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Drug Evaluation

Rosiglitazone: a new therapy for Type 2 diabetes

Pages 1709-1719 | Published online: 23 Feb 2005

Bibliography

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  • •Good basic science and early clinical review of thiazolidinediones.
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  • ••Landmark 15-year study on the effect of glycaemic controlon complications associated with Type 2 diabetes.
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  • ••Study demonstrates effectiveness of rosiglitazone inreducing peripheral insulin resistance in the obese rat model.
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  • •Seminal study suggests that improvements in insulin action and glucose metabolism with rosiglitazone is mediated in part by reductions in lipid availability.
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  • •Study suggests that improvements in insulin action with rosiglitazone is due in part to increased glucose transport in adipocytes.
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