The multivalent minigene approach to vaccine development

Bibliography

• VAN DER MOST RB, SETTE A, OSEROFF C et al.: Analysisof cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection. J. Immunol. (1996) 157:5543–5554.
   Google Scholar
• LIVINGSTON BD, CRIMI C, GREY H et al.: The hepatitis Bvirus-specific CTL responses induced in humans by lipopeptide vaccination are comparable to those elicited by acute viral infection. J. Immunol. (1997) 159:1383–1392.
   PubMed Web of Science ®Google Scholar
• OSEROFF C, SETTE A, WENTWORTH P et al.: Pools oflipidated HTL-CTL constructs prime for multiple HBV and HCV CTL epitope responses. Vaccine (1998) 16:823–833.
   PubMed Web of Science ®Google Scholar
• KLAVINSKI LS, WHITTON JL, JOLY E, OLDSTONE MBA:Molecularly engineered vaccine which expressed an immunodominant T-cell epitope induces cytotoxic T lymphocytes that confer protection from lethal virus infection. J. Virol. (1989) 63:4311–4316.
   PubMed Web of Science ®Google Scholar
• •Demonstration that CTL epitope alone expressed in recombinant vaccinia protected mice from lymphocytic choriomeningitis virus challenge.
   Google Scholar
• PLEBANSKI M, GILBERT SC, SCHNEIDER J et al.: Protec-tion from Plasmodium berghei infection by priming and boosting T cells to a single class I-restricted epitope with recombinant carriers suitable for human use. Eur. I Immunol. (1998) 28:4345–4355.
   PubMed Web of Science ®Google Scholar
• DEL VAL M, SCHLICHT HJ, VOLKMER H, MESSERLE M,REDDEHASE MJ, KOSZINOWSKI UH: Protection against lethal cytomegalovirus infection by a recombinant vaccine containing a single nonameric T-cell epitope. J. Vim]. (1991) 65:3641–3646.
   Web of Science ®Google Scholar
• •Shows that the protection of cytomegalovirus infection can be induced by a CTL-specific minigene.
   Google Scholar
• SCHULZ M, AICHELE P, VOLLENWIDER M et al: Major histocompatibility complex-dependent T cell epitopes of lymphocytic choriomeningitis virus nucleoprotein and their protective capacity against viral diseases. Eur. j Immunol. (1989) 19:1657–1668.
   PubMed Web of Science ®Google Scholar
• •The early description that recombinant vaccinia expressing distinct T-cell epitiopes protected mice from viral infection.
   Google Scholar
• MOSS B: Poxvirus vectors: cytoplasmic expression oftransferred genes. Curr. Opin. GenetDev. (1993) 3:86–90.
   PubMedGoogle Scholar
• TOES RE, HOEBEN RC, VAN DER VOORST El etal.: Protec-tive anti-tumor immunity induced by vaccination with recombinant adenovirus encoding multiple tumor-associated cytotoxic T lymphocyte epitope in a string-of-beads fashion. Proc. Natl. Acad. Sci. USA (1997) 94:14660–14665.
   Google Scholar
• ROLPH MS, RAMSHAW IA: Recombinant viruses as vaccines and immunological tools. Curr. Opin. Immunol. (1997) 9:517524.
   Google Scholar
• SUHRBIER A: Multi-epitope DNA vaccines. Immunol. Cell Biol. (1997) 75:402–408.
   PubMed Web of Science ®Google Scholar
• AN L-L., WHITTON LJ: Multivalent minigene vaccines against infectious disease. Curr. Opin. Mol. Therap. (1999) 1:17–21.
   Google Scholar
• ANTON LC, YEWDELL JW, BENNINK JR.: MHC class I-associated peptides produced from endogenous gene products with vastly different efficiencies. J. Immunol (1997) 158:2535–2542.
   Google Scholar
• ••A systematic comparison of the efficiency for processing andpresenting of different endogenous peptides.
   Google Scholar
• PARKHURST MR, SALGALLER ML, SOUTHVVOOD S et al: Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding peptides. J. Immunol. (1996) 157:2539–2548.
   PubMed Web of Science ®Google Scholar
• AHLERS JD, TAKESHITA T, PENDLETON CD, BERZOFSKYJA: Enhanced immunogenicity of HIV-1 vaccine construct by modification of the native peptide sequence. Proc. Nati Acad. Sci. USA (1997) 94:10856–10861.
   PubMed Web of Science ®Google Scholar
• TSAI V, SOUTHWOOD S, SIDNEY J et al.: Identification ofsubdominant CTL epitopes of the GP100 melanoma-associated tumor antigen by primary in vitro immuni-zation with peptide-pulsed dendritic cells. J. Immunol (1997) 158:1796–1802.
   PubMed Web of Science ®Google Scholar
• SAROBE P, PENDLETON CD, AKATRUKA T et al.: Enhanced in vitro potency and in vivo immunogen-icity of a CTL epitope from hepatitis C virus core protein following amino acid replacement at secondary HLA-A2.1 binding positions. J. Clin. Invest. (1998) 102:1239–1248.
   Google Scholar
• FU TM, MYLIN LM, SCHELL TD et al: An endoplasmic reticulum-targeting signal sequence enhances the immunogenicity of an immunorecessive simian virus 40 large T antigen cytotoxic T-lymphocyte epitope. J. Virol. (1998) 72:1469–1481.
   PubMed Web of Science ®Google Scholar
• YEWDELL JW, SNYDER HL, BACIK I et al.: TAP-independent delivery of antigenic peptides to the endoplasmic reticulum: therapeutic potential and insights into TAP-dependent antigen processing. Immunotherapy (1998) 2:127–131.
   Google Scholar
• RODRIGUEZ F, AN L-L, HARKINS S et al.: DNA immuniza-tion with minigenes: low frequency of memory CTL and inefficient antiviral protection are rectified by ubiquitination. j Virol. (1998) 72:5174–5181.
   PubMed Web of Science ®Google Scholar
• ALEXANDER J, FIKES J, HOFFMAN S et al: The optimiza-tion of helper T lymphocytes (HTL) function in vaccine development. Immunol. Res. (1998) 2:79–92.
   Google Scholar
• WHITTON JL, SHENG N, OLDSTONE MBA, MCKEE TA: A 'string-of-beads' vaccine, comprising linked minigenes, confers protection from lethal-dose virus challenge. J. Virol. (1993) 67:348–352.
   PubMed Web of Science ®Google Scholar
• ••The initial report using a single construct of multipleminigenes to protect against lymphocytic choriomenigitis virus infection in different strains of mice.
   Google Scholar
• OLDSTONE MBA, TISHON M, EDDLESTON JC, DELATORRE Y, MCKEE T, WHITTON JL: Vaccination to prevent persistent viral infection. J. Virol. (1993) 67:4372–4378.
   PubMed Web of Science ®Google Scholar
• YU Z, KAREM KL, KANANGAT S, MANICKAN E, ROUSE BT: Protection by minigenes: a novel approach of DNA vaccines. Vaccine (1998) 17:1660–1667.
   Google Scholar
• •Protection against herpes simplex virus by plasmid DNA containing Ab, CTL and HLT-specific minignes.
   Google Scholar
• THOMSON SA, ELLIOT SL, SHERRITT MA et al: Recombi- nant polyepitope vaccines for the delivery of multiple CD8 cytotoxic T cell epitopes. J. Immunol. (1996) 157:822–826.
   PubMed Web of Science ®Google Scholar
• •Multiple CTL minigenes delivered protection against different viral infections.
   Google Scholar
• AN L-L, WHITTON JL: A multiple minigene vaccine containing B cell, CTL, and Th epitopes from several microbes, induces appropriate responses in vivo, and confers protection against more than one pathogen. J. Vim]. (1997) 71:2292–2302.
   Web of Science ®Google Scholar
• ••Shows that Ab, CTL and HTL-specific responses can beinduced by a multiple minigene contruct.
   Google Scholar
• GAILLARD JL, BERCHE P, SANSONETTI PJ: Transposon mutagenesis as a tool to study the role of hemolysin in the virulence of listeria monocytogenes. Infect. Immun. (1986) 55:2822–2829.
   Google Scholar
• AN L-L, PAMER E, WHITTON JL: A recombinant minigene vaccine containing a nonameric cytotoxic-T-lymphocyte epitope confers limited protection against listeria monocytogenes infection. Infect. Immun. (1997) 64:1685–1693.
   Web of Science ®Google Scholar
• SHI YP, HASNAIN SE, SACCI JB et al.: Immunogenicity and in vitro protective efficacy of a recombinant multistage plasmodium falciparum candidate vaccine. Proc. Nati Acad. Sci. USA (1999) 96:1615–1620.
   PubMed Web of Science ®Google Scholar
• HANKE T, SCHNEIDER J, GILBERT SC, HILL AV, MCMICHEAL A: DNA multi-CTL epitope vaccines for HIV and plasmodium falciparum: immunogenicity in mice. Vaccine (1998) 16:426–435.
   PubMed Web of Science ®Google Scholar
• ••Demonstration that a multiple CTL epitope minigene fromHIV and Plasmodium falciparum induced specific immune responses by DNA immunisation.
   Google Scholar
• RIPALTI A, BOCCUNI MC, CAMPANINI F et al.: Construc-tion of a polyepitope fusion antigen of human cytomegalovirus ppUL32 and detection of specific antibodies by ELISA. New Microbiol. (1995) 18:1–12.
   PubMedGoogle Scholar
• CIERNIK IF, BERZOFSKY JA, CARBONE DP: Induction of cytotoxic T lymphocytes and antitumor immunity with DNA vaccines expressing single T cell epitope. Immunol. (1996) 156: 2369–2375.
   Web of Science ®Google Scholar
• •Using ER signal sequence to enhance the immunity of a single CTL minigene DNA vaccine.
   Google Scholar
• ZAJAC P, OERTLI D, SPAGNOLI GC, NOPPEN C, SCHAEFER C, HEVERER M: Generation of tumorcidal cytotoxic T lymphocytes from healthy donors after in vitro stimulation with a replication-incompetent vaccinia virus encoding MART-1/Melan-A 27-35 epitope. Int. J. Cancer. (1997) 71:491–496.
   PubMed Web of Science ®Google Scholar
• MCCABE BJ, IRVINE KR, NISHIMURA MI et al. Minimal determinant expressed by a recombinant vaccinia virus elicits therapeutic antitumor cytolytic T lympho-cyte response. Cancer Res. (1995) 55:1741–1747.
   PubMed Web of Science ®Google Scholar
• IWASAKI A, BARVER BH: Induction by DNA immuniza-tion of a protective antitumor cytotoxic T lymphocyte response against a minimal-epitope-expressing tumor. Cancer Immunol Immunother. (1998) 45:273–279.
   PubMed Web of Science ®Google Scholar
• RUIZ PJ, GARREN H, RUIZ IU et al: Suppressive immuni-zation with DNA encoding a self-peptide prevents autoimmune disease: modulation of T cell costimula-tion. j Immunol. (1999) 162:3336–3341.
   PubMed Web of Science ®Google Scholar
• KULKARNI AB, COLLINS P, BACIK I et al.: Cytotoxic T cells specific for a single peptide on the M2 protein of respiratory syncytial virus are the sole mediators of resistance induced by immunization with M2 encode a recombinant vaccinia virus. J. Virol. (1 9 9 5) 69:1261-1264.
   Google Scholar
• BLANEY JE JR, NOBUSAWA E, BREHM MA et al.: Immuni-zation with a single major histocompatibility complex class I-restricted cytotoxic T-lymphocyte recognition epitope of herpes simplex virus Type 2 confers protec-tive immunity. J. Virol. (1998) 72:9567–9574.
   PubMed Web of Science ®Google Scholar
• LI SQ, RODRIGUES M, RODRIGUEZ D et al: Priming with recombinant influenza virus followed by administra-tion of recombinant vaccinia virus induced CD8+ T-cell-mediated protective immunity against malaria. Proc. Natl. Acad. Sci. USA (1993) 90:5214–5218.
   PubMed Web of Science ®Google Scholar
• HSU S-C, OBEID OE, COLLINS M, IQBAL M, CHARGE-LEGUE D, STEWARD MW: Protective cytotoxic T lymphocyte responses against paramyxoviruses induced by epitope-based DNA vaccines: involvement of IFN-y. Int. Immunol (1998) 10:1441–1447.
   PubMed Web of Science ®Google Scholar
• WANG R, DOOLAN DL, LE TP et al.: Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine. Science (1998) 282:476–480.
   PubMed Web of Science ®Google Scholar
• THOMSON SA, SHERRITT, MA, MEDVECZKY J et al.: Delivery of multiple CD8 cytotoxic T cell epitopes by DNA vaccination. J. Immunol. (1998) 160 (4):1717–23.
   PubMed Web of Science ®Google Scholar
• HANKE T, NEUMANN VC, BLANCHARD TJ et al.: Effectiveinduction of HIV-specific CTL by multi-epitope using gene gun in a combined vaccination regime. Vaccine (1999) 17:589–596.
   PubMed Web of Science ®Google Scholar
• ISHIOKA GY, FIKES J, HERMANSON G et al.: Utilization of MHC class I transgenic mice for development of minigene DNA vaccines encoding multiple HLA restricted CTL epitopes. J. Immunol. (1 9 9 9) 162:3915-3925.
   Google Scholar
• ••Initial demonstration that multiple human HLA restrictedCTL responses can be induced in transgenic mice by DNA immunisation.
   Google Scholar
• KAST WM, BRANDT RMP, SIDNEY J et al.: The role of HLA-A mortifs in identification of potential CTL epitopes in human papillomavirus Type 16 E6 and E 7 proteins. J. Immunol. (1994) 152:3904–3912.
   PubMed Web of Science ®Google Scholar
• RUPPERT J, SIDNEY J, CELIS E, KUBO RT, GREY HM, SETTE A: Prominent role of secondary anchor residues in peptide binding to HLA-A2.1 molecules. Cell (1993) 74:929–937.
   Google Scholar
• GULUKOTA K, SIDNEY J, SETTE A, DELISI C.: Two complementary methods for predicting peptides binding to major histocompatibility complex molecules. J. Mot. Biol. (1997) 267(5):1258–1267.
   Google Scholar
• BERTONI R, SIDNEY J, FOWLER P, CHISARI F, SETTE A: Human histocompatibility leukocyte antigen-binding supermotifs predict broadly cross-reactive cytotoxic T lymphocyte responses inpatients with acute hepatitis. Clin. Invest. (1997) 100:503–513.
   Google Scholar
• DOOLAN DL, HOFFMAN SL, SOUTHWOOD S et al.: Degenerate cytotoxic T cell epitopes from P. falciparum restricted by multiple HLA-A and HLA-B supertype alleles. Immunity (1997) 7 (0 :97–112.
   Google Scholar
• SIDNEY J., GREY, HM, KUBO RT, SETTE A: Practical, Biochemical and Evolutionary Implications of the Discovery of HLA Class I Supermotifs. Immunol. Today (1996) 17:261–266.
   PubMedGoogle Scholar
• SETTE A, SIDNEY J: HLA supertypes and supermotifs: a functional perspective on HLA polymorphism. Curr. Opin. Immunol. (1998) 10:478–482.
   PubMed Web of Science ®Google Scholar
• •A review describing the predominance of HLA polymor-phism and practical implications.
   Google Scholar
• THOMSON SA, BURROW SR, MISKO IS, COUPAR BE, KHANNA R.: Targeting a polyepitope protein incorpo-rating multiple class II-restricted viral eiptopes to the secretory/endocytic pathway facilitates immune recognition by CD4+ cytotoxic T lymphocytes: a novel approach to vaccine design. J. Vim]. (1998) 72:2246–2252.
   Google Scholar
• WU TC, GUARNIERI FG, STAVELEY-OVARROLL KF et al: Engineering an intracellular pathway for major histocompatibility complex class II presentation of antigens. Proc. Natl. Acad. Sci. USA (1995) 92:11671–11675.
   PubMed Web of Science ®Google Scholar
• ROWELL JF, RUFF AL, GUARNIERI FG et al.: Lysosome-associated membrane protein-l-mediated targeting of the HIV-1 envelope protein to an endosomal/lysosomal compartment enhances its presentation to MHC class II-restricted T cells. J Immunol. (1995) 155:1818–1828.
   PubMed Web of Science ®Google Scholar