK N, OLIVER J, HOLT BJ, MCMENAMIN PG: lmmunoregulation of asthma: con-trol of T-lymphocyte activation in the respiratory tract. Eur. Respir. J. (1991) 4(S13):6s–15s.
   Google Scholar
• HOLT PG, DEGEBRODT A, O'LEARY C, KRSKA K, PLOZZA T: T-cell activation by antigen-presenting cells from lung tissue digests: suppression by endogenous macro-phages. Clin. Exp. Immunol. (1985) 62:586–593.
   PubMed Web of Science ®Google Scholar
• HOLT PG, SCHON-HEGRAD MA, OLIVER J: MHC class II antigen-bearing dendritic cells in pulmonary tissues of the rat: regulation of antigen presentation activity by endogenous macrophage populations. J. Exp. Med. (1988) 167:262–274.
   PubMed Web of Science ®Google Scholar
• ROCHESTER CL, GOODELL EM, STOLTENBORG JK, BOW-ERS WE: Dendritic cells from rat lung are potent acces-sory cells. Am. Rev. Respir. Dis. (1988) 138:121–128.
   PubMedGoogle Scholar
• HARMSEN AG, MUGGENBERG BA, SNIPES MB, BICE DE: The role of macrophages in particle translocation from lungs to lymph nodes. Science (1985) 230:1277–1280.
   PubMed Web of Science ®Google Scholar
• ULRICH SE, HERSCOWITZ HB: Immunologic function of alveolar macrophages: interaction with a soluble pro-tein antigen and the immunogenicity of alveolar macro-phage-associated antigen. J. Reticuloendothel. Soc. (1980) 28:111.
   PubMedGoogle Scholar
• SHELLITO J, KALTREIDER HB: Heterogeneity of itrunu-nologic function among subfractions of normal rat alveolar macrophages. Am. Rev. Respir. Dis. (1984) 129:747–753.
   PubMed Web of Science ®Google Scholar
• HOLT PG: Alveolar macrophages. IV. Interspecies dif-ferences in activity in proliferating lymphocyte cul-tures. Cell Immunol. (1980) 50:210–215.
   Google Scholar
• HOLT PG: Inhibitory activity of unstimulated alveolar macrophages on T-lymphocyte blastogenic response. Am. Rev. Respir. Dis. (1978) 118:791–793.
   PubMed Web of Science ®Google Scholar
• HOLT PG: Alveolar macrophages. H. Inhibition of lym-phocyte proliferation by purified macrophages from rat lung. Immunology (1979) 37:429–436.
   Google Scholar
• PENNLINE KJ, HERSCOWITZ HB: Dual role for alveolar macrophages in humoral and cell-mediated immune responses: evidence for suppressor and enhancing functions. J. Reticuloendothel. Soc. (1981) 30:205.
   PubMedGoogle Scholar
• YEAGER HJR, SWEENEY JA, HERSCOWITZ HB, BARSOUMIS, KAGAN E: Modulation of mitogen-induced prolifera-tion of autologous peripheral blood lymphocytes by human alveolar macrophages. Infect. Immunol. (1982) 38:260–266.
   PubMed Web of Science ®Google Scholar
• THEPEN T, VAN ROOIJEN N, KRAAL G: Alveolar macro-phage elimination in vivo is associated with an increase In pulmonary immune response in mice. J. Exp. Med. (1989) 170:499–509–
   Google Scholar
• BILYK N, BOLT PG: Inhibition of the immunosuppres-sive activity of resident pulmonary alveolar macro-phages by granulocyte/macrophage colony stimulating factor. J. E7Cp . Med. (1993) 177:1773–1777.
   Web of Science ®Google Scholar
• OPPENHEIM JJ, ZACHARIAE COG, MUKAIDA N, MAT-SUSHIMA K: Properties of the novel proinflammatory supergene `intercrine cytokine family. Ann. Rev. Immu-nol. (1991) 9:617–648.
   PubMed Web of Science ®Google Scholar
• SCHALL TJ: Biology of the RANTES/sis cytokine family. Cytokine (1991) 3:165–183.
   PubMed Web of Science ®Google Scholar
• STANDIFORD TJ, KUNKEL SL, STRIETER RM: Interleukin-8: a major mediator of acute pulmonary inflammation. Reg. Immunol. (1993) 5:134–141.
   PubMedGoogle Scholar
• ALAM R, STAFFORD S, FORSYTHE P, HARRISON R, FAU-BION D, LETT-BROWN M, GRANT JA: RANTES is a chemo-tactic and activating factor for human eosinophils. J. Immunol. (1993) 150:3442–3447.
   PubMed Web of Science ®Google Scholar
• ALAM R, FORSYTHE PA, STAFFORD S, LETT-BROWN MA, GRANT JA: Macrophage inflammatory protein-la acti-vates basophils and mast cells. J. Exp. Med. (1992) 176:781–786.
   PubMed Web of Science ®Google Scholar
• BISCHOFF SC, KRIEGER M, BRUNNER T, ROT A, TSCHARNER VV, BAGGIOLINI M, DAHINDEN CA: RANTES and related chemokines activate human basophil granulocutes through different G protein-coupled re-ceptors. Eur. J. Immunol. (1993) 23 :761–767 .
   PubMed Web of Science ®Google Scholar
• STANDIFORD TJ, ROLFE MW, KUNKEL SL, LYNCH JP III, BURDICK MD, GILBERT AR, ORRINGER MB, WHYTE RI, STRIETER RM: Macrophage inflammatory protein-la expression in interstitial lung disease. J. Immunol. (1993) 151:2852–2863.
   PubMed Web of Science ®Google Scholar
• SCHALL TJ, BACON K, CAMP RDR, ICASPARI JW, GOEDDEL DV: Human macrophage inflammatory protein -a (MW-la) and MIP-1l chemokines attract distinct populations of lymphocytes. J. Exp. Med. (1993) 177:1821–1825.
   PubMed Web of Science ®Google Scholar
• DENHOLM EM: Continuous secretion of monocyte chemotactic factors and fibroblast growth factors by alveolar macrophages following a single exposure to bleomycin in vitro. Am. J. Path. (1993)141:965–971.
   Web of Science ®Google Scholar
• PAINE RIII, ROLFE MW, STANDIFORD TJ, BURDICK NM, ROLLINS BJ, STRIETER RM: MCP-1 expression by rat type II alveolar epithelial cells in primary culture. J. Immunol. (1993) 150:4561–4570.
   PubMed Web of Science ®Google Scholar
• ANTONIADES HN, NEVILLE-GOLDEN J, GALANOPOULOS T, KRADIN RL, VALENTE AJ, GRAVES DT: Expression of monocyte chemoattractant protein 1 mRNA in human idiopathic pulmonary fibrosis. Proc. Nat. Acad. Sci. USA (1992) 89:5371–5375.
   PubMed Web of Science ®Google Scholar
• ROLLINS BJ, PROBER JS: Interleukin-4 induces the syn-thesis and secretion of MCP-1/JE by human endothelial cells. Am. J. Path. (1991) 138:1315–1319.
   PubMed Web of Science ®Google Scholar
• BURD PR, ROGERS HW, GORDON JR, MARTIN CA, JAYARAMAN S, WILSON SD, DVORAK AM, GALLI SJ, DORF ME: Interleuldn-3 dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines. J Exp. Med. (1989) 170:245–257.
   PubMed Web of Science ®Google Scholar
• OHMORI Y, WYNER L, NARUMI S, ARMSTRONG D, STOLER M, HAMILTON TA: Tumour necrosis factor-a induces cell type and tissue-specific expression of chemoattractant cytokines in vivo. Am. J. Path. (1993) 142:861–870.
   PubMed Web of Science ®Google Scholar
• MEURER R, VAN RIPER G, FEENEY W, CUNNINGHAM P, HORA DJR, SPRINGER MS, MACINTYRE DE, ROSEN H: Formation of eosinophilic and monocytic intradermal Inflammatory sites in the dog by injection of human RANTES but not human monocyte chemoattractant protein 1, human macrophage inflammatory protein-la, or human interleukin-8. j. Exp. Med. (1993) 178:1913–1921.
   PubMed Web of Science ®Google Scholar
• EVANS RM: The steroid and thyroid hormone receptor superfarnily. Science (1988) 240:889–895.
   PubMed Web of Science ®Google Scholar
• GUSTAFSSON JA, CARLSTEDT-DUKE J, STROMSTEDT PE, WILKSTROM AC, DENIS M, OKRET S, DONG Y: Structure, function and regulation of the glucocorticoid receptor. Prog. Clin. Biol. Res. (1990) 322:65–80.
   PubMedGoogle Scholar
• FLOWER RJ, ROTH WELL NJ: Lipocortin-1: cellular mecha-nisms and clinical relevance. Trends Pharmacol. Sci. (1994) 15:71–76.
   PubMed Web of Science ®Google Scholar
• GOULDING NJ, GUYRE PM: Ghicocorticoids, lipocortins and the immune response. curr. opin. Immunol. (1993) 5:108–113.
   PubMed Web of Science ®Google Scholar
• GOULDING NJ, GUYRE PM: Regulation of inflammation by lipocortin 1. Immunol. Today (1992) 13:295–297.
   PubMedGoogle Scholar
• DE CATERINA R, SICARI R, GIANNESSI D, PAGGIARO PL, PAOLETTI P, LAZZERINI G, BERNINI W, SOLITO E, PAR-ENTE L: Macrophage-specific eicosanoid synthesis inhi-bition and lipocortin-1 induction by glucocorticoids. J. Appl. Physiol. (1993) 75:2368–2375.
   PubMed Web of Science ®Google Scholar
• SIEBENLIST U, FRANZOSO G, BROWN K: Structure, regu-lation and function of NF-KB. Ann. Rev. Cell. Biol. (1994) 10:405–455.
   PubMedGoogle Scholar
• BAEUELE PA: The inducible transcription activator NE-icB: regulation by distinct protein subunits. Biochim. Biophys. Acta (1991) 1072:63–80.
   PubMed Web of Science ®Google Scholar
• GRILLI M, CHIU JJ-S, LENARDO MJ: NF-KB and Reb partici-pants in a multiform transcriptional regulatory system. Int. Rev. Cytol. (1993) 143:1.
   PubMed Web of Science ®Google Scholar
• BAEUELE PA, HENKEL T: Function and activation of NF-KB in the immune system. Ann. Rev. Immunol. (1994):141.
   PubMed Web of Science ®Google Scholar
• SCHEINMAN RI, COGSWELL PC, LOFQUIST AK, BALDWIN ASJR: Role of transcriptional activation of IxBa in me-diation of immunosupression by glucocorticoids. Sci-ence (1995) 270:283–286.
   PubMed Web of Science ®Google Scholar
• AUPHAN N, DIDONATO JA, ROSE 11E C, HELMBERG A, KARIN M: Imtnunosupression by glucocorticoids: inhi-bition of NF-KB activity through induction of NB syn-thesis. Science (1995) 270:286–290.
   PubMed Web of Science ®Google Scholar
• CRONSTEIN BN, KIMMEL SC, LEVIN RI, MARTINRIK F, WEISSMANN G: A mechanism for the anti-inflammatory effects of corticosteroids: The glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion mole-cule-1 and intracellular adhesion molecule 1. Proc. Natl. Acad. Sci. USA (1992) 89:9991–9995.
   PubMed Web of Science ®Google Scholar
• KAISER J, BICKEL CA, BOCHNER BS, SCHLEIMER RP: The effects of the potent glucocorticoid budesonide on adhesion of eosinophiLs to human vascular endothelial cells and on endothelial expression of adhesion mole-cules. J. Pharm. E. Ther. (1993) 267:245–249.
   PubMed Web of Science ®Google Scholar
• YAMAMOTO KR: Steroid receptor regulated transcrip-tion of specific genes and gene networks. Ann. Rev. Immunol. (1985) 19:209–252.
   Web of Science ®Google Scholar
• HSIN-FANG Y-Y, CHAMBARD J-C, SUN Y-L, SMEAL T, SCHMIDT TJ, DROUIN J, KARIN M: Transcriptional inter-ference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell (1990) 62:1205–1215.
   PubMed Web of Science ®Google Scholar
• JONAT C, RAHMSDORF HJ, PARK K-K, CATO ACB, GEBEL S, PONTA H, HERRLICH P: Antitumor promotion and anti-inflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell (1990) 62:1189–1204.
   PubMed Web of Science ®Google Scholar
• SCHULE R, RANGARAJAN P, KILEWER S, RANSONE LJ, BOLADO J, YANG N, VERMA IM, EVANS RM: Functional antagonism between oncoprotein c-Jun and the gluco-corticoid receptor. Cell (1990) 62:1217–1226.
   PubMed Web of Science ®Google Scholar
• NORTHROP JP, HO SN, CHEN L, THOMAS DJ, TIMMERMAN LA, NOLAN GP, ADMON A, CRAI3TREE GR: NF-AT compo-nents define a family of transcription factors targeted In T-cell activation. Nature (1994) 369:497–502.
   PubMed Web of Science ®Google Scholar
• RAO A: NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes. immu-ne/. Today (1994), 15:274–281.
   PubMed Web of Science ®Google Scholar
• PALIOGIANNI F, RAPTIS A, AHUJA SS, NAJJAR SM, BOUM-PAS DT: Negative transcriptional regulation of human interleukin-2 (IL-2) gene by glucocorticoids through Interference with nuclear transcription factors AP-1 and NF-AT. Clin. Invest. (1993) 91:1481–1489.
   Google Scholar
• COCKERLLL PN, SHANNON MF, BERT AG, RYAN GR, VADAS MA: The granulocyte-macrophage colony-stimulating factor/interleulcin-3 locus is regulated by an inducible cyclosporin A-sensitive enhancer. Proc. Natl. Acad. Sci. USA (1993) 90:2466–2470.
   PubMed Web of Science ®Google Scholar
• LEE HJ, MASUDA ES, ARAI N, ARAI K, YOKOTA T: Defini-tion of cis-regulatory elements of the mouse inter-leukin-5 gene promotor. J. Biol. Chem. (1995) 270:17451–17550.
   Google Scholar
• WU CY, FARGEAS C, NAKAJIMA T, DELESPESSE G: Ghico-corticoids suppress the production of interleukin 4 by human lymphocytes. Eur. J. Immunol. (1991) 21:2645–2647.
   PubMed Web of Science ®Google Scholar
• WU CY, SARFATI M, HEUSSER C, FOURNIER S, RUBIO-TRU-JILLO M, PELEMAN R, DELESPESSE G: Glucocorticoids increase the synthesis of inununog,lobulin E by inter-leukin-4 -stimulated human lymphocytes. J. Clin. Invest. (1991) 87:870–877.
   PubMed Web of Science ®Google Scholar
• ZIEG G, LACK G, HARBECK RJ, GELFAND EW, LEUNG DYM: In vivo effects of glucocorticoids on IgE production. J. Allergy Clin. Immunol. (1994) 94:222–230.
   PubMed Web of Science ®Google Scholar
• GAJEWSKI TF, SCHELL SR, FITCH FW: Evidence implicat-ing utilization of different T-cell receptor-associated signalling pathways by Till and TH2 clones.J. Immunol. (1990) 144:4110–4120.
   PubMed Web of Science ®Google Scholar
• ROONEY JW, HODGE MR, MCCAFFREY PG, RAO A, GLIM-CHER LH: A common factor regulates both Thl- and Th2-specific cytokine gene expression. EMBO J. (1994) 13:625–633.
   PubMed Web of Science ®Google Scholar
• ROONEY JW, HOEY T, GLIMCHER LH: Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene. Immunity (1995) 2:473–483.
   PubMed Web of Science ®Google Scholar
• ORTH DN, KOVACS WJ, DEBOLD CR: The adrenal cortex. In: Williams Textbook of Endocrinology, 8th Edition. Wilson JD, Foster DW (Eds.), WB Saunders Company, Philadelphia (1992).
   Google Scholar