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Miscellaneous

Gene therapy for arthritis

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Pages 837-840 | Published online: 23 Feb 2005

Bibliography

  • EVANS CH, ROBBINS PD: Gene therapy as a treatment for rheumatoid arthritis. Exp. Opin. Invest. Drugs (1995) 4 (9) :843–852.
  • EVANS CH, ROBBINS PD: Pathways to gene therapy in rheumatoid arthritis. Curr. Opin. Rheumatol (1996) 8:230–234.
  • ROBBINS PD, EVANS CH: Prospects for treating autoim-mune and inflammatory diseases by gene therapy. Gene Ther. (1996) 3:187–189.
  • EVANS CH, GHIVIZZANI SC, KANG R, HERNDON JH,ROBBINS PD: Progress towards arthritis gene therapies. Rheum. Arthr. - ID Res. Alert (1997) 1:241–245.
  • KANG R, GHIVIZZANI SC, HERNDON JH, ROBBINS PD, EVANS CH: Gene therapy for arthritis: principles and clinical practice. Biochem. Soc. Trans. (1997) 25:533–537.
  • MAKAROV SS, BALDWIN AS: Local suppression of NF-id3 inhibits experimental arthritis in rats. Arthr. Rheum. (1996) 39(Suppl. S121). Abstract 563.
  • SHIOZAWA S, SHIMIZU K, TANAKA K, HINO K: Studies on the contribution of c-fos/ AP-1 to arthritic joint destruc-tion. J. Clin. Invest (1997) 99:1210-1216. An intriguing novel approach to treatment, using decoy oligonu-cleotides delivered intraperitoneally. These produce surprisingly good anti-arthritic effects.
  • DOHERTY PJ: Gene therapy and arthritis. J. Rheumatol. (1995) 22:1220–1223.
  • FIRESTEIN G: Invasive fibroblast-like synoviocytes in rheumatoid arthritis: passive responders or trans-formed aggressors? Arthr. Rheum. (1996) 39:1781–1790.
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  • NITA I, GHIVIZZANI SC, GALEA-LAURI J et af: Direct gene therapy to synovium: an evaluation of potential vectors in vitro and in vivo. Arthr. Rheum. (1996) 39:820–828.
  • SAWCHUK SJ, BOIVIN GP, DUWEL LE et al.: Anti-T cell receptor monoclonal antibody prolongs transgene ex-pression following adenovirus-mediated in vivo gene transfer to mouse. Hum. Gene Ther. (1996) 7:499–506.
  • GHIVIZZANI SC, LECHMAN ER, TIO C eta].: Direct retroviral mediated gene transfer to the synoviurn o f the rabbit knee: implications for arthritis gene therapy. Gene Ther. (In Press.) This is the first report using retroviruses to deliver genes tojoints by direct intra-articular injection.
  • TOMITA T, TOMITA N, NAKAMURA N eta].: In vivo direct gene transfer into joints using HVJ-liposome s [abstract]. Trans. Orthop. Res. Soc. (1995) 20:250.
  • OTANI K, NITA I, MACAULAY W et aL: Suppression of antigen-induced arthritis by gene therapy. J. Immunol (1996) 156:3558-3562. [16] and [17] are the first reports of suppression of an animal model of arthritis by gene therapy.
  • MAKAROV SS, OLSEN JC, JOHNSTON WN et al.: Suppression of experimental arthritis by gene transfer of inter-leukin-1 receptor antagonist cDNA. Proc. Natl. Acad. Sci. USA (1996) 93:402–406 and [17] are the first reports of suppression of an animal model of arthritis by gene therapy.
  • VAN DE LOO FAJ, BAKKER A, JOOSTEN L et al: Gene transfer of human IL-1Ra into the knee prevented arthritis in both knees and draining paw [abstract]. Arthr. Rheum. (1996) 39:578. Abstract 312.
  • MeLLER-LADNER U, ROBERTS CR, FRANKLIN BN et al:
  • ••Human IL-1Ra gene transfer into human synovial fi-broblasts is chondroprotective. J. Immunol. (1997) 158:3592–3598.
  • This uses a novel, in vivo, SCID mouse model to demonstrate a chondroprotective effect of gene transfer in human tissue.
  • MeLLER-LADNER U, FRANKLIN BN, ROBERTS CR et al.: Gene transfer of interleukin-10 into human synovial fibroblasts and implantation into SCID mouse [ab-stract]. Arthr. Rheum. (1996) 39:S160. Abstract 797.
  • GHIVIZZANI SC, KANG R, HATTON C et al.: In vivo delivery of genes encoding soluble receptors for IL-1 and TNF-a results in a synergistic therapeutic effect in antigen-induced arthritis in the rabbit knee. Arthr. Rheum. (1996) 39:S308. Abstract 1068.
  • EVANS CH, ROBBINS PD, GHIVIZZANI SC et al: Clinical trial to assess the safety, feasibility, and efficacy oftransferring a potentially anti-arthritic cytokine gene to human joints with rheumatoid arthritis. Hum. Gene Ther. (1996) 7:1261–1280.
  • This describes the first human arthritis gene therapy protocol in detail.
  • EVANS CH, ROBBINS PD: Possible orthopaedic applica-tions of gene therapy. J. Bone Joint Surg. (1995) 77A: 1103–1114.
  • GERICH TG, KANG R, FUF, ROBBINS PD, EVANS CH: Gene transfer to the rabbit patellar tendon: potential for genetic enhancement of tendon and ligament healing. Gene Ther. (1996) 3:1089–1093.
  • LOU J, MANSKI PR, AOKI M, JOYCE ME: Adenovirus-me-diated gene transfer into tendon and tendon sheath. J. Orthop. Res. (1996) 14:513–317.
  • NAKAMURA N, HORIBE S, MATSUMOTO N etaL: Transient introduction of a foreign gene into healing rat patellar ligament. J. Clin. Invest. (1996) 97:226–231.
  • KANG R, MARUI T, GHIVIZZANI SC eta].: Ex vivo gene transfer to chondrocytes in full-thickness articular car-tilage defects: a feasibility study. Osteoarth. Cart. (1997) 5:139–143.
  • This is the first report of gene transfer to cartilage in vivo.
  • PEREIRA RF, HALFORD KW, O'HARA MD eta].: Cultured adhered cells from marrow can serve as lorg-lasting precursor cells for bone, cartilage, and lung in irradi-ated mice. Proc. Natl. Acad. Sci. USA (1995) 92:4857–4861.
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  • PELLETIER JP, CARON J, EVANS CH eta].: In vivo suppression of early experimental osteoatthritis by IL-1Ra using gene therapy. Arthr. Rheum. (1997) 40:1012-1019. This is the first report of gene therapy for osteoarthritis.
  • GHIVIZZANI SC, KANG R, GEORGESCU HI et al: Constitutive intraarticular expression of human IL-1I3 following gene transfer to rabbit synoviurn produces all major pathologies of human rheumatoid arthritis. J. Immunol. (In Press.)

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