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Expert Opinion on Investigational Drugs Volume 8, 1999 - Issue 10
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Drug Evaluation

Ganaxolone: a novel positive allosteric modulator of the GABAA receptor complex for the treatment of epilepsy

Edward P Monaghan CoCensys, Inc., 201 Technology Drive, Irvine, CA 92618,USA. [email protected]
,
James W McAuley The Ohio State University, Division of Pharmacy Practice and Administration, College of Pharmacy, 500 West 12th Avenue, Columbus, OH 43210-1291, USA. [email protected]
&
Joann L Data The Ohio State University, Division of Pharmacy Practice and Administration, College of Pharmacy, 500 West 12th Avenue, Columbus, OH 43210-1291, USA. [email protected]
Pages 1663-1671 | Published online: 23 Feb 2005

Bibliography

  • BELELLI D, BOLGER MB, GEE KW: Anticonvulsantprofile of the progesterone metabolite 5a-pregan-3a-o1-20-one. Eur. J. Pharmacol. (1989) 166:325–329.
  • GEE KW, BOLGER MB, BRINTON RE, COIRINI H, MCEWENBS: Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action. J. Pharmacol. Exp. Ther. (1988) 246:803–812.
  • •Summary of the pharmacology of neuroactive steroids.
  • GEE KW, MCCAULEY LD, LAN NC: A putative receptor for neurosteriods on the GABAA receptor complex: the pharmacological properties and therapeutic potential of epalons. Grit. Rev. Neurobiol. (1995) 9(2&3):207–227.
  • ••Excellent review of neuroactive steroids.
  • MORROW AL, PACE JR, ROBERT HP, PAUL SM: Charac- terization of steroid interactions with y-aminobutyric acid receptor-gated chloride ion channels: evidence for multiple steroid recognition sites. Molecular Pharm. (1990) 37:263–270.
  • EDGAR DM, SEIDEL WF, GEE KW et al.: CCD-3693: an orally bioavailable analog of the endogenous neuroac-tive steroid, pregnanolone, demonstrates potent sedative hypnotic actions in the rat. J. Pharmacol. Exp. Ther. (1997) 282:420–429.
  • SHORVON SD: Epidemiology, classification, natural history, and genetics of epilepsy. Lancet (1990) 336:93–96.
  • BRODIE M: Lamotrigine. Lancet (1992) 339:1397–1400.
  • ANNEGERS JF: The epidemiology of epilepsy. In: The Treatment of Epilepsy: Principles and Practice. 2nd ed. Wyllie E (Ed.), Williams & Wilkins, Baltimore, MD, USA (1996):165–172.
  • DEVINSKY 0: Patients with refractory seizures. New Engl. J. Med (1999) 1340:1565–1570.
  • HRACHOVY RA, FROST JD: Severe encephalopathic epilepsy in infants: infantile spasms. In: Pediatric Epilepsy: Diagnosis and Therapy Dodson WE, Pellock JM (Eds.), Demos, New York, NY (1993):135–146.
  • SNEAD OC: ACTH and steriods. In: Pediatric Epilepsy: Diagnosis and Therapy Dodson WE, Pellock JM (Eds.), Demos, New York, NY (1993):331–335.
  • MORTON LD, PELLOCK JM: Diagnosis and treatment of epilepsy in children and adolescents. Drugs (1996) 51(3):399–414.
  • CARTER RB, WOOD PL, WIELAND S et al. Characteriza- tion of the anticonvulsant properties of ganaxolone (CCD 1042: 3a-hydroxy-3a-methy1-5a-pregnan-20--one), a selective, high-affinity, steroid modulator of the y-aminobutyric acidA receptor. J. Pharmacol. Exp. Ther. (1997) 280:1284–1295.
  • ••Overview of anticonvulsant pharmacology of ganaxolone.
  • GASIOR MJ, CARTER RB, WITKIN JM: Neuroactive steroids: potential therapeutic use in neurological and psychiatric disorders. TIPS. (1999) 20:107–112.
  • •Summary of the pharmacology of neuroactive steroids.
  • GASIOR MJ, BEEKMAN M, CARTER RB, GOLDBERG R, WITKIN JM: Antiepileptogenic effects of the novel synthetic neuroactive steroid, ganaxolone, against pentylenetetrazol-induced kindled seizures: comparison with diazepam and valproate. Drug Devel Res. (1998) 44:21–33.
  • BEEKMAN M, UNGARD JT, GASIOR M et al.: Reversal ofbehavioral effects of pentylenetetrazol by the neuroac-tive steroid ganaxolone. J. Pharmacol. Exp. Ther. (1998) 284:868–877.
  • MONAGHAN EP, NAVALTA LA, SHUM L, ASHBROOK DW, LEE DA: Initial human experience with ganaxolone, a neuroactive steroid with antiepileptic activity. Epilepsia (1997) 38:1026–1031.
  • DEVINSKY 0, FAUGHT RE, WILDER BJ et al.: Efficacy of felbamate monotherapy in patients undergoing presurgical evaluation of partial seizures. Epilepsy Res. (1995) 20(3):241–246.
  • THEODORE WH, ALBERT P, STERTX B et al.: Felbamate monotherapy: implications for antiepileptic drug development. Epilepsia (1995) 36(11) :1105–1110.
  • BERGEY GK, MORRIS HH, ROSENFELD W et al.: An 8-day, double-blind, dose-controlled, multicenter study in hospitalized patients with refractory complex partial or secondarily generalized seizures. Neurology (1997) 49:739–745.
  • SCHACHTER SC, VAZQUEZ B, FISHER RS et al.:Oxcarbazepine: double-blind, randomized, placebo-control, monotherapy trial for partial seizures. Neurology (1999) 52:732–737.
  • MONAGHAN EP, HARRIS S, BLUM D et al.: Ganaxolone inthe treatment of complex partial seizures: A double-blind, presurgical trial design. Epilepsia (1997) 38(8) :179.
  • CHIRON C, DULAC 0, BEAUMONT D, PALACIOS L, PAJOT N, MUMFORD J: Therapeutic trial of vigabatrin in refractory infantile spasms. J. Child Neurol. (1991) 6\(Suppl. 2):S52–S59.
  • CHANG S, MCAULEY JW: Pharmacotherapeutic issues for women of childbearing age with epilepsy. Ann. Pharmacother. (1998) 32:794–801.
  • HERZOG AG, KLEIN P, RANSIL BJ: Three patterns of catamenial epilepsy. Epilepsia (1997) 38(10):1082–1088.
  • •Overview of catamenial epilepsy.
  • HERZOG AG: Progesterone therapy in women with complex partial and secondary generalized seizures. Neurology (1995) 45:1660–1662.

Websites

  • Epilepsy: A Report to the Nation. Epilepsy Foundation of America Website. Available at: http://www.efa.orginews/ nationination.html. Accessed May 1999.

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