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Expert Opinion on Investigational Drugs Volume 9, 2000 - Issue 11
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Review

Therapeutic potential of H3-receptor agonists in myocardial infarction

Christina J Mackins Cornell University, Weill Medical College, 1300 York Avenue, New York, NY 10021, USA. [email protected]
&
Roberto Levi Cornell University, Weill Medical College, 1300 York Avenue, New York, NY 10021, USA. [email protected]
Pages 2537-2542 | Published online: 23 Feb 2005

  • BRAUNWALD E, SOBEL BE: Coronary blood flow and myocardial ischemia. In: Heart Disease, a Textbook of Cardiovascular Medicine. Braunwald E (Ed.), WB Saunders, Philadelphia, USA (1988):1191–1221.
  • SCHOMIG A, RICHARDT G, KURZ T: Sympatho-adrenergic activation of the ischemic myocardium and its arrhythmogenic impact. Herz (1995) 20 (3):169–186.
  • AIRAKSINEN KE: Autonomic Mechanisms and Sudden Death After Abrupt Coronary Occlusion. Ann. Med. (1999) 31 (4):240–245.
  • SCHOMIG A, HAASS M, RICHARDT G: Catecholamine release and arrhythmias in acute myocardial ischaemia. Eur. Heart .1: (1991) 12 (Suppl. F):38–47.
  • LEVI R, SMITH NCE: Histamine H3-receptors: a new frontier in myocardial ischemia. J. Pharmacol. Exp. Ther. (2000) 292(3):825–830.
  • KURZ T, OFFNER B, SCHREIECK J, RICHARDT G, TOLG R, SCHOMIG A: Nonexocytotic noradrenaline release and ventricular fibrillation in ischemic rat hearts. Naunyn-Schmiedebergs Arch. Pharmacol. (1995) 352 (5):491–496.
  • IMAMURA M, LANDER HM, LEVI R: Activation of histamine H3-receptors inhibits carrier-mediated norepinephrine release during protracted myocardial ischemia - comparison with adenosine Ai-receptors and A2-adrenoceptors. Circ. Res. (1996) 78(3):475–481.
  • HATTA E, MARUYAMA R, MARSHALL SJ, IMAMURA M,LEVI R: Bradykinin promotes ischemic norepinephrine release in guinea pig and human hearts. J. Pharmacol. Exp. Ther. (1999) 288(3):919–927.
  • BENEDICT CR, SHELTON B, JOHNSTONE DE et al: Prognostic significance of plasma norepinephrine in patients with asymptomatic left ventricular dysfunc-tion. Circulation (1996) 94(4):690–697.
  • ARDLIE NG, CAMERON HA, GARRETT J: Platelet activa-tion by circulating levels of hormones: a possible link in coronary heart disease. Thromb. Res. (1984) 36 (4):315–322.
  • LARSSON PT, WALLEN NH, HJEMDAHL P: Norepinephrine-induced human platelet activation in vivo is only partly counteracted by aspirin. Circulation (1994) 89(5):1951–1957.
  • TRACHTE GJ, STEIN E: Platelet-generated thrombox an e A2 enhances norepinephrine release from adrenergic nerves. J. Pharmacol. Exp. Ther. (1988) 247(3):1139–1145.
  • IMAMURA M, POLI E, OMONIYI AT, LEVI R: Unmasking of activated histamine H3-receptors in myocardial ischemia: their role as regulators of exocytoticnorepi-nephrine release. J. Pharmacol. Exp. Ther. (1994) 271 (3):1259–1266.
  • HEY JA, DEL PRADO M, EGAN RW, KREUTNER W, CHAPMAN RW: Inhibition of sympathetic hypertensive responses in the guinea-pig by prejunctional histamine H3-receptors. Br. J. Pharmacol (1992) 107 (2):347–351.
  • MALINOWSKA B, GODLEWSKI G, SCHLICKER E: Histamine H3 receptors: general characterization and their function in the cardiovascular system. J Physic]. Pharmacol. (1998) 49(2):191–211.
  • MAZENOT C, RIBUOT C, DURAND R, JOULIN Y, DEMENGE P, GODIN-RIBUOT D: In vivo demonstration of H3-histaminergic inhibition of cardiac sympathetic stimulation by R-a-methyl-histamine and its prodrug BP 2.94 in the dog. Br. J. Pharmacol. (1999) 126 (1):264–268.
  • DART AM, DU X-J: Unexpected drug effects onautonomic function during myocardial ischaemia. Cardiovasc. Res. (1993) 27(6):906–914.
  • LAMERIS TVV, DE ZEEUVV S, ALBERTS G et al.: Time course and mechanism of myocardial catecholamine release during transient ischemia in vivo. Circulation (2000) 101 (22):2645–2650.
  • KURZ T, RICHARDT G, SEYFARTH M, SCHOMIG A: Nonexocytotic noradrenaline release induced by pharmacological agents or anoxia in human cardiac tissue. Naunyn-Schmiedebergs Arch. Pharmacol (1996) 354(1)7–16.
  • KURZ T, RICHARDT G, HAGL S, SEYFARTH M, SCHOMIG A: Two different mechanisms of noradrenaline release during normoxia and simulated ischemia in human cardiac tissue./ Mol. Cell Cardiol. (1995) 27 (5):1161–1172.
  • HATTA E, YASUDA K, LEVI R: Activation of histamine H3receptors inhibits carrier-mediated norepinephrine release in a human model of protracted myocardial ischemia. j Pharmacol. Exp. Ther. (1997) 283 (2):494–500.
  • CANTIELLO HF, LANIER SM: a2-Adrenergic receptorsand the Na+/Ie exchanger in the intestinal epithelial cell line, HT-29. j Biol. Chem. (1989) 264 (27) :16000–16007.
  • ENDOU M, POLI E, LEVI R: Histamine H3-receptorsignaling in the heart: possible involvement of Gi/Go proteins and N-type Ca2+ channels. J. Pharmacol. Exp. Ther. (1994) 269(1):221–229.
  • LOVENBERG TVV, ROLAND BL, WILSON SJ et al.: Cloningand functional expression of the human histamine H3 receptor. Mol. Pharmacol (1999) 55(6):1101–1107.
  • CHERIFI Y, PIGEON C, LE ROMANCER M, BADO A, REYL-DESMARS F, LEWIN MJ: Purification of a histamine H3 receptor negatively coupled to phosphoinositide turnover in the human gastric cell line HGT1. j Biol. Chem. (1992) 267(35):25315–25320.
  • LEURS R, BLANDINA P, TEDFORD C, TIMMERMAN H: Therapeutic potential of histamine H3 receptor agonists and antagonists. Trends Pharmacol ScL (1998) 19 (5):177–183.
  • HEY JA, ASLANIAN R, BOLSER DC et al.: Studies on the pharmacology of the novel histamine H3 receptor agonist Sch 50971. Arzneimittelforschung (1998) 48 (9):881–888.
  • KCJBLER W, STRASSER RH: Signal transduction in myocardial ischaemia. Eur. Hearil (1994) 15(4)437–445.
  • THÉROUX P: Myocardial cell protection - a challenging time for action and a challenging time for clinical research. Circulation (2000) 101 (25):2874–2876.
  • RUPPRECHT HJ, VOM DAHL J, TERRES W et al.: Cardio-protective effects of the Na+/H+ exchange inhibitor cariporide in patients with acute anterior myocardial infarction undergoing direct PTCA. Circulation (2000) 101 (25):2902–2908.

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