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Review

Postnatal glucocorticosteroid therapy for treatment and prevention of neonatal chronic lung disease

Pages 53-67 | Published online: 23 Feb 2005

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  • O'SHEA TM, KOTHADIA JM, KLINEPETER KL et al: Randomized placebo-controlled trial of a 42-day tapering course of dexamethasone to reduce the duration of ventilator dependency in very low birth weight infants: outcome of study participants at 1-year adjusted age. Pediatrics (1999) 104:15–21.
  • KONIG P, SHATELY M, LEVINE C, MASHINNEY TP: Clinical observations of nebulised flunisolide in infants and young children with asthma and bronchopulmonary dysplasia. Pediatr. Pulmonol (1992) 13:209–214.
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  • LIU EA, HELDT GP: A trial of the safety of inhaled beclomethasone in ventilator-treated neonates. J. Pediatr. (1996) 129:154–156.
  • GAL P, DIAZ PR, RANSOM JL, THORSON DW: Beclomethasone for treating premature infants with bronchopulmonary dysplasia. J. Pediatr. (1993) 123:490–491.
  • DIMITRIOU G, GREENOUGH A, GIFFIN FJ, KAVADIA V: Inhaled versus systemic steroids in chronic oxygen dependency of preterm infants. Eur. J. Pediatr. (1997) 156:51–55.
  • •Assessment of onset of effect of systemic versus inhaled steroid therapy.
  • SUCHOMSKI SJ, CUMMINGS JJ: Randomized trial of inhaled (NH) vs. intravenous (IV) steroid in ventilator dependent preterm infants. Pediatr. Res. (1996) 39:247 Abstract.
  • •Research meeting abstract comparing effect of systemic dexamethasone therapy with inhaled steroid therapy.
  • ARNON S, GRIGG J, SILVERMAN M: Effectiveness of budesonide aerosol in ventilator-dependent preterm babies: a preliminary report. Pediatr. Pulmonol. (1996) 21:231–235.
  • COLE CH, COLTON T, SHAH BL et al: Early inhaled glucocorticoid therapy for prevention of bronchopul-monary dysplasia. N Engl. J. Med. (1999) 340:1005–1010.
  • •Large randomized trial reflecting some benefits in respira-tory outcomes in infants treated with prophylactic inhaled beclomethasone therapy, but no reduction in CLD.
  • GUPTA GK, COLE CH, ABBASI S et al.: Effect of beclomethasone therapy on tracheal aspirate interleukin-8 and interleukin-1 receptor antagonist in preterm ventilated infants at risk for bronchopul-monary dysplasia (BPD). Pediatr. Res.(1999) 45:303 Abstract.
  • •Rcent research meeting abstract reflecting less tracheal aspirate inflammation in beclomethasone treated infants.
  • ABBASI S, COLE CH, FRANTZ I, YKORUK R, GERDES J: Effect of early glucocorticoid therapy on tracheobron-chial lesions I mechanically ventilated preterm infants. Pediatr. Res. (1999) 45:179 (Abstract).
  • •Recent research meeting abstract showing inhaled beclomethasone is associated with less tracheobronchial mucosal injury.
  • FOK TF, LAM K, DOLOVICH M et al.: Randomized controlled study of early use of inhaled corticosteroid in preterm infants with respiratory distress syndrome. Arch. Dis. Child Fetal Neonatal Ed. (1999) 80:F203–F208.
  • •Interesting pilot study of prophylactic fluticasone therapy in infants at risk for CLD.
  • NG PC, FOK TF, WONG GWK et al: Pituitary-adrenal suppression in preterm, very low birth weight infants after inhaled fluticasone propionate treatment. J. Clin. Endo. Metab. (1998) 83:2390–2393.
  • •Interesting study and discussion of CRH stimulation test for P-A assessment.
  • DOLOVICH M: Aerosol delivery to children: What to use, How to choose. Pediatric Pulmonol. (1999) 18:79–82.
  • •Excellent review and discussion regarding aerosol delivery to infants and children.
  • BISGAARD H: Delivery of inhaled medication to children. J. Asthma (1997) 34 (6):443–467.
  • •Detailed review regarding aerosol delivery to infants and children.
  • DOLOVICH M: Changing delivery methods for obstruc-tive lung diseases. Curr. Opin. Pulm. Med. (1997) 3(3):177–189.
  • •Updated review of aerosol delivery systems and new formulations of aerosol drugs.

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