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Review

Novel triazole antifungal agents

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Pages 593-605 | Published online: 24 Feb 2005

Bibliography

  • PFALLER MA, JONES RN, MESSER SAet al.: National surveillance of nosocomial blood stream infection due to species of Candida other than Candida albicans: frequency of occurrence and antifungal susceptibility in the SCOPE Program. SCOPE Participant Group. Surveillance and Control of Pathogens of Epidemiol-ogic. Diagn. Microbial. Infect. Dis. (1998) 30:121-129.
  • PFALLER MA, MESSER SA, HOLLIS RJ et al: Trends in species distribution and susceptibility to fluconazole among blood stream isolates of Candida species in the United States. Diagn. Microbiol. Infect. Dis. (1999) 33:217–222.
  • REX JH, RINALDI MG, PFALLER MA: Resistance ofCandida species to fluconazole. Antimicrob. Agents Chemother. (1995) 39:1–8.
  • MAENZA JR, MERZ WG, ROMAGNOLI MJ et al.: Infectiondue to fluconazole-resistant Candida in patients with AIDS: prevalence and microbiology. Clin. Infect. Dis. (1997) 24:28–34.
  • TROKE PF, BELL AS, DICKINSON RP et al: UK-109,496, Anovel, wide-spectrum triazole derivative for the treatment of fungal infection: Discovery and Antifungal properties. 35th Intel-science Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA, USA (1995). Abstract F69.
  • RICHARDSON K, BELL AS, DICKINSON RP et al.:UK-109,496, A novel, wide-spectrum triazole deriva-tive for the treatment of fungal infections: Synthesis and SAR. 35th Intel-science Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA, USA (1995). Abstract F69.
  • PATTERSON BE, COATES PE: UK-109,496, A novel,wide-spectrum triazole derivative for the treatment of fungal infection: Pharmacokinetics in man. 35th Intel-science Conference on Antimicrobial Agents and Chemotherapy San Francisco, CA, USA (1995). Abstract F78.
  • TROKE PF, BRAMMER KW, HITCHCOCK CA et al.:UK-109,496, A novel, wide-spectrum triazole deriva-tive for the treatment of fungal infections: Activity in systemic candidiasis models and early clinical efficacy in oropharyngeal candidiasis. 35th Intel-science Confer-ence on Antimicrobial Agents and Chemotherapy. San Francisco, CA, USA (1995). Abstract F73.
  • DUPONT B, DENNING D, LODE H et al.: UK-109,496, Anovel, wide-spectrum triazole derivative for the treatment of fungal infection: Clinical efficacy in chronic invasive Aspergillosis. 35th Intel-science Confer-ence on Antimicrobial Agents and Chemotherapy. San Francisco, CA, USA (1995). Abstract F81.
  • DENNING D, DEL FAVERO A, GLUCKMAN E et al.: UK-109,496, A novel, wide-spectrum triazole deriva-tive for the treatment of fungal infection: Clinical effecacy in acute invasive Aspergillosis. 35th Intersci-ence Conference on Antimicrobial Agents and Chemotherapy San Francisco, CA, USA (1995). Abstract F80.
  • SCHWARTZ S, MILATOVIC D, THIEL E: Successfultreatment of cerebral aspergillosis with a novel triazole (voriconazole) in a patient with acute leukaemia [see comments]. Br. J. Haematol. (1997) 97:663–665.
  • •Successful case report with use of voriconazole.
  • PATTERSON BE, ROFFEY S, JEZEQUEL SG et al.:UK-109,496, A novel, wide-spectrum triazole deriva-tive for the treatment of fungal infection: Disposition in man. 35th Intel-science Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA, USA (1995). Abstract F70.
  • NOMEIR AA, KUMARI P, GUPTA S et al.: Pharmacoki-netics of SCH 59884, an IV prodrug for the oral antifungal SCH 56592 in animals, and its conversion to Sch 56592 by human tissues. 39th Intel-science Confer-ence on Antimicrobial Agents and Chemotherapy. San Francisco, CA, USA (1999). Abstract 1934.
  • LOEBENBERG D, MENZEL F, CORCORAN E et al.: SCH 59884, the intravenous prodrug of the antifungal trazole SCH 56592. 39th Intel-science Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA, USA (1999). Abstract 1933.
  • GIRIJAVALLABHAN VM, BENNETT F, SAKSENA AK et al.: SCH 59884, a water-soluble prodrug of SCH 56592 for intravenous formulation. 39th Intel-science Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA, USA (1999). Abstract 1932.
  • NOMEIR A, KUMARI P, HILBERT MJ et al.: Comparative pharmacokinetics of a new triazole antifungal agent, SCH 56592, in mice, rats, rabbits, dogs and cynomolgus monkeys. 35th Intel-science Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA, USA (1995). Abstract F68.
  • THONOOR M, GUPTA S, SOLON E et al.: Pharmacoki-netics of 14C-SCH 56592 in rats and dogs. 37th Intel-sci-ence Conference on Antimicrobial Agents and Chemotherapy. Toronto, Ontario, Canada (1997). Abstract A–85.
  • RADWANSKI E, KOSOGLOU T, LIM J et al.: SCH 56592: Bioavailability of an oral suspension relative to a solid dosage form in healthy volunteers. 37th Intel-science Conference on Antimicrobial Agents and Chemotherapy Toronto, Ontario, Canada (1997). Abstract A–86.
  • LAUGHLIN M, PAI S, MENON S: SCh 56592: Rising multiple-dose safety, tolerance, and pharmacokinetic evaluation in health volunteers. 37th Interscience Conference on Antimicrobial Agents and Chemotherapy Toronto, Ontario, Canada (1997). Abstract A–75.
  • KRIETER P, ACHANFUO-YEBOAH J, SHEA M et al.: Biliary excretion an enterohepatic circulation of the antifungal agent 14C-SCH 56592 in male and female rats. 39th Intel-science Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA, USA (1999). Abstract 1199.
  • NAKAMURA T, SAKAI R, SONODA J et al.: ER-30346, a novel antifungal triazole: IV pharmacokinetic and toxicological studies in mice, rats and dogs. 35th Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA, USA (1995). Abstract F94.
  • HATA K, KIMURA J, MIKI H et al.: In vitro and in vivo antifungal activities of ER-30346, a novel oral triazole with a broad antifungal spectrum. Antimicrob. Agents Chemother. (1996) 40:2237–2242.
  • PFALLER MA, MESSER SA, HOLLIS RJ etal.: In vitro suscep-tibilities of Candida bloodstream isolates to the new triazole antifungal agents BMS-207147, Sch 56592, and voriconazole. Antimicrob. Agents Chemother. (1998) 42:3242–3244.
  • ••Published data comparing voriconazole, posaconazole andravuconazole. © Ashley Publications Ltd. All rights reserved.Exp. Opin. Invest. Drugs (2000) 9(3)
  • DIEKEMA DJ, PFALLER MA, MESSER SA et al: In vitro Activities of BMS-207147 against Over 600 Contempo-rary Clinical Bloodstream Isolates of Candida Species from the SENTRY Antimicrobial Surveillance Program in North America and Latin America. Antimicrob. Agents Chemother. (1999) 43:2236–2239.
  • RUHNKE M, SCHMIDT-WESTHAUSEN A, TRAUTMANN M: In vitro activities of voriconazole (UK-109,496) against fluconazole- susceptible and -resistant Candida albicans isolates from oral cavities of patients with human immunodeficiency virus infection. Antimicrob. Agents Chemother. (1997) 41:575–577.
  • BELANGER P, NAST CC, FRATTI R et al.: Voriconazole (UK-109,496) inhibits the growth and alters the morphology of fluconazole-susceptible and -resistant Candida species. Antimicrob. Agents Chemother. (1997) 41:1840–1842.
  • KAUFFMAN CA, ZARINS LT: In vitro activity of voricona-zole against Candida species. Diagn. Microbic)]. Infect. Dis. (1998) 31:297–300.
  • BARRY AL, BROWN SD: In vitro studies of two triazole antifungal agents (voriconazole [UK- 109,496] and fluconazole) against Candida species. Antimicrob. Agents Chemother. (1996) 40:1948–1949.
  • MARCO F, PFALLER MA, MESSER S et al.: In vitro activities of voriconazole (UK-109,496) and four other antifungal agents against 394 clinical isolates of Candida spp. Antimicrob. Agents Chemother. (1998) 42:161–163.
  • LAW D, MOORE CB, DENNING DW: Activity of SCH56592 compared with those of fluconazole and itraconazole against Candida spp. Antimicrob. Agents Chemother. (1997) 41:2310–2311.
  • NGUYEN MH, YU CY: Voriconazole against fluconazole-susceptible and resistant candida isolates: in-vitro efficacy compared with that of itraconazole and ketoconazole. J. Antimicrob. Chemother. (1998) 42:253–256.
  • FUNG-TOMC JC, HUCZKO E, MINASSIAN B et al.: In vitro activity of a new oral triazole, BMS-207147 (ER-30346). Antimicrob. Agents Chemother. (1998) 42:313–318.
  • PFALLER MA, MESSER SA, GEE S et al.: In vitro suscepti-bilities of Candida dubliniensis isolates tested against the new triazole and echinocandin antifungal agents. Clin. Microbic)]. (1999) 37:870–872.
  • SANATI H, BELANGER P, FRATTI R et al.: A new triazole, voriconazole (UK-109,496), blocks sterol biosynthesis in Candida albicans and Candida krusei. Antimicrob. Agents Chemother. (1997) 41:2492–2496.
  • MUNAYYER H, SHAW KJ, HARE RS et al.: SCH 56592 is a potent inhibitor of sterol C14 demethylation in fungi. 36th Interscience Conference on Antimicrobial Agents and Chemotherapy. New Orleans, LA, USA (1996). Abstract F92.
  • GHANNOUM MA, OKOGBULE-WONODI I, BHAT N et al.: Antifungal activity of voriconazole (UK-109,496), fluconazole and amphotericin B against hematoge-nous Candida krusei infection in neutropenic guinea pig model. J. Chemother. (1999) 11:34–39.
  • CACCIAPUOTI A, PARMEGIANI R, LOEBENBERG D et al.:Efficacy of SCH 56592 in pulmonary Aspergillosis and Candidiasis in mice. 35th Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA, USA (1995). Abstract F66.
  • COLEMAN JM, HOGG GG, ROSENFELD JV et al: Invasive central nervous system aspergillosis: cure with liposomal amphotericin B, itraconazole, and radical surgery, case report and review of the literature. Neurosurgery (1995) 36:858–863.
  • VON EIFF M, ROOS N, SCHULTEN R et al.: Pulmonary aspergillosis: early diagnosis improves survival. Respiration (1995) 62:341–347.
  • ABRAHAM OC, MANAVAATHU EK, CUTRIGHT JL et al.: In vitro susceptibilities of Aspergillus species to voriconazole, itraconazole, and amphotericin B. Diagn. Microbiol Infect. Dis. (1999) 33:7–11.
  • MURPHY M, BERNARD EM, ISHIMARU T et al.: Activity of voriconazole (UK-109,496) against clinical isolates of Aspergillus species and its effectiveness in an experi-mental model of invasive pulmonary aspergillosis. Antimicrob. Agents Chemother. (1997) 41:696–698.
  • OAKLEY KL, MOORE CB, DENNING DW: In-vitro activity of voriconazole against Aspergillus spp. and comparison with itraconazole and amphotericin B. J. Antimicrob. Chemother. (1998) 42:91–94.
  • WILDFEUER A, SEIDL HP, PAULE I et al.: In vitro evalua-tion of voriconazole against clinical isolates of yeasts, moulds and dermatophytes in comparison with itraconazole, ketoconazole, amphotericin B and griseofulvin. Mycoses (1998) 41:309–319.
  • OAKLEY KL, MOORE CB, DENNING DW: In vitro activity of SCH-56592 and comparison with activities of amphotericin B and itraconazole against Aspergillus spp. Antimicrob. Agents Chemother. (1997) 41:1124–1126.
  • PETRAITIENE R, PETRAITIS V, GROLL A: Efficacy of SCH 56592 in treatment and prevention of invasive pulmonary Aspergillosis in persistently neutropenic rabbits. 39th Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA, USA (1999). Abstract 2004.
  • MARTIN MV, YATES J, HITCHCOCK CA: Comparison ofvoriconazole (UK-109,496) and itraconazole in prevention and treatment of Aspergillus fumigatus endocarditis in guinea pigs. Antimicrob. Agents Chemother. (1997) 41:13–16.
  • VAN HEK LG, VERWEIJ PE, WEEMAES CM etal.: Successfultreatment with voriconazole of invasive aspergillosis in chronic granulomatous disease. Am. J. Respir. Grit. Care Med. (1998) 157:1694–1696.
  • •Successful case report with use of voriconazole.
  • KLEPSER ME, WOLFE EJ, JONES RN et al.: Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B tested against Candida albicans. Antimicrob. Agents Chemother. (1997) 41:1392–1395.
  • KLEPSER ME, WOLFE EJ, PFALLER MA: Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B against Cryptococcus neoformans. J. Antimicrob. Chemother. (1998) 41:397–401.
  • MALONE D, LEWIS R, ERNST E et al: Evaluation ofvoriconazole pharmacodynamic activity using time-kill methodology. International Congress on Clinical Pharmacy. Orlando, FL, USA (1999). Abstract 84.
  • LEVITZ SM: The ecology of Cryptococcus neoformansand the epidemiology of cryptococcosis. Rev. Infect. Dis. (1991) 13:1163–1169.
  • PFALLER MA, ZHANG J, MESSER SA et al.: In vitro activi-ties of voriconazole, fluconazole, and itraconazole against 566 clinical isolates of Cryptococcus neofor-mans from the United States and Africa. Antimicrob. Agents Chemother. (1999) 43:169–171.
  • PERFECT JR, COX GM, DODGE RK et al.: In vitro and invivo efficacies of the azole SC1156592 against Crypto-coccus neoformans. Antimicrob. Agents Chemother. (1996) 40:1910–1913.
  • ESPINEL-INGROFF A: In vitro activity of the new triazolevoriconazole (UK-109,496) against opportunistic filamentous and dimorphic fungi and common and emerging yeast pathogens. J. Clin. Microbiol. (1998) 36:198–202.
  • MCGINNIS MR, PASARELL L, SUTTON DA et al.: In vitroevaluation of voriconazole against some clinically important fungi. Antimicrob. Agents Chemother. (1997) 41:1832–1834.
  • SUGAR AM, LIU XP: In vitro and in vivo activities of SCH56592 against Blastomyces dermatitidis. Antimicrob. Agents Chemother. (1996) 40:1314–1316.
  • CONNOLLY P, WHEAT J, SCHNIZLEIN-BICK C et al. Comparison of a new triazole antifungal agent, Schering 56592, with itraconazole and amphotericin B for treatment of histoplasmosis in immunocompetent mice. Antimicrob. Agents Chemother. (1999) 43:322–328.
  • LUTZ JE, CLEMONS KV, ARISTIZABAL BH et al.: Activity of the triazole SCH 56592 against disseminated murine coccidioidomycosis. Antimicrob. Agents Chemother. (1997) 41:1558–1561.
  • MARCO F, PFALLER MA, MESSER SA et al.: Antiftmgal activity of a new triazole, voriconazole (UK-109,496), compared with three other antifungal agents tested against clinical isolates of filamentous fungi. Med. Mycol. (1998) 36:433–436.
  • GIRMENIA C, LUZI G, MONACO M et al.: Use of voricona-zole in treatment of Scedosporium apiospermum infection: case report. J. Clin. Microbiol (1998) 36:1436–1438.
  • •Successful case report with use of voriconazole.
  • LOZANO-CHIU M, ARIKAN S, PAETZNICK VL et al.: Treatment of murine fusariosis with SCH 56592. Antimicrob. Agents Chemother. (1999) 43:589–591.
  • Fluconazole package insert. New York NY. Pfizer, Inc. (1996).
  • Itraconazole package insert. Titusville, NJ. Janssen Pharmaceutica, Inc. (1997).
  • HOBAN DJ, ZHANEL GG, KARLOWSKY JA: In vitro susceptibilities of Candida and Cryptococcus neofor-mans isolates from blood cultures of neutropenic patients. Antimicrob. Agents Chemother. (1999) 43:1463–1464.

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