Bibliography
- KUCZMARSKI RJ, FLEGAL KM, CAMPBELL SM, JOHNSON CL: Increasing prevalence of overweight among US adults: the National Health and Nutrition Examination Surveys 1960-1991. JAMA (1994) 270:205–211.
- Obesity is worst chronic health problem: Scrip (1997) 2244 (June 27) :25
- SUNYER FX: Medical hazards of obesity. Ann. Intern. Med. (1993) 119:655–660.
- MCGINNIS JM, FORGE WH: Actual causes of death in the United States. JAMA (1993) 119:655–660.
- ZHANG Y. PROENCA R, MAFFEI M, BARONE M, LEOPOLD L, FRIEDMAN JM: Positional cloning of the mouse obese gene and its human homologue. Nature (1994) 372:425.
- NAGGERT JK, FRISKER LD, VARLAMOV 0 et al: Hyper-proinsulinemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enxyme activity. Nature Gen. (1995) 10:135–142.
- NOBEN-TRAUTH K, NAGGERT JK, NORTH MA, NISHINAPM: A candidate gene for the mouse mutation tubby. Nature (1996) 380:534–538.
- KLEYN PW, FAN W, KOVATS SG et al.: Identification and characterisation of the mouse obesity gene tubby: a member of a novel gene family. Cell (1996) 85:281–290.
- CARPENTER KJ, MAYER J: Physiologic observation on yellow obesity in the mouse. Am. J. Physiol. (1958) 193:499–504.
- MANNE J, ARGESON AC, SIRACUSA LD: Mechanism forthe pleiotrophic effects of the agouti gene. Proc. Natl. Acad. Sci USA (1995) 92:4721–4724.
- BULTMAN SJ, MICHAUD EJ, WOYCHIK RP: Molecular characterisation of the mouse agouti locus. Cell (1992) 71:1195–1204.
- ••This paper reported the cloning of the agoutigene, therebyopening up the molecular and biochemical characterisation of the gene and protein. In addition, the demonstration that the Ay mouse was a regulatory mutant had profound impli-cations for the mechanism of obesity in these animals.
- CONE RG, LU D, KOPPULA S et al.: The melanocortin re-ceptors: agonists, antagonists, and the hormonal con-trol of pigmentation. Recent Prog. Hormone Res. (1996) 51:287–318.
- MOUNTJOY KP, ROBBINS LS, MORTRUD MT, AND CONERD: The cloning of a family of genes that encode the melanocortin receptors. Science (1992) 257:1248–1251.
- MOUNTJOY KG, MORTRUD MT, LOW MJ, SIMERLY RB,CONE RD: Localisation of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mot. Endocrinology (1994) 8:1298–1308.
- ROSELLI-REHFUSS L, MOUNTJOY KG, ROBBINS LS et al.:Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypo-thalamus and limbic system. Proc. Natl. Acad. Sci USA (1993) 90:8856–8860.
- LABBE F, DESANAUD F, EGGERICKX D, VASSART G, PAR-MENTIER M: Molecular cloning of a mouse melano-cortin 5 receptor gene widely expressed in peripheral tissues. Biochemistry (1994) 33:4543–4549.
- LU D, WILLARD D, PATEL IR: Agouti protein is an antago-nist of the melanocyte-stimulating hormone receptor. Nature (1994) 371:799–802.
- ••The demonstration that agouti was an antagonist of MC-1Rwas an inmportant finding to explain the action of agouti in pigmentation. Additionally, the activity at the centrally ex-pressed MC-4R offered a potential explanation for its effects on obesity.
- HUSZAR D, LYNCH CA, FAIRCHILD-HUNTRESS V et al:Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell (1997) 88:131–141.
- ••This papaer provide direct genetic proof that the MC-4r wasinvolved in obesity.
- FAN W, BOSTON BA, KESTERSON RA, HRUBY VJ, AND CONE RD: Role of melanocortinergic neurones in feed-ing and the agouti obesity syndrome. Nature (1997) 385:165–168.
- •In combination with the previous paper, the pharmacologi-cal manipulation of central malanocortin receptor activity reported in this paper helped define the melanocortino-genic system with respect to feeding behaviour.
- SHUTTER JR, GRAHAM M, KINSEY AC, SCULLY S, LeTHY R, STARK KL: Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and dia-betic mutant mice. Genes and Dev. (1997) 11:593–602.
- •The cloning and characterisation of Agrp (named ART in this reference) identified a potential key regulator of the melano-cortinogenic pathway, and provided the first evidence that this pathway may be regulated by leptin.
- KLEBIG ML, WILKINSON JE, GEISLER JG, AND WOYCHIK RP: Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur. Proc. Nat. Acad. Sci. USA (1995) 92:4728–4732.
- OLLMANN MM, WILSON BD, YANG YK et al.: Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science (1997) 278:135–138.
- •This paper (along with [24]) provided the first biochemical characterisation of AGRP showing activity at central melano-cortin receptors. In addition, it provided direct proof (also [23] that overexpression of this gene caused odesity and hyperphagia.
- GRAHAM M, SHUTTER JR, SARMIENTO U, SAROSI I, STARK KL: Overexpression of Agrt leads to obesity in transgenic mice. Nature Gen. (1997) 17:273–274.
- •See [22]
- FONG TM, MAO C, MACNEIL T et al.: ART (protein prod- uct of Agouti-related transcript) as an antagonist of MC-3 and MC-4 receptors. Biochem. Biophys. Res. Comm. (1997) 237:629–631.
- •See [22]
- FLIER JS, MARATOS-FLIER E: Obesity and the hypothala-mus: Novel peptides for new pathways. Cell (1998) 92:437–440.
- CHEUNG CC, CLIFTON DK, STEINER RA: Proopiomela-nocortin neurones are direct targets for leptin in the hypothalamus. Endocrinology (1997) 138:4489–4492.
- THORNTON JE, CHEUNG CC, CLIFTON DK, STEINER RA:Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice. Endocrinology (1997) 138:5063–5066.
- HALAAS JL, BOOZER C, BLAIR-WEST J et al.: Physiologi-cal response to long-term peripheral and central leptin infusion in lean and obese mice. Proc. Nat. Acad. ScL USA (1997) 94:8878–8883.
- SEELEY RJ, YAGALOFF KA, FISHER SL et al: Melanocortin receptors in leptin effects. Nature (1997) 390:349.
- BOSTON BA, BLAYDON KM, VARNERIN J, CONE RD: In-dependent and additive effects of central POMC and leptin pathways on murine obesity. Science (1997) 278:1641–1644.
- MONTAGUE CT, FAROOQI IS, WHITEHEAD JP et al.: Con-genital leptin deficiency is associated with severe early-onset obesity in humans. Nature (1997) 387:903–908.
- ERICKSON JC, CLEGG KE, PALMITER RD: Sensitivity toleptin and susceptiblity to seizures of mice lacking neuropeptide Y. Nature (1996) 381:415–418.