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Mimotope vaccination – from allergy to cancer

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Pages 493-506 | Published online: 03 Apr 2009

Bibliography

  • Lebecque S, Dolecek C, Laffer S, et al. Immunologic characterization of monoclonal antibodies that modulate human IgE binding to the major birch pollen allergen Bet v 1. J Allergy Clin Immunol 1997;99(3):374-84
  • Yip YL, Smith G, Koch J, et al. Identification of epitope regions recognized by tumor inhibitory and stimulatory anti-ErbB-2 monoclonal antibodies: implications for vaccine design. J Immunol 2001;166(8):5271-8
  • Bauchau V, Durham SR. Prevalence and rate of diagnosis of allergic rhinitis in Europe. Eur Respir J 2004;24(5):758-64
  • Cohen SG, Frankland AW, Dworetzky M. Noon and Freeman on prophylactic inoculation against hay fever. J Allergy Clin Immunol 2003;111(5):1142-50
  • Durham SR, Walker SM, Varga EM, et al. Long-term clinical efficacy of grass-pollen immunotherapy. N Engl J Med 1999;341(7):468-75
  • Frew AJ. 25. Immunotherapy of allergic disease. J Allergy Clin Immunol 2003;111(2 Suppl):S712-9
  • Hafner T, DuBuske L, Kosnik M. Long-term efficacy of venom immunotherapy.Ann Allergy Asthma Immunol 2008;100(2):162-5
  • Bousquet J, Lockey R, Malling HJ. Allergen immunotherapy: therapeutic vaccines for allergic diseases. A WHO position paper. J Allergy Clin Immunol 1998;102(4 Pt 1):558-62
  • Mobs C, Slotosch C, Loffler H, et al. Cellular and humoral mechanisms of immune tolerance in immediate-type allergy induced by specific immunotherapy. Int Arch Allergy Immunol 2008;147(3):171-8
  • Gleich GJ, Zimmermann EM, Henderson LL, et al. Effect of immunotherapy on immunoglobulin E and immunoglobulin G antibodies to ragweed antigens: a six-year prospective study. J Allergy Clin Immunol 1982;70(4):261-71
  • Gehlhar K, Schlaak M, Becker W, et al. Monitoring allergen immunotherapy of pollen-allergic patients: the ratio of allergen-specific IgG4 to IgG1 correlates with clinical outcome. Clin Exp Allergy 1999;29(4):497-506
  • Jarolim E, Poulsen LK, Stadler BM, et al. A long-term follow-up study of hyposensitization with immunoblotting. J Allergy Clin Immunol 1990;85(6):996-1004
  • Jensen-Jarolim E, Vogel M, de Weck AL, et al. Anti-IgE autoantibodies mistaken for specific IgG. J Allergy Clin Immunol 1992;89(1 Pt 1):31-43
  • Wachholz PA, Soni NK, Till SJ, et al. Inhibition of allergen-IgE binding to B cells by IgG antibodies after grass pollen immunotherapy. J Allergy Clin Immunol 2003;112(5):915-22
  • Akdis M, Akdis CA. Mechanisms of allergen-specific immunotherapy. J Allergy Clin Immunol 2007;119(4):780-91
  • Akdis CA, Blesken T, Akdis M, et al. Role of interleukin 10 in specific immunotherapy. J Clin Invest 1998;102(1):98-106
  • McHugh SM, Deighton J, Stewart AG, et al. Bee venom immunotherapy induces a shift in cytokine responses from a TH-2 to a TH-1 dominant pattern: comparison of rush and conventional immunotherapy. Clin Exp Allergy 1995;25(9):828-38
  • Roy SR, Sigmon JR, Olivier J, et al. Increased frequency of large local reactions among systemic reactors during subcutaneous allergen immunotherapy. Ann Allergy Asthma Immunol 2007;99(1):82-6
  • Rezvani M, Bernstein DI. Anaphylactic reactions during immunotherapy. Immunol Allergy Clin North Am 2007;27(2):295-307, viii
  • Jarolim E, Rumpold H, Endler AT, et al. IgE and IgG antibodies of patients with allergy to birch pollen as tools to define the allergen profile of Betula verrucosa. Allergy 1989;44(6):385-95
  • Focke M, Marth K, Flicker S, et al. Heterogeneity of commercial timothy grass pollen extracts. Clin Exp Allergy 2008;38(8):1400-8
  • Tavares B, Rordigues F, Pereira C, et al. Development of new IgE specificities to hymenoptera allergens during venom-specific immunotherapy. Eur Ann Allergy Clin Immunol 2005;37(5):171-6
  • Moverare R, Elfman L, Vesterinen E, et al. Development of new IgE specificities to allergenic components in birch pollen extract during specific immunotherapy studied with immunoblotting and Pharmacia CAP System. Allergy 2002;57(5):423-30
  • Ball T, Sperr WR, Valent P, et al. Induction of antibody responses to new B cell epitopes indicates vaccination character of allergen immunotherapy. Eur J Immunol 1999;29(6):2026-36
  • Valenta R, Niederberger V. Recombinant allergens for immunotherapy. J Allergy Clin Immunol 2007;119(4):826-30
  • Wachholz PA, Durham SR. Induction of ‘blocking’ IgG antibodies during immunotherapy. Clin Exp Allergy 2003;33(9):1171-4
  • Daeron M, Latour S, Malbec O, et al. The same tyrosine-based inhibition motif, in the intracytoplasmic domain of FcγRIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation. Immunity 1995;3(5):635-46
  • Hantusch B, Scholl I, Harwanegg C, et al. Affinity determinations of purified IgE and IgG antibodies against the major pollen allergens Phl p 5a and Bet v 1a: discrepancy between IgE and IgG binding strength. Immunology Lett 2005;97(1):81-9
  • Flicker S, Valenta R. Renaissance of the blocking antibody concept in type I allergy. Int Arch Allergy Immunol 2003;132(1):13-24
  • Visco V, Dolecek C, Denepoux S, et al. Human IgG monoclonal antibodies that modulate the binding of specific IgE to birch pollen Bet v 1. J Immunol 1996;157(2):956-62
  • Jensen-Jarolim E, Wiedermann U, Ganglberger E, et al. Allergen mimotopes in food enhance type I allergic reactions in mice. FASEB J 1999;13(12):1586-92
  • Scholl I, Kalkura N, Shedziankova Y, et al. Dimerization of the major birch pollen allergen Bet v 1 is important for its in vivo IgE-cross-linking potential in mice. J Immunol 2005;175(10):6645-50
  • Bredehorst R, David K. What establishes a protein as an allergen? J Chromatogr B Biomed Sci Appl 2001;756(1-2):33-40
  • Mahler M, Bluthner M, Pollard KM. Advances in B-cell epitope analysis of autoantigens in connective tissue diseases. Clin Immunol 2003;107(2):65-79
  • Forster-Waldl E, Riemer AB, Dehof AK, et al. Isolation and structural analysis of peptide mimotopes for the disialoganglioside GD2, a neuroblastoma tumor antigen. Mol Immunol 2005;42(3):319-25
  • Christiansen J, Rajasekaran AK. Biological impediments to monoclonal antibody-based cancer immunotherapy. Mol Cancer Ther 2004;3(11):1493-501
  • Waldmann TA, Morris JC. Development of antibodies and chimeric molecules for cancer immunotherapy. Adv Immunol 2006;90:83-131
  • Boyiadzis M, Foon KA. Approved monoclonal antibodies for cancer therapy. Expert Opin Biol Ther 2008;8(8):1151-8
  • Newsome BW, Ernstoff MS. The clinical pharmacology of therapeutic monoclonal antibodies in the treatment of malignancy; have the magic bullets arrived? Br J Clin Pharmacol 2008;66(1):6-19
  • Slamon DJ, Godolphin W, Jones LA, et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 1989;244(4905):707-12
  • Slamon DJ, Clark GM, Wong SG, et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987;235(4785):177-82
  • Garrett TP, McKern NM, Lou M, et al. The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors. Mol cell 2003;11(2):495-505
  • Sliwkowski MX, Schaefer G, Akita RW, et al. Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin. J Biol Chem 1994;269(20):14661-5
  • Sliwkowski MX. Ready to partner. Nat Struct Biol 2003;10(3):158-9
  • Valabrega G, Montemurro F, Aglietta M. Trastuzumab: mechanism of action, resistance and future perspectives in HER2-overexpressing breast cancer. Ann Oncol 2007;18(6):977-84
  • Hudis CA. Trastuzumab–mechanism of action and use in clinical practice. N Engl J Med 2007;357(1):39-51
  • Fendly BM, Winget M, Hudziak RM, et al. Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2/neu gene product. Cancer Res 1990;50(5):1550-8
  • Sliwkowski MX, Lofgren JA, Lewis GD, et al. Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin). Semin Oncol 1999;26(4 Suppl 12):60-70
  • Stancovski I, Hurwitz E, Leitner O, et al. Mechanistic aspects of the opposing effects of monoclonal antibodies to the ERBB2 receptor on tumor growth. Proc Natl Acad Sci USA 1991;88(19):8691-5
  • Cho HS, Mason K, Ramyar KX, et al. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature 2003;421(6924):756-60
  • Riemer AB, Kraml G, Scheiner O, et al. Matching of trastuzumab (Herceptin®) epitope mimics onto the surface of Her-2/neu–a new method of epitope definition. Mol Immunol 2005;42(9):1121-4
  • Smith GP. Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. Science 1985;228(4705):1315-7
  • Geysen HM, Rodda SJ, Mason TJ. The delineation of peptides able to mimic assembled epitopes. Ciba Found Symp 1986;119:130-49
  • Azzazy HM, Highsmith WE Jr. Phage display technology: clinical applications and recent innovations. Clin Biochem 2002;35(6):425-45
  • Felici F, Luzzago A, Folgori A, et al. Mimicking of discontinuous epitopes by phage-displayed peptides, II. Selection of clones recognized by a protective monoclonal antibody against the Bordetella pertussis toxin from phage peptide libraries. Gene 1993;128(1):21-7
  • Luzzago A, Felici F, Tramontano A, et al. Mimicking of discontinuous epitopes by phage-displayed peptides, I. Epitope mapping of human H ferritin using a phage library of constrained peptides. Gene 1993;128(1):51-7
  • Hill HR, Stockley PG. Phage presentation. Mol Microbiol 1996;20(4):685-92
  • Felici F, Castagnoli L, Musacchio A, et al. Selection of antibody ligands from a large library of oligopeptides expressed on a multivalent exposition vector. J Mol Biol 1991;222(2):301-10
  • Davies JM, O'Hehir RE, Suphioglu C. Use of phage display technology to investigate allergen-antibody interactions. J Allergy Clin Immunol 2000;105(6 Pt 1):1085-92
  • Parmley SF, Smith GP. Antibody-selectable filamentous fd phage vectors: affinity purification of target genes. Gene 1988;73(2):305-18
  • Riemer A, Scheiner O, Jensen-Jarolim E. Allergen mimotopes. Methods 2004;32(3):321-7
  • Szalai K, Fuhrmann J, Pavkov T, et al. Mimotopes identify conformational B-cell epitopes on the two major house dust mite allergens Der p 1 and Der p 2. Mol Immunol 2008;45(5):1308-17
  • Mumey BM, Bailey BW, Kirkpatrick B, et al. A new method for mapping discontinuous antibody epitopes to reveal structural features of proteins. J Comput Biol 2003;10(3-4):555-67
  • Halperin I, Wolfson H, Nussinov R. SiteLight: binding-site prediction using phage display libraries. Protein Sci 2003;12(7):1344-59
  • Schreiber A, Humbert M, Benz A, et al. 3D-Epitope-Explorer (3DEX): localization of conformational epitopes within three-dimensional structures of proteins. J Comput Chem 2005;26(9):879-87
  • Enshell-Seijffers D, Denisov D, Groisman B, et al. The mapping and reconstitution of a conformational discontinuous B-cell epitope of HIV-1. J Mol Biol 2003;334(1):87-101
  • Huang YX, Bao YL, Guo SY, et al. Pep-3D-Search: a method for B-cell epitope prediction based on mimotope analysis. BMC bioinformatics 2008;9:538. Published online 16 December 2008, doi:10.1186/1471-2105-9-538
  • Huang J, Gutteridge A, Honda W, et al. MIMOX: a web tool for phage display based epitope mapping. BMC bioinformatics 2006;7:451. Published online 12 October 2006, doi:10.1186/1471-2105-7-451
  • Ganglberger E, Grunberger K, Sponer B, et al. Allergen mimotopes for 3-dimensional epitope search and induction of antibodies inhibiting human IgE. FASEB J 2000;14(14):2177-84
  • Kohlbacher O, Lenhof HP. BALL–rapid software prototyping in computational molecular biology. Biochemicals algorithms library. Bioinformatics 2000;16(9):815-24
  • Gonnet GH, Cohen MA, Benner SA. Exhaustive matching of the entire protein sequence database. Science 1992;256(5062):1443-5
  • Available from: http://www.rcsb.org/pdb/
  • Neumann D, Kohlbacher O, Lenhof HP, et al. Lectin–sugar interaction. Calculated versus experimental binding energies. Eur J Biochem FEBS 2002;269(5):1518-24
  • Partidos CD. Peptide mimotopes as candidate vaccines. Curr Opin Mol Ther 2000;2(1):74-9
  • Wauben MH. Immunological mechanisms involved in experimental peptide immunotherapy of T-cell-mediated diseases. Crit Rev Immunol 2000;20(6):451-69
  • Meola A, Delmastro P, Monaci P, et al. Derivation of vaccines from mimotopes. Immunologic properties of human hepatitis B virus surface antigen mimotopes displayed on filamentous phage. J Immunol 1995;154(7):3162-72
  • Olszewska W, Obeid OE, Steward MW. Protection against measles virus-induced encephalitis by anti-mimotope antibodies: the role of antibody affinity. Virology 2000;272(1):98-105
  • Ho PC, Mutch DA, Winkel KD, et al. Identification of two promiscuous T cell epitopes from tetanus toxin. Eur J Immunol 1990;20(3):477-83
  • Kaumaya PT, Kobs-Conrad S, Seo YH, et al. Peptide vaccines incorporating a ‘promiscuous’ T-cell epitope bypass certain haplotype restricted immune responses and provide broad spectrum immunogenicity. J Mol Recognit 1993;6(2):81-94
  • Ganglberger E, Barbara S, Scholl I, et al. Monovalent fusion proteins of IgE mimotopes are safe for therapy of type I allergy. FASEB J 2001;15(13):2524-6
  • Tam JP. Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system. Proc Natl Acad Sci USA 1988;85(15):5409-13
  • Bramswig KH, Knittelfelder R, Gruber S, et al. Immunization with mimotopes prevents growth of carcinoembryonic antigen positive tumors in BALB/c mice. Clin Cancer Res 2007;13(21):6501-8
  • Leitner A, Vogel M, Radauer C, et al. A mimotope defined by phage display inhibits IgE binding to the plant panallergen profilin. Eur J Immunol 1998;28(9):2921-7
  • Jensen-Jarolim E, Leitner A, Kalchhauser H, et al. Peptide mimotopes displayed by phage inhibit antibody binding to Bet v 1, the major birch pollen allergen, and induce specific IgG response in mice. FASEB J 1998;12(15):1635-42
  • Hantusch B, Krieger S, Untersmayr E, et al. Mapping of conformational IgE epitopes on Phl p 5a by using mimotopes from a phage display library. J Allergy Clin Immunol 2004;114(6):1294-300
  • Hantusch B, Knittelfelder R, Wallmann J, et al. Internal images: human anti-idiotypic Fab antibodies mimic the IgE epitopes of grass pollen allergen Phl p 5a. Mol Immunol 2006;43(14):2180-7
  • Wallmann J, Proell M, Stepanoska T, et al. A mimotope gene encoding the major IgE epitope of allergen Phl p 5 for epitope-specific immunization. Immunol Lett 2009;122(1):68-75
  • Untersmayr E, Szalai K, Riemer AB, et al. Mimotopes identify conformational epitopes on parvalbumin, the major fish allergen. Mol Immunol 2006;43(9):1454-61
  • Furmonaviciene R, Tighe PJ, Clark MR, et al. The use of phage-peptide libraries to define the epitope specificity of a mouse monoclonal anti-Der p 1 antibody representative of a major component of the human immunoglobulin E anti-Der p 1 response. Clin Exp Allergy 1999;29(11):1563-71
  • Pacios LF, Tordesillas L, Cuesta-Herranz J, et al. Mimotope mapping as a complementary strategy to define allergen IgE-epitopes: peach Pru p 3 allergen as a model. Mol Immunol 2008;45(8):2269-76
  • van Neerven RJ. The role of allergen-specific T cells in the allergic immune response: relevance to allergy vaccination. Allergy 1999;54(6):552-61
  • Scholl I, Wiedermann U, Forster-Waldl E, et al. Phage-displayed Bet mim 1, a mimotope of the major birch pollen allergen Bet v 1, induces B cell responses to the natural antigen using bystander T cell help. Clin Exp Allergy 2002;32(11):1583-8
  • Popkov M, Sidrac-ghali S, Alakhov V, et al. Epitope-specific antibody response to HT-1080 fibrosarcoma cells by mimotope immunization. Clin Cancer Res 2000;6(9):3629-35
  • Qiu J, Luo P, Wasmund K, et al. Towards the development of peptide mimotopes of carbohydrate antigens as cancer vaccines. Hybridoma 1999;18(1):103-12
  • Yu AL, Uttenreuther-Fischer MM, Huang CS, et al. Phase I trial of a human–mouse chimeric anti-disialoganglioside monoclonal antibody ch14.18 in patients with refractory neuroblastoma and osteosarcoma. J Clin Oncol 1998;16(6):2169-80
  • Riemer AB, Forster-Waldl E, Bramswig KH, et al. Induction of IgG antibodies against the GD2 carbohydrate tumor antigen by vaccination with peptide mimotopes. Eur J Immunol 2006;36(5):1267-74
  • Fest S, Huebener N, Weixler S, et al. Characterization of GD2 peptide mimotope DNA vaccines effective against spontaneous neuroblastoma metastases. Cancer Res 2006;66(21):10567-75
  • Bolesta E, Kowalczyk A, Wierzbicki A, et al. DNA vaccine expressing the mimotope of GD2 ganglioside induces protective GD2 cross-reactive antibody responses. Cancer Res 2005;65(8):3410-8
  • Wagner S, Hafner C, Allwardt D, et al. Vaccination with a human high molecular weight melanoma-associated antigen mimotope induces a humoral response inhibiting melanoma cell growth in vitro. J Immunol 2005;174(2):976-82
  • Riemer AB, Hantusch B, Sponer B, et al. High-molecular-weight melanoma-associated antigen mimotope immunizations induce antibodies recognizing melanoma cells. Cancer Immunol Immunother 2005;54(7):677-84
  • Luo W, Ko E, Hsu JC, et al. Targeting melanoma cells with human high molecular weight-melanoma associated antigen-specific antibodies elicited by a peptide mimotope: functional effects. J Immunol 2006;176(10):6046-54
  • Hafner C, Wagner S, Jasinska J, et al. Epitope-specific antibody response to Mel-CAM induced by mimotope immunization. J Invest Dermatol 2005;124(1):125-31
  • Bender H, Grapow M, Schomburg A, et al. Effects of diagnostic application of monoclonal antibody on survival in melanoma patients. Hybridoma 1997;16(1):65-8
  • Mittelman A, Chen ZJ, Liu CC, et al. Kinetics of the immune response and regression of metastatic lesions following development of humoral anti-high molecular weight-melanoma associated antigen immunity in three patients with advanced malignant melanoma immunized with mouse antiidiotypic monoclonal antibody MK2-23. Cancer Res 1994;54(2):415-21
  • Wagner S, Krepler C, Allwardt D, et al. Reduction of human melanoma tumor growth in severe combined immunodeficient mice by passive transfer of antibodies induced by a high molecular weight melanoma-associated antigen mimotope vaccine. Clin Cancer Res 2008;14(24):8178-83
  • Yarden Y. The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. Eur J Cancer 2001;37(Suppl 4):S3-8
  • Vaisman N, Nissim A, Klapper LN, et al. Specific inhibition of the reaction between a tumor-inhibitory antibody and the ErbB-2 receptor by a mimotope derived from a phage display library. Immunol Lett 2000;75(1):61-7
  • Riemer AB, Klinger M, Wagner S, et al. Generation of peptide mimics of the epitope recognized by trastuzumab on the oncogenic protein Her-2/neu. J Immunol 2004;173(1):394-401
  • Riemer AB, Kurz H, Klinger M, et al. Vaccination with cetuximab mimotopes and biological properties of induced anti-epidermal growth factor receptor antibodies. J Nat Cancer Inst 2005;97(22):1663-70
  • Dakappagari NK, Douglas DB, Triozzi PL, et al. Prevention of mammary tumors with a chimeric HER-2 B-cell epitope peptide vaccine. Cancer Res 2000;60(14):3782-9
  • Dakappagari NK, Pyles J, Parihar R, et al. A chimeric multi-human epidermal growth factor receptor-2 B cell epitope peptide vaccine mediates superior antitumor responses. J Immunol 2003;170(8):4242-53
  • Jasinska J, Wagner S, Radauer C, et al. Inhibition of tumor cell growth by antibodies induced after vaccination with peptides derived from the extracellular domain of Her-2/neu. Int J Cancer 2003;107(6):976-83
  • Wagner S, Jasinska J, Breiteneder H, et al. Delayed tumor onset and reduced tumor growth progression after immunization with a Her-2/neu multi-peptide vaccine and IL-12 in c-neu transgenic mice. Breast Cancer Res Treat 2007;106(1):29-38
  • Countouriotis A, Moore TB, Sakamoto KM. Cell surface antigen and molecular targeting in the treatment of hematologic malignancies. Stem cells 2002;20(3):215-29
  • Li M, Yan Z, Han W, et al. Mimotope vaccination for epitope-specific induction of anti-CD20 antibodies. Cell Immunol 2006;239(2):136-43
  • Turner MC, Chen Y, Krewski D, et al. Cancer mortality among US men and women with asthma and hay fever. Am J Epidemiol 2005;162(3):212-21
  • Neuchrist C, Kornfehl J, Grasl M, et al. Distribution of immunoglobulins in squamous cell carcinoma of the head and neck. Int Arch Allergy Immunol 1994;104(1):97-100
  • Fu SL, Pierre J, Smith-Norowitz TA, et al. Immunoglobulin E antibodies from pancreatic cancer patients mediate antibody-dependent cell-mediated cytotoxicity against pancreatic cancer cells. Clin Exp Immunol 2008;153(3):401-9
  • Nagy E, Berczi I, Sehon AH. Growth inhibition of murine mammary carcinoma by monoclonal IgE antibodies specific for the mammary tumor virus. Cancer Immunol Immunother 1991;34(1):63-9
  • Kershaw MH, Darcy PK, Trapani JA, et al. Tumor-specific IgE-mediated inhibition of human colorectal carcinoma xenograft growth. Oncol Res 1998;10(3):133-42
  • Gould HJ, Mackay GA, Karagiannis SN, et al. Comparison of IgE and IgG antibody-dependent cytotoxicity in vitro and in a SCID mouse xenograft model of ovarian carcinoma. Eur J Immunol 1999;29(11):3527-37
  • Karagiannis P, Singer J, Hunt J, et al. Characterisation of an engineered trastuzumab IgE antibody and effector cell mechanisms targeting HER2/neu-positive tumour cells. Cancer Immunol Immunother published online 22 October 2008, doi: 10.1007/s00262-008-0607-1
  • Jensen-Jarolim E, Achatz G, Turner MC, et al. AllergoOncology: the role of IgE-mediated allergy in cancer. Allergy 2008;63(10):1255-66
  • Untersmayr E, Jensen-Jarolim E. The role of protein digestibility and antacids on food allergy outcomes. J Allergy Clin Immunol 2008;121(6):1301-8; quiz 9-10
  • Mekori YA, Metcalfe DD. Mast cells in innate immunity. Immunol Rev 2000;173:131-40
  • Riemer AB, Untersmayr E, Knittelfelder R, et al. Active induction of tumor-specific IgE antibodies by oral mimotope vaccination. Cancer Res 2007;67(7):3406-11
  • Khazaeli MB, Conry RM, LoBuglio AF. Human immune response to monoclonal antibodies. J Immunother Emphasis Tumor Immunol 1994;15(1):42-52
  • Garcia-Lora A, Algarra I, Garrido F. MHC class I antigens, immune surveillance, and tumor immune escape. J Cell Phys 2003;195(3):346-55
  • Khong HT, Restifo NP. Natural selection of tumor variants in the generation of “tumor escape” phenotypes. Nat Immunol 2002;3(11):999-1005
  • Lenz HJ. Management and preparedness for infusion and hypersensitivity reactions. Oncologist 2007;12(5):601-9

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