Progress in xenotransplantation

Bibliography

• 1997 OPTN/SR AR 1988–1996. UNOS; DOT/HRSA/DHHS
   Google Scholar
• MICHAELS MG, SIMMONS RL: Xenotransplant-associated zoonoses. Transplantation (1994) 57(1):1–7.
   PubMed Web of Science ®Google Scholar
• CALNE RY: Organ transplantation between widely dis-parate species. Transpl. Proc. (1970) 2:550–556.
   PubMed Web of Science ®Google Scholar
• PLATT JL, BACH FH: The barrier to xenotransplanta-tion. Transplantation (1991) 52(6):937–947.
   PubMedGoogle Scholar
• DALMASSO AP, VERSELLOTTI GM, FISCHEL RJ, BOLMAN RM, BACH FH, PLATT JL: Mechanism of complement ac-tivation in the hyperacute rejection of porcine organs transplanted into primate recipients. Am. J. Pathol. (1992) 140:1157–1166.
   PubMed Web of Science ®Google Scholar
• ••A concise description of the immunpathology of hyperacuterejection in the pig-to-primate model.
   Google Scholar
• KAPLON RJ, MICHLER RE, XU H, KWIATKOWSKI PA, ED-WARDS NM, PLATT JL: Absence of hyperacute rejection in newborn pig-to-baboon cardiac xenografts. Trans-plantation (1995) 59(0:1–6.
   Google Scholar
• GOOD AH, COOPER DKC, MALCOLM AJ et al.: Identifica-tion of carbohydrate structures that bind human anti-porcine antibodies: implications for discordant xenografting in humans. Transpl. Proc. (1992) 24(2):559–562.
   PubMed Web of Science ®Google Scholar
• SANDRIN MS, VAUGHAN HA, DABKOWSKI PL, MCKENZIEIFC: Anti-pig IgM antibodies in human serum react pre-dominantly with Gal(a1-3)Gal epitopes. Proc. Natl. Acad. Sci. USA (1993) 90:11391–11395.
   PubMed Web of Science ®Google Scholar
• COLLINS BH, PARKER W, PLATT JL: Characterization ofporcine endothelial cell determinants recognized by human natural antibodies. Xenotransplantation (1994) 1:36–46.
   Google Scholar
• GALILI U: Interaction of the natural anti-gal antibodywith a-galactosyl epitopes: a major obstacle for xeno-transplantation in humans. Immunol. Today (1993) 14(10)480–482.
   Google Scholar
• GALILI U, CLARK MR, SHOHET SB, BEUHLER J, MACHERBA: Evolutionary relationship between the natural anti-gal antibody and the Gala1-3Gal epitope in pri-mates. Proc. Natl. Acad. ScL USA (1997) 84:1369–1373.
   Google Scholar
• LARSEN RD, RIVERA-MARRERO CA, ERNST LK, CUM-MINGS RD, LOWE JB: Frameshift and nonsense muta-tions in a human genomic sequence homologous to a murine UDP-gaka-D-Gal(1,4)-D-G1cNAc a (1,3)-galact-osyltransferase cDNA. J. Biol. Chem. (1990) 265(12)7055–7061.
   Google Scholar
• GALILI U, MANDRELL RE, HAMADEH RM, SHOHET SB,GRIFFISS JM: Interaction between human natural anti-a-galactosyl immunoglobulin G and bacteria of the human flora. Infect. Immun. (1988) 56 (7):1730–1737.
   PubMed Web of Science ®Google Scholar
• COOPER DKC, GOOD AH, KOREN E et al.: Identificationof alpha-galactosyl and other carbohydrates that are bound by human anti-pig antibodies: relevance to dis-cordant xenografting in man. Transpl. Immunol (1993) 1:198–205.
   PubMedGoogle Scholar
• NEETHLING FA, KOREN E, YE Y et al. Protection of pig kidney (PK15) cells from the cytotoxic effect of anti-pig antibodies by a-galactosyl oligosaccharides. Trans-plantation (1994) 57(6):959–963.
   Google Scholar
• VAUGHAN HA, LOVELAND BE, SANDRIN MS: Gala(1,3)gal is the major xenoepitope expressed on pig endothelial cells recognized by naturally occur-ring cytotoxic human antibodies. Transplantation (1994) 58(8)879–882.
   Google Scholar
• CHARTRAND C, OREGAN S, ROBITAILLE P, PINTO-BLONDE M: Delayed rejection of cardiac xenografts in C6-deficient rabbits. Immunology (1979) 38:245–248.
   PubMed Web of Science ®Google Scholar
• BRAUER RB, BALDWIN WM III, DAHA MR, PRUITT SK,SANFILIPPO F: Use of C6-deficient rats to evaluate the mechanism of hyperacute rejection of discordant car-diac xenografts. j Immunol. (1993) 151(12):7240–7248.
   PubMed Web of Science ®Google Scholar
• GEWURZ H, CLARK DS, COOPER MD, VARCO RL, GOODRA: Effect of cobra venom-induced inhibition of com-plement activity on allograft and xenograft rejection reactions. Transplantation (1967) 5 (5):1296–1303.
   PubMedGoogle Scholar
• LEVENTHAL JR, DALMASSO AP, CROMWELL JW et al.: Pro-longation of cardiac xenograft survival by depletion of complement. Transplantation (1993) 55(4):857–866.
   PubMed Web of Science ®Google Scholar
• PRUITT SK, KIRK AD, BOLLINGER RR et al: The effect ofsoluble complement receptor Type 1 on hyperacute rejection of porcine xenografts. Transplantation (1994) 57(3)363–370.
   Google Scholar
• ALEXANDRE GPJ, SQUIFFLET JP, DE BRUYERE M et al. Present experience in a series of 26 ABO-incompatible living donor renal allografts. Transpl. Proc. (1987) 19(6)4538–4542.
   Google Scholar
• TAUBE DH, WILLIAMS DG, CAMERON JS et al.. Renaltransplantation after removal and prevention of re-synthesis of HLA antibodies. Lancet (1984) 1(8381)824–828.
   Google Scholar
• COOPER DKC, HUMAN PA, LEXER G et al.: Effects of cy-closporine and antibody adsorption on pig cardiac xe-nograft survival in the baboon. J. Heart Transplant (1988) 7:238–246.
   PubMedGoogle Scholar
• FISCHEL RJ, MATAS AJ, PLATT JL et al: Cardiac xenograft-ing in the pig-to-rhesus monkey model: Manipulation of antiendothelial antibody prolongs survival. J. Heart Lung Transpl. (1992) 11:965–974.
   PubMed Web of Science ®Google Scholar
• GIANELLO PR, LATINNE D, ALEXANDRE GPJ: Pig-to-baboon renal xenografts. Xenotransplantation (1995) 3(2)26–30.
   Google Scholar
• LEVENTHAL JR, SAKIYALAK P, WITSON J et al: The syner-gistic effect of combined antibody and complement depletion on discordant cardiac xenograft survival in nonhuman primates. Transplantation (1994) 57(6)974–978.
   Google Scholar
• FUKUSHIMA N, BOUCHART F, GUNDRY SR: The role of anti-pig antibody in pig-to-baboon cardiac xenotrans-plant rejection. Transplantation (1994) 57(0923–928.
   PubMed Web of Science ®Google Scholar
• SABLINSKI T, LATINNE D, GIANELLO P et al.: Xenotrans-plantation of the pig kidneys to nonhuman primates:I. Development of the model. Xenotransplantation (1995) 2(4):264–270.
   Google Scholar
• BAROCCI S, NOCERA A: In vitro removal of anti-HLA IgG antibodies from highly sensitized transplant recipi-ents by immunoadsorption with protein A and protein G sepharose columns:a comparison. Transpl. Int. (1993) 6(1)29–33.
   Google Scholar
• PALMER A, TAUBE D, WELSH K, BEWICK M, GJORSTRUP P, THICK M: Removal of anti-HLA antibodies by extra-corporeal immunoadsorption to enable renal trans-plantation. Lancet (1989) 1 (8628) :10–12.
   PubMed Web of Science ®Google Scholar
• PALMER A, GJORSTRUP P, SEVERN A, WELSH K, TAUBE D: Treatment of systemic lupus erythematosus by extra-corporeal immunoadsorption. Lancet (1988) 2(8600:272.
   PubMedGoogle Scholar
• LEVENTHAL JR, JOHN R, FRYER JP et al.: Removal of ba-boon and human antiporcine IgG and IgM natural anti-bodies by immunoadsorption. Transplantation (1995) 59(2)294–300.
   Google Scholar
• UN SS, WEIDNER BC, BYRNE GW et al.: The role of anti-bodies in acute vascular rejection to pig-to-baboon car-diac transplants. J. Clin. Invest. (1998) 101 (8) :1745–1756.
   PubMed Web of Science ®Google Scholar
• ••First publication to define a pivotal role for antibody in acutevascular rejection in the pig-to-primate model.
   Google Scholar
• BANNETT AD, MCALACK RF, RAJA R, BAQUERO A, MOR-RIS M: Experiences with known ABO-mismatched re-nal transplants. Transpl. Proc. (1987) 19(6):4543–4546.
   PubMed Web of Science ®Google Scholar
• AGISHI T, TAKAHASHI K, OTA K, YAGISAWA T, JAPANESE BIOSYNSORB RESEARCH GROUP: Comparative evalua-tion of immunoadsorption and double filtration plas-mapheresis for removal of anti-A or -B antibody in ABO-incompatible kidney transplantation. Transpl. Proc. (1992) 24(2):557–558.
   PubMed Web of Science ®Google Scholar
• TOMA H: ABO-incompatible renal transplantation. Re-nal Vasc. Dis. Transpl. (1994) 21(2):299–310.
   Google Scholar
• COOPER DKC, CAIRNS TDH, TAUBE DH: Extracorporeal immunoadsorption of aGal antibodies. Xenotransplan-tation (1996) 4(2):27–29.
   Google Scholar
• LAMBRIGTS D, VAN CALSTER P, XU Y et al.: Pharma-cologic immunosuppressive therapy and extracorpo-real immunoadsorption in the suppression of anti-aGal antibody in the baboon. Xenotransplantation (1998) 5:274–283.
   PubMed Web of Science ®Google Scholar
• KOZLOWSKI T, MONROY R, XU Y et al. Anti-Gala1-3Gal antibody response to porcine bone marrow in un-modified baboons and baboons conditioned for toler-ance induction. Transplantation (1998) 66(2) 176–182
   PubMed Web of Science ®Google Scholar
• LISZEWSKI MK, FARRIES TC, LUBLIN DM, ROONEY IA, AT-KINSON JP: Control of the complement system. Adv. Im-munol. (1996) 61:201–283.
   PubMed Web of Science ®Google Scholar
• PLATT JL, VERCELLOTTI GM, DALMASSO AP et al.: Trans-plantation of discordant xenografts: a review of prog-ress. Immunol Tod. (1990) 11:450–456.
   PubMedGoogle Scholar
• MIYAGAWA S, HIROSE H, SHIRAKURA R et al.: The mechanism of discordant xenograft rejection. Trans-plantation (1988) 46(6):825–830.
   Google Scholar
• ••First time homologous restriction of complement regulatoryproteins implicated in hyperacute rejection of organs from discordant species.
   Google Scholar
• COCHRANE CG, MeLLER-EBERHARD HJ, AIKIN BS: De-pletion of plasma complement in vivo by a protein of cobra venom: its effect on various immunologic reac-tions. J. Immunol. (1970) 105(0:55–69.
   PubMedGoogle Scholar
• VOGEL CW, SMITH CA, MeLLER-EBERHARD HJ: Cobra venom factor: structural homology with the third component of human complement. J. Immunol. (1984) 133 (6):3235–3241.
   PubMed Web of Science ®Google Scholar
• KOBAYASHI T, TANIGUCHI S, NEETHLING FA et al.: De-layed xenograft rejection of pig-to-baboon cardiac transplants after cobra venom factor therapy. Trans-plantation (1997) 64 (9) :1255–1261.
   Google Scholar
• TANIGUCHI S, KOBAYASHI T, NEETHLING FA et al.: Co-bra venom factor stimulates anti-a-galactose antibody production in baboons. Transplantation (1996) 62(5)678–681.
   Google Scholar
• WEISMAN HF, BARTOW T, LEPPO MK et al.: Soluble hu-man complement receptor Type 1: In vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis. Science (1990) 249:146–151.
   PubMed Web of Science ®Google Scholar
• PRUITT SK, BOLLINGER RR, COLLINS BH et al. Continu-ous complement inhibition using soluble C receptor Type 1 (sCR1): effect on hyperacute rejection (HAW of pig-to-primate cardiac xenografts. Transpl Proc. (1996) 28(2)756.
   Web of Science ®Google Scholar
• LAMBRIGTS D, SACHS DH, COOPER DKC: Discordant or-gan xenotransplantation in primates. Transplantation (1998) 66(5):547–561.
   PubMed Web of Science ®Google Scholar
• ••A comprehensive overview of various therapies and out-comes in the pig-to-primate model system.
   Google Scholar
• MCCURRY KR, KOOYMAN DL, DIAMOND LE, BYRNE GW, LOGAN JS, PLATT JL: Transgenic expression of human complement regulatory proteins in mice results in di-minished complement deposition during organ xenoperfusion. Transplantation (1995) 59 (8):1177–1182.
   PubMed Web of Science ®Google Scholar
• BYRNE GW, MCCURRY KR, KAGAN D et al: Protection of xenogeneic cardiac endothelium from human com-plement by expression of CD59 or DAF in transgenic mice. Transplantation (1995) 60(10):1149–1156.
   PubMed Web of Science ®Google Scholar
• DIAMOND LE, MCCURRY KR, OLDHAM ER et al.: Human CD59 expressed in transgenic mouse hearts inhibits the activation of complement. Transpl. Immunol. (1995) 3:305–312.
   PubMedGoogle Scholar
• VAN DENDEREN BJ, PEARSE MJ, KATERELOS M et al. Ex-pression of functional decay-accelerating factor(CD55) in transgenic mice protects against human complement-mediated attack. Transplantation (1996) 61(0582–588.
   PubMed Web of Science ®Google Scholar
• COWEN PJ, CHEN CG, SHINKEL TA et al: Knock out of al-phal, 3-galactosyltransferase or expression of al-phal,2-ftwosyltransferase further protects CD55- and CD59-expressing mouse hearts in an ex vivo model of xenograft rejection. Transplantation (1998) 65 (12):1599–1604.
   PubMed Web of Science ®Google Scholar
• THORLEY BR, MILLAND J, CHRISTIANSEN D et al: Trans-genic expression of a CD46 (membrane cofactor pro-tein) minigene: studies of xenotransplantation and measles virus infection. Eur. j Immunol. (1997) 27:726–734.
   PubMed Web of Science ®Google Scholar
• MCCURRY KR, KOOYMAN DL, ALVARADO CG et al.: Hu-man complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury. Nature Med. (1995) 1(5):423–427.
   PubMed Web of Science ®Google Scholar
• ••First demonstration that expression of human complementregulatory proteins in transgenic pig organs can overcome hyperacute rejection upon transplantation into primates.
   Google Scholar
• DIAMOND LE, MCCURRY KR, MARTIN MJ et al.: Charac-terization of transgenic pigs expressing functionally active human CD59 on cardiac endothelium. Trans-plantation (1996) 61(8):1241–1249.
   Google Scholar
• BYRNE GW, MCCURRY KR, MARTIN MJ, MCCLELLAN SM, PLATT JL, LOGAN JS: Transgenic pigs expressing hu-man CD59 and decay-accelerating factor produce an intrinsic barrier to complement-mediated damage. Transplantation (1997) 63 (1) :149–155.
   PubMed Web of Science ®Google Scholar
• DIAMOND LE, MARTIN MJ, ADAMS D et al.: Transgenic pig hearts and kidneys expressing human CD59, CD55, or CD46 are protected from hyperacute rejec-tion upon transplantation into baboons. The 4th Inter-national Congress for Xenotransplantation. Nantes, France (1997) Abstract: 0185
   Google Scholar
• ROSENGARD AM, CARY NRB, LANGFORD GA, TUCKER AW, WALLWORK J, WHITE DJG: Tissue expression of hu-man complement inhibitor, decay-accelerating factor, in transgenic pigs. Transplantation (1995) 59(9):1325–1333.
   PubMed Web of Science ®Google Scholar
• WHITE DJG: hDAF transgenic pig organs: are they con-cordant for human transplantation? Xenotransplanta-tion (1996) 4(3):50–54.
   Google Scholar
• WATERWORTH PD, COZZI E, TOLAN MJ et al.: Pig-to-primate cardiac xenotransplantation and cyclophos-phamide therapy. Transpl Proc. (1997) 29:899–900.
   PubMed Web of Science ®Google Scholar
• SCHMOECKEL M, BHATTI FNK, ZAIDI A et al: Orthotopic heart transplantation in a transgenic pig-to-primate model. Transplantation (1998) 65 (12) :1570–1577.
   PubMed Web of Science ®Google Scholar
• ZAIDI A, SCHMOECKEL M, BHATTI F et al.: Life-supporting pig-to-primate renal xenotransplantation using genetically modified donors. Transplantation (1998) 65(12):1584–1590.
   PubMed Web of Science ®Google Scholar
• BHATTI FNK, ZAIDI A, SCHMOECKEL M et al: Survival of life -supporting HDAF transgenic kidneys in primates is enhanced by splenectomy. Transpl. Proc. (1998) 30:2467.
   PubMed Web of Science ®Google Scholar
• THALL AD, MALY P, LOWE JB: Oocyte Gal alpha 1,3Galepitopes implicated in sperm adhesion to the zona pel-lucida glycoprotein ZP3 are not required for fertiliza-tion in the mouse. J Biol Chem (1 9 9 5) 270(37)21437–21440.
   Google Scholar
• TEARLE RG, TANGE MJ, ZANNETTINO ZL et al: The a-1,3-galactosyltransferase knockout mouse. Transplanta-tion (1996) 61(1):13–19.
   PubMed Web of Science ®Google Scholar
• WILMUT I, SCHNIEKE AE, MCWHIR J, KIND AJ, CAMPBELLKHS: Viable offspring derived from fetal and adult mammalian cells. Nature (1997) 385:810–813.
   PubMed Web of Science ®Google Scholar
• CIBELLI JB, STICE SL, GOLUEKE PJ et al.: Cloned trans-genic calves produced from nonquiescent fetal fibro-blasts. Science (1998) 280:1256–1258.
   PubMed Web of Science ®Google Scholar
• STEWART C: An udder way of making lambs. Nature(1997) 385:769–771.
   PubMed Web of Science ®Google Scholar
• SHARMA A, OKABE J, BIRCH P et al.: Reduction in thelevel of Gal(a1,3)Gal in transgenic mice and pigs by the expression of an a(1,2)ftwosyltransferase. Proc. Natl. Acad. Sci. USA (1996) 93:7190–7195.
   PubMed Web of Science ®Google Scholar
• SANDRIN MS, FODOR WL, MOUHTOURIS et al. Enzy- matic remodelling of the carbohydrate surface of a xe-nogenic cell substantially reduces human antibody binding and complement-mediated cytolysis. Nature Med. (1995) 1(12):1261–1267.
   PubMed Web of Science ®Google Scholar
• CHEN C-G, FISICARO N, SHINKEL TA et al.: Reduction inGal-a1,3-Gal epitope expression in transgenic mice expressing human H-transferase. Xenotransplantation (1996) 3:69–75.
   Web of Science ®Google Scholar
• KOIKE C, KANNAGI R, TAKUMA Y et al.: Introduction ofa(1-2)-ftwosyltransferase and its effect on a-Gal epi-topes in transgenic pig. Xenotransplantation (1996) 3:81–86.
   Web of Science ®Google Scholar
• OSMAN N, MCKENZIE IFC, OSTENRIED K, IOANNOU YA,DESNICK RJ, SANDRIN MS: Combined transgenic ex-pression of a-galactosidase and a1,2-fucosyltransferase leads to optimal reduction in the major xenoepitope Gala(1,3)Gal. Proc. Natl. Acad. Sci. USA (1997) 94:14677–14682.
   PubMed Web of Science ®Google Scholar
• MCCURRY KR, PARKER W, COTTERELLAH et al: Humoralresponses to pig-to-baboon cardiac transplantation: Implications for the pathogenesis and treatment of acute vascular rejection and for accommodation. Hu-man Immunol. (1997) 58:91–105.
   PubMed Web of Science ®Google Scholar
• DAVIS EA, PRUITT SK, GREENE PS et al. Inhibition of complement, evoked antibody, and cellular response prevents rejection of pig-to-primate cardiac xeno-grafts. Transplantation (1996) 62(7):1018–1023.
   PubMed Web of Science ®Google Scholar
• GALILI U, LATEMPLE DC, WALGENBACH AW, STONE KR:Porcine and bovine cartilage transplants in cynomol-gus monkey. Transplantation (1997) 63 (5):646–651.
   PubMedGoogle Scholar
• COTTERELL AH, COLLINS BH, PARKER W, HARLAND RC,PLATT JL: The humoral immune response in humans following cross-perfusion of porcine organs. Trans-plantation (1995) 60(8):861–868.
   Google Scholar
• BAQUERIZO A, MHOYAN A, KEARNES-JONKER M et al.: Characterization of human xenoreactive antibodies in liver failure patients exposed to pig hepatocytes after bioartificial liver treatment. Transplantation (1999) 67(0:5–18.
   PubMedGoogle Scholar
• RYDBERG L, BJORCK S, HALLBERG E et al.: Extracorpo-real (ex vivo') connection of pig kidneys to humans. II. The anti-pig antibody response. Xenotransplantation (1996) 3:340–353.
   PubMed Web of Science ®Google Scholar
• GALILI U, TIBELL A, SAMUELSSON BO, RYDBERG L, GROTH CG: Increased anti-gal activity in diabetic pa-tients transplanted with fetal porcine islet cell clus-ters. Transplantation (1995) 59 (11) :1549–1556.
   PubMed Web of Science ®Google Scholar
• UN SS, KOOYMAN DL, DANIELS LJ et al.: The role of natu-ral anti-Gala1-3Gal antibodies in hyperacute rejection of pig-to-baboon cardiac xenotransplants. Transpl. Im-munol (1997) 5:212–218.
   PubMed Web of Science ®Google Scholar
• MASTRANGELO F, PRETAGOSTINI R, BERLOCO P et al.: Immunoadsorption with protein A in humoral acute rejection of kidney transplants: multicenter experi-ence. Transpl. Proc (1995) 27(0:892–895.
   PubMedGoogle Scholar
• PERSSON NH, BUCIN D, EKBERG H et al.: Immunoad-sorption in acute vascular rejection after renal trans-plantation. Transpl. Proc. (1995) 27(6)3466.
   Google Scholar
• YANG YG, DEGOMA E, OHDAN H et al.: Tolerization of anti-Galalphal-3gal natural antibody-forming B cells by induction of mixed chimerism. J. Exp. Med. (1998) 187(8)1335–1342.
   Google Scholar
• BRACY JL, SACHS DH, IACOMINI J: Inhibition of xenore-active natural antibody production by retroviral gene therapy. Science (1998) 281:1845–1847.
   PubMed Web of Science ®Google Scholar
• BACH FH, ROBSON SC, WINKLER H et al.: Barriers to xe-notransplantation. Nature Med. (1995) 1(9)869–873.
   Google Scholar
• PALMETSHOFER A, GALILI U, DALMASSO AP, ROBSON SC, BACH FH: a-galactosyl epitope-mediated activation of porcine aortic endothelial cells. Type I Activation. Transplantation (1998) 65(6)844–853.
   Google Scholar
• ••Ref 90 and 91 are carefully detailed studies of Type I andType II endothelial cell activation.
   Google Scholar
• PALMETSHOFER A, GALILI U, DALMASSO AP, ROBSON SC, BACH FH: a-galactosyl epitope-mediated activation of porcine aortic endothelial cells. Type II Activation. Transplantation (1998) 65(7)971–978.
   Google Scholar
• ••Ref 90 and 91 are carefully detailed studies of Type I andType II endothelial cell activation.
   Google Scholar
• LAWSON JH, PLATT JL: Molecular barriers to xenotrans-plantation. Transplantation (1996) 62 (3):303–310.
   PubMedGoogle Scholar
• INVERARDI L, SAMAJA M, MOTTERLINI R, MANGILI F, BENDER JR, PARDI R: Early recognition of a discordant xenogeneic organ by human circulating lymphocytes. Immunol (1992) 149(01416–1423.
   Web of Science ®Google Scholar
• MILLAN MT, GECZY C, STUHLMEIER KM, GOODMAN DJ, FERRAN C, BACH FH: Human monocytes activate por-cine endothelial cells, resulting in increased e-selectin, interleukin-8, monocyte chemotactic protein-1, and plasminogen activator inhibitor-type-1 expression. Transplantation (1997) 63(3)421–429.
   Google Scholar
• PRUITT SK, BOLLINGER RR, COLLINS BH et al. Effect of continuous complement inhibition using soluble complement receptor Type 1 on survival of pig-to-primate cardiac xenografts. Transplantation (1997) 63(6) 900–914
   PubMed Web of Science ®Google Scholar
• XU H, GUNDRY SR, HANCOCK WW eta].: Prolonged dis-cordant xenograft survival and delayed xenograft re-jection in a pig-to-baboon orthotopic cardiac xenograft model. J. Thorac. Cardiovasc. Surg. (1998) 115:1342–1349.
   Google Scholar
• AUCHINCLOSS H, SACHS DH: Xenogeneic transplanta-tion. Annu. Rev. Immunol (1998) 16:433–470.
   PubMed Web of Science ®Google Scholar
• CHAN DV, AUCHINCLOSS H JR: Human anti-pig cell-mediated cytotoxicity in vitro involves non-T as well as T cell components. Xenotransplantation (1996) 3:158–165.
   Web of Science ®Google Scholar
• SEEBACH JD, YAMADA K, MCMORROW IM, SACHS DH,DERSIMONIAN H: Xenogeneic human anti-pig cytotox-icity mediated by activated natural killer cells. Xeno-transplantation (1996) 3:188–197.
   Google Scholar
• SEEBACH JD, COMRACK C, GERMANA S, LEGUERN C, SACHS DH, DERSIMONIAN H HLA-Cw3 expression on porcine endothelial cells protects against xenogeneic cytotoxicity mediated by a subset of human NK cells. J. Immunol. (1997) 159(7):3655–3661.
   PubMed Web of Science ®Google Scholar
• MUNZ C, HOLMES N, KING A et al. Human histocom- patibility leukocyte antigen (HLOG molecules inhibit NKAT3 expressing natural killer cells. J. Exp. Med. (1997) 185(3) 385–391
   PubMed Web of Science ®Google Scholar
• SACHS D: The pig as a potential xenograft donor. Vet Immunol. Immunopathol. (1994) 43 (1-3) 185–191.
   PubMed Web of Science ®Google Scholar
• SACHS DH, SABLINSKI T: Tolerance across discordant xenogeneic barriers. Xenotransplantation (1995) 2 (3):234–239.
   Google Scholar
• KOZLOWSKI T, SHIMIZU A, LAMBRIGTS D et al. Porcine kidney and heart transplantation in baboons undergo-ing a tolerance induction regimen and antibody ad-sorption. Transplantation (1999) 67(1) 18–30
   PubMed Web of Science ®Google Scholar
• RAO AS, FONTES P, ROGERS J eta].: Evidence for long-term persistence of donor cell chimerism after ba-boon _ neonatal pig bone marrow xenotransplanta-tion (XTx). The 4th International Congress for Xenotransplantation. Nantes, France (1997) Abstract: 0181.
   Google Scholar
• DEACON T, SCHUMACHER J, DINSMORE J et al. Histo- logical evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's dis-ease Nature Med. (1997) 3(3):350–353.
   Google Scholar
• GROTH CG, KORSGREN 0, TIBELL A et al. : Transplanta-tion of porcine fetal pancreas to diabetic patients. Lan-cet (1994) 344:1402–1404.
   Google Scholar
• EXNER BG, NEIPP, M, ILDSTAD, ST: Baboon bone mar-row transplantation in humans: application of cross-species disease resistance. World J. Surg. (1997) 21:962–967.
   PubMed Web of Science ®Google Scholar
• TODARO GJ, BENVENISTE RE, LIEBER MM, SHERR CJ: Characterization of a Type C virus released from the porcine cell line PK (15). Virology (1974) 58:65–74.
   PubMed Web of Science ®Google Scholar
• PATIENCE C, TAKEUCHI Y, WEISS RA: Infection of hu-man cells by an endogenous retrovirus of pigs. Nature Med. (1997) 3(3):282–286.
   PubMed Web of Science ®Google Scholar
• WILSON CA, WONG S, MULLER J, DAVIDSON CE, ROSE TM, BURD P: Type C retrovirus released from procine primary peripheral blood mononuclear cells infects human cells. J. Virol (1998) 72(4):3082–3087.
   PubMed Web of Science ®Google Scholar
• LE TISSIER P, STOYE JP, TAKEUCHI Y, PATIENCE C, WEISS RA: Two sets of human-tropic pig retrovirus. Nature (1997) 389:681–682.
   PubMed Web of Science ®Google Scholar
• AKIYOSHI DE, DENARO M, ZHU H, GREENSTEIN JL, BAN-ERJEE P, FISHMAN JA: Identification of a full-length cDNA for an endogenous retrovirus of miniature swine. J. Virol. (1998) 72(5):4503–4507.
   PubMed Web of Science ®Google Scholar
• TAKEUCHI Y, PATIENCE C, MAGRE S et al.: Host range and interference studies of three classes of pig endoge-nous retrovirus. j Virol (1998) 72(12):9986–9991.
   PubMed Web of Science ®Google Scholar
• HENEINE W, TIBELL A, SWITZER WM et al.: No evidence of infection with porcine endogenous retrovirus in re-cipients of porcine islet-cell xenografts. Lancet (1998) 352:695–699.
   PubMed Web of Science ®Google Scholar
• PATIENCE C, PATTON GS, TAKEUCHI Y et al.: No evi-dence of pig DNA or retroviral infection in patients with short-term extracorporeal connection to pig kid-neys. Lancet (1998) 352:699–701.
   PubMed Web of Science ®Google Scholar
• MARTIN U, STEINHOFF G, KIESSIG V et al.: Porcine en-dogenous retrovirus (PERV) was not transmitted from transplanted porcine endothelial cells to baboons in vivo. Transpl. Int. (1998) 11(4):247–251. Lisa E Diamond Nextran, Inc., 303B College Road East, Princeton, NJ 8540, USA Tel.: +1 609 243 0009; Fax: +1 609 252 1235; Email: [email protected]
   Google Scholar