Bibliography
- KITA H, GLEICH GJ: The Eosinophil: structure and functions. In: Allergy (Edition 2). Allen P Kaplan, (Ed.), W.B. Saunders, Philadelphia, USA (1997) 11:148–178.
- ••Review of the pathobiology of the eosinophil.
- MORI A, KAMINUMA 0, SUKO M et al.: Cellular and molecular mechanisms of IL-5 synthesis in atopic diseases: a study with allergen-specific human helper T cells. J. Allergy Clin. Immunol (1997) 100 (Pt 2):S56–S64.
- TILLS, WALKER S, DICKASON R et al.: IL-5 production by allergen-stimulated T cells following grass pollen immunotherapy for seasonal allergic rhinitis. Clin. Exp. Immunol (1997) 110:114–121
- GIBSON PG, ZLATIC K, SCOTT J et al.: Chronic cough resembles asthma with IL-5 and granulocyte-macrophage colony-stimulating factor gene expres-sion in bronchoalveolar cells. J. Allergy Clin. Immunol (1998)101:320–326.
- SEHMI R, WOOD LJ, WATSON R et al.: Allergen-induced increases in IL-5 receptor alpha-subunit expression on bone marrow-derived CD34+ cells from asthmatic subjects. A novel marker of progenitor cell commit-ment towards eosinophilic differentiation. J. Clin. Invest. (1997) 100:2466–2475.
- SEDGWICK JB, CALHOUN WJ, GLEICH GJ et al.: Immediate and late airway response of allergic rhinitis patients to segmental antigen challenge: characterisa-tion of eosinophil and mast cell mediators. Am. Rev. Respir. Dis. (1991) 144:1274–1281.
- HAMID Q, AZZAWI M, YING S et al: Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma. J. Clin. Invest. (1991) 87:1541–1546.
- HAMID Q, AZZAWI M, YING S et al: Interleukin-5 mRNAin mucosal bronchial biopsies from asthmatic subjects. Int. Arch. Allergy AppL ImmunoL (1991) 94:169–170.
- ROBINSON DS, YING S, BENTLEY AM et al: Relation-ships among numbers of bronchoalveolar lavage cells expressing messenger ribonucleic acid for cytokines, asthma symptoms, and airway methacholine respon-siveness in atopic asthma. J. Allergy Clin. Immunol (1993)92:397–403.
- OHNISHI T, KITA H, WEILER D et al: IL-5 is the predomi-nant eosinophil-active cytokine in the antigen-induced pulmonary late-phase reaction. Am. Rev. Respir. Dis. (1993) 147:901–907.
- ••IL-5 secretion is related to clinical asthma.
- ROBINSON DS, HAMID Q, YING S et al: PredominantT112-like broncheoalveolar T-lymphocyte population in atopic asthma. N Engl. J. Med. (1992) 326:298–304.
- HUMBERT M, YING S, CORRIGAN C et al.: Bronchialmucosal expression of the genes encoding chemokines RANTES and MCP-3 in symptomatic atopic and nonatopic asthmatics: relationship to the eosinophil-active cytokines interleukin granulocyte macrophage-colony-stimulating factor, and IL-3. Am. J. Respir. Cell Mol. Biol. (1997) 16:1–8.
- HUMBERT M, CORRIGAN CJ, KIMMITT et al.: Relation- ship between IL-4 and IL-5 mRNA expression and disease severity in atopic asthma. Am. J. Respir. Grit. Care Med. (1997) 156(Pt 0:704–708.
- ••IL-5 secretion correlates with asthma severity.
- SANDERSON CJ, O'GARRA A, WARREN DJ et al.: Eosino-phil differentiation factor also has B-cell growth factor activity: proposed name interleukin 4. Proc. Natl. Acad. Sci. USA (1986) 83:437–440.
- CLUTTERBUCK EJ, SANDERSON CJ: Human eosinophil haematopoiesis studied in vitro by means of murine eosinophil differentiation factor (IL5): production of functionally active eosinophils from normal human bone marrow. Blood (1988) 71:646–651.
- KITA H, WEILER DA, ABU-GHAZALEH R et al: Release of granule proteins from eosinophils cultured with IL-5. Immunol (1992) 149:629–635.
- WEDI B, RAAP U, LEWRICK H, KAPP A: Delayed eosino-phil programmed cell death in vitro: a common feature of inhalant allergy and extrinsic and intrinsic atopic dermatitis. J. Allergy Clin. Immunol.(1997) 100:536–543.
- DRUILHE A, AROCK M, LE GOFF L,PRETOLANI M: Human eosinophils express bc1-2 family proteins: modulation of Mc-1 expression by IFN-gamma. Am. J. Respir. Cell Mol Biol. (1998) 18:315–322.
- SAKAI I, KRAFT AS: The kinase domain of Jak2 mediates induction of bc1-2 and delays cell death in hemato-poietic cells. J. Biol. Chem. (1997) 272:12350–12358.
- SIMON HU, YOUSEFI S, DIBBERT B et al.: Anti-apoptotic signals of granulocyte-macrophage colony-stimulating factor are transduced via Jak2 tyrosine kinase in eosinophils. Eur. J. Immunol. (1997) 27:3536–3539.
- KITAGAKI K, NAGAI H, HAYASHI S et al: Facilitation of apoptosis by cyclosporins A and H, but not FK506 in mouse bronchial eosinophils. Eur. J. Pharmacol (1997) 337:283–289.
- OHTA K,YAMASHITA N: Apoptosis of eosinophils and lymphocytes in allergic inflammation. J. Allergy Clin. Immunol. (1999) 104:14–21.
- MINSHALL EM, HOGG JC, HAMID QA: Cytokine mRNA expression in asthma is not restricted to the large airways. J. Allergy Clin. Immunol (1998) 101:386–390.
- SUGAYA H, AOKI M, YOSHIDA T et al.: Eosinophilia and intracranial worm recovery in interleukin-5 transgenic and interleukin-5 receptor alpha chain-knockout mice infected with Angiostrongylus cantonensis. Parasitol. Res. (1997) 83:583–590.
- COOK EB, STAHL JL, LILLY CM et al.:Epithelial cells are a major cellular source of the chemokine eotaxin in the guinea pig lung. Allergy Asthma Proc. (1998) 19:15–22.
- TAKUTSU K: Interleukin-5. In: Cytokine Regulation of Humoral Immunity. CM Snapper (Ed.) Wiley & Sons, NY, USA. (1996):217–249.
- ••Review of the biology of IL-5 and IL–5R.
- LOPEZ, AF, ELLIOTT, MJ, WOODCOCK, J et al.: GM-CSF, IL-3 and IL-5: cross-competition on human haemopoietic cells. Immunology Today (1992) 13:495–500.
- CORNELIS S, PLAETINCK G, DEVOS R et al.: Detailed analysis of the IL-5-IL-5R alpha interaction: characteri-sation of crucial residues on the ligand and the receptor. EMBO (1995) 14:3395–3402.
- CORNELIS S, FACHE I, VAN DER HEYDEN J et al.: Charac-terization of critical residues in the cytoplasmic domain of the human interleukin-5 receptor alpha chain required for growth signal transduction. Eur. J. Immunol. (1995) 25:1857–1864.
- OGATA N, KOURO T, YAMADA A et al.: JAK2 and JAK1 constitutively associate with an Interleukin-5 (11–5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation. Blood (1998) 91:2264-2271. BENSON DA, BOGUSKI MS, LIPMAN DJ et al.: GenBank. Nucl. Acids Res. (1998) 26:1-7. Introduction to and review of the GenBank. MILBURN MV, HASSELL AM, LAMBERT MH et al.: A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5. Nature (1993) 363:172-176. Crystal structure of human IL–5.
- TANABE T, KONISHI M, MIZUTA T, NOMA T, HONJO T: Molecular cloning and structure of the human interleukin-5 gene. J. Biol. Chem. (1987) 262:16580–16584.
- ••Human IL-5 gene organisation.
- AZUMA C, TANABE T, KONISHI M et al.: Cloning of cDNA for human T-cell replacing factor (interleukin-5) and comparison with the murine homologue. Nucleic Acids Res. (1986) 14:9149–9158.
- ••The sequence of human IL-5 cDNA.
- VAN LEEUWEN, BH, MARTINSON ME, WEBB GC, YOUNG IG: Molecular organization of the cytokine gene cluster, involving the human 11-3, 11-4, IL-5 and GM-CSF genes on chromosome 5. Blood (1988) 73:1142–1148.
- ••The cytokine gene cluster on human chromosome 5.
- ISOBE M, KUMURA Y, MURATA Y et al.: Localization of the gene encoding the alpha subunit of the human interleukin-5 receptor (IL5RA) to chromosome region 3p24-3p26. Genomics (1992) 14:755–758.
- SHEN Y, BAKER E, CALLEN DF et al.: Localization of the human GM-CSF receptor beta chain gene to chromo-some 22q12.2-22q13.1. Cytogenet. Cell Genet. (1992) 61:175–177.
- MENG Q, YING S, CORRIGAN CJ et al.: Effects of rapamycin, cyclosporin A, and dexamethasone on interleukin 5-induced eosinophil degranulation and prolonged survival. Allergy (1997) 52:1095–1101.
- BRAUN CM, HUANG SK, BASHIAN GG et al.: Corticos-teroid modulation of human, antigen-specific Thl and Th2 responses. J. Allergy Clin. Immunol. (1997) 100:400–407.
- MORI A, KAMINUMA 0, SUKO M et al.: Two distinctpathways of interleukin-5 synthesis in allergen-specific human T-cell clones are suppressed by glucocorticoids. Blood (1997) 89:2891–2900.
- OKAYAMA H, FUSHIMI T, SHIMURA S, SASAKI H, SHIRATO K: Glucocorticoids suppressed production and gene expression of interleukin-5 by peripheral blood mononuclear cells in atopic patients and normal subjects. J. Allergy Clin. Immunol. (1994) 93:1006–1012.
- WELTMAN JK: The use of inhaled corticosteroids inasthma. Allergy Asthma Proc. (1999) 20:255–260.
- KIKUCHI Y, MIGITA M, TAKAKI S, TOMINAGA, TAKATSUK: Biochemical and functional characterization of soluble form of IL-5 receptor alpha (sIL-5R alpha). Development of ELISA system for detection of sIL-5R alpha. J. Immunol Methods (1994) 167:289–298.
- MONAHAN J, SIEGEL N, KEITH R et al.: Attenuation ofIL-5-mediated signal transduction, eosinophil survival, and inflammatory mediator release by a soluble human IL-5 receptor. J. Immunol. (1997) 159:4024–4034.
- YASRUEL Z, HUMBERT M, KOTSIMBOS TC et al.: Membrane-bound and soluble alpha IL-5 receptor mRNA in the bronchial mucosa of atopic and nonatopic asthmatics. Am. J. Respir. Grit. Care Med. (1997) 155:1413–1418.
- DANZIG M, CUSS F: Inhibition of interleukin-5 with a monoclonal antibody attenuates allergic inflamma-tion. Allergy (1997) 52:787–794.
- ••In vivo use of monoclonal anti-IL-5 antibodies.
- GARLISI CG, KUNG TT, WANG P eta].: Effects of chronicanti-interleukin-5 monoclonal antibody treatment in a murine model of pulmonary inflammation. Am. J. Respir. Cell Mol. Biol. (1999) 20:248–255.
- MATHUR M, HERRMANN K, LI X et al.: TRFK-5 reversesestablished airway eosinophilia but not established hyperresponsiveness in a murine model of chronic asthma. Am. J. Respir. Grit. Care Med. (1999) 159:580–587.
- SHARDONOFSKY FR, VENZOR J 3RD, BARRIOS R, LEONG KP, HUSTON DP: Therapeutic efficacy of an anti-IL-5 monoclonal antibody delivered into the respiratory tract in a murine model of asthma. J. Allergy Clin. Immunol. (1999) 104(1):215–221.
- ••The beginning of topical anti-IL-5 therapy in experimentalasthma.
- WELTMAN JK, KARIM AS: Interleukin-5: A proeosino- philic cytokine mediator of inflammation in asthma and a target for antisense therapy. Asthma and Allergy Proc. (1998) 19:257–261.
- ••Report of a pharmacologically active antisense human IL-5oligonucleotide.
- MOLET S, RAMOS-BARBON D, MARTIN JG, HAMID Q: Adoptively transferred late allergic response is inhibited by IL-4, but not IL-5, antisense oligonucleo-tide. J. Allergy Clin. Immunol. (1999) 104:205–214.
- METZGER WJ, NYCE JW: Oligonucleotide therapy of allergic asthma. J. Allergy Clin. Immunol. (1999) 104:260–266.
- ••An oligonucleotide, antisense to the adenosine receptor,used to treat experimental asthma in a rabbit model.
- MAUSER PJ, PITMAN AM, FERNANDEZ X et al.: Effects of an antibody to interleukin-5 in a monkey model of asthma. Am. J. Respir. Grit. Care Med. (1995) 152:467–472.
- ••Intravenous administration of an antimurine IL-5 mAb(TRFK-5) in a cynomolgus monkey model of allergic asthma reduced pulmonary eosinophilia and bronchial hyper-responsiveness for up to three months.
- LECKIE MJ, TENBRINKE A, LORDAN J: A humanized anti-i1-5 monoclonal antibody. initial single dose safety and activity in patients with asthma. Am. J. Respir. Grit. Care Med. (1999) 159:624A.
- ••The first administration of an anti-IL-5 mAb in humans. Asingle iv. dose reduced the blood eosinophilia but affected neither the early asthmatic response (EAR) nor the late asthmatic response (LAR). Patents