Bibliography
- FRANKEN E, TEUSCHEL U, HAIN R: Recombinant pro- teins from transgenic plants. Curr. Opin. Biotechnol (1997) 8:411–416.
- •This review summarises in brief many recent developments. They distinguish between uses of plants for production, 'm-olecular farming', and in situ uses for pest control, 'molec-ular breeding'.
- PEN J: Comparison of host systems for the production of recombinant proteins. In: Transgenic plants: a pro-duction system for industrial and pharmaceutical proteins. Owen, MRL, Pen J (Eds.), John Wiley and Sons Ltd, Chiches-ter, UK (1996):149–167.
- ••This article summarises the features of the available expres-sion systems and compares their productivity and ability to produce native-like proteins.
- MIELE L: Plants as bioreactors for biopharmaceuticals: regulatory considerations. Trends Biotechnol (1997) 15:45–50.
- •Discussion of the regulatory issues surrounding plant-based biopharmaceutical production.
- PERSIDIS A: Biotechnology in 1998 and beyond. NatureBiotechnol (1998) 16:1378–1379.
- KUSNADI AR, HOOD EE, WITCHER DR, HOWARD JA, NIK-OLOV ZL: Production and purification of two recombi-nant proteins from transgenic corn. Biotechnol. Prog. (1998) 14:149–155.
- •Reports the production and purification of two recombinant proteins from transgenic corn and provides a summary of expression levels obtained for a range of recombinant pro-teins expressed in transgenic plants.
- VERWOERD TC, VAN PARIDON PA, VAN 00YEN AJJ, VAN LENT JWM, HOEKEMA A, PEN J: Stable accumulation of Aspergillus niger phytase in transgenic tobacco leaves. Plant Physiol. (1995) 109:1199–1205.
- CONRAD U, FEIDLER U: Compartment-specific accumu-lation of recombinant immunoglobulins in plant cells: an essential tool for antibody production and immu-nomodulation of physiological functions and patho-gen activity. Plant Mol. Biol. (1998) 38:101–109.
- •Comprehensive recent review of production of antibodies in plant cells. Includes useful summary tables of expression data for whole IgG and scFv.
- FIEDLER U, CONRAD U: High-level production and long term storage of engineered antibodies in transgenic tobacco seeds. Bio/7'echnology (1995) 13:1090–1093.
- CHRISPEELS M J, FAYE L: The production of recombi-nant glycoproteins with defined non-immunogenic glycans. In: Transgenic plants: a production system for in-dustrial and pharmaceutical proteins. Owen MRL, Pen J (Eds.), John Wiley & Sons Ltd, Chichester, UK (1996):99–113.
- •The review compares mammalian and plant glycoforms and describes possible procedures to manipulate plants to pro-duce proteins with mammalian-like carbohydrate.
- FITCHETTE-LAINÉ A-C, DENMAT L-A, LEROUGE P, FAYE L: Analysis of N and 0-glycosylation of plant proteins. In: Methods in Biotechnology Vol. 3. Recombinant proteins from plants: production and isolation of clinically useful compounds. Cunningham C, Porter AJR (Eds.), Humana Press Inc, Totowa, NJ, USA (1998):271–290.
- LEROUGE P, CABANES-MACHETEAU M, RAYON C, FISCHETTE-LAINÉ A-C, GOMORD V, FAYE L: N-glycoprotein biosynthesis in plants: recent develop-ments and future trends. Plant Mol Biol. (1998) 38:31–48.
- •A comprehensive review of current understanding of carbo-hydrate composition and function in plants.
- MA JK-C, HIATT A: Expressing antibodies in plants for immunotherapy. In: Transgenic plants: a production sys-tem for industrial and pharmaceutical proteins. Owen MRL, Pen J (Eds.), John Wiley & Sons Ltd, Chichester, UK (1996):229–243.
- SCHOLTHOF HB, SCHOLTHOF, K-BG: Plant virus gene vectors for transient expression of foreign proteins in plants. Ann. Rev. Phytopathol. (1996) 34: 299–323.
- •Useful review of the strategies that have been employed for foreign gene expression in various virus-based vectors.
- HANSEN E: Production of recombinant antigens in plants for animal and human immunisation - a re-view. Braz. J. Genet. (1997) 20:703–711.
- MASON HS, LAM DM-K, ARNTZEN CJ: Expression of hepatitis B surface antigen in transgenic plants. Proc. Natl. Acad. Sci. USA (1992) 89:11745–11749.
- ••Important paper containing the first detailed report on ex-pression of a recombinant antigen in plants and characteri-sation of the expressed protein.
- LIU Y-E, WANG J-F, QIU B-S, ZHAO S-Z, TIAN B: Expres-sion of hepatitis B virus surface antigen gene in trans-genic tobacco. Science in China (Series B) (1994) 37:37–41.
- EHSANI P, KHABIRI A, DOMANSKY N : Polypeptides of hepatitis B surface antigen produced in transgenic po-tato. Gene (1997) 190:107–111.
- HAQ TA, MASON HS, CLEMENTS JD, ARNTZEN CJ: Oral immunisation with a recombinant bacterial antigen produced in transgenic plants. Science (1995) 268:714–716.
- •First report that feeding of a transgenic plant expressing a foreign antigen will elicit an immune response in mice.
- MASON HS, HAQ TA, CLEMENTS JD, ARNTZEN CJ: Edible vaccine protects mice against Escherichia coil heat- labile enterotoxin (LT): potatoes expressing a syn-thetic LT-B gene. Vaccine (1998) 16:1336–1343.
- •An outstanding contribution to the plant-derived vaccine literature.
- MCGARVEY PB, HAMMOND J, DIENELY MM et al.: Ex-pression of the rabies virus glycoprotein in transgenic tomatoes. Bio/Technology (1995) 13:1484–1487.
- MASON HS, BALL JM, SHI J-J, JIANG X, ESTES MK, ARNTZEN CJ: Expression of Norwalk virus capsid pro-tein in transgenic tobacco and potato and its oral im-munogenicity in mice. Proc. Natl. Acad. Sci. USA (1996) 93:5335–5340.
- HEIN MB, YEO T-C, WANG F, STURTEVANT A: Expres-sion of cholera toxin subunits in plants. Ann. New York Sci. (1996) 792:50–56.
- ARAKAWAT, CHONG DKX, MERRITT JL, LANGRIDGE WHR: Expression of cholera toxin B subunit oligomers in transgenic potato plants. Transgenic Res. (1997) 6:402–413.
- MA S-W, ZHAO D-L, YIN Z-Q et al.: Transgenic plants ex-pressing autoantigens fed to mice to induce oral im-mune tolerance. Nature Med. (1997) 3:793–796.
- ••Important contribution providing the first report that a trans-genic plant-expressed autoantigen can induce oral toler-ance in mice.
- TSUDA S, YOSHIOKA K, TANAKA, T eta].: Application of the human hepatitis B virus core antigen from trans-genic tobacco plants for serological diagnosis. Vox. Sang. (1998) 74:148–155.
- ARAKAWA T, CHONG DKX, LANGRIDGE WHR: Efficacy of a food plant-based oral cholera toxin B subunit vac-cine. Nature Biotechnol. (1998) 16:292–297.
- JOELSON T, AKERBLOM L, OXELFELT P, STRANDBERG B, TOMENIUS K, MORRIS TJ: Presentation of a foreign pep-tide on the surface of tomato bushy stint virus. J. Gen. Virol. (1997) 78:1213–1217.
- YUSIBOV V, MODELSKA A, STEPELWSKI K, AGADJANYAN M, WEINER D, HOOPER DC, KOPROWSKI H: Antigens produced in plants by infection with chimaeric plant viruses immunise against rabies virus and HIV-1. Proc. Nag Acad. Sci. USA (1997) 94:5784–5788.
- MODELSKA A, DIETZSCHOLD B, SLEYSH N eta].: Immu-nisation against rabies with plant-derived antigen. Proc. Natl. Acad. Sci. USA (1998) 95:2481–2585.
- TURPEN TH, REINL SJ, CHAROENVIT Y, HOFFMAN SL, FALLARME V, GRILL LK: Malarial epitopes expressed on the surface of recombinant tobacco mosaic virus. Bio/7'echnology (1995) 13:53–57.
- SUGIYAMA Y, HAMAMOTO H, TAKEMOTO S, WATANABE Y, OKADA Y: Systemic production of foreign peptides on the particle surface of tobacco mosaic virus. FEBS Letters (1995) 359:247–250.
- BEACHY RN, FITCHEN JH, HEIN MB: Use of plant viruses for delivery of vaccine epitopes. Ann. New York Acad. Sci. (1996) 792:43–49.
- MCLAIN L, PORTA C, LOMONOSSOFF GP, DURRANI Z, DIMMOCK NJ: Human immunodeficiency virus Type 1-neutralizing antibodies raised to a glycoprotein 41 peptide expressed on the surface of a plant virus. AIDS Res. Hum. Retroviruses (1995) 11:27–334.
- MCLAIN L, DURRANI Z, WISNIEWSKI LA, PORTA C, LO-MONOSSOFF GP, DIMMOCK NJ: Stimulation of neutral-ising antibodies to human immunodeficiency virus Type 1 in three strains of mice immunised with a 22 amino acid peptide of gp41 expressed on the surface of a plant virus. Vaccine (1996) 14:799–810.
- BRENNAN FR, BELLABY T, HELLIWELL SM et al.: Chi-maeric plant virus particles administered nasally and orally induce systemic and mucosal immune re-sponses in mice. J. Vim]. (1999) 73:930–938.
- BRENNAN FR, JONES TD, GILLELAND LB et al.: Pseudo-monas aeruginosa outer membrane protein F epi-topes are highly immunogenic in mice when expressed on a plant virus. Microbiology (1999) 145:211–220.
- THANAVALA Y, YANG Y-F, LYONS P, MASON HS, ARNTZEN C: Immunogenicity of transgenic plant-derived hepatitis B surface antigen. Proc. Natl. Acad. Sci. USA (1995) 92:3358–3361.
- ARAKAWA T, YU J, CHONG DKX, HOUGH J, ENGEN PC,LANGRIDGE WHR: A plant-based cholera toxin B subunit-insulin fusion protein protects against the de-velopment of autoimmune diabetes. Nature Biotechnol. (1998) 16:934–938.
- MCCORMICK AA, KUMAGAI MH, HANLEY K et al.: Rapidproduction of specific vaccines for lymphoma by ex-pression of the tumor-derived single-chain Fv epi-topes in tobacco plants. Proc. Natl. Acad. Sci. USA (1999) 96:703–708.
- PORTA C, SPALL VE, LOVELAND J, JOHNSON JE, BARKER PJ, LOMONOSSOFF GP: Development of cowpea mosaic virus as a high-yielding system for the presentation of foreign peptides. Virology (1994) 202:949–955.
- DALSGAARD K, UTTENTHAL A, JONES TD et al.: Plant-derived vaccine protects target animals against a virus disease. Nature Biotechnol (1997) 15:248–252.
- •First report of a plant-derived vaccine conferring protection against an infectious disease.
- DURRANI Z, MCINERNEY TL, MCLAIN L et al.: Intranasalimmunisation with a plant virus expressing a peptide from HIV-1 gp41 stimulates better mucosal and sys-temic HIV-1 specific IgA and IgG than oral immunisa-tion. J. Immunol Methods (1998) 220:93–103.
- TACKET CO, MASON HS, LOSONSKY G, CLEMENTS JD, LEVINE MM, ARNTZEN CJ: Immunogenicity in humans of a recombinant bacterial antigen delivered in a trans-genic potato. Nature Med. (1998) 4:607–609.
- ••Seminal paper describing the first clinical study of a plant-derived vaccine.
- WRIGHT A, MORRISON SL: Effect of glycosylation on an-tibody function: implications for genetic engineering. Trends Biotechnol. (1997) 15:26–32.
- CO MS, DESCHAMPS M, WHITLEY RJ, QUEEN C: Human-ised antibodies for antiviral therapy. Proc. Natl. Acad. Sci. USA (1991) 88:2869–2873.
- HIATT A, CAFFERKEY R, BOWDISH K: Production of an- tibodies in transgenic plants. Nature (1989) 342:469–470.
- ••First published description of expression of immunoglobu-lin from plants.
- OWEN M, GANDECHA A, COCKBURN B, WHITELAM G: Synthesis of a functional anti-phytochrome single-chain Fv protein in transgenic tobacco. Bio/7'echnology (1992) 10:790–794.
- HELLSTROM I, GARRIGUES HJ, GARRIGUES U, HELL-STROM KE: Highly tumor-reactive, internalising, mouse monoclonal antibodies to Le lykelated cell sur-face antigens. Cancer Res. (1990) 50:2183–2190.
- ZEITLIN L, OLMSTED SS, MOENCH TR et al.: A humanised monoclonal antibody produced in transgenic plants for immunoprotection of the vagina against genital herpes. Nature Biotechnol (1998) 16:1361–1364.
- MA JK-C, HIKMAT BY, WYCOFF K et al.: Characterization of a recombinant plant monoclonal secretory anti-body and preventive immunotherapy in humans. Na-ture Med. (1998) 4:601–606.
- ••First report of the clinical use of a secretory antibody pro-duced in plants.
- MA JK-C, HIATT A, HEIN M et al.: Generation and assem- bly of secretory antibodies in plants. Science (1995) 268:716–719.
- ••First report of the expression of a secretory antibody withtherapeutic potential in plants.
- VERCH, T, YUSIBOV, V, KOPROWSKI H: Expression and assembly of a full-length monoclonal antibody in plants using a plant virus vector. J. Immunol. Meth. (1998) 220:69–75.
- MA JK-C, LEHNER T, STABILA P, FUX CI, HIATT A: Assem-bly of monoclonal antibodies with IgG1 and IgA heavy chain domains in transgenic tobacco plants. Eur. J. Im-munol. (1994) 24:131–138.
- •Report of the expression of an antibody with therapeutic po-tential in plants.
- LEHNER T, CALD WELL J, SMITH R: Local passive immuni-sation by monoclonal antibodies against streptococcal antigen I/II in the prevention of dental caries. Infect. Immun. (1985) 50:796–799.
- WRIGHT A, TAO MH, KABAT EA, MORRISON SL: Anti-body variable region glycosylation: position effects on antigen binding and carbohydrate structure. EMBO (1991) 10:2717–2723.
- DE HAAN L, VERWEIJ W, AGSTERIBBE E, WILSCHUT, J: The role of ADP-ribosylation and Gmi-binding activity in the mucosal immunogenicity and adjuvanticity of the Escherichia coil heat-labile enterotoxin and Vi-brio cholerae cholera toxin. Immunol. Cell Biol. (1998) 76:270–279.
- CLEMENTS JD, HARTZOG NM, LYON FL: Adjuvant activ-ity of Escherichia coli heat-labile enterotoxin and ef-fect on the induction of oral tolerance in mice to unrelated protein antigens. Vaccine (1988) 6:269–277.
- GRDIC D, HORNQUIST E, KJERRULF M, LYCKE NY: Lack of local suppression in orally tolerant CD8-deficient mice reveals a critical regulatory role of CD8+ T cells in the normal gut mucosa. J. Immunol. (1998) 160:754–762.
- OLIVER AR, SILBART LK, KEREN DF, VAN KRUININGEN HJ: Mucosal unresponsiveness to aflatoxin B1 is not broken by cholera toxin. Immunol Cell Biol. (1998) 75:47–53.
- NEDRUD JG, SIGMUND N: Cholera toxin as a mucosaladjuvant; III. Antibody responses to nontarget dietary antigens are not increased. Reg. Immunol (1991) 3:217–222.