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Review

Therapeutic potential of total homocysteine-lowering drugs on cardiovascular disease

, &
Pages 2637-2652 | Published online: 23 Feb 2005

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  • ••Critical review of the tHcy story.
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  • ••Important prospective study establishing elevated tHcyplasma concentrations as CVD risk marker in dialysis patients.
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  • •Good study examining the effect of folic acid, vitamin B6 and vitamin B12 on tHcy levels in renal transplant patients.
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  • ••First randomised controlled study examining the effect ofhigh dose folic acid versus low dose folic acid therapy on tHcy plasma levels in dialysis patients.
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  • •This study shows that oral therapy with reduced folates has no better effect on tHcy levels in dialysis patients as compared with folic acid.
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