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Review

New developments in IL-6 dependent biology and therapy: where do we stand and what are the options?

, &
Pages 1327-1349 | Published online: 23 Feb 2005

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  • •Shows that IL-6 deficiency prevents collagen-induced, but not TNF-a induced arthritis.
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  • •A biotechnological success story.
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  • •Shows that generation of antiDNA antibodies depends on IL-6, but that they are not causally involved in the genesis of lupus nephritis.
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  • ••The soluble IL-6R renders endothelial cells responsive toIL-6 and causes them to express leucocyte attracting chemokines.
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  • •Neutrophils may be the source for soluble IL-6R that makes endothelial cells responsive to IL–6.
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  • ••An excellent study on early effects of hepatic overexpres-sion of IL-6 and soluble IL-6R in mice. Shows that coexpres-sion of IL-6 and soluble IL-6R lead to endothelitis and hepatoma.
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  • •Shows that protection against autoimmune disease in IL-6 deficient mice is due to a defect in T-cell differentiation.
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  • ••Transfers the principle of generating anti-idiotypicantibodies to cytokines.
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  • •A good reference to start reading into anti-apoptotic effects that depend on STAT3 activation.
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  • •This and the preceding reference summarize the different views on a potential involvement of KHSV in the genesis of multiple myeloma.
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  • ••A very important paper demonstrating that viral IL-6 cancause haematopoiesis, plasmocytosis and increased tumour vascularization in vivo
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  • •An interesting analysis of KHSV related pathology.
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  • •Shows that IL-6 has angiogenic potency by inducing VEGF expression.
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  • •First paper to establish an epidemiological link between KHSV infections and Kaposi's sarcoma
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  • •180–182: A series of good papers that strongly suggest an IL-6 involvement in prostate carcinoma.
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  • ••Two papers that reveal an antimyeloma effect of pamidro-mate that prolongs survival of these patients.
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  • ••Demonstrates in a clinical trial that cytokines IL-2, IL-6 andTNF-a combined with highly active antiretroviral therapy might further reduce resident HIV-pools in CD4+ T-cells.
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  • ••An unusually thorough study of conditional gp130 / mice. Agood start to read into gp130 dependent biological effects.
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  • ••A landmark study. Shows that cardiospecific gp130knock-out does not result in cardiac abnormalities under physiological conditions, despite a strong cardiac phenotype in conditional complete gp130 / mice.
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