Necatoriasis: treatment and developmental therapeutics

Bibliography

• HOTEZ PJ, PRITCHARD DI: Hookworm infection. Sci. Am. (1995) 272(6):68–74.
   PubMed Web of Science ®Google Scholar
• SARINAS PS, CHITKARA RK: Ascariasis and hookworm. Semin. Respir. Infect. (1997) 12 (2) :130–137.
   PubMedGoogle Scholar
• WALDEN J: Other roundworms. Trichuris, hookworm and Strongyloides. Primary Care (1991) 18(1)53–74.
   Google Scholar
• BROWN A, GIROD N, BILLETT EE, PRITCHARD DI: Necator americanus (human hookworm) aspartyl proteinases and digestion of skin macromolecules during skin penetration. Am. J. Trop. Med. Hyg. (1999) 60(5)840–847.
   Google Scholar
• HOTEZ P, HAGGERTY J, HAWDON J et al.: Metalloprote-inases of infective Ancylostoma hookworm larvae and their possible functions in tissue invasion and ecdysis. Infect. Immunol. (1990) 58:3883–3892.
   PubMed Web of Science ®Google Scholar
• BROWN A, PRITCHARD DI: The immunogenicity ofhookworm (Necator americanus) acetylcholines-terase (AchE) in man. Parasite Immunol. (1993) 15(4):195–203.
   PubMed Web of Science ®Google Scholar
• MCLAREN DJ: The anterior glands of Necatoramericanus (Nematoda: strongyloidea). 1. Ultrastruc-tural studies. Int. J. Parasitol (1974) 4:25–37.
   PubMedGoogle Scholar
• OGILVIE BM, BARTLETT A, GODFREY RC, TURTON JD,WORMS MJ, YEATES RA: Antibody responses in self infections with Necator americanus. Trans. R. Soc. Trop. Med. Hyg. (1978) 72:66–71.
   PubMed Web of Science ®Google Scholar
• PHILLIPP M: Acetylcholinesterases secreted byintestinal nematodes. 1. Evidence for secretion of the enzyme by a number of nematode species. Int. J. Parasitol. (1984) 3:589–597.
   Google Scholar
• DOCTOR BP, CHAPMAN TC, CHRISTNER CE et al.: Complete amino acid sequence of fetal bovine acetyl-cholinesterase and its comparison in various regions with other cholinesterases. FEBS (1990) 286:123–127.
   Web of Science ®Google Scholar
• ROMSTAD A, GASSER RB, NANSEN P, POLDERMAN AM,CHILTON NB: Necatoramericanus(Nematoda: Ancylo-mastidae) from Africa and Malaysia have different ITS-2 rDNA sequences. Int. J. Parasitol (1998) 28(4) 611–615.
   PubMed Web of Science ®Google Scholar
• STOLTZFUS RJ, DREYFUSS ML, CHWAYA HM, ALBONICOM: Hookworm control as a strategy to prevent iron deficiency. Nutr. Rev. (1997) 55(6):223–232.
   PubMed Web of Science ®Google Scholar
• ALBONICO M, STOLTZFUS RJ, SAVIOLI L etal.: Epidemiol-ogical evidence for a differential effect of hookworm species, Ancylostoma duodenale or Necator americanus, on iron status of children. Int. J. Epidemiol. (1998) 27(3):530–537.
   Google Scholar
• SRINIVASAN V, RADHAKRISHNA S, RAMANATHAN AM, JABBAR S: Hookworm infection in a rural community in south India and its association with haemoglobin levels. Trans. R. Soc. Trop. Med. Hyg. (1987) 81:973–977.
   PubMed Web of Science ®Google Scholar
• GEORGIEV V ST: Parasitic infections. Treatment anddevelopmental therapeutics. 1. Necatoriasis. Curr. Pharm. Design (1999) 5(7):545–554.
   Google Scholar
• MAXWELL C, HUSSAIN R, NUTMAN R et al.: The clinicaland immunologic responses of normal human volunteers to low dose hookworm (Necator americanus) infection. Am. J. Trop. Med. Hyg. (1987) 37:126–134.
   PubMed Web of Science ®Google Scholar
• CLINE BL, LITTLE M, BARTHOLOMEW R, HALSEY N: Larvacidal activity of albendazole against Necator americanus in human volunteers. Am. J. Trop. Hyg. (1984) 33:387–394.
   PubMed Web of Science ®Google Scholar
• BEAVER PC: Observation on Necator infectionresulting from exposure to three larvae. Rev. Iberica Parasitol (1955) 1:1–9.
   Google Scholar
• BIROUM-NERJASIN N: Serum IgE concentrations inrelation to anthelminthic treatment in a javanese population with hookworm. Clin. Exp. Immunol. (1973) 13:545–551.
   PubMed Web of Science ®Google Scholar
• KOJIMA S, YOKOGAWA M, TADA T: Raised levels of serum IgE in human helminthiasis. Am. J. Trop. Med. Hyg. (1972) 21:913–918.
   PubMed Web of Science ®Google Scholar
• GROVE DI, BURSTON TO, FORBES IJ: Fall in IgE levelsafter treatment for hookworm. Gin. Exp. Immunol (1978) 18:565–569.
   Google Scholar
• CAPPUCCINELLI P, FRENTZEL-BEYME R, SENA L,CAVALLO G: Immunoglobulins and parasitic infections. II. Significance of raised IgE levels in different protozoal and helminthic infections. J. Bacteriol Vim]. Immunol. (1971) 64:162–167.
   Google Scholar
• KUMAR N, GUPTA PS, SAHA K, MISRA R, AGARWAL D,CHUTTANI H: Serum and intestinal immunoglobulins in patients with ancylostomiasis. Indian J. Med. Res. (1980) 71:531.
   PubMed Web of Science ®Google Scholar
• JOHANSSON SGO, MELLBIN T, VAHLQUIST B: Immuno-globulin levels in Ethiopian preschool children with special reference to high concentrations of immuno-globulin E (IGNE). Lancet (1968) 2:1118–1121.
   Google Scholar
• RADERMEEKER M, BEKHTI A, PONCELET E, SALMON J:Serum IgE in protozoal and helminthic infections. Allergy (1974) 47:285–295.
   Web of Science ®Google Scholar
• PRITCHARD DI, WALSH EA, QUINNELL RJ, RAIKO A.,EDMONDS P, KEYMER AE: Isotypic variation in antibody responses in a community in Papua New Guinea to larval and adult antigens during infection and following reinfection, with the hookworm Necator americanus. Parasite Immunol. (1992) 149(6):617–631.
   Google Scholar
• QUINNELL RJ, WOOLHOUSE MEJ, WALSH EA, PRITCHARD DJ: Immunoepidemiology of human necatoriasis: correlations between antibody responses and parasite burdens. Parasite Immunol (1995) 17(6):313–318.
   PubMed Web of Science ®Google Scholar
• PRITCHARD DI, BROWN A, KASPER G et al.: A hookwormallergen which strongly resembles calreticuline. Parasite Immunol. (1999) 21(9)439–450.
   Google Scholar
• PRITCHARD DI, QUINNELL RJ, WALSH EA: Immunity inhumans to Necator americanus: IgE, parasite weight and fecundity. Parasite Immunol. (1995) 17 (2):71–75.
   PubMed Web of Science ®Google Scholar
• PALMER DR, BRADLEY M, BUNDY DA: IgG4 responses toantigens of adult Necator americanus: potential for use in large-scale epidemiological studies. Bull. World Health Organ. (1996) 74(4):381–386.
   PubMed Web of Science ®Google Scholar
• PRITCHARD DI, WALSH EA: The specificity of thehuman IgE response to Necator americanus. Parasite Immunol. (1995) 17(10:605–607.
   PubMed Web of Science ®Google Scholar
• OLATUNDE BO, ONYEMELUKWE GC: Immunosuppres-sion in Nigerians with hookworm infection. Afr. J. Med. Sci. (1994) 23(3):221–225.
   Google Scholar
• TIMOTHY LM, BEHNKE JM: Necator americanus in inbred mice: evidence in support of genetically determined differences in the cellular immune response to a primary infection. Parasitology (1997) 114 (Pt. 1)53–63.
   Google Scholar
• TIMOTHY LM, BEHNKE JM: Necator americanus in inbread mice: a re-evaluation of primary infection kinetics. Parasitology (1993) 107 (Pt. 4)425–431 (published erratum: Parasitology (1994) 108\(Pt. 3):369).
   Google Scholar
• HAWDON JM: Differentiation between the human hookworms Ancylostoma duodenale and Necator americanus using PCR-RFLP. J. Parasitol. (1996) 82(4)642–647.
   Google Scholar
• ROMSTAD A, GASSER RB, NANSEN P, POLDERMAN AM, MONTI JR, CHILTON NB: Characterization of Oesopha-gostomum bifurcum and Necator americanus by PCR-RFLP of rDNA. J. Parasitol. (1997) 85(5)963–966.
   Google Scholar
• TIMOTHY LM, COULSON PS, BEHNKE JM, WILSON RA: Cross-reactivity between Necator americanus and Schistosoma mansoni in mice. Int. J. Parasitol. (1992) 22(8):1143–1149.
   PubMed Web of Science ®Google Scholar
• PRITCHARD DI, QUINNELL RJ, MCKEAN PG et al.: Antigenic cross-reactivity between Necator americanus and Ascaris lumbricoides in a community in Papua New Guinea infected predomi-nantly with hookworm. Trans. R. Soc. Trop. Med. Hyg. (1991) 85(4):511–514.
   PubMed Web of Science ®Google Scholar
• STURCHLER D: Chemotherapy of human intestinal helminthiasis: a review, with particular reference to community treatment. Adv. Pharmacol. Chem. (1982) 19:129–154.
   PubMedGoogle Scholar
• MIGASENA S, GILLES HM: Treatment of disease. In: Human Parasitic Diseases, Hookworm Infections. Vol. 1. Gilles HM, Ball PAJ (Eds.), Elsevier, Amsterdam (1990:195–203.
   Google Scholar
• COOK GC: Intestinal parasitic infections: a soluble public health problem. Parasitol. Today (1990) 6:133–136.
   PubMedGoogle Scholar
• FELDMEIER H, BIENZLE U, DOHRING E, DIETRICH M: Flubendazole versus mebendazole in intestinal helminthic infections. Acta Trop. (1982) 39:185–189.
   PubMed Web of Science ®Google Scholar
• KAN SP: Efficacy of single doses of mebendazole in the treatment of Trichuris trichiura. Am. J. Trop. Med. Hyg. (1983) 32:118–122.
   PubMed Web of Science ®Google Scholar
• KEYSTONE JS, MURDOCH JK: Diagnosis and treatment, drugs Ewe years later, mebendazole. Ann. Int. Med. (1979) 91:582–586.
   PubMed Web of Science ®Google Scholar
• NONTASUT P, SINGHASIVANON V, PRARINYANUPARP V et al.: Effect of single-dose albendazole and single-dose mebendazole on Necator americanus. Southeast Asian Trop. Med. Public Health (1989) 20(2):237–242.
   PubMedGoogle Scholar
• PENE P, MOJON M, GARIN JP, COULAUD JP, ROSSIGNOL JF: Albendazole: a new broad spectrum anthelminthic: double-blind multicenter clinical trial. Am. J. Trop. Med. Hyg. (1982) 31:263–266.
   PubMed Web of Science ®Google Scholar
• VIRAVAN C, MIGASENA S, BUNNAG D, HARINASUTA T:Clinical trial of albendazole in hookworm infection. Southeast Asian J. Trop. Med. Public Health (1982) 13:654–657.
   PubMedGoogle Scholar
• RAMALINGAM S, SINNIAH B, KRISHNAN U: Albendazole, an effective single dose, broad spectrum anthelmin-thic drug. Am. J. Trop. Med. Hyg. (1983) 32:984–989.
   PubMed Web of Science ®Google Scholar
• SAVIOLI L, BUNDY D, TOMKINS A: Intestinal parasitic infections: a soluble public health problem. Trans. R. Soc. Trop. Med. Hyg. (1992) 86:353–354.
   PubMed Web of Science ®Google Scholar
• JAGOTA SC: Albendazole, a broad-spectrum anthel-minthic, in the treatment of intestinal nematode and cestode infection: a multicenter study in 480 patients. Clin. Ther. (1986) 8:226–231.
   PubMed Web of Science ®Google Scholar
• LACEY E: Mode of action of benzimidazoles. Parasitol Today (1990) 6:112–115.
   PubMedGoogle Scholar
• LIU XL, WELLER PF: Antiparasitic drugs. N Engl. J. Med. (1996) 334:1178–1184.
   PubMed Web of Science ®Google Scholar
• ALBONICO M, SMITH PG, HALL A, CHWAYA HM, ALAWI KS, SAVIOLI L: A randomized controlled trial comparing mebendazole and albendazole against Ascaris, Trichuris and hookworm infections. Trans. R. Soc. Trop. Med. Hyg. (1994) 88:585–589.
   PubMed Web of Science ®Google Scholar
• ALBONICO M, RANGANATHAN E, BOSMAN A, KISUMKI UM, ALAWI KS, SAVIOLI L: Efficacy of a single dose of mebendazole on prevalence and intensity of soil-transmitted nematodes in Zanzibar. Trop. Geog. Med. (1994) 46:142–146.
   PubMedGoogle Scholar
• ISMAIL MM, PREMARATNE UN, SURAWEERA MG: Comparative efficacy of single dose anthelminthic in relation to intensity of geohelminth infections. Ceylon Med. J. (1991) 36:162–167.
   PubMedGoogle Scholar
• WORLD HEALTH ORGANIZATION: Prevention and control of intestinal parasitic infections: report of a WHO Expert Committee. WHO Tech. Rep. Ser. (1987) 749.
   Web of Science ®Google Scholar
• KULKUMTHORN M, KRAIVICHIAN M, YINGYOURD P: Clinical trial of a 500 mg dose of mebendazole in hookworm infection. Chulalongkorn Med. J. (1985) 29:1069.
   Google Scholar
• CHONGSUPHAJAISIDDHI T, SABCHAROEN A, ATTANATH P, PANASOPONKUL C, RADOMYOS P: Treatment of soil-transmitted nematode infection in children with mebendazole. Ann. Trop. Med. Parasitol (1978) 72:59–63.
   PubMed Web of Science ®Google Scholar
• NONTASUT P, WAIKAGUL J, MUENNO0 C, SANGUANKAIT S, NUAMTANONG S, MAIPANICH W: Minimum effective doses of mebendazole in treatment of soil-transmitted helminths. Southeast Asian J. Trop. Med. Public Health (1997) 28(2):326–328.
   PubMedGoogle Scholar
• NONTASUT P, SINGHASIVANON V, MAIPANICH W, YAMPUT S, VASIASSUK K: Comparative study of different doses of mebendazole in hookworm infections. Southeast Asian J. Trop. Med. Public Health (1987) 18:211–214.
   PubMedGoogle Scholar
• CHAVARRIA AP, SWARTZWELDER JC, VILLAREJOS VM, ZELEDON R: Mebendazole, an effective broad spectrum anthelminthic. Am. J. Trop. Med. Hyg. (1973) 22:592–595.
   PubMed Web of Science ®Google Scholar
• CABRERA BD, VALDEZ EV, GO TG: Clinical trial of broad spectrum anthelminthics against soil-transmitted helminthiasis. Southeast Asian J. Trop. Med. Public Health (1980) 11:502–506.
   PubMedGoogle Scholar
• RICHARD-LENOBLE D, KOMBILA M, ABANJA ML, GENTILINI M: Mebendazole et nematodes intestinales au Gabon: tolerance et efficacite en prices uniques at multiples. Bull. Soc. Path. ExoL Filiales (1981) 74:444.
   PubMed Web of Science ®Google Scholar
• HOLZER BR, FREY FJ: Differential efficacy of mebenda-zole and albendazole against Necator americanus but not for Trichuris trichiura infestations. Eur. J. Clin. Pharmacol. (1987) 32:635–637.
   PubMed Web of Science ®Google Scholar
• SHIELD J: A study of the effectiveness of mebendazole and pyrantel pamoate as combination anthelminthic in Papua New Guinean children. P. N G. Med. J. (1985) 28:41–44.
   PubMed Web of Science ®Google Scholar
• ROSSIGNOL JF, MAISONNEUVE H: Albendazole: placebo-controlled study in 870 patients with intestinal helminthiasis. Trans. R. Soc. Trop. Med. Hyg. (1983) 77:707–711.
   PubMed Web of Science ®Google Scholar
• MAISSONEUVE H, ROSSIGNOL JF, ADDO A, MOJON M: Ovicidal effects of albendazole in human ascariasis, ancylostomiasis and trichuriasis. Ann. Trop. Med. Parasitol. (1995) 79:79–82.
   Google Scholar
• TAYLOR M, PILLAI G, KVALSVIG JD: Targeted chemotherapy for parasite infestations in rural black preschool children. S. Afr. Med. J. (1995) 85:870–874.
   PubMed Web of Science ®Google Scholar
• BRADLEY M: Rate of expulsion of Necator americanus and the false hookworm Ternidens deminutus Railleiet and Henry 1909 (Nematoda) from humans following albendazole treatment. Trans. R. Soc. Trop. Med. Hyg. (1990) 84(5):720.
   PubMed Web of Science ®Google Scholar
• ZHANG XR, YANG WJ, YANG C et al.: Effect of albenda-zole and pyrantel in treating intestinal helminthiasis and controlling the recurrence of hookworm infections. Chung Kuo Chi Sheng Chung Hsueh Yu Chi Sheng Chung Ping Tsa Chih (1990) 8(2):96–99.
   Google Scholar
• DE SILVA DG, HETTIARACHI SP, FONSEKA PH: Albenda-zole in the treatment of geohelminth infections in children. Ceylon Med. J. (1989) 34:185–189.
   PubMedGoogle Scholar
• PENICULT B, BECK C, MAUGEIN P et al.: Albendazole:perfil farmacocinetico. Compend. Invest. Clin. Latinoam. (1981) 1 (Suppl. 0:61–66.
   Google Scholar
• WAGNER ED, PENA-CHEVARRIA A: In vivo effects of anew anthelminthic, mebendazole (R-17,635) on the eggs of Trichuris trichiura and hookworms. Am. J. Trop. Med. Hyg. (1974) 23:151–153.
   PubMed Web of Science ®Google Scholar
• WAGNER ED, REXINGER DD: In vivo effects of mebenda-zole and levamisole in the treatment of trichuriasis and ascariasis. Am. J. Trop. Med. Hyg. (1978) 27:203–205.
   PubMed Web of Science ®Google Scholar
• PAMBA HO, BWIBO NO, CHUNGE CN, ESTAMBALE BB: A study of the efficacy and safety of albendazole (Zentel) in the treatment of intestinal helminthiasis in Kenyan children less than 2 years of age. East Afr. Med. J. (1989) 66:197–202.
   PubMed Web of Science ®Google Scholar
• SACKO M, DE CLERCQ D, BEHNKE JM, GILBERT FS, DORNY P, VERCRUYSSE J: Comparison of the efficacy of mebendazole, albendazole and pyrantel in treatment of human hookworm infections in the southern region of Mali, West Africa. Trans. R. Soc. Trop. Med. Hyg. (1999) 93(2):195–203.
   PubMed Web of Science ®Google Scholar
• RICHARDS JC, BEHNKE JM, DUCE IR: In vitro studies on the relative sensitivity to ivermectin of Necator americanus and Ancylostoma ceylanicum. Int. J. Parasitol (1995) 25:1185–1191.
   PubMed Web of Science ®Google Scholar
• CAMPBELL WC: Progress and prospects in the chemotherapy of nematode infections of man and other animals. J. Nematology (1983) 15:608–615.
   PubMed Web of Science ®Google Scholar
• CAMPBELL WC, BENZ GW: Ivermectin: a review of efficacy and safety. J. Vet. Pharmacol. Ther. (1984) 7:1–16.
   PubMed Web of Science ®Google Scholar
• BEHNKE JM, ROSE R, GARSIDE P: Sensitivity toivermectin and pyrantel of Ancylostoma ceylanicum and Necator americanus. Int. J. ParasitoL (1993) 23 (7):945–952.
   PubMed Web of Science ®Google Scholar
• RAJASEKARIAH GR, DEB BN, DHAGE KR, BOSE S: Response of laboratory-adapted human hookworm and other nematodes to ivermectin. Ann. Trop. Med. Parasitol (1986) 80:615–621.
   PubMed Web of Science ®Google Scholar
• XIA ZH, SU YL, TAO SY et al.: Clinical observation on efficacy of ivermectin in the treatment of intestinal nematode infections. Chung Kuo Chi Sheng Chung Hsueh Yu Chi Sheng Chung Ping Tsa Chih (1992) 10:279–282.
   Google Scholar
• NAQUIRA C, JIMENEZ G, GUERRA JG et al.: Ivermectin for human strongyloidiasis and other intestinal helminths. Am. J. Trop. Med. Hyg. (1989) 40:304–309.
   PubMed Web of Science ®Google Scholar
• WHITWORTH JAG, MORGAN D, MAUDE GH, MCNICHOLAS AM, TAYLOR DW: A field study of the effect of ivermectin on intestinal helminths in man. Trans. R. Soc. Trop. Hyg. (1991) 85(2):232–234.
   PubMed Web of Science ®Google Scholar
• XIAO SH, REN HN, DAI ZQ, YANG YQ, ZHANG CW: Light and electron microscopic observations on effects of tribendimin on cuticle of Necator americanus and small intestinal mucosa of infected golden hamsters. Chung Kuo Yao Li Hsueh Pao (1989) 10(0:90–92.
   PubMed Web of Science ®Google Scholar
• YANG YQ, YANG HZ, REN HM, CHENG BZ: Histological and histochemical effects of tribendimin on Necator americanus. Chung Kuo Yao Li Hsueh Pao (1988) 9:264–267.
   PubMed Web of Science ®Google Scholar
• KUMAR S: The response of adult and free-living stages of Necator americanus, in vitro, to anthelminthics. Rev. Biol. Trop. (1987) 35:73–76.
   PubMed Web of Science ®Google Scholar
• CAUWENBERG G: The effect of single dose mebenda-zole on the egg reduction rates (ERR) and cure rate (CR) in patients with Ascaris, Trichuris and hookworm infestations. Clinical Research Report. Janssen Res. Prod. Info. Service, February, R 17635/51.
   Google Scholar
• VANDEPITTE J: Le mebendazole, un nouvel anthhel-minthic a tres large spectre active dans la trichocepha-lose. Bull. Soc. Pathol. ExoL Filiales (1973) 66:165–169.
   PubMedGoogle Scholar
• PENICAUT B, MAUGEIN PH, MAISONNEUVE H, ROSSIGNOL JF: Pharmacocinetique at metabolism urinaire de l'albendazole chex l'homme. Bull. Soc. Pathol Exot. Fihales (1983) 76:698–708.
   PubMed Web of Science ®Google Scholar
• MUNST GJ, KARLAGANIS G, BIRCHER J: Plasma concen-trations of mebendazole during treatment of echino-coccosis. Eur. j Gun. Pharmacol (1980) 17:375–378.
   Web of Science ®Google Scholar
• DE CLERCQ D, SACKO M, BEHNKE J, GILBERT F, DORNY P, VERCRUYSSE J: Failure of mebendazole in treatment of human hookworm infections in the southern region of Mali. Am. J. Trop. Med. Hyg. (1997) 57(1)25–30.
   Google Scholar
• WALLER PJ: Resistance in nematode parasites of livestock to the benzimidazole anthelminthics. Parasitol. Today (1990) 6:127–129.
   PubMedGoogle Scholar
• COLES GC, BORGSTEEDE FHM, GEERTS S: Anthelminthic-resistance nematodes in the EU. Parasitol. Today (1994) 10:288–290.
   Google Scholar
• CONDOR GA: Chemotherapy of nematode infectionsof veterinary importance, with special reference to drug resistance. Arch. Parasitol. (1995) 35:1–84.
   Web of Science ®Google Scholar
• DONALD AD: Anthelminthic resistance in relation tohelminth control and grazing systems. In: Facts and Reflections IV. Resistance of Parasites to Anthelminthics. Borgsteede FHM, Henriksen SA, Over HJ (Eds.), Central Veterinary Institute, Lelystad, The Netherlands (1983):187–198.
   Google Scholar
• COLES GC, PAPADOPOULOS E, HIMONAS CA: Tubulin resistance and worms. Parasitol. Today (1995) 11:183–184.
   Google Scholar
• CERAMI A, WARREN KS: Drugs. Parasitol. Today (1994)10:404–406.
   PubMedGoogle Scholar
• SMITH G: Chemotherapy: future problems. In:Hookworm Disease. Current Status and New Directions. Warren KS, Schad GA (Eds.), Taylor & Francis, London, UK (1990):291–303.
   Google Scholar
• KELLY JD, CHEVIS RAF, GOODMAN HT: Effect of particle size on the anthelminthic efficacy of mebendazole against Nippostrongylus brasiliensis in the rat. Int. J. Parasitol. (1975) 5:275–280.
   PubMed Web of Science ®Google Scholar
• WESHE D, BARNISH GA: A comparative study of the effectiveness of mebendazole (Janssen) and generi-cally equivalent mebendazole (Nordia) in intestinal helminthiasis in Papua New Guinean children. P. N G. Med. J. (1994) 37:7–11.
   PubMed Web of Science ®Google Scholar
• HOTEZ PJ: Hookworm disease in children. Pediatr. Infect. Dis. J. (1989) 8(8):16–520.
   PubMed Web of Science ®Google Scholar
• HOY H, NELSON GS: Helminths in the aetiology of anaemia in the tropics, with special preference to hookworms and schistosomes. Exp. Parasitol (1963) 14:240–262.
   PubMed Web of Science ®Google Scholar
• WOODRUFF AW: Recent work concerning anemia in the tropics. Semin. Haematol (1982) 19:141–147.
   PubMed Web of Science ®Google Scholar
• PRITCHARD DI, MCKEAN PG, TIGHE PJ, QUINNELL RJ: Recent and predicted advances in hookworm biology. In: Parasite Nematodes. Antigenes, Membranes and Genes. Kennedy MW (Ed.), Taylor & Francis, London (1990:140–169.
   Google Scholar
• KALKOFEN UP: Intestinal trauma resulting from feeding activities of Ancylostoma caninum. Am. J. Trop. Med. Hyg. (1974) 23:1046–1053.
   PubMed Web of Science ®Google Scholar
• GERRITSEN T, HEINZ HJ, STAFFORD GH: Estimating blood loss in hookworm infestation with Fe. Science (1954) 119:412–413.
   PubMed Web of Science ®Google Scholar
• ROCHE M, LAYRISSE M: Nature and causes of hookworm anaemia. Am. J. Trop. Med. Hyg. (1966) 15:1031–1101.
   Web of Science ®Google Scholar
• GILES HM, WATSON-WILLIAMS EJ, BALL PAJ: Hookworm infection and anaemia: an epidemiological, clinical and laboratory study. Q. J. Med. (1964) 33:1–24.
   PubMedGoogle Scholar
• LOEB L, SMITH AJ: The presence of a substance inhibiting the coagulation of the blood in Ancylo-stoma. Proc. Pathol. Soc. (1904) 7:173–187.
   Google Scholar
• LOEB L, FLEISHER MS: The influence of extracts of Ancylostoma caninum on the coagulation of the blood and on haemolysis. J. Infect. Dis. (1910) 7:625–631.
   Google Scholar
• CAPPELLO M, VLASUK GP, BERGUM GP, HUANG S, HOTEZ PJ: Ancylostoma caninum anticoagulant peptide, a hookworm-derived inhibitor of human coagulation Factor Xa. Proc. Natl. Acad. Sci. USA (1995) 92:6152–6156.
   PubMed Web of Science ®Google Scholar
• CAPPELLO M, CLYNE LP, MCPHEDRAN P, HOTEZ PJ: Ancylostoma Factor Xa inhibitor: partial purification and its identification as a major hookworm-derived anticoagulant in vitro. J. Infect. Dis. (1993) 167:1474–1477.
   PubMed Web of Science ®Google Scholar
• PRITCHARD DI, FURMIDGE B: The anti-haemostatic strategies of the human hookworm Necator americanus. Thromb. HaemosL (1995) 73(3):546.
   PubMed Web of Science ®Google Scholar
• FURMIDGE BA, HORN LA, PRITCHARD DI: The anti-haemostatic strategies of the human hookworm Necator americanus. Thromb. HaemosL (1995) 73:546.
   PubMed Web of Science ®Google Scholar
• FURMIDGE BA, HORN LA, PRITCHARD DI: The anti-haemostatic strategies of the hookworm Necator americanus. Parasitology (1995) 112:81–87.
   Web of Science ®Google Scholar
• EIFF JA: Nature of an anticoagulant from the cephalic glands of Ancylostoma caninum. J. Parasitol (1966) 52:833–843.
   PubMed Web of Science ®Google Scholar
• SPELLMAN GG, NOSSELL HK: Anticoagulant activity of dog hookworm. Am. J. Parasitol. (1971) 4:922–927.
   Google Scholar
• CAROLL SM, HOWSE DJ, GROVE DI: The anticoagulant effects of hookworm, Ancylostoma ceylanicum: observations in human and dog blood in vitro and infected dogs in vivo. Thromb. Haemost. (1984) 51:222–227.
   PubMed Web of Science ®Google Scholar
• HOTEZ PJ, CERAMI A: Secretion of a proteolytic antico-agulant by Ancylostoma worms. J. Exp. Med. (1983) 157:1594–1603.
   PubMed Web of Science ®Google Scholar
• HOTEZ PJ, LE TRANG N, MCKERROW JH, CERAMI A: Isolation and characterization of a proteolytic enzyme from the adult hookworm Ancylostoma caninum. J. Biol. Chem. (1985) 260:7343–7348.
   PubMed Web of Science ®Google Scholar
• STEEN VM, HOLMSEN H: Current aspects on human platelet activation and responses. Eur. J. Haematol. (1987) 38:383–399.
   PubMed Web of Science ®Google Scholar
• MILETICH JP, JACKSON CM, MAJERUS PW: Interaction of coagulation Factor Xa with human platelets. Proc. Natl. Acad. Sci. USA (1977) 47:4033–4036.
   Web of Science ®Google Scholar
• HYNES RO: The complexity of platelet adhesion to extracellular matrices. Thromb. Haemost. (1991) 66:40–43.
   PubMed Web of Science ®Google Scholar
• NACHMAN RL, LEUNG RL: Complex formation of platelet membrane glycoproteins fib and Ma with fibrinogen. J. Clin. Invest. (1982) 69:263–269.
   PubMed Web of Science ®Google Scholar
• NURDEN AT, CAEN JP: An abnormal glycoprotein pattern in three cases of Glanzmann's thrombostenia. Br. J. Haematol (1974) 28:253–259.
   PubMed Web of Science ®Google Scholar
• MCEVER RP, BENNETT EM, MARTIN MN: Identification of two structurally and fuctionally distinct sites on human platelet membrane glycoprotein fib-Ifia using monoclonal antibodies. J. Biol. Chem. (1983) 258:5269–5275.
   PubMed Web of Science ®Google Scholar
• SHATTIL SJ: Regulation of platelet anchorage and signaling by integrin c11b133. Thromb. Haemost. (1993) 70:224–228.
   PubMed Web of Science ®Google Scholar
• SHATTIL SJ, HOXIE JA, CUNNINGHAM M, BRASS LF: Changes in the platelet membrane glycoprotein fib/Ifia complex during platelet activation. J. Biol. Chem. (1985) 260:11107–11114.
   PubMed Web of Science ®Google Scholar
• PRITCHARD DI, QUINNELL RJ, SLATER AEG et al.: Epidemiology and immunology of Necator americanus infection in a community in Papua New Guinea humoral responses to excretory-secretory and cuticular collagen antigens. Parasitology (1990) 100:317–326.
   PubMed Web of Science ®Google Scholar
• COOK JD: Clinical evaluation of iron deficiency. Semin. Haematol. (1982) 19:7–18.
   Web of Science ®Google Scholar
• FINCH CA, COOK JD: Iron deficiency. Am. J. Clin. Nutr. (1984) 39:471–477.
   PubMed Web of Science ®Google Scholar
• PRITCHARD DI, QUINNELL RJ, MOUSTAFA M et al: Hookworm (Necator americanus) infection and storage iron depletion. Trans. R. Soc. Trop. Med. Hyg. (1991) 85(2):235–238.
   PubMed Web of Science ®Google Scholar
• STOLTZFUS RJ, ALBONICO M, CHWAYA HM et al.: Hemoquant determination of hookworm-related blood loss and its role in iron deficiency in African children. Am. J. Trop. Med. Hyg. (1996) 55:399–404.
   PubMed Web of Science ®Google Scholar
• SCHWARTZ S, DAHL J, ELLEFSON M, ANLQUIST D: The IlemoQuane test: a specific and quantitative determi-nation of heme (hemoglobin) in feces and other materials. Clin. Chem. (1983) 29:2061–2067.
   PubMed Web of Science ®Google Scholar
• GENTA RM, WOODS KL: Endoscopic diagnosis of hookworm infection. Gastrointest. Endosc. (1991) 37(4):476–478.
   PubMed Web of Science ®Google Scholar
• CROMPTON DWT, WHITEHEAD RR: Hookworm infections and human metabolism. Parasitology (1993) 107(Suppl.):S137–S145.
   Google Scholar
• LOUGHREY MB, IRVINE AD, GIRDWOOD RW, MCMILLAN JC: Cutaneous larva migrans: the case for routine oral treatment. Br. J. Dermatol (1997) 137 (1) :155–156.
   PubMed Web of Science ®Google Scholar
• BEAVER PC, JUNG RC, CUPP EW: The strongylida: hookworms and other bursate nematode. In: Craig and Faust's Clinical Parasitology. 9th Edition. Beaver PC, Jung RC, Cupp EW, Craig CF (Eds.), Lea & Fabiger, Philadelphia, USA (1984):277–287.
   Google Scholar
• DONOWITZ GR, MANDELL GL: In: Principles and Practice of Infectious Disease. Vol. 1, 3rd ed. Mandell GL, Bennett JE (Eds.), Churchill Livingstone, New York, USA (1990):551.
   Google Scholar
• BALL PAJ, BARTLETT A: Serological reactions to infections with Necator americanus. Trans. R. Soc. Trop. Med. Hyg. (1969) 63:362–369.
   PubMed Web of Science ®Google Scholar
• BEAVER PC: Cutaneous larva migrans. Industrial Med. Surg. (1964) 33:319–321.
   PubMedGoogle Scholar
• DAVIES HD, SAKULS P, KEYSTONE JS: Creeping eruption: a review of clinical presentation and management of 60 cases presenting to a tropical disease unit. Arch. Dermatol. (1993) 129:588–591.
   PubMed Web of Science ®Google Scholar
• JONES SK, REYNOLDS NJ, OLIWIECKI S, HARMAN RRM: Oral albendazole for the treatment of cutaneous larva migrans. Br. J. Dermatol. (1990) 122:99–101.
   PubMed Web of Science ®Google Scholar
• ORIHUELA AR, TORRES JR: Single dose of albendazole in the treatment of cutaneous larva migrans. Arch. Dermatol. (1990) 126:398–399.
   PubMed Web of Science ®Google Scholar
• JONES SK: Cutaneous larva migrans - 'recurrence'. Br. J. Dermatol. (1994) 130:546.
   PubMed Web of Science ®Google Scholar
• STONE O, MULLINS J: Thiabendazole effectiveness in creeping eruption. Arch. Dermatol. (1965) 91:427–429.
   PubMed Web of Science ®Google Scholar
• CAUMES E, DATRY A, PARIS L, DANIS M, GENTILINI M, GAXOTTE P: Efficacy of ivermectin in the therapy of cutaneous larva migrans. Arch. Dermatol. (1992) 128:994–995.
   PubMed Web of Science ®Google Scholar
• FREEDMAN DO: Travel medicine. Curr. Opin. Infect. Dis. (1994) 7:570–574.
   Web of Science ®Google Scholar
• LWAMBO HJS, BUNDY DAP, MEDLEY GFH: A new approach to morbidity risk assessment in hookworm endemic communities. Epidemiol. Infect. (1992) 108:469–481.
   PubMed Web of Science ®Google Scholar
• HOTEZ PJ, GHOSH K, HAWDON JM et al.: Experimental approaches to the development of a recombinant hookworm vaccine. Immunol Rev. (1999) 171:163–171.
   PubMed Web of Science ®Google Scholar