11
Views
0
CrossRef citations to date
0
Altmetric
Miscellaneous

New prospects for cardiovascular gene therapy

Pages 1691-1696 | Published online: 23 Feb 2005

Bibliography

  • DENEFLE P, DUVERGER N, BRANELLEC D: Genetic thera-pies for vascular diseases and lipid disorders. Exp. Opin. Invest. Drugs (1995) 4 (11) :1129–1137.
  • RADE JJ, SCHULICK AH, VIRMANI R, DICHEK DA: Local adenoviral-mediated expression of recombinant hi-rudin reduces neointima formation after arterial in-jury. Nature Med. (1996) 2(3):293–298.
  • This is the first report of local delivery of the potent thrombininhibitor hirudin to a site of arterial injury. Secretion of hi-rudin following in vivoAd-mediated gene delivery to injured rat carotid arteries resulted in a 35% reduction in neointima formation. The data support the notion that local thrombin activity contributes to the arterial response to injury and thus constitutes a novel target for cardiovascular gene therapy of restenosis.
  • LEMARCHAND P, JONES M, YAMADA I, CRYSTAL RG: In vivo gene transfer and expression in normal uninjured blood vessels using replication-deficient recombinant adenovirus vectors. Circ. Res. (1993) 72 (5):1132–1138.
  • GUZMAN RJ, LEMARCHAND P, CRYSTAL RG, EPSTEIN SE, FINKEL T: Efficient and selective adenovirus-mediated gene transfer into vascular neointima. Circulation (1993) 88(6)2838–2848.
  • GUZMAN RJ, HIRSCHOWITZ EA, BRODY SL et al.: In vivo suppression of injury-induced vascular smooth muscle cell accumulation using adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene. Proc. Natl. Acad. Sci. USA (1994) 91 (22) :10732–10736.
  • STEG PG, FELDMAN LJ, SCOAZEC JY et al.: Arterial gene transfer to rabbit endothelial and smooth muscle cells using percutaneous delivery of an adenoviral vector. Circulation (1994) 90(4) :1648–1656.
  • FELDMAN LI STEG PG, ZHENG LP et al: Low-efficiency of percutaneous adenovirus-mediated arterial gene trans-fer in the atherosclerotic rabbit [see comments]. J. Clin. Invest. (1995) 95(6):2662–2671.
  • LANDAU C, PIRWITZ MJ, WILLARD MA et al.: Adenoviral mediated gene transfer to atherosclerotic arteries after balloon angioplasty. Am. Heart J. (1995) 129(6)1051–1057.
  • GUZMAN RJ, LEMARCHAND P, CRYSTAL RG, EPSTEIN SE,FINKEL T: Efficient gene transfer into myocardium by direct injection of adenovirus vectors. Circ. Res. (1993) 73 (6):1202–1207.
  • KASS-EISLER A, FALCK-PEDERSEN E, ALVIRA M et al: Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo. Proc. Natl. Acad. Sci. USA (1993) 90 (24) :11498–11502.
  • BARR E, CARROLL J, KALYNYCH AM et al.: Efficient catheter-mediated gene transfer into the heart using replication-defective adenovirus. Gene Ther. (1994) 1 (0 :51–58.
  • OHNO T, GORDON D, SAN H et al.: Gene therapy for vas-cular smooth muscle cell proliferation after arterial in-jury [see comments]. Science (1994) 265 (5173) 781–784.
  • CHANG MW, BARR E, SELTZER J et al. Cytostatic gene therapy for vascular proliferative disorders with a constitutively active form of the retinoblastoma gene prod-uct. Science (1995) 267(5197):518–522.
  • YANG Y, ERTL HC, WILSON JM: MHC class I-restricted cy-totoxic T lymphocytes to viral antigens destroy hepato-cytes in mice infected with El-deleted recombinant adenoviruses. Immunity (1994) 1 (5) 433–442.
  • YANG Y, LI Q, ERTL HC, WILSON JM: Cellular and humo-ral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant ad-enoviruses. j Virol. (1995) 69(4) :2004–2015.
  • SCHULICK AH, NEWMAN KD, VIRMANI R, DICHEK DA: In vivo gene transfer into injured carotid arteries. Optimi-zation and evaluation of acute toxicity. Circulation (1995) 91 (9) :2407–2414.
  • NEWMAN KD, DUNN PF, OWENS JAN et al: Adenovirus-mediated gene transfer into normal rabbit arteries re-sults in prolonged vascular cell activation, inflamma-tion, and neointimal hyperplasia. J. Clin. Invest. (1995) 96(6) 2955–2965.
  • SCHULICK AH, VASSALLI G, DUNN PF et al.: Established immunity precludes adenovirus-mediated gene trans-fer in rat carotid arteries. Potential for immunosup-pression and vector engineering to overcome barriers of immunity. J. Clin. Invest. (1997) 99 (2) :209–219.
  • This paper provides an evaluation of the use of Ad vectors ina clinically relevant context, and underlines the host immune response issues hampering their use in the cardiovascular system.
  • BRAMSON JL, GRAHAM FL, GAULDIE J: The use of adeno-viral vectors for gene therapy and gene transfer in vivo. Curr. Opin. Biotechnol (1995) 6(5):590–595.
  • ENGELHARDT JF, YE X, DORANZ B, WILSON JM: Ablation of E2A in recombinant adenoviruses improves trans-gene persistence and decreases inflammatory re-sponse in mouse liver. Proc. Natl. Acad. Sci. USA (1994) 91(13)6196–6200.
  • FANG B, WANG H, GORDON G et al: Lack of persistence of El-recombinant adenoviral vectors containing a temperature-sensitive E2A mutation in immunocom-petent mice and hemophilia B dogs. Gene Ther. (1996) 3(3):217–222.
  • BETT AJ, HADDARA W, PREVEC L, GRAHAM FL: An effi-cient and flexible system for construction of adenovi-rus vectors with insertions or deletions in early regions 1 and 3. Proc. Natl. Acad. Sci. USA (1994) 91 (19) :8802–8806.
  • GAO GP, YANG Y, WILSON JM: Biology of adenovirus vectors with El and E4 deletions for liver- directed gene therapy. J. Virol. (1996) 70(12):8934–8943.
  • FISHER KJ, CHOI H, BURDA J, CHEN SJ, WILSON JM: Re-combinant adenovirus deleted of all viral genes for gene therapy of cystic fibrosis. Virology (1996) 217(1):11–22.
  • KOCHANEK S, CLEMENS PR, MITANI K et al: A new adeno-viral vector: replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase. Proc. Natl. Acad. Sci. USA (1996) 93(12):5731–5736.
  • YEH P, DEDIEU JF, ORSINI C et al.: Efficient dual trans-complementation of adenovirus El and E4 regions from a 293-derived cell line expressing a minimal E4 functional unit. J. Virol. (1996) 70(1):559–565.
  • ZHOU H, O'NEAL W, MORRAL N, BEAUDET AL: Develop-ment of a complementing cell line and a system for construction of adenovirus vectors with El and E2a de-leted. J. Virol. (1996) 70(l0):7030–7038.
  • GNATENKO D, ARNOLD TE, ZOLOTUKHIN S et al.: Char-acterization of recombinant adeno-associated virus-2 as a vehicle for gene delivery and expression into vas-cular cells. J. Invest. Med. (1997) 45(2):87–98.
  • This paper describes gene transfer to HUVEC and to over90% of endothelial and SMC in rat carotid arteries using crude lysate preparations of AAV and rAAV vectors.
  • ARNOLD TE, GNATENKO D, BAHOU WF: In vivo gene transfer into rat arterial walls with novel adeno- associ-ated virus vectors. J. Vasc. Surg. (1997) 25(2):347–355.
  • This paper is a extension of the work presented in [28] by thesame group of investigators. They show that the percentage of cells in the vessel wall that contained the transgene de-creased over time, but gene expression remained detectable for up to 1 month in tissue lysates prepared from the arteries.
  • FISHER KJ, GAO GP, WEITZMAN MD et al.: Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis. J. Virol. (1996) 70(0:520–532.
  • FERRARI FK, SAMULSKI T, SHENK T, SAMULSKI RJ: Second-strand synthesis is a rate-limiting step for effi-cient transduction by recombinant adeno-associated virus vectors. J. Virol. (1996) 70(5):3227–3234.
  • LYNCH CM, HARA PS, LEONARD JC et al.: Adeno-associated virus vectors for vascular gene delivery. Circ. Res. (1997) 80(4):497–505.
  • This paper demonstrates rAAV-mediated transduction (i.e.,gene expression) in endothelial and SMC from a variety of species and in situ in the vessel wall of atherosclerotic cyno-molgus monkeys using purified vector. Interestingly, micro-vascular endothelial cells in the adventitia preferentially expressed the transgene and transduction was enhanced by balloon injury.
  • ROLLING F, NONG Z, PISVIN S, COLLEN D: Adenoassociated virus-mediated gene transfer into rat carotid arteries. Gene Ther. (1997) 4(750:761.
  • This paper describes transduction of medial and adventialcells in rat carotid arteries with higher efficiency transduction in injured vessels using purifed rAAV vector. Transgene ex-pression increased over time and persisted long-term as com-pared to Ad delivery.
  • KAPLITT MG, XIAO X, SAMULSKI RJ et al.: Long-term gene transfer in porcine myocardium after coronary infu-sion of an adeno-associated virus vector. Ann. Thorac. Surg. (1996) 62 (6): 1669–1676 .
  • This paper demonstrated long-term wide spread transduc-tion of cardiac myocytes after infusion of rAAV vectors in porcine coronary arteries without apparent toxicity or inflam-mation.
  • SIMONS M, EDELMAN ER, DEKEYSER JL, LANGER R, RO-SENBERG RD: Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo. Nature (1992) 359(639067–70.
  • BIRO S, FU YM, YU ZX, EPSTEIN SE: Inhibitory effects of antisense oligodeoxynucleotides targeting c-myc mRNA on smooth muscle cell proliferation and migra-tion. Proc. Natl. Acad. Sci. USA (1993) 90(2):654–658.
  • BENNETT MR, ANGLIN S, MCEWAN JR et al.: Inhibition of vascular smooth muscle cell proliferation in vitro and in vivo by c-myc antisense oligodeoxynucleotides. J. Clin. Invest. (1994) 93 (2) :820–828.
  • SHI Y, FARD A, GALEO A et al: Transcatheter delivery ofc-myc antisense oligomers reduces neointimal forma-tion in a porcine model of coronary artery balloon in-jury. Circulation (1994) 90(2)944–951.
  • VILLA AE, GUZMAN LA, POPTIC EJ et al: Effects of an-tisense c-myb oligonucleotides on vascular smooth muscle cell proliferation and response to vessel wall in-jury. Circ. Res. (1995) 76(4):505–513.
  • MORISHITA R, GIBBONS GH, ELLISON KE et al: Single in-traluminal delivery of antisense cdc2 kinase and prolif-erating- cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia. Proc. Natl. Acad. Sci. USA (1993) 90(18):8474–8478.
  • MANN MJ, GIBBONS GH, TSAO PS et al.: Cell cycle inhibi-tion preserves endothelial function in genetically engi-neered rabbit vein grafts. J. Clin. Invest. (1997) 99 (6):1295–1301.
  • SPEIR E, MODALI R, HUANG ES et al.: Potential role of hu-man cytomegalovirus and p53 interaction in coronary restenosis [see comments]. Science (1994) 265(5170)391–394.
  • MORISHITA R, GIBBONS GH, ELLISON KE et al: Intimalhyperplasia after vascular injury is inhibited by an-tisense cdk 2 kinase oligonucleotides. J. Clin. Invest. (1994) 93 (4) :1458–1464.
  • AUTIERI MV, YUE TL, FERSTEIN GZ, OHLSTEIN E: An-tisense oligonucleotides to the p65 subunit of NF-kB in-hibit human vascular smooth muscle cell adherence and proliferation and prevent neointima formation in rat carotid arteries. Biochem. Biophys. Res. Commun. (1995) 213(3):827–836.
  • YANG ZY, SIMARI RD, PERKINS ND et al: Role of the p21cyclin-dependent kinase inhibitor in limiting intimal cell proliferation in response to arterial injury. Proc. Natl. Acad. Sci. USA (1996) 93(15):7905–7910.
  • INDOLFI C, AVVEDIMENTO EV, RAPACCIUOLO A eta].: In-hibition of cellular ras prevents smooth muscle cell proliferation after vascular injury in vivo [see com-ments]. Nature Med. (1995) 1 (6) :541–545.
  • WEIR L, CHEN D, PASTORE C, ISNER JM, WALSH K: Expres-sion of gax, a growth arrest homeobox gene, is rapidly down-regulated in the rat carotid artery during the pro-liferative response to balloon injury. J. Biol. Chem. (1995) 270(105457–5461.
  • MORISHITA R, GIBBONS GH, HORIUCHI M et al: A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle prolifera-tion in vivo. Proc. Natl. Acad. Sci. USA (1995) 92(13):5855–5859.
  • VON DER LEYEN HE, GIBBONS GH, MORISHITA R et al: Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene. Proc. Natl. Acad. Sci. USA (1995) 92(4):1137–1141.
  • TAKESHITA S, TSURUMI Y, COUFFINAHL T et al.: Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo. Lab. Invest. (1996) 75 (4):487–501.
  • ISNER JM, PIECZEK A, SCHAINFELD R et al: Clinical evi-dence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb [see com-ments]. Lancet (1996) 348 (9024) :370–374.
  • GIORDANO FJ, PING P, MCKIRNAN MD eta].: Intracoro-nary gene transfer of fibroblast growth factor-5 in-creases blood flow and contractile function in an ischemic region of the heart [see comments]. Nat. Med. (1996) 2(5)534–539.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.