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Drug Evaluation

Tolterodine: a new antimuscarinic agent for the treatment of the overactive bladder

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Pages 1073-1078 | Published online: 23 Feb 2005

Bibliography

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  • ••This is an article that reviews the pharmacologic propertiesof tolterodine.
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  • ••This article reviews the pharmacologic properties oftolterodine and helps explain its clinical usefulness.
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  • BRYNNE N, STAHL MM, HALLEN B et al.: Pharmacoki-netics and pharmacodynamics of tolterodine in man: a new drug for the treatment of urinary bladder overactivity. Int. J. Chn. Pharmocol. Ther. (1997) 35 (7):287–295.
  • BRYNNE N, DALEN P, ALVAN G et al.: Influence ofCYP2D6 polymorphism on the pharmacokinetics and pharmacodynamics of tolterodine. Clin. Pharmacol. Ther. (1998) 63:529–539.
  • POSTLIND H, DANELSON A, LINDGREN A et al.:Tolterodine, a new muscarinic receptor antagonist, is metabolized by cytochromes P450 2D6 and 3A in human liver microsomes. Drug Met. Disp. (1998) 26:289–293.
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  • ••This is an excellent article that reviews the various clinicaltrials that have been performed using tolterodine.
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  • •This article describes one of the clinical studies performed involving this new antimuscarinic.
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  • •This is another article involving a clinical study of tolterodine versus placebo.

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