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Drug Evaluation

Ebselen: prospective therapy for cerebral ischaemia

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Pages 607-619 | Published online: 24 Feb 2005

Bibliography

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  • •Clinical study in a volunteer of metabolism of ebselen labelled in the selenium moiety, clearly establishing that selenium remains within the molecule.
  • YAMAGUCHI T, SANO K, TAKAKURA K et al.: Ebselen in acute ischemic stroke. A placebo-controlled, double-blind clinical trial. Stroke (1998) 29:12–17.
  • ••Pivotal clinical trial.
  • SAITO I, ASANO T, SANO K et al.: Neuroprotective effect of an antioxidant, ebselen, in patients with delayed neurological deficits after subarachnoid hemorrhage. Neurosurgery (1998) 42:269–278.
  • ••Pivotal clinical trial.
  • OGAWA A, YOSHIMOTO T, KIKUCHI H et al.: Ebselen in acute middle cerebral artery occlusion: a placebo-controlled, double-blind clinical trial. Cerebrovasc. Dis. (1999) 9:112–118.
  • ••Pivotal clinical trial Michael Parnhaml & Helmut Siest2

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