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Review

Transgenic animals as drug factories: a new source of recombinant protein therapeutics

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Pages 1683-1690 | Published online: 23 Feb 2005

Bibliography

  • LUBON H, PALEYANDA RK, VELANDER WH, DROHAN WN: Blood proteins from transgenic animal bioreac-tors. Transfusion Med. Rev. (1996) 10:131–143.
  • NARANG H: Origin and implications of bovine spongi-form encephalopathy. Proc. Soc. Exp. Biol. Med. (1996) 211:306–322.
  • KOSHIHARA K, QIAN J, LOLLAR P, HOYER, LW: Im-munoblot cross-reactivity of factor VIII inhibitors with porcine factor VIII. Blood (1995) 86(6):2183–2190.
  • LOLLAR P: Analysis of factor VIII inhibitors using hy-brid human/porcine factor VIII. Thromb. Haemost. (1997) 78(1):647–651.
  • GRINNELL BW, WALLS JD, GERLITZ B et al.: Native and modified recombinant human protein c: function, se-cretion, and post-translational modifications. In: Pro-tein C and Related Anticoagulants. Bruley DF, Drohan WN (Eds.), Gulf Publishing Co., Houston, TX (1990):29–63.
  • PITTMAN DD, TOMKINSON KN, KAUFMAN RJ: Post-translational requirements for functional factor V and factor VIII secretion in mammalian cells. J. Biol. Chem. (1994) 269(25):17329–17337.
  • MCCLURE DB, WALLS JD, GRINNELL BW: Post-translational processing events in the secretion path-way of human protein C, a complex vitamin K-dependent antithrombotic factor. J. Biol. Chem. (1992) 267:19710–19717.
  • YAN SCB, GRINNELL BW, WOLD F: Post-translationalmodifications of proteins: some problems left to solve. Trends Biochem. Sci. (1989) 14:264–268.
  • PITTMAN DD, KAUFMAN RJ: Structure-function rela-tionships of factor VIII elucidated through recombi-nant DNA technology. Thromb. Haem. (1989) 61 (2):161–165.
  • KAUFMAN RJ, WASLEY LC, FURIE BC, FURIE B, SHOE-MAKER CB: Expression, purification, and characteriza-tion of recombinant gamma-carboxylated factor IX synthesized in Chinese hamster ovary cells. J. Biol. Chem. (1986) 261:9622–9628.
  • MORCOL T, AKERS RM, JOHNSON JL et al.: The porcinemammary gland as a bioreactor for complex proteins. Ann. NY Acad. Sci. (1994) 721:218–233.
  • ANONYMOUS: Points to consider in the manufactureand testing of therapeutic products for human use de-rived from transgenic animals. Docket No. 95D-0131. US Food and Drug Administration, Center for Biologics Evalua-tion and Research. (1995).
  • ANONYMOUS: Points to consider in the manufactureand testing of monoclonal antibody products for hu-man use. Docket No. 94D-0259. US Department of Health and Human Services, Food and Drug Administration, Center for Biologics Evaluation and Research. (1997).
  • ADAMSON R: Design and operation of a recombinantmammalian cell manufacturing process for rEVIII. Ann. Hematol. (1994) 68 (Suppl. 3):S9–S14.
  • ANONYMOUS: Draft public health service guideline oninfectious disease issues in xenotransplantation. Fed-eral Register (1996) 61(185):49919–49932.
  • VAN COTT KE, LUBON H, RUSSELL CG et al.: Phenotypicand genotypic stability of multiple lines of transgenic pigs expressing recombinant human protein C. Trans-genic Res. (1997) 6:203–212.
  • CARVER AS, DALRYMPLE MA, WRIGHT G, COTTOM DS etal: Transgenic livestock as bioreactors: stable expres-sion of human alpha-1-antitrypsin by a flock of sheep. Bio/7'echnology (1993) 11:1263–1270.
  • CIBELLI JB, STICE SL, GOLUEKE PJ et al.: Cloned trans-genic calves produced from nonquiescent fetal fibro-blasts. Science (1998) 280:1256–1258.
  • BISCHOFF R, DEGRYSE E, PERRAUD F et al.: A 17.6 kbpregion located upstream of the rabbit WAP gene di-rects high level expression of a functional human pro-tein variant in transgenic mouse milk. FEBS Let. (1992) 305:265–268.
  • REDDY VB, VITALE J, WET C et al.: Expression of humangrowth hormone in the milk of transgenic mice. Ani-mal Biotech. (1991) 2:15–29.
  • JHAPPAN C, GEISER AG, KORDON EC et al: Targeting ex-pression of a transforming growth factor 131 transgene to the pregnant mammary gland inhibits alveolar de-velopment and lactation. EMBO J (1993) 12: 1835-1845.
  • ZIOMEK CA: Minimization of viral contamination in human pharmaceuticals produced in the milk of transgenic goats. Dev. Biol. Stand. (1996) 88:265–268.
  • BARRETT PN, MEYER H, WACHTEL I, EIBL J, DORNER F: Inactivation of hepatitis A virus in plasma products by vapor heating. Transfusion (1997) 37:215–220.
  • DODD RY: Infectious complications of blood transfu-sion. Hem. Oncol. Ann. (1994) 2:280–287.
  • BARROWCLIFFE TW: Viral inactivation vs. biological ac-tivity. In: Virological Safety Aspects of Plasma Derivatives. Brown F (Ed.), Dev. Biol. Stand. (1993) 81:125–135.
  • VELANDER WH, MORCOL T, CLARK DB, GEE G, DROHANWN: Technological challenges for large-scale purifica-tion of protein C. In: Protein C and Related Anticoagu-lants. Bruley DF, Drohan WN (Eds.), Gulf Publishing Com-pany, Houston, TX (1990):11–27.
  • KOZAK RW, GOLKER CF, STADLER P: Transmissible spongiform encephalopathies (TSE): minimizing the risk of transmission by biological/biopharmaceutical products: an industry perspective. Dev. Biol. Stand. (1996) 88:257–264.
  • ROSEN JM, LI S, RAUGHT B, HADSELL D: The mammary gland as a bioreactor: factors regulating the efficient expression of milk protein-based transgenes. Am. J. Clin. Nutr. (1996) 63(4):627S-632S.
  • VELANDER WH, JOHNSON JL, PAGE RL et al.: High-level expression of a heterologous protein in the milk of transgenic swine using the cDNA encoding human protein C. Proc. Natl. Acad. Sci. USA. (1992)0 89:12003–12007.
  • VAN COTT KE, WILLIAMS BL, GWAZDAUSKAS FC et al:Affinity purification of biologically active and inactive forms of recombinant human protein C produced in the porcine mammary gland. J. Mol. Recog. (1997) 9:407–414.
  • VAN COTT KE: Upstream and downstream issues in the production of recombinant vitamin K-dependent pro-teins in the milk of transgenic livestock. PhD Disserta-tion, Virginia Tech. (1996).
  • LEE, TK, DROHAN WN, LUBON H: Proteolytic process-ing of human protein C in swine mammary gland. J. Biochem. (1995) 118:81–87.
  • BUTLER SP, VAN COTT KE, SUBRUMANIAN A, GWAZDAUSKAS FC, VELANDER WH: Current progress in the production of recombinant human fibrinogen in the milk of transgenic animals. Thromb. HaemosL (1997) 78(1):537–542.
  • PALEYANDA RK, VELANDER WH, LEE TK et al.: Trans-genic pigs produce functional human factor VIII in milk. Nature Biotechnol. (1997) 15:971–975.
  • DREWS R, PALEYANDA RK, LEE TK et al.: Proteolytic maturation of protein C upon engineering the mouse mammary gland to express furin. Proc. Natl. Acad. Sci. USA (1995) 92:10462–10466.
  • KERR DE, HANG F, BONDIOLI KR et al.: The bladder as abioreactor: urothelium production and secretion of growth hormone into urine. Nature Biotechnol. (1998) 16:75–79.
  • MEADE H, ZIOMEK C: Urine as a substitute for milk? Na-ture Biotechnol. (1998) 16:21–22.
  • LO D, PURSEL V, LINTON PJ et al: Expression of mouse IgA by transgenic mice, pigs and sheep. Eur. J. Immunol. (1991) 21:1001–1006.
  • SWANSON ME, MARTIN MJ, O'DONNELL K et al: Produc-tion of functional human hemoglobin in transgenic swine. Bio/7'echnology (1992) 10:557–559.
  • ABEYDEERA LR, WANG WH, CANTLEY TC, RIEKE A, DAY BN: Coculture with follicular shell pieces can enhance the developmental competence of pig oocytes after in vitro fertilization: relevance to intracellular glu-tathione. Biol. Reprod. (1998) 58:213–218.
  • NIEMANN H: Transgenic farm animals get off the ground. Transgenic Res. (1998) 7:73–75.
  • SHIM H, GUTIERREZ-ADAN A, CHEN LR et al: Isolation ofpluripotent stem cells from cultured porcine primor-dial germ cells. Biol. Reprod. (1997) 57(5):1089–1095.
  • YULL F, BINAS B, HAROLD G, WALLACE R, CLARK AJ: Transgene rescue in the mammary gland is associated with transcription but does not require translation of BLG transgenes. Transgenic Res. (1997) 6:11–17.
  • DAWSON M, WELLS GAH, PARKER BNJ, SCOTT AC: Trans-mission studies of BSE in cattle, hamsters, pigs and do-mestic fowl. In: Subacute Spongiform Encephalopathies. Bradley R, Savey M, Marchant B (Eds.), Kluwer Academic Publishers, Dordrecht, The Netherlands (1990:25–32.
  • DAWSON M, WELLS GAH, PARKER BNJ, SCOTT AC: Pri-mary parenteral transmission of bovine spongiform encephalopathy to the pig. Vet. Record (1990) 126:338.
  • GROET S, MEADE H: Antithrombin III - clinical develop-ment results and future plans. IBC's Third Annual Inter-national Symposium on Producing the Next Generation of Therapeutics: Exploiting Transgenic Technologies. West Palm Beach, FL, (Feb 5–6, 1997).
  • DENMAN J, HAYES M, O'DAY C eta]: Transgenic expres-sion of a variant of human tissue-type plasminogen ac-tivator in goat milk: purification and characterization of the recombinant enzyme. Bio/7'echnology (1991) 9:839–843.
  • CHANG J, JIN J, LOLLAR P et al.: Changing residue 338 inhuman factor IX from arginine to alanine causes an in-crease in catalytic activity. J. Biol. Chem. (1998) 273(20)12089–12094.

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