Bibliography
- YANAGISAWA M, KURIHARA H, KIMURA S et al.: A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature (1988) 332:411–415.
- •First description of endothelin.
- KOHAN DE: Endothelins in the kidney: Physiology and pathophysiology. Am. J. Kidney Dis. (1993) 4:493–510.
- •A comprehensive review up to 1993.
- KURIHARA H, YAMAOIKI K, NAGAI R et al: Endothelin: A potent vasoconstrictor associated with coronary vasospasm. Life Sci. (1989) 44:1937–1944.
- KRAMER BK, ACKERMANN M, KOHLER SM, RIEGGER GAJ: Role of endothelin in hypertension. Clin. Invest. (1994) 72:88–93.
- HOCHER B, ROHMEISS P, ZART R et al: Function and expression of endothelin receptor subtypes in the kidney of spontaneously hypertensive rats. Cardio-vasc. Res. (1996) 31:499–510.
- HOCHER B, THONE-REINEKE C, BAUER C, RASCHACK M, NEUMAYER HH: The paracrine endothelin system. pathophysiology and implications in clinical medicine. Eur. J. Chn. Chem. Clin. Biochem. (1997) 35:175–189.
- STEWART DJ: Endothelium in cardiopulmonary disease: Factor paracrine vs. neurohormonal. Eur. Heart J. (1993) 14:48–54.
- KITAMURA K, TANAKA K, KATO J, ETO T, TANAKA K: Regional distribution of immunoreactive endothelin in porcine tissue: abundance in inner medulla of the kidney. Biochem. Biophys. Res. Commun. (1989) 161:348–352.
- YOSHIMI H, HIRATA Y, FUKADA Y: Regional distribu-tion of immunoreactive endothelin in rats. Peptides (1989) 10:805–808.
- MARSDEN PA, DORFMAN DM, COLLINS T, BRENNER BM,ORKIN SH, BALLERMANN BJ: Regulated expression of endothelin-1 in glomerular capillary capillary endothelial cells. Am. J. Physiol. (1991) 261:F117–F125.
- KOHAN DE, FIEDOREK FTJ: Endothelin synthesis by rat inner medullary collecting duct cells. J. Am. Soc. Nephrol. (1991) 2:150–155.
- KASINATH BS, FRIED TA, DAVALATH S, MARSDEN PA: Glomerular epithelial cells synthesize endothelin peptides. Am. J. Pathol (1992) 141:279–283.
- KOHAN DE: Production of endothelin-1 by ratmesangial cells: regulation by tumor necrosis factor. J. Lab. Clin. Med. (1992) 119:477–484.
- SUGIURA M, SNADJAR RM, SCHWARTZBERG M, BADR KF,INAGAMI T: Identification of two types of specific endothelin receptors in rat mesangial cells. Biochem. Biophys. Res. Commun. (1989) 162:1396–1401.
- REBIBOU JM, HE CJ, DELARUE F et al: Functionalendothelin-1 receptors on human glomerular podocytes and mesangial cells. Nephrol. Dial. Transplant (1992) 7:288–292.
- SUMMER MJ, CANNON TR, MUNDIN JW, WHITE DG, WATTS IA: Endothelin ETA and ETB receptors mediate vascular smooth muscle contraction. Br. J. Pharmacol. (1992) 107:858–860.
- TERADA Y, TOMITA K, NONOGUCHI H, MARUMO F: Different localization of two types of endothelin receptor mRNA in microdissected rat nephron segments using reverse transcription and polymerase chain reaction assay. J. Clin. Invest. (1992) 90:107–112.
- PERNOW J, FRANCO-CERCEDA A, MARTRAN R, LUNDBERG JM: Effect of endothelin-1 on regional vascular resistances in the pig. J. Cardiovasc. Pharmacol. (1989) 13:S205–S206.
- MADEDDU P, ROFFA C, GLORIOSO N et al.: Effect ofendothelin on regional hemodynamics and renal function in awake normotensive rats. J. Cardiovasc. Pharmacol. (1989) 14:818–825.
- ROHMEISS P, PHOTIADIS J, ROHMEISS S, UNGER T:Hemodynamic actions of intravenous endothelin in rats: comparison with sodium nitroprusside and methoxamine. Am. J. Physic)]. (1990) 258:H337–H346.
- BRAUN C, LANG C, HOCHER B, GRETZ N, VAN DER WOUDE FJ, ROHMEISS P: Influence of the renal endothelin system on the autoregulation of renal blood flow in spontaneously hypertensive rats. Kidney Blood Pres. Res. (1997) 20:6–10.
- KON V, YOSHIOKA T, FOGO A, ICHIKAVA I: Glomerularactions of endothelin in vivo. J. Clin. Invest. (1989) 83:1762–1767.
- OHNO A, NARUSE M, KATO S et al.: Endothelin-specificantibodies decrease blood pressure and increase glomerular filtration rate and renal plasma flow in SHR. j Hypertens. (1992) 10:781–785.
- WATANABE T, SUZUKI N, SHIMAMOTO N, FUJINO M, IMADA A: Endothelin on myocardial infarction. Nature (1990) 344:144.
- KOHAN DE: Endothelins in the normal and diseased kidney. Am. J. Kidney Dis. (1997) 29:2–26.
- ••Detailed review of the renal ET system.
- GRAY GA, WEBB DJ: The endothelin system and its potential as a therapeutic target in cardiovascular disease. Pharmacol Ther. (1996) 2:109–148.
- •A comprehensive review of the cardiovascular ET system.
- MASAKI T, YANAGISAWA N: Physiology and pharma-cology of endothelins. Med. Res. Rev. (1992) 4:391–421.
- SIMONSON MS: Endothelins: multifunctional renal peptides. Physic)]. Rev. (1993) 2:375–411.
- RUBANYI GM, POLOKOFF MA: Endothelins: Molecular biology, biochemistry, pharmacology, physiology and pathophysiology. Pharmacol Rev. (1994) 46:325–415.
- ROHMEISS P, BIRCK R, BRAUN C, KIRCHENGAST M, VAN DER WOUDE FJ: Targets for endothelin in the diseased kidney: Clues for therapeutical intervention. Exp. Nephrol. (1999) 7:1–10.
- INOUE A, YANAGISAWA M, KIMURA S et al.: The humanendothelin family: Three structurally and pharmaco-logically distinct isopeptides predicted by three seperate genes. Proc. Natl. Acad. Sci. USA (1989) 86:2863–2867.
- BLOCK KD, FREIDRICH SP, LEE ME, EDDY RL, QUERTER-MOUS T: Structural organisation and chromosomal assignment of the gene encoding endothelin. J. Biol. Chem. (1989) 164:10851–10857.
- BLOCK KD, HONG CC, EDDY RL, SHOWS TB, QUERTER-MOUS T: cDNA cloning and chromosomal assignment of the endothelin-2 gene: vasoactive intestinal contractor peptide is rat endothelin-2. Genomics (1991) 10:236–242.
- BLOCK KD, EDDY RL, SHOWS TB, QUERTERMOUS T: cDNA cloning and chromosomal assignment of the gene encoding endothelin-3. J. Biol. Chem. (1989) 264:18156–18161.
- KLOOG Y, AMBAR I, SOKOLOVSKY M, KOCHVA E, WOLLBERG Z, BDOLAH A: Sarafatoxin, a novel vasoconstrictor peptide. phosphoinositide hydrolysis in rat heart and brain. Science (1988) 242:268–270.
- LEMONNIER DEGOUVILLE AC, LIPPTON HL, CAVERO I, SUMMER WR, HYMAN AL: Endothelin - a new family of endothelium-derived peptides with widespread biological properties. Life Sci. (1989) 45:1499–1513.
- SIMONSON MS, WANN S, MEINE P et al.: Endothelin stimulates phospholipase C, Neill+ exchange, c-fos expression and mitogenesis in rat mesangial cells. J. Clin. Invest. (1989) 83:708–712.
- HIRATA Y, TAKAGI Y, FUKUDA Y, MARUMO F: Endothelin is a potent mitogen for rat vascular smooth muscle cells. Atherosclerosis (1989) 78:225–228.
- HIRATA Y, YOSHIMI H, TAKAICHI S, YANAGISAWA M,MASAKI T: Binding and receptor down-regulation of the novel vasoconstrictor endothelin in cultured rat vascular smooth muscle cells. FEBS Lett (1988) 239:13–17.
- OPGENORTH T, WU WONG JR, SHIOSAKI K: Endothelin-converting enzymes. FASEB J. (1992) 6:2653–2659.
- SHIMADA K, TAKAHASHI M, TANZAWA K: Cloning andfunctional expression of endothelin-converting enzyme from rat endothelial cells. J. Biol. Chem. (1994) 269:18275–18278.
- SHIMADA K, MATSUSHITA Y, WAKABAYASHI K et al.:Cloning and functional expression of endothelin-converting enzyme cDNA. Biochem. Biophys. Res. Commun. (1995) 207:807–812.
- GASIC S, WAGNER OF, VIERHAPPER H, NOWOTNY P, WALDHAUSL W: Regional hemodynamic effects and clearance of endothelin-1 in humans: renal and peripheral tissue may contribute to the overall disposal of the peptide. J. Cardiovasc. Pharmacol. (1992) 19:176–180.
- LAM HC, TAKAHASHI K, GHATEI MA, WARRENS AN, REESAJ, BLOOM SR: Immunoreactive endothelin in human plasma, urine, milk and saliva. J. Cardiovasc. Pharmacol. (1991) 17:S390–S393.
- WEITZBERG E, AHLBORG G, LUNDBERG JM: Long-lasting vasoconstriction and efficient regional extraction of endothelin-1 in human splanchnic and renal tissues. Biochem. Biophys. Res. Commun. (1991) 180:1298–1303.
- ARAI H, HORI S, ARAMORI I, OHKUBO H, NAKANISHI S: Cloning and expression of a cDNA encoding an endothelin receptor. Nature (1990) 348:730–732.
- HOSODA K, NAKAO K, TAMURA N et al: Organization, structure, chromosomal assignment and expression of the gene encoding the human endothelin A receptor. J. Biol. Chem. (1992) 267:18797–18804.
- SAKURAI T, YANAGISAWA M, TAKUWA Y et al.: Cloning of a cDNA encoding a non-isopeptide selective subtype of the endothelin receptor. Nature (1990) 348:732–735.
- BAX WA, SAXENA PR: The current endothelin receptor classifcation: time for reconsideration? Trends Pharmacol. Sci. (1994) 15:379–386.
- KARNE S, JAYAWICKREME CK, LERNER MR: Cloning and characterisation of an endothelin-3 specific receptor (ETC-receptor) from Xenopus laevis dermal melano-phores. J. Biol. Chem. (1993) 268:19126–19133.
- KING AJ, BRENNER BM, ANDERSON S: Endothelin: A potent renal and systemic vasoconstrictor peptide. Am. J. Physiol. (1989) 256:F1051–1058.
- RUIZ-ORTEGA M, GOMEZ-GARRE D, ALCAZAR R et al: Involvement of angiotensin II and endothelin in matrix protein production and renal sclerosis. J. Hypertens. (1994) 12:551–558.
- WARNER A, DE NUCCI G, VANE JR: Rat endothelin is a vasodilator in the isolated perfused mesentery of the rat. Eur. J. Pharmacol. (1989) 159:325–326.
- DE NUCCI G, THOMAS R, D'ORLEANS-JUSTE P et al: Pressor effects of circulating endothelin are limitated by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor. Proc. Natl. Acad. Sci. USA (1988) 85:9797–9800.
- SUMNER MJ, CANNON TR, MUNDIN JW, WHITE DG, WATTS IS: Endothelin ETA and ETB receptors mediate vascular smooth muscle contraction. Br. J. Pharmacol (1992) 107:858–860.
- POLLOCK DA, OPGENORTH TJ: Evidence for endothelin-induced renal vasoconstriction independent of ETA receptor activation. J. Physic]. (1993) 264:R222–R226
- NAMBI P, PULLEN M, WU HL, AIYAR N, OHLSTEIN EH,EDWARDS EM: Identification of endothelin receptor subtypes in human renal cortex and medulla using subtype-selective ligands. Endocrinology (1992) 131:1081–1086.
- KARET F, KUC R, DAVENPORT A: Novel ligands BQ123 and BQ3020 characterize endothelin receptor subtypes ETA and ETB in human kidneys. Kidney Int. (1993) 44:36–42.
- SCHNERMANN J, LORENZ JN, BRIGGS JP, KEISER JA: Induction of water diuresis by endothelin in rats. Am. J. Physiol. (1992) 263:F516–F526.
- WARNER TD: Endothelin receptor antagonists. Cardio-vasc. Drug Rev. (1994) 2:105–122.
- KURIHARA Y, KURIHARA H, SUZUKI H et al.: Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1. Nature (1994) 368:703–710.
- PUFFENBERGER EG, HOSODA K, WASHINGTON SS et al.: A missense mutation of the endothelin-B receptor gene in multigenic Hirschsprung's disease. Cell (1994) 79:1257–1266.
- HOCHER B, THONE.RHEINEKE C, ROHMEISS P et al.: Endothelin-1 transgenic mice develop glomeruloscle-rosis, interstitial fibrosis and renal cysts but not hypertension. J. Clin. Invest. (1997) 6:1380–1389.
- KARET FE, DAVENPORT AP: Localization of endothelin peptides in human kidney. Kidney Int. (1996) 49:382–387.
- WAGNER OF, CHRIST G, WOJTA T: Polar secretion of endothelin-1 by cultured endothelial cells. J. Biol. Chem. (1992) 267:16066–16068.
- LERMAN A, HILDEBRAND FLJ, AARHUS LL, BURNETT JCJ: Endothelin has biological actions at pathophysio-logical concentrations. Circulation (1991) 83:1808–1814.
- KURIHARA H, YOSHIZUMI M, SUGIYAMA T et al.: Transforming growth factor-0 stimulates the expres-sion of endothelin mRNA by vascular endothelial cells. Biochem. Biophys. Res. Commun. (1989) 159:1435–1440.
- IMAI T, HIRATA Y, EMORI T, YANAGISAWA M, MASAKI T: Induction of endothelin-1 gene by angiotensin and vasopressin in endothelial cells. Hypertension (1992) 19:753–757.
- TOMITA K, UJIIE K, NAKANISHI T et al.: Plasmaendothelin levels in patients with acute renal failure. N Eng]. J. Med. (1989) 1127:1989.
- MARGULIES KB, HILDEBRAND FLJ, HEUBLEIN DM, BURNETT JCJ: Radiocontrast increases plasma and urinary endothelin-1. J. Am. Soc. Nephrol. (1991) 2:1041–1045.
- WATSCHINGER B, VYCHYTIL A, SCHULLER M, HARTTERE, TRAINDL 0: The pathophysiological role of endothelin in acute vascular rejection after renal transplantation. Transplantation (1991) 52:743–746.
- TAKAYAMA K, NAGAI T, KINUGASA E, AKIZAWA T, KOSHIKAWA S: Changes in endothelial vasoactive substances under recombinant human erythropoietin therapy in hemodialysis patients. ASAIO Trans. (1991) 37:M187–M188.
- PERICO N, DADAN J, REMUZZI G: Endothelin mediatesthe renal vasoconstriction induced by cyclosporine in the rat. J. Am. Soc. Nephrol. (1990) 1:76–83.
- MOUTABARRIK A, ISHIBASHI M, FUKUNAGA M et al.:FK506-induced kidney tubular cell injury. Transplanta-tion (1992) 54:1041–1047.
- OHTA K, HIRATA Y, SCHICHIRI M, ICHIOKA M, KUBOTAT, MARUMO F: Cisplatin-induced urinary endothelin excretion. JAMA (1991) 265:1391–1392.
- SIEGLER RL, EDWIN SS, CHRISTOFFERSON RD, MITCHELLMD: Endothelin in the urine of children with the hemolytic uremic syndrome. Pediatrics (1991) 88:1063–1066.
- YOKOKAWA K, TAHARA H, KOHNO M et al.: Hyperten-sion associated with endothelin-secreting malignant hemangioendothelioma. Ann. Intern. Med. (1991) 114:213–215.
- KON V, YOSHIOKA T, FOGO A, ICHIKAWA I: Glomerularactions of endothelin in vivo. J. Clin. Invest. (1989) 83:1762–1767.
- SHIBOUTA Y, SUZUKI N, SHINO A et al.: Pathophysio-logical role of endothelin in acute renal failure. Life Sci. (1990) 46:1611–1618.
- ROUBERT P, CORNET S, PLAS P et al.: Upregulation of renal endothelin receptor in glycerol-induced acute renal failure in the rat. J. Cardiovasc. Pharmacol. (1993) 22:S303–S305.
- NAMBI P, PULLEN M, JUGUS M, GELLAI M. Rat kidneyendothelin receptor in ischaemia-induced acute renal failure. J. Pharmacol. Exp. Ther. (1993) 264:345–348.
- LOPEZ-FARRE A, GOMEZ-GARRE D, BERNABEU F, LOPEZ-NO VOAJM: A role for endothelin in the mainte-nance of postischaemic renal failure in the rat. J. Physiol (1991) 444:513–522.
- GELLAI M, JUGUS M, FLETCHER T, DEWOLF R, NAMBI P: Reversal of postischemic acute renal failure with a selective endothelin-A receptor antagonist in the rat. J. Clin. Invest. (1994) 93:900–906.
- BIRCK R, KNOLL T, BRAUN C et al.: Improvement of postischemic acute renal failure with the novel orally active endothelin A receptor antagonist LU135252 in the rat. J. Cardiovasc. Pharmacol. (1998) 32:80–86.
- GELLAI M, JUGUS M, FLETCHER T et al.: Nonpeptideendothelin receptor antagonists V: Prevention and reversal of acute renal failure in the rat by SB 209670.1 Pharmacol. Exp. Ther. (1995) 275:200–202.
- MINO N, KOBAYASHI M, NAKAJIMA A et al.: Protectiveeffect of a selective endothelin receptor antagonist, BQ-123, in ischemic acute renal failure in rats. Eur. J. Pharmacol. (1992) 221:77–83.
- CHAN L, CHITTINANDANA A, SHAPIRO JI, SHANLEY PF,SCHRIER RW: Effect of an endothelin-receptor antago-nist on ischemic acute renal failure. Am. J. Physiol (1994) 266:F135–F138.
- BROOKS DP, DEPALMA PD, PULLEN M, NAMBI P: Charac-terization of canine renal endothelin receptor subtypes and their function. J. Pharmacol Exp. Ther. (1994) 268:1091–1097.
- CRISTOL JP, WARNER TD, THIEMERMANN C, VANE JR:Mediation via different receptors of the vasocon-strictor effect of endothelins and sarafotoxins in the systemic circulation and renal vasculature of the anaesthetized rat. Br. J. Pharmacol. (1993) 108:776–779.
- MATSURA T, MIURA K, EBARA T et al.: Renal vasculareffects of the selective endothelin receptor antagonists in anaesthetized rats. Br. J. Pharmacol (1997) 122:81–86.
- KAASJAGER KA, SHAW S, KOOMANS HA, RABELINK TJ:Role of endothelin receptor subtypes in the systemic and renal response to endothelin-1 in humans. J. Am. Soc. Nephrol (1997) 8:32–39.
- ONG AC, JOWETT TP, FIRTH JD, BURTON S, KARET FE, FINE LG: An endothelin-1 mediated autocrine growth loop involved in human renal tubular regeneration. Kidney Int. (1995) 48:390–401.
- LANGMAN LJ, YATSCOFF RW: Comparison of the effects of cyclosporin G, cyclosporin A and their metabolites on the release of endothelin and prostacyclin from primary renal and aortic endothelial cell lines. Ther. Drug Monit. (1994) 16:450–457.
- IWASAKI S, HOMMA T, KON V: Site specific regulation in the kidney of endothelin and its receptor subtypes by cyclosporine. Kidney Int. (1994) 45:592–597.
- LANESE DM, CONGER BD: Effects of endothelin receptor antagonist on cyclosporine-induced vasoconstriction in isolated rat renal arterioles. J. Clin. Invest. (1993) 91:2144–2149.
- CONGER JD, KIM GE, ROBINETTE JB: Effects of ANGII,ETA and TxA2 receptor antagonists on cyclosporine A renal vasoconstriction. Am. J. Physiol. (1 99 4) 267:F443–F449.
- BROOKS DP, CONTINO LC: Prevention of cyclosporineA-induced renal vasoconstriction by the endothelin receptor antagonist 5B209670. Eur. J. Pharmacol. (1995) 294:571–576.
- HEYMAN SN, CLARK BA, KAISER N et al.: Radiocontrastagents induce endothelin release in vivo and in vitro. J. Am. Soc. Nephrol (1992) 3:58–65.
- HEYMAN SN, CLARK BA, CANTLEY L et al.: Effects of ioversol versus iothalamate on endothelin release and radiocontrast nephropathy. Invest. Radio]. (1993) 28:313–318.
- CANTLEY LG, SPOKES K, CLARK B, MCMAHON EG, CARTER J, EPSTEIN FH: Role of endothelin and prosta-glandins in radiocontrast-induced renal artery constriction. Kidney Int. (1993) 44:1217–1223.
- OLDROYD S, SLEE S, HAYLOR J, MORCOS SK, WILSON C: Role for endothelin in the renal responses to radiocontrast media in the rat. Clin. Sci. (1994) 87:427–434.
- POLLOCK DM, POLAKOWSKI JS: Beneficial effect of ETA receptor blockade in radiocontrast-induced nephro-pathy in the rat. J. Am. Soc. Nephrol. (1995) 6:667 (Abstract).
- RUSSO D, MINUTOLO R, CIANCIARUSO B, MEMOLI B, CONTE G, DE NICOLA L: Early effects of contrast media on renal hemodynamics and tubular function in chronic renal failure. J. Am. Soc. Nephrol. (1995) 6:1451–1458.
- BARD KF, MURRAY JJ, BREYER MD, TAKAHASHI K, INAGAMI T, HARRIS RC: Mesangial cell, glomerular and renal vascular responses to endothelin in the rat kidney. J. Clin. Invest. (1989) 83:708–712.
- MACNULTY EE, PLEVIN R, WAKELAM MJ: Stimulation of the hydrolysis of phosphatidylinositol 4,5-biphosphate and phosphatidylcholine by endothelin, a complete mitogen for Rat-1 fibroblasts. Biochem. J. (1990) 272:761–766.
- BOBIK A, GROOMS A, MILLAR JA, MITCHELL A, GRINPUKEL S: Growth factor activity of endothelin on vasculature smooth muscle. Am. J. Physiol. (1990) 258:C408–C415.
- RUIZ-ORTEGA M, GOMEZ-GARRE D, ALCAZAR R et al: Involvement of angiotensin II and endothelin in matrix protein production and renal sclerosis. J. Hypertens. (1994) 12:551–558.
- HAHN AWA, REGENASS S, KERN F, WEILER FR, RESINK TJ: Expression of soluble and insoluble fibronectin in rat aorta: Effects of angiotensin II and endothelin-1. Biochem. Biophys. Res. Commun. (1993) 192:189–197.
- KOHNO M, HORIO T, YOKOKAWA K, YASUNARI K, KURIHARA N, TAKEDA T: Endothelin modulates the mitogenic effect of PDGF on glomerular mesangial cells. Am. J. Physiol. (1994) 266:F894–F900.
- BAKRIS GL, RE RN: Endothelin modulates angiotensin ffinduced mitogenesis of human mesangial cells. Am. Physiol. (1993) 264:F937–F942.
- NAKAMURA T, EBIHARA I, FUKUI M, TOMINO Y, KOIDE H: Effects of a specific endothelin receptor A antago-nist on mRNA levels for extracellular matrix components and growth factors in diabetic rat glomeruli. Diabetes (1995) 44:895–899.
- MORABITO E, CORSICO N, SERAFINI S, MARTELLI EA: Elevated urinary excretion of endothelins in strepto-zotocin diabetic rats. Life Sci. (1994) 54:197–200.
- YAMAUCHI T, OHNAKA K, TAKAYANAGI R, UMEDA F, NAWATA H: Enhanced secretion of endothelin-1 by elevated glucose levels from cultured bovine aortic endothelial cells. FEBS Lett. (1990) 267:16–18.
- NAKAMURA T, EBIHARA I, SHIRATO I, FUKUI M, TOMINO Y, KOIDE H: Endothelin-1 mRNA expression by peripheral blood monocytes in IgA nephropathy. Lancet (1993) 342:1147–1148.
- NAKAMURA T, EBIHARA I, FUKUI M et al.: Renal expres-sion of mRNAs for endothelin-1, endothelin-3 and endothelin receptors in NZB/WF1 mice. Renal Physiol Biochem. (1993) 16:233–243.
- NAKAMURA T, EBIHARA I, TOMINO Y, KOIDE H: Effect of a specific endothelin A receptor antagonist on murine lupus nephritis. Kidney Int. (1995) 47:481–789.
- BENIGNI A, PERICO N, GASPARI F et al: Increased renal endothelin production in rats with reduced renal mass. Am. J. Physiol. (1991) 260:F331–F339.
- BENIGNI A, ZOJA C, CORNA D et al.: A specific endothelin subtype A receptor antagonist protects against injury in renal disease progression. Kidney Int. (1993) 44:440–444.
- BENIGNI A, ZOJA C, CORNA D et al.: Blocking both type A and B endothelin receptors in the kidney attenutes renal injury and prolongs survival in rats with remnant kidney. Am. J. Kidney Dis. (1996) 3:416–423.
- NABOKOV A, AMANN K, WAGNER J, GEHLEN F, WINTER K, RITZ E: Influence of specific and non-specific endothelin receptor antagonists on renal morphology in rats with surgical renal ablation. Nephrol. Dial. Transplant (1999) 11:514–520.
- WOLF SC, BREHM BR, GASCHLER F et al.: Protective effects of endothelin antagonists in chronic renal failure. Nephrol Dial. Transplant (1999) 14\(Suppl. 4)29–30.
- GIANELLO P, FISHBEIN J, BESSE T et al.: Measurement of the vasoconstrictive substances endothelin, angiotensin II and thromboxane B2 in cold storage solution can reveal previous renal ischemic insults. Transplant Int. (1994) 7:11–16.
- HERRERO I, TORRAS J, RIERA M et al.: Prevention of cold ischaemia-reperfusion injury by an endothelin receptor antagonist in experimental renal transplan-tation. Nephrol. Dial. Transplant (1999) 14(4):872–880.
- BRAUN C, VETTER S, CONZELMANN T et al.: Improved recovery following posttransplant acute renal failure in rat renal isografts with an oral endothelin-A receptor antagonist. Exp. Nephrol (In press).
- WATSCHINGER B, SAYEGH MH: Endothelin in organ transplantation. Am. J. Kidney Dis. (1996) 27:151–161.
- ••An excellent overview of the role of ET in transplantation.
- DOUGLAS SA, LOUDEN C, VICKERY-CLARK LM, STORER BL, HART T, FEUERSTEIN GZ: A role for endogenous endothelin-1 in neointimal formation after rat carotid artery balloon angioplasty. Protective effects of the novel nonpeptide endothelin receptor antagonist SB 209670. Circ Res. (1994) 1:190–197.
- OKADA K, NISHIDA Y, MURAKAMI H et al.: Role of endogenous endothelin in the development of graft arteriosclerosis in rat cardiac allografts. Circulation (1998) 97:2346–2351.
- BRAUN C, CONZELMANN T, VETTER S et al.: Prevention of chronic renal allograft rejection in rats with an oral endothelin receptor antagonist. Transplantation (1999) 68:739–746.
- ORTH SR, ODONI G, AMANN K, STRZELCZYK P, RASCHACK M, RITZ E: The ET(A) receptor blocker LU 135252 prevents chronic transplant nephropathy in the „Fisher to Lewis' model. J. Am. Soc. Nephrol. (1999) 10:387–391.