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Review

The prospects for in utero stem cell transplantation

Pages 1819-1824 | Published online: 23 Feb 2005

Bibliography

  • OWEN RD: Immunogenetic consequences of vascular anastomoses between bovine twins. Science (1945) 102:400.
  • •Seminal paper that is often cited as one of the basic tenets of immunology.
  • KLING J: Gene transfer to the mothers of all cells. Na- ture Biotechnol (1996) 14:269.
  • ••Good review article, indicating what problems lie ahead forgene therapy.
  • JONES DRE, BUT TH, ANDERSON EM et al.: In utero hae- matopoietic stem cell transplantation: current perspectives and future potential. Bone Marrow Trans-plant. (1996) 18:831–837.
  • ••Thorough review of the state of the art for in uterotransplan-tation. All cases recorded by mid-1996 are reported in this article and comment provided on the outcomes in each dis-ease category.
  • JONES DRE, BUT TH: Fetal therapy: prospects for trans- plantation early in pregnancy. Mol. Med. Today (1998) 4:10–11.
  • •Report of the Second International Symposium on In Utero Transplantation and Gene Therapy, held in Nottingham, UK, in September 1997. An up-to-date account of cases and outcomes and insights into current research in this area.
  • JONES DRE, ANDERSON EM, EVANS AA, LIU DTY: Long-term storage of human fetal hematopoietic progenitor cells and their subsequent reconstitution - implica-tions for in utero transplantation. Bone Marrow Trans-plant. (1995) 16:297–301.
  • ZANJANI ED, ASCENSAO JL, TAVASSOLI M: Liver-derived fetal hematopoietic stem cells selectively and prefer-entially home to the fetal bone marrow. Blood (1993) 81:399–404.
  • •Seminal paper showing the route of engraftment of cells traansplanted in utero. Uses an animal model.
  • FLAKE AW, PUCK JM, ALMEIDA-PORADA G et al.: Treat- ment of X-linked severe combined immunodeficiency by in utero transplantation of paternal bone marrow. New Engl. J. Med. (1996) 335:1806–1810.
  • •First report of 100% success using JUT for SCID.
  • LANFRANCHI AA, NEVA K, TETTONI R: In utero trans- plantations (IUT) of parental CD34+ cells in three pa-tients affected by primary immunodeficiencies. Bone Marrow Transplant. (1998) 21:S127.
  • •Three cases of SCID transplanted in utero, again reporting success.
  • ANDREANI M, MANNA M, LUCARELLI G et al: Persistence of mixed chimerism in patients transplanted for the treatment of thalassemia. Blood (1996) 87:3494–3499.
  • ANDERSON EM, JONES DRE, LIU DTY, EVANS AA: Gesta-tional age and cell viability determine the effect of fro-zen storage on human fetal hematopoietic progenitor cell preparations. Fetal Diagn. Ther. (1996) 11:427–432.
  • BREEMS DA, BLOKLAND EAW, SIEBEL KE et al.: Stroma-contact prevents loss of hematopoietic stem cell qual-ity during ex vivo expansion of CD34(+) mobilized pe-ripheral blood stem cells. Blood (1998) 91:111–117.
  • •Important paper discussing the impact of ex vivo expansion protocols on the quality of stem cells (and by implication, the effects this will have on engraftment after a transplant procedure).
  • SHIMIZU Y, OGAWA M, KOBAYASHI M, ALMEIDA-PORADA G, ZANJANI ED: Engraftment of cultured hu-man hematopoietic cells in sheep. Blood (1998) 91:3688–3692.
  • GLUCKMAN E, ROCHA V, BOYER A et al.: Outcome ofcord-blood transplantation from related and unre-lated donors. New Engl. J. Med. (1997) 337:373–381.
  • ZANJANI ED, ALMEIDA-PORADA G, LIVINGSTON AG, FLAKE AW, OGAWA M: Human bone marrow CD34(-) cells engraft in vivo and undergo multilineage expression that includes giving rise to CD34(+) cells. Exp. Hematol. (1998) 26:353–360.
  • WENGLER GS, LANFRANCHI A, FRUSCA T: In utero trans-plantation of parental CD34 haemaopoietic progeni-tor cells in a patient with X-linked severe combined immunodeficiency (SCIDX0. Lancet (1996) 348:1484–1487.
  • •A successful foetal SCID patient transplanted in utero.
  • FLAKE AW, ZANJANI ED: In utero hematopoietic stem cell transplantation. A status report. J. Am. Med. Assoc. (1997) 278:932–937.
  • •A good review outlining the advantages and drawbacks of the various in utero protocols.
  • ZANJANI ED, ASCENSAO JL, HARRISON MR, TAVASSOLIM: Ex vivo incubation with growth factors enhances the engraftment of fetal hematopoietic cells trans-planted in sheep fetuses. Blood (1992) 79:3045–3049.
  • FLAKE AW, ZANJANI ED: In utero transplantation of he-matopoietic stem cells. Grit. Rev. Oncol. Hematol. (1993) 15:35–48.
  • MONNI G, IBBA RM, ZOPPI MA, FLORIS M: In utero stemcell transplantation. Croat Med. J. (1998) 39:220–223.
  • MYCHALISKA GB, MUENCH MO, RICE HE et al: The biol-ogy and ethics of banking fetal liver hematopoietic stem cells for in utero transplantation. J. Pediatr. Surg. (1998) 33:394–399.
  • JONES DRE, LIU DTY, ANDERSON EM, LAMMING GE: Transplantation of human fetal liver-derived haema-topoietic stem cells into sheep, in utero. In: Correction of Genetic Disorders by Transplantation (Vol. IV). Ringdon O, Hobbs JR, Steward CG (Eds.), COGENT Trust, London. (1997) :130–136.
  • WYNN RF, CROSS MA, HATTON C et al.: Accelerated telo-mere shortening in young recipients of allogeneic bone-marrow transplants. Lancet (1998) 351:178–181.
  • ••Important data relating to the fate of stem cells after trans-plantation. Accelerated proliferation of these cells in the re-cipient could lead to their premature demise.
  • SHAY JW: Accelerated telomere shortening in bone marrow recipients. Lancet (1998) 351:153–154.
  • ••Good review of the telomere theory: reasons why stem cellsare restricted to a finite number of cell divisions and how this process could be accelerated in transplant recipients.
  • LANSDORP PM: Telomere length and proliferation po- tential of hematopoietic stem cells. J. Cell Sci. (1995) 108:1–6.
  • ••Excellent report on telomeres in stem cells from varioussources and the implications for transplantation. The supe-rior qualities of foetal stem cells are clearly shown.

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