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Miscellaneous

Mechanisms of action of DNA vaccines

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Pages 1987-1995 | Published online: 23 Feb 2005

Bibliography

  • BENVENISTY N, RESHEF L: Direct introduction of genes into rats and expression of the genes. Proc. Natl. Acad. ScL USA (1986) 83:9551–9555.
  • WOLFF JA, MALONE RW, WILLIAMS P et al.: Direct gene transfer into mouse muscle in vivo. Science (1990) 247:1465–1468.
  • TANG D-C, DEVIT M, JOHNSTON SA: Genetic immunisa-tion is a simple method for eliciting an immune re-sponse. Nature (1992) 356:152–154.
  • ULMER JB, DONNELLY JJ, PARKER SE et al.: Heterologous protection against influenza by injection of DNA en-coding a viral protein. Science (1993) 259:1745–1749.
  • DONNELLY JJ, ULMER JB, SHIVER JW, LIU MA: DNA vac-cines. Ann. Rev. Immunol. (1997) 15:617–648.
  • YORK IA, ROCK KL: Antigen processing and presenta-tion by the class I major histocompatibility complex. Ann. Rev. Immunol. (1996) 14:369–396.
  • DAVIS HL, DEMENEIX BA, QUANTIN B, COULOMBE J,WHALEN RG: Plasmid DNA is superior to viral vectors for direct gene transfer into adult mouse skeletal mus-cle. Hum. Gene Ther. (1993) 4:733–740.
  • MANTHORPE M, CORNEFERT-JENSEN F, HARTIKKA J etal.: Gene therapy by intramuscular injection of plas-mid DNA: studies on firefly luciferase. Gene expres-sion in mice. Hum. Gene Ther. (1993) 4:419–431.
  • TIGHE H, CORR M, ROMAN M, RAZ E: Gene vaccination: plasmid DNA is more than just a blueprint. Immunol. Today (1998) 19:89–97.
  • ROUSE RJ, MAIR SK, LYDY SL, BOWEN JC, ROUSE BT: In-duction in vitro of primary cytotoxic T-lymphocyte re-sponses with DNA encoding herpes simplex virus proteins. J. Virol. (1994) 68:5685–5689.
  • GRABBE S, BEISSERT S, SCHWARTZ T, GRANSTEIN RD: Dendritic cells as initiators of tumor immune re-sponses: a possible strategy for tumor immunother-apy? Immunol. Today (1995) 16:117–121.
  • ALIJAGIC S, MOLLER P, ARTUC M et al.: Dendritic cells generated from peripheral blood transfected with hu-man tyrosinase induce specific T cell activation. Eur. J. Immunol. (1995) 25:3100–3107.
  • BOCZKOWSKI D, NAIR SK, SNYDER D, GILBOA E: Den-dritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo. J. Exp. Med. (1996) 184:465–472.
  • BROSSART P, BEVAN MJ: Presentation of exogenousprotein antigens on major histocompatibility com-plex class I molecules by dendritic cells: pathway of presentation and regulation by cytokines. Blood (1997) 90:1594–1599.
  • MANICKAN E, KANANGAT S, ROUSE RJ, YU Z, ROUSE BT:Enhancement of immune response to naked DNA vac-cine by immunization with transfected dendritic cells. J. Leukocyte Biol. (1997) 61:125–132.
  • YOUNG JW, INABA K: Dendritic cells as adjuvants for class I major histocompatibility complex-restricted antitumor immunity. J. Exp. Med. (1996) 183:7–11.
  • REEVES ME, ROYAL RE, LAM JS, ROSENBERG SA, HWU P: Retroviral transduction of human dendritic cells with a tumor-associated antigen gene. Cancer Res. (1996) 56:5672–5677.
  • DOE B, SELBY M, BARNETT S, BAENZIGER J, WALKER CM: Induction of cytotoxic T lymphocytes by intramuscu-lar immunization with plasmid DNA is facilitated by bone marrow-derived cells. Proc. Natl. Acad. ScL USA (1996) 93:8578–8583.
  • CORR M, LEE DJ, CARSON DA, TIGHE H: Gene vaccina-tion with naked plasmid DNA: mechanism of CTL priming. J. Exp. Med. (1996) 184:1555–1560.
  • IWASAKI A, TORRES CA, OHASHI PS, ROBINSON HL, BAR-BER BH: The dominant role of bone marrow-derived cells in CTL induction following plasmid DNA immuni-zation at different sites. J. Immunol. (1997) 159:11–14.
  • FU TM, ULMER JB, CAULFIELD MJ et al.: Priming of cyto-toxic T lymphocytes by DNA vaccines: requirement for professional antigen presenting cells and evidence for antigen transfer from myocytes. Mol. Medicine (1997) 3:362–371.
  • LEW D, PARKER SE, LATIMER T et al.: Cancer gene ther-apy using plasmid DNA: pharmacokinetic study of DNA following injection in mice. Hum. Gene Ther. (1995) 6:553–64.
  • FYNAN EF, WEBSTER RG, FULLER DH et al: DNA vac-cines: protective immunizations by parenteral, muco-sal, and gene-gun inoculations. Proc. Natl. Acad. Sci. USA (1993) 90:11478–11482.
  • CONDON C, WATKINS SC, CELLUZZI CM THOMPSON K,FALO LD, Jr.: DNA-based immunization by in vivo trans-fection of dendritic cells. Nature Med. (1996) 2:1122–1128.
  • KLINMAN DM, SECHLER JM, CONOVER J, GU M, ROSEN-BERG AS: Contribution of cells at the site of DNA vacci-nation to the generation of antigen-specific immunity and memory. J. Immunol. (1998) 160:2388–2392.
  • KUNDIG TM, BACHMANN MF, DIPAOLO C et al.: Fibro-blasts as efficient antigen-presenting cells in lym-phoid organs. Science (1995) 268:1343–1347.
  • BARRY MA, JOHNSTON SA: Biological features of ge-netic immunization. Vaccine (1997) 15:788–791.
  • TORRES CA, IWASAKI A, BARBER BH, ROBINSON HL: Dif-ferential dependence on target site tissue for gene gun and intramuscular DNA immunizations. J. Immunol (1997) 158:4529–4532.
  • CHATTERGOON MA, ROBINSON TM, BOYER JD, WEINERDB: Specific immune induction following DNA-based immunization through in vivo transfection and activa-tion of macrophages/antigen-presenting cells. J. Im-munol. (1998) 160:5707–5718.
  • CASARES S, INABA K, BRUMEANU TD, STEINMAN RM, BONA CA: Antigen presentation by dendritic cells after immunization with DNA encoding a major histocom-patibility complex class 11-restricted viral epitope. Exp. Med. (1997) 186:1481–1486.
  • HUANG AY, GOLUMBEK P, AHMADZADEH M et al.: Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens. Science (1994) 264:961–965.
  • PARDOLL DM, BECKERLEG AM: Exposing the immunol-ogy of naked DNA vaccines. Immunity (1995) 3:165–169.
  • ALBERT ML, SAUTER B, BHARDWAJ N: Dendritic cells ac-quire antigen from apoptotic cells and induce class I-restricted CTLs. Nature (1998) 392:86–89.
  • RODRIGUEZ F, AN LL, HARKINS S, ZHANG J et al.: DNA immunization with minigenes: low frequency of mem-ory cytotoxic T lymphocytes and inefficient antiviral protection are rectified by ubiquitination. j Vim]. (1998) 72:5174–5181.
  • TOBERY TW, SILICIANO RF: Targeting of HIV-1 antigens for rapid intracellular degradation enhances cytotoxic T lymphocyte (CTL) recognition and the induction of de novo CTL responses in vivo after immunization. J. Exp. Med. (1997) 185:909–920.
  • RODRIGUEZ F, SHANG J, WHITTON JL: DNA immuniza-tion: ubiquitination of a viral protein enhances cyto-toxic T-lymphocyte induction and antiviral protection but abrogates antibody induction. J. Vim]. (1997) 71:8497–8503.
  • WU Y, KIPPS TJ: Deoxyribonucleic acid vaccines encod-ing antigens with rapid proteasome-dependent degra-dation are highly efficient inducers of cytolytic T lymphocytes. J. Immunol. (1997) 159:6037–6043.
  • BOYLE JS, KONIARAS C, LEW AM: Influence of cellular location of expressed antigen on the efficacy of DNA vaccination: cytotoxic T lymphocyte and antibody re-sponses are suboptimal when antigen is cytoplasmic after intramuscular DNA immunization. Int. Immunol. (1997) 9:1897–1906.
  • BOYLE JS, BRADY JL, LEW AM: Enhanced responses to a DNA vaccine encoding a fusion antigen that is directed to sites of immune induction. Nature (1998) 392:408–411.
  • SRIVASTAVA PK, UDONO H, BLACHERE NE, LI Z: Heatshock proteins transfer peptides during antigen proc-essing and CTL priming. Immunogenetics (1994) 39:93–98.
  • ULMER JB, DECK RR, DEWITT CM et al: Generation ofMHC class I-restricted cytotoxic T-lymphocytes by ex-pression of a viral protein in muscle cells. Antigen presentation by non-muscle cells. Immunology (1996) 89:59–67.
  • GOEBELS N, MICHAELIS D, WEKERLE H, HOHLFELD R:Human myoblasts as antigen-presenting cells. J. Immu-nol. (1992) 149:661–667.
  • HORSPOOL JH, PERRIN PJ, WOODCOCK JB et al: Nucleicacid vaccine-induced immune responses require CD28 costimulation are regulated by CTLA4. J. Immunol. (1998) 160:2706–2714.
  • KIM JJ, BAGARAZZI ML, TRIVEDI N, HU Y et al.: Engineer-ing of in vivo immune responses to DNA immuniza-tion via codelivery of costimulatory molecule genes. Nature Biotechnol. (1997) 15:641–646.
  • PASQUINI S, XIANG Z, WANG Y et al: Cytokines and costimulatory molecules as genetic adjuvants. Immu-nol. Cell Biol. (1997) 75:397–401.
  • CONRY RM, WIDERA G, LOBUGLIO AF et al.: Selected strategies to augment polynucleotide immunization. Gene Therapy (1996) 3:67–74.
  • BUELER H, MULLIGAN RC: Induction of antigen-specific tumor immunity by genetic and cellular vaccines against MAGE: enhanced tumor protection by coex-pression of granulocyte-macrophage colony-stimulating factor and B7-1. Mol. Medicine (1996) 2:545–555.
  • CORR M, TIGHE H, LEE D et al: Costimulation providedby DNA immunization enhances antitumor immunity. Immunol. (1997) 159:4999–5004.
  • IWASAKI A, STIERNHOLM BJ, CHAN AK, BERINSTEIN NL,BARBER BH: Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines. j Immunol. (1997) 158:4591–4601.
  • TSUJI T, HAMAJIMA K, ISHII N et al: Immunomodulatory effects of a plasmid expressing B7-2 on human immu-nodeficiency virus-l-specific cell-mediated immunity induced by a plasmid encoding the viral antigen. Eur. J. Immunol. (1997) 27:782–787.
  • TAYLOR SF, ASKONAS BA: Influenza nucleoprotein-specific cytotoxic T cell clones are protective in vivo. Immunology (1998) 58:417–420.
  • TITE JP, HUGHES-JENKINS CM et al: Anti-viral immunity inducted by recombinant nucleoprotein of influenza A virus. II. Protection from influenza infection and mechanism of protection. Immunol. (1990) 71:202–207.
  • TITE JP, GAO XM, HUGHES-JENKINS CM, LIPSCOMBE D et al.: Anti-viral immunity inducted by recombinant nu-cleoprotein of influenza A virus. III. Delivery of recom-binant nucleoprotein to the immune system using attenuated Salmonella typhimurium as a live carrier. Immunology (1990) 70:540–546.
  • TOPHAM DJ, DOHERTY PC: Clearance of an influenza AVirus by CD4+ T cells is inefficient in the absence of B cells. J. Vim]. (1998) 72:882–885.
  • ULMER JB, FU T-M, DECK RR et al.: Protective CD4+ andCD8+ T cells against influenza induced by vaccination with nucleoprotein DNA. J. Virol. (1998) 72:5648–5653.
  • CHEN Y, WEBSTER RG, WOODLAND DL: Induction ofCD8+ T cell responses to dominant and subdominant epitopes and protective immunity to Sendai virus in-fection by DNA vaccination. J. Immunol. (1998) 160:2425–2432.
  • DOOLAN DL, SEDEGAH M, HEDSTROM RC et al: Circum-venting genetic restriction of protection against ma-laria with multigene DNA immunization: CD8±cell-, interferon gamma-, and nitric oxide-dependent im-munity. J. Exp. Med. (1996) 183:1739–1746.
  • ZIMMERMAN C, SEILER PI, ZINKERNAGEL RM: Antiviralimmune responses in CTLA4 transgenic mice. J. Vim]. (1997) 71:1802–1807.
  • JONES DH, CORRIS S, MCDONALD, CLEGG JCS, FARRARGH: Poly(m-lactide-coglycolide)-encapsulated plas-mid DNA elicits systemic and musosal antibody re-sponses to encoded protein after oral administration. Vaccine (1997) 15:814–817.
  • KLAVINSKIS LS, GAOL, BARNFIELD C, LEHNER T, PARKERS: Mucosal immunization with DNA-liposome com-plexes. Vaccine (1997) 15:818–820.
  • CHEN SC, JONES DJ, FYNAN EH et al: Protective immu-nity induced by oral immunization with a rotavirus DNA vaccine encapsulated in microparticles. J. Virol. (1998) 72:5757–5761.
  • TOKUNAGA T, YANO O, KURAMOTO E et al.: Syntheticoligonucleotides with particular base sequences form the cDNA encoding proteins of Mycobacterium bovis BCG induce interferons and activate natural killer cells. Microbiol Immunol. (1992) 36:55–66.
  • MESSINA JP, GILKESON GS, PISETSKY DS: Stimulation ofin vitro murine lymphocyte proliferation by bacterial DNA. J. Immunol. (1991) 147:1759–1764.
  • KRIEG AM, YI AK, MATSON S et al: CpG motifs in bacte-rial DNA trigger direct B-cell activation. Nature (1995) 374:546–549.
  • SUN S, BEARD C, JAENISCH R, JONES P, SPRENT J: Mito-genicity of DNA from different organisms for murine B cells. J. Immunol. (1997) 159:3119–3125.
  • SUNS, KISHIMOTO H, SPRENT J: DNA as an adjuvant: ca-pacity of insect DNA and synthetic oligonucleotides to augment T cell responses to specific antigen. J. Exp. Med. (1998) 187:1145–1150.
  • KRIEG AM, YI AE, SCHORR J, DAVIS HL: The role of CpGdinucleotides in DNA vaccines. Trends Microbiol (1998) 6:23–27.
  • YI AK, KLINMAN DM, MARTIN TL, MATSON S, KRIEG AM:Rapid immune activation by CpG motifs in bacterial DNA. Systemic induction of IL-6 transcription through an antioxidant-sensitive pathway. J. Immunol. (1996) 157:5394–5402.
  • STACEY KJ, SWEET MJ, HUME DA: Macrophages ingestand are activated by bacterial DNA. J. Immunol. (1996) 157:2116–2122.
  • DAVIS HL, WEERANTA R, WALDSCHMIDT TJ et al CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface anti-gen. J. Immunol. (1998) 160:870–876.
  • ROMAN M, MARTIN-OROZCO E, GOODMAN JS et al: Im- munostimulatory DNA sequences function as T helper-l-promoting adjuvants. Natl. Med. (1997) 3:849–854.
  • LIPFORD GB, BAUER M, BLANK C et al: CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vac-cine adjuvants. Eur. j Immunol. (1997) 27:2340–2344.
  • KLINE JN, WALDSCHMIDT TJ, BUSINGA TR et al: Modula-tion of airway inflammation by CpG oligodeoxynu-cleotides in a murine model of asthma. J. Immunol (1998) 160:2555–2559.
  • LECLERC C, DERIAUD E, ROJAS M, WHALEN RG: The pref-erential induction of a Thl immune response by DNA-based immunization is mediated by the immunostimu-latory effect of plasmid DNA. Cell. Immunol. (1997) 179:97–106.
  • WEINER GJ, LIU HM, WOOLDRIDGE JE, DAHLE CE, KRIEG AM: Immunostimulatory oligodeoxynucleotides con-taining the CpG motif are effective as immune adju-vants in tumor antigen immunization. Proc. Natl. Acad. Sci. USA (1997) 94:10833–10837.
  • BALDWIN SL, D'SOUZA CD, ORME IM et al: Immunogen-icity and protective efficacy of DNA vaccines encoding secreted and non-secreted forms of M. tuberculosis Ag85A. Tubercle Lung Dis. (In Press.)
  • SATO Y, ROMAN M, TIGHE H et al: Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science (1996) 273:352–354.
  • KLINMAN DM, YAMSHCHIKOV G, ISHIGATSUBO Y: Con-tribution of CpG motifs to the immunogenicity of DNA vaccines. J. Immunol. (1997) 158:3635–3639.
  • MOR G, SINGLA M, STEINBERG AD et al.: Do DNA vac-cines induce autoimmune disease? Hum. Gene Ther. (1997) 8:293–300.
  • GILKESON GS, RUIZ P, PIPPEN AM et al.: Modulation of renal disease in autoimmune NZB/NZW mice by im-munization with bacterial DNA. J. Exp. Med. (1996) 183:1389–1397.
  • CALAROTA S, BRATT G, NORDLUN D et al: Cellular cyto-toxic response induced by DNA vaccination in 11IV-1-infected patients. Lancet (1998) 351:1320–1325.

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