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Review

Novel chemotherapeutic agents for the treatment of brain cancer

Pages 2815-2829 | Published online: 23 Feb 2005

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  • •Paclitaxel demonstrated activity against recurrent oligodendroglioma.
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  • •Paclitaxel demonstrated activity against recurrent AA.
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  • ••Temozolomide has modest activity against recurrent MBT.
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  • ••Iv. cisplatin and etoposide is very active against MBT fromlung and breast.
  • GELMAN M, CHAKERES DW, NEWTON HB: Brain tumors: Complications of cerebral angiography accompanied by intra-arterial chemotherapy. Radio]. (1999) 213:135–140.
  • ••Ia. chemotherapy is active against PBT and MBT, with a lowcomplication rate.
  • NEWTON HB, SNYDER MA, STEVENS C et al: Intra-arterial carboplatin and intravenous etoposide for the treatment of metastatic brain tumors. Ann. Oncol. (2000) 11:131–132.
  • ••Ia. chemotherapy very active against MBT.
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  • ••Ia. chemotherapy with blood-brain barrier disruption hasactivity against PBT and MBT.
  • SHAPIRO JR, COONS SW: Genetics of adult malignant gliomas. BNI Quarterly (1998) 14:27–42.
  • ••A thorough review.
  • SCHECK AC: Molecular biology of chemotherapy and resistance. BNI Quarterly (1998) 14:43–54.
  • ••A thorough review.
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  • •Review and commentary of the MMACUPTEN gene and molecular neuro-oncology.
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  • •Seminal paper demonstrating genetic abnormalities predic-tive of chemosensitivity in anaplastic oligodendrogliomas.
  • SMITH JS, PERRY A, BORELL TJ et al.: Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas and mixed oligoastrocytomas. J. Clin. Oncof (2000) 18:636–645.
  • ••Detailed study finds loss of lp and 19q predictive in allgrades of oligo, but not astrocytomas or mixed oligoastrocytomas.

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