Bibliography
- MAGGI CA: The effects of tachykinins on inflammatory and immune cells. Reg. Peptides (1997) 70:75–90.
- KUCHARCZYK N: Tachykinin antagonists in develop-ment. Exp. Opin. Invest. Drugs (1995) 4:299–311.
- ICHINOSE M, MIURA M, YAMAUCHI H et al.: A neuroki-nin 1-receptor antagonist improves exercise-induced airway narrowing in asthmatic patients. Am. Rev. Respir. Grit. Care Med (1996) 153:936–941.
- FAHY J, WONG H, GEPPETTI P et al.: Effect of an NK1 re-ceptor antagonist (CP-99,994) on hypertonic saline-induced bronchoconstriction and cough in male asth-matic subjects. Am. Rev. Respir. Grit. Care Med. (1995) 152:879–884.
- VAN SCHOOR J, JOOS G, CHASSON B et al: The effect of the oral nonpeptide NK2 receptor antagonist SR-48968 on neurokinin A-induced bronchoconstriction in asthmatics. Eur. Resp. J. (1996) 9:289.
- KUDLACZ EM, KNIPPENBERG RW: In vitro and in vivo ef-fects of tachykinins on immune cell function in guinea pig airways. J. Neuroimmunol (1994) 50:119–125.
- TURNER CR, ANDRESEN CJ, PATTERSON DK et al: Dualantagonism of NKi and NK2 receptors by CP-99,994 and SR 48,968 prevents airway hyper-reponsiveness in primates. Am. J. Rev. Respir. Dis. (1996) 153:160.
- OLLERENSHAW S, JAR VIS D, SULLIVAN C, WOOLCOCK A:Substance P immunoreactive nerves in airways from asthmatics and nonasthmatics. Eur. Respir. J. (1991) 4:673–682.
- BONINI S, LAMBIASE A, BONINI S et al: Circulatingnerve growth factor levels are increased in humans with allergic diseases and asthma. Proc. Natl. Acad. Sci. (1996) 93:10955–10960.
- BLACK JL, JOHNSON PR, ARMOUR CL: Potentiation of thecontractile effect of neuropeptides in human bron-chus by an enkephalinase inhibitor. Pulm. Pharmacol (1988) 1:21–24.
- NIEBER K, BAUMGARTEN C, RATHSACK R et al.: Sub-stance P and 0-endorphin-like immunoreactivity in lavage fluid of subjects with and without allergic asthma. J. Allergy Clin. Immunol (1992) 90:646–652.
- ADCOCK IM, PETERS M, GELDER C et al.: Increased tachykinin receptor gene expression in asthmatic lung and its modulation by steroids. J. Mol. Endocrinol. (1993) 11:1–7.
- BAI T, ZHOU D, WEIR T et al.: Substance P (NK1)- and neurokinin A (NK2)-receptor gene expression in in-flammatory airway diseases. Am. J. Physiol. (1995) 269:L309–L317.
- FISCHER A, McGREGOR GP, SARIA A et al.: Induction oftachykinin gene and peptide expression in guinea pig nodose primary afferent neurons by allergic airway inflammation. J. Clin. Invest. (1996) 98:2284–2291.
- KUDLACZ EM, SHATZER SA, KNIPPENBERG RW et al.: In vitro and in vivo characterization of MDL 105,212A, a non-peptide NK1/NK2tachykinin receptor antagonist. J. Pharmacol Exper. Ther. (1996) 277:840–851.
- ICHINOSE M, NAKAJIMA N, TAKAHASHI T et al.: Protec-tion against bradykinin-induced bronchoconstriction in asthmatic patients by neurokinin receptor antago-nists. Lancet (1992) 340:1248–1251.
- SCHMIDT D, JORRES RA, RABE KF et al.: Reproducibility of airway response to inhaled bradykinin and effects of the neurokinin receptor antagonist FK-224 in asth-matic subjects. Eur.J. Clin. Pharmacol (1996) 50:269–273.
- JOOS G, VAN SCHOOR J, KIPS J et al.: The effect of in-haled FK224, a tachykinin NKi and NK2 receptor antagonist, on neurokinin A-induced bronchocon-striction in asthmatics. Am. J. Respir. Grit. Care Med. (1996) 153:1781–1784.
- ROBINEAU P, LONCHAMPT M, KUCHARCYZK N et al: Invitro and in vivo pharmacology of S16474, a novel dual tachykinin NK1 and NK2 receptor antagonist. Eur. J. Pharmacol. (1995) 294:677–684.
- BURKHOLDER TP, KUDLACZ EM, LE T-B et al: Identifica-tion and chemical synthesis of MDL 105,212, a non-peptide tachykinin antagonist with high affinity for NK1 and NK2 receptors. Bioorg. Med. Chem. Lett. (1996) 6:951–956.
- KUDLACZ EM, KNIPPENBERG RW, LOGAN DE et al: Ef-fect of MDL 105,212, a nonpeptide NK1/NK2 receptor antagonist in an allergic guinea pig model. J. Pharma-col. Exper. Ther. (1996) 279:732–739.
- BURKHOLDER TB, KUDLACZ EM, MAYNARD GD et al:Synthesis and structure-activity relationships for a se-ries of substituted pyrrolidine NK1/NK2 receptor an-tagonists. Bioorg. Med. Chem. Lett. (1997) 7:2531–2536.
- KUDLACZ EM, KNIPPENBERG RW, SHATZER SA et al: Theperipheral NK1/NK2 receptor antagonist MDL 105,172A inhibits tachykinin-mediated respiratory ef-fects in guinea pigs. J. Autonom. Pharmacol (1997) 17:109–119.
- DO PATROCINIO M, WARTH TN, MALDONADO E et al: Neurokinin depletion attenuates pulmonary changes induced by antigen challenge in sensitised guinea pigs. Am. J. Physic)]. (1995) 268:L781–L788.
- GENTILINI G, FRANCHI-MICHELI S, CIUFFI M et al.: Cap-saicin and anaphylactic reactions in the guinea-pig air-ways. Agents Actions (1990) 30:92–94.
- MANZNI S, MAGGI CA, GEPPETTI P et al: Capsaicin de-sensitisation protects from antigen-induced broncho-spasm in conscious guinea pigs. Eur. J. Pharmacol (1987) 138:307–308.
- MATSUSE T, THOMSON RJ, CHEN X-R et al.: Capsaicin in-hibits airway hyper-reponsiveness but not lipoxyge-nase activity or eosinophilia after repeated aerosolized antigen in guinea pigs. Am. J. Respir. Dis. (1991) 144:368–372.
- BERTRAND C, NADEL JA, YAMAWAKI I et al.: Role of ki-nins in the vascular extravasation evoked by antigen and mediated by tachykinins in guinea pig trachea. J. Immunol. (1993) 150:1479–1485.
- BERTRAND C, GEPPETTI P, GRAF PD et al.: Involvementof neurogenic inflammation in antigen-induced bron-choconstriction in guinea pigs. Am. J. Physiol. (1993) 265:L507–L511.
- BOICHOT E, GERMAIN N, LAGENTE V et al.: Preventionby the tachykinin NK2 receptor antagonist, SR 48,968, of antigen-induced airway hyper-reponsiveness in sensitised guinea pigs. Br. J. Pharmacol. (1995) 114:259–261.
- MIZUGUCHI M, FUJIMURA M, AMEMIYA T et al.: Involve-ment of NK2 receptors rather than NKi receptors in bronchial hyper-reponsiveness induced by allergic re-action in guinea-pigs. Br. J. Pharmacol (1996) 117:443–448.
- SHAH SK, HALE JJ, QU H et al.: Discovery of substitutedspiroindolinopiperidines as orally active dual antago-nists of NKi and NK2 receptors. American Chemical Soci-ety National Meeting. Orlando, FL, USA (25–29 August 1996); 414724. Abstract 212.
- MOSIMANN B, WHITE M, HOHMAN R etal.: Substance P,calcitonin gene-related peptide and vasoactive intesti-nal peptide increase in nasal secretions after allergen challenge in atopic patients. J. Allergy Clin. Immunol (1993) 92:95-104. \ © Ashley Publications Ltd. All rights reserved.Exp. Opin. Invest. Drugs (1998) 7(7)
- BAUMGARTEN CR, O'CONNOR A, DOKIC D et al.: Sub-stance P is generated in vivo following nasal challenge of allergic individuals with bradykinin. Gun. Exper. Al-lergy (1997) 27:1322–1327.
- BRAUNSTEIN G, FAJAC I, LACRONIQUE J et al: Clinical and inflammatory responses to exogenous tachyki-nins in allergic rhinitis. Am. Rev. Respir. Dis. (1991) 144:630–635.
- SANICO AM, PHILIP G, PROUD D et al: Comparison of nasal mucosal responsiveness to neuronal stimulation in non-allergic and allergic rhinitis: effects of capsai-cin nasal challenge. Clin. Exp. Allergy (1996) 28:92–100.
- LACROIX JS, BUVELOT JM, POLLA BS et al.: Improvement of symptoms of non-allergic chronic rhinitis by local treatment with capsaicin. Clin. Exp. Allergy (1991) 21:595–600.
- SANICO AM, ATSUTA S, PROUD D eta].: Dose-dependent effects of capsaicin nasal challenge: in vivo evidence of human airway neurogenic inflammation. J. Allergy Immunol (1997) 100:632–641.
- BERTRAND C, GEPPETTI P, BAKER J et al.: Role of neuro-genic inflammation in antigen-induced vascular extra-vasation in guinea pig trachea. J. Immunol. (1993) 150:1479–1485.
- KUDLACZ EM, SHATZER S, LOGAN D et al.: A role for his-tamine and substance P in immediate allergic re-sponses in guinea pig airways: characterization of MDL 108,207DA, a dual Hi/NKi receptor antagonist. Int. Arch. Allergy Immunol (1998) 115:169–178.
- MAYNARD GD, BRATTON LD, KANE JM et al.: Synthesis and SAR of 4-(1H-benzimidazole-2-carbonyl) piperidines with dual histamine Hi/tachykinin NKi receptor antagonist activity. Bioorg. Med. Chem. Lett. (1997) 7:2819–2824.
- VAZ RJ, MAYNARD GD, KUDLACZ EM et al.: Use of CoMFA in validating the conformation used in designing 4-(1H-benzimidazole-2-carbonyDpiperidines with 1-11/NK1 receptor antagonist activity. Bioorg. Med. Chem. Lett. (1997) 7:2825–2830.
- TOHDA Y, NAKAJIMA S, SHIZAWA T et al: The inhibitoryeffect of TMK688, a novel anti-allergic drug having both 5-lipoxygenase inhibitory activity and anti-histamine activity, against bronchoconstriction, leu-kotriene production and increased inflammatory cell infiltration in sensitised guinea pigs. Clin. Exp. Allergy (1997) 27:110–118.
- ZHANG MQ, VAN DE STOLPE A, ZUIDERVELD OP et al.: Synthesis and pharmacological evaluation of some amino-acid-containing cyproheptadine derivatives as dual antagonists of histamine Hi- and leukotriene D4-receptors. Eur. J. Med. Chem. (1997) 32:95–102.
- MERLOS M, GIRAL M, BALSA D et al.: Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF). J. Pharmacol. Exp. Ther. (1997) 280:114–121.
- KARLSSON JA: A role for capsaicin sensitive, tachykinin-containing nerves in chronic coughing and sneezing but not in asthma: a hypothesis. Thorax (1993) 48:396–400.