Skeletal tissue engineering using mesenchymal or embryonic stem cells: clinical and experimental data

Bibliography

• Rodrigues MT, Gomes ME, Viegas CA, et al. Tissue-engineered constructs based on SPCL scaffolds cultured with goat marrow cells: functionality in femoral defects. J Tissue Eng Regen Med 2011;5:41-9
   PubMed Web of Science ®Google Scholar
• Lu H, Kawazoe N, Tateishi T, et al. In vitro proliferation and osteogenic differentiation of human bone marrow-derived mesenchymal stem cells cultured with hardystonite (Ca2ZnSi 2O7) and {beta}-TCP ceramics. J Biomater Appl 2010;25:39-56
   PubMed Web of Science ®Google Scholar
• Zhu W, Chen K, Lu W, et al. In vitro study of nano-HA/PLLA composite scaffold for rabbit BMSC differentiation under TGF-beta1 induction. In Vitro Cell Dev Biol Anim 2014;50(3):214-20
   PubMed Web of Science ®Google Scholar
• Zreiqat H. Mimicking bone microenvironment for directing adipose tissue-derived mesenchymal stem cells into osteogenic differentiation. Methods Mol Biol 2014;1202:161-71
   PubMedGoogle Scholar
• Bongso A, Fong CY. The therapeutic potential, challenges and future clinical directions of stem cells from the Wharton’s jelly of the human umbilical cord. Stem Cell Rev 2013;9:226-40
   PubMed Web of Science ®Google Scholar
• Li G, Wang X, Cao J, et al. Coculture of peripheral blood CD34+ cell and mesenchymal stem cell sheets increase the formation of bone in calvarial critical-size defects in rabbits. Br J Oral Maxillofac Surg 2014;52(2):134-9
   PubMed Web of Science ®Google Scholar
• Chen D, Zhang X, He Y, et al. Co-culturing mesenchymal stem cells from bone marrow and periosteum enhances osteogenesis and neovascularization of tissue-engineered bone. J Tissue Eng Regen Med 2012;6:822-32
   PubMed Web of Science ®Google Scholar
• Moshaverinia A, Chen C, Akiyama K, et al. Encapsulated dental-derived mesenchymal stem cells in an injectable and biodegradable scaffold for applications in bone tissue engineering. J Biomed Mater Res A 2013;101:3285-94
   PubMed Web of Science ®Google Scholar
• Radtke CL, Nino-Fong R, Esparza Gonzalez BP, et al. Characterization and osteogenic potential of equine muscle tissue- and periosteal tissue-derived mesenchymal stem cells in comparison with bone marrow- and adipose tissue-derived mesenchymal stem cells. Am J Vet Res 2013;74:790-800
   PubMed Web of Science ®Google Scholar
• Quarto R, Thomas D, Liang CT. Bone progenitor cell deficits and the age-associated decline in bone repair capacity. Calcif Tissue Int 1995;56:123-9
   PubMed Web of Science ®Google Scholar
• Gomes ME, Azevedo HS, Moreira AR, et al. Starch-poly(epsilon-caprolactone) and starch-poly(lactic acid) fibre-mesh scaffolds for bone tissue engineering applications: structure, mechanical properties and degradation behaviour. J Tissue Eng Regen Med 2008;2:243-52
   PubMed Web of Science ®Google Scholar
• Gomes ME, Holtorf HL, Reis RL, Mikos AG. Influence of the porosity of starch-based fiber mesh scaffolds on the proliferation and osteogenic differentiation of bone marrow stromal cells cultured in a flow perfusion bioreactor. Tissue Eng 2006;12:801-9
   PubMedGoogle Scholar
• Giannoudis PV, Dinopoulos H, Tsiridis E. Bone substitutes: an update. Injury 2005;36(Suppl 3):S20-7
   PubMed Web of Science ®Google Scholar
• Lu Z, Roohani-Esfahani SI, Wang G, Zreiqat H. Bone biomimetic microenvironment induces osteogenic differentiation of adipose tissue-derived mesenchymal stem cells. Nanomedicine 2012;8:507-15
   PubMed Web of Science ®Google Scholar
• Carrancio S, Lopez-Holgado N, Sanchez-Guijo FM, et al. Optimization of mesenchymal stem cell expansion procedures by cell separation and culture conditions modification. Exp Hematol 2008;36:1014-21
   PubMed Web of Science ®Google Scholar
• Battula VL, Bareiss PM, Treml S, et al. Human placenta and bone marrow derived MSC cultured in serum-free, b-FGF-containing medium express cell surface frizzled-9 and SSEA-4 and give rise to multilineage differentiation. Differentiation 2007;75:279-91
   PubMed Web of Science ®Google Scholar
• Heckmann L, Fiedler J, Mattes T, Brenner RE. Mesenchymal progenitor cells communicate via alpha and beta integrins with a three-dimensional collagen type I matrix. Cells Tissues Organs 2006;182:143-54
   PubMed Web of Science ®Google Scholar
• Friedenstein AJ, Chailakhjan RK, Lalykina KS. The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet 1970;3:393-403
   PubMedGoogle Scholar
• Reinisch A, Bartmann C, Rohde E, et al. Humanized system to propagate cord blood-derived multipotent mesenchymal stromal cells for clinical application. Regen Med 2007;2:371-82
   PubMed Web of Science ®Google Scholar
• Doucet C, Ernou I, Zhang Y, et al. Platelet lysates promote mesenchymal stem cell expansion: a safety substitute for animal serum in cell-based therapy applications. J Cell Physiol 2005;205:228-36
   PubMed Web of Science ®Google Scholar
• Muller I, Kordowich S, Holzwarth C, et al. Animal serum-free culture conditions for isolation and expansion of multipotent mesenchymal stromal cells from human BM. Cytotherapy 2006;8:437-44
   PubMed Web of Science ®Google Scholar
• Lange C, Cakiroglu F, Spiess AN, et al. Accelerated and safe expansion of human mesenchymal stromal cells in animal serum-free medium for transplantation and regenerative medicine. J Cell Physiol 2007;213:18-26
   PubMed Web of Science ®Google Scholar
• Bernardi M, Albiero E, Alghisi A, et al. Production of human platelet lysate by use of ultrasound for ex vivo expansion of human bone marrow-derived mesenchymal stromal cells. Cytotherapy 2013;15:920-9
   PubMed Web of Science ®Google Scholar
• Malaval L, Modrowski D, Gupta AK, Aubin JE. Cellular expression of bone-related proteins during in vitro osteogenesis in rat bone marrow stromal cell cultures. J Cell Physiol 1994;158:555-72
   PubMed Web of Science ®Google Scholar
• Cheifetz S, Li IW, McCulloch CA, et al. Influence of osteogenic protein-1 (OP-1;BMP-7) and transforming growth factor-beta 1 on bone formation in vitro. Connect Tissue Res 1996;35:71-8
   PubMed Web of Science ®Google Scholar
• Fromigue O, Marie PJ, Lomri A. Bone morphogenetic protein-2 and transforming growth factor-beta2 interact to modulate human bone marrow stromal cell proliferation and differentiation. J Cell Biochem 1998;68:411-26
   PubMed Web of Science ®Google Scholar
• Gregory CA, Prockop DJ, Spees JL. Non-hematopoietic bone marrow stem cells: molecular control of expansion and differentiation. Exp Cell Res 2005;306:330-5
   PubMed Web of Science ®Google Scholar
• Hanada K, Dennis JE, Caplan AI. Stimulatory effects of basic fibroblast growth factor and bone morphogenetic protein-2 on osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells. J Bone Miner Res 1997;12:1606-14
   PubMed Web of Science ®Google Scholar
• Rawadi G, Vayssiere B, Dunn F, et al. BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop. J Bone Miner Res 2003;18:1842-53
   PubMed Web of Science ®Google Scholar
• Sampath TK, Maliakal JC, Hauschka PV, et al. Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro. J Biol Chem 1992;267:20352-62
   PubMed Web of Science ®Google Scholar
• Yeh LC, Tsai AD, Lee JC. Osteogenic protein-1 (OP-1, BMP-7) induces osteoblastic cell differentiation of the pluripotent mesenchymal cell line C2C12. J Cell Biochem 2002;87:292-304
   PubMed Web of Science ®Google Scholar
• Jager M, Fischer J, Dohrn W, et al. Dexamethasone modulates BMP-2 effects on mesenchymal stem cells in vitro. J Orthop Res 2008;26:1440-8
   PubMed Web of Science ®Google Scholar
• Kim MJ, Lee B, Yang K, et al. BMP-2 peptide-functionalized nanopatterned substrates for enhanced osteogenic differentiation of human mesenchymal stem cells. Biomaterials 2013;34:7236-46
   PubMed Web of Science ®Google Scholar
• Geesink RG, Hoefnagels NH, Bulstra SK. Osteogenic activity of OP-1 bone morphogenetic protein (BMP-7) in a human fibular defect. J Bone Joint Surg Br 1999;81:710-18
   PubMedGoogle Scholar
• Cook SD, Barrack RL, Shimmin A, et al. The use of osteogenic protein-1 in reconstructive surgery of the hip. J Arthroplasty 2001;16:88-94
   PubMed Web of Science ®Google Scholar
• Maegawa N, Kawamura K, Hirose M, et al. Enhancement of osteoblastic differentiation of mesenchymal stromal cells cultured by selective combination of bone morphogenetic protein-2 (BMP-2) and fibroblast growth factor-2 (FGF-2). J Tissue Eng Regen Med 2007;1:306-13
   PubMed Web of Science ®Google Scholar
• Crouzier T, Sailhan F, Becquart P, et al. The performance of BMP-2 loaded TCP/HAP porous ceramics with a polyelectrolyte multilayer film coating. Biomaterials 2011;32:7543-54
   PubMed Web of Science ®Google Scholar
• Park JS, Yang HN, Jeon SY, et al. Osteogenic differentiation of human mesenchymal stem cells using RGD-modified BMP-2 coated microspheres. Biomaterials 2010;31:6239-48
   PubMed Web of Science ®Google Scholar
• Na K, Kim SW, Sun BK, et al. Osteogenic differentiation of rabbit mesenchymal stem cells in thermo-reversible hydrogel constructs containing hydroxyapatite and bone morphogenic protein-2 (BMP-2). Biomaterials 2007;28:2631-7
   PubMed Web of Science ®Google Scholar
• Kanczler JM, Ginty PJ, White L, et al. The effect of the delivery of vascular endothelial growth factor and bone morphogenic protein-2 to osteoprogenitor cell populations on bone formation. Biomaterials 2010;31:1242-50
   PubMed Web of Science ®Google Scholar
• Liu J, Chen W, Zhao Z, Xu HH. Reprogramming of mesenchymal stem cells derived from iPSCs seeded on biofunctionalized calcium phosphate scaffold for bone engineering. Biomaterials 2013;34:7862-72
   PubMed Web of Science ®Google Scholar
• Zomorodian E, Baghaban Eslaminejad M. Mesenchymal stem cells as a potent cell source for bone regeneration. Stem Cells Int 2012;2012:980353
   PubMedGoogle Scholar
• Eslaminejad MB, Nikmahzar A, Taghiyar L, et al. Murine mesenchymal stem cells isolated by low density primary culture system. Dev Growth Differ 2006;48:361-70
   PubMed Web of Science ®Google Scholar
• Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006;8:315-17
   PubMed Web of Science ®Google Scholar
• Covas DT, Panepucci RA, Fontes AM, et al. Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146+ perivascular cells and fibroblasts. Exp Hematol 2008;36:642-54
   PubMed Web of Science ®Google Scholar
• Pittenger MF, Mosca JD, McIntosh KR. Human mesenchymal stem cells: progenitor cells for cartilage, bone, fat and stroma. Curr Top Microbiol Immunol 2000;251:3-11
   PubMed Web of Science ®Google Scholar
• Shang Q, Wang Z, Liu W, et al. Tissue-engineered bone repair of sheep cranial defects with autologous bone marrow stromal cells. J Craniofac Surg 2001;12:586-93; discussion 594-5
   PubMed Web of Science ®Google Scholar
• Weng Y, Wang M, Liu W, et al. Repair of experimental alveolar bone defects by tissue-engineered bone. Tissue Eng 2006;12:1503-13
   PubMedGoogle Scholar
• Chang SC, Chuang H, Chen YR, et al. Cranial repair using BMP-2 gene engineered bone marrow stromal cells. J Surg Res 2004;119:85-91
   PubMed Web of Science ®Google Scholar
• Matsushima A, Kotobuki N, Tadokoro M, et al. In vivo osteogenic capability of human mesenchymal cells cultured on hydroxyapatite and on beta-tricalcium phosphate. Artif Organs 2009;33:474-81
   PubMed Web of Science ®Google Scholar
• Kon E, Muraglia A, Corsi A, et al. Autologous bone marrow stromal cells loaded onto porous hydroxyapatite ceramic accelerate bone repair in critical-size defects of sheep long bones. J Biomed Mater Res 2000;49:328-37
   PubMed Web of Science ®Google Scholar
• Kruyt MC, Dhert WJ, Yuan H, et al. Bone tissue engineering in a critical size defect compared to ectopic implantations in the goat. J Orthop Res 2004;22:544-51
   PubMed Web of Science ®Google Scholar
• Zhu L, Liu W, Cui L, Cao Y. Tissue-engineered bone repair of goat-femur defects with osteogenically induced bone marrow stromal cells. Tissue Eng 2006;12:423-33
   PubMedGoogle Scholar
• Liu G, Zhao L, Zhang W, et al. Repair of goat tibial defects with bone marrow stromal cells and beta-tricalcium phosphate. J Mater Sci Mater Med 2008;19:2367-76
   PubMed Web of Science ®Google Scholar
• Kruyt MC, Dhert WJ, Oner FC, et al. Analysis of ectopic and orthotopic bone formation in cell-based tissue-engineered constructs in goats. Biomaterials 2007;28:1798-805
   PubMed Web of Science ®Google Scholar
• Hing KA, Revell PA, Smith N, Buckland T. Effect of silicon level on rate, quality and progression of bone healing within silicate-substituted porous hydroxyapatite scaffolds. Biomaterials 2006;27:5014-26
   PubMed Web of Science ®Google Scholar
• Mastrogiacomo M, Corsi A, Francioso E, et al. Reconstruction of extensive long bone defects in sheep using resorbable bioceramics based on silicon stabilized tricalcium phosphate. Tissue Eng 2006;12:1261-73
   PubMedGoogle Scholar
• Mastrogiacomo M, Papadimitropoulos A, Cedola A, et al. Engineering of bone using bone marrow stromal cells and a silicon-stabilized tricalcium phosphate bioceramic: evidence for a coupling between bone formation and scaffold resorption. Biomaterials 2007;28:1376-84
   PubMed Web of Science ®Google Scholar
• Kitsugi T, Yamamuro T, Nakamura T, Kokubo T. Bone bonding behavior of MgO-CaO-SiO2-P2O5-CaF2 glass (mother glass of A.W-glass-ceramics). J Biomed Mater Res 1989;23:631-48
   PubMed Web of Science ®Google Scholar
• Ryu HS, Lee JK, Seo JH, et al. Novel bioactive and biodegradable glass ceramics with high mechanical strength in the CaO–SiO2–B2O3 system. J Biomed Mater Res A 2004;68:79-89
   PubMedGoogle Scholar
• Lee JH, Lee CK, Chang BS, et al. In vivo study of novel biodegradable and osteoconductive CaO-SiO2-B2O3 glass-ceramics. J Biomed Mater Res A 2006;77:362-9
   PubMedGoogle Scholar
• Lee JH, Seo JH, Lee KM, et al. Fabrication and evaluation of osteoblastic differentiation of human mesenchymal stem cells on novel CaO-SiO2-P2O5-B2O3 glass-ceramics. Artif Organs 2013;37:637-47
   PubMed Web of Science ®Google Scholar
• Link DP, Gardel LS, Correlo VM, et al. Osteogenic properties of starch poly(epsilon-caprolactone) (SPCL) fiber meshes loaded with osteoblast-like cells in a rat critical-sized cranial defect. J Biomed Mater Res A 2013;101:3059-65
   PubMed Web of Science ®Google Scholar
• Kang SH, Chung YG, Oh IH, et al. Bone regeneration potential of allogeneic or autogeneic mesenchymal stem cells loaded onto cancellous bone granules in a rabbit radial defect model. Cell Tissue Res 2014;355(1):81-8
   PubMed Web of Science ®Google Scholar
• Kim SJ, Chung YG, Lee YK, et al. Comparison of the osteogenic potentials of autologous cultured osteoblasts and mesenchymal stem cells loaded onto allogeneic cancellous bone granules. Cell Tissue Res 2012;347:303-10
   PubMed Web of Science ®Google Scholar
• Tran CT, Gargiulo C, Thao HD, et al. Culture and differentiation of osteoblasts on coral scaffold from human bone marrow mesenchymal stem cells. Cell Tissue Bank 2011;12:247-61
   PubMed Web of Science ®Google Scholar
• Ohgushi H, Kotobuki N, Funaoka H, et al. Tissue engineered ceramic artificial joint – ex vivo osteogenic differentiation of patient mesenchymal cells on total ankle joints for treatment of osteoarthritis. Biomaterials 2005;26:4654-61
   PubMed Web of Science ®Google Scholar
• El-Adl G, Mostafa MF, Enan A, Ashraf M. Biphasic ceramic bone substitute mixed with autogenous bone marrow in the treatment of cavitary benign bone lesions. Acta Orthop Belg 2009;75:110-18
   PubMed Web of Science ®Google Scholar
• Marcacci M, Kon E, Moukhachev V, et al. Stem cells associated with macroporous bioceramics for long bone repair: 6- to 7-year outcome of a pilot clinical study. Tissue Eng 2007;13:947-55
   PubMedGoogle Scholar
• Kalia P, Blunn GW, Miller J, et al. Do autologous mesenchymal stem cells augment bone growth and contact to massive bone tumor implants? Tissue Eng 2006;12:1617-26
   PubMedGoogle Scholar
• Morishita T, Honoki K, Ohgushi H, et al. Tissue engineering approach to the treatment of bone tumors: three cases of cultured bone grafts derived from patients’ mesenchymal stem cells. Artif Organs 2006;30:115-18
   PubMed Web of Science ®Google Scholar
• Rackwitz L, Eden L, Reppenhagen S, et al. Stem cell- and growth factor-based regenerative therapies for avascular necrosis of the femoral head. Stem Cell Res Ther 2012;3:7
   PubMedGoogle Scholar
• Kawate K, Yajima H, Ohgushi H, et al. Tissue-engineered approach for the treatment of steroid-induced osteonecrosis of the femoral head: transplantation of autologous mesenchymal stem cells cultured with beta-tricalcium phosphate ceramics and free vascularized fibula. Artif Organs 2006;30:960-2
   PubMed Web of Science ®Google Scholar
• Tadokoro M, Kanai R, Taketani T, et al. New bone formation by allogeneic mesenchymal stem cell transplantation in a patient with perinatal hypophosphatasia. J Pediatr 2009;154:924-30
   PubMed Web of Science ®Google Scholar
• Jakobsen C, Sorensen JA, Kassem M, Thygesen TH. Mesenchymal stem cells in oral reconstructive surgery: a systematic review of the literature. J Oral Rehabil 2013;40:693-706
   PubMed Web of Science ®Google Scholar
• Tsiridis E, Ali Z, Bhalla A, et al. In vitro proliferation and differentiation of human mesenchymal stem cells on hydroxyapatite versus human demineralised bone matrix with and without osteogenic protein-1. Expert Opin Biol Ther 2009;9:9-19
   PubMed Web of Science ®Google Scholar
• Siegel HJ, Baird RC 3rd, Hall J, et al. The outcome of composite bone graft substitute used to treat cavitary bone defects. Orthopedics 2008;31:754
   PubMedGoogle Scholar
• Maneerit J, Meknavin S, Hanpanitkitkan S. Percutaneous versus open bone grafting in the treatment of tibial fractures: a randomized prospective trial. J Med Assoc Thai 2004;87:1034-40
   PubMedGoogle Scholar
• Goel A, Sangwan SS, Siwach RC, Ali AM. Percutaneous bone marrow grafting for the treatment of tibial non-union. Injury 2005;36:203-6
   PubMed Web of Science ®Google Scholar
• Hernigou P, Poignard A, Beaujean F, Rouard H. Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells. J Bone Joint Surg Am 2005;87:1430-7
   PubMed Web of Science ®Google Scholar
• Quarto R, Mastrogiacomo M, Cancedda R, et al. Repair of large bone defects with the use of autologous bone marrow stromal cells. N Engl J Med 2001;344:385-6
   PubMed Web of Science ®Google Scholar
• Vulcano E, Murena L, Cherubino P, et al. Treatment of severe post-traumatic bone defects with autologous stem cells loaded on allogeneic scaffolds. Surg Technol Int 2012;22:291-301
   PubMedGoogle Scholar
• Bajada S, Harrison PE, Ashton BA, et al. Successful treatment of refractory tibial nonunion using calcium sulphate and bone marrow stromal cell implantation. J Bone Joint Surg Br 2007;89:1382-6
   PubMed Web of Science ®Google Scholar
• Funk JF, Matziolis G, Krocker D, Perka C. [Promotion of bone healing through clinical application of autologous periosteum derived stem cells in a case of atrophic non-union]. Z Orthop Unfall 2007;145:790-4
   PubMed Web of Science ®Google Scholar
• Porter RM, Liu F, Pilapil C, et al. Osteogenic potential of reamer irrigator aspirator (RIA) aspirate collected from patients undergoing hip arthroplasty. J Orthop Res 2009;27:42-9
   PubMed Web of Science ®Google Scholar
• Tzioupis C, Panteliadis P, Gamie Z, Tsiridis E. Revision of a nonunited subtrochanteric femoral fracture around a failed intramedullary nail with the use of RIA products, BMP-7 and hydroxyapatite: a case report. J Med Case Rep 2011;5:87
   Google Scholar
• Arts JJ, Gardeniers JW, Welten ML, et al. No negative effects of bone impaction grafting with bone and ceramic mixtures. Clin Orthop Relat Res 2005;438:239-47
   PubMed Web of Science ®Google Scholar
• van Haaren EH, Smit TH, Phipps K, et al. Tricalcium-phosphate and hydroxyapatite bone-graft extender for use in impaction grafting revision surgery. An in vitro study on human femora. J Bone Joint Surg Br 2005;87:267-71
   PubMed Web of Science ®Google Scholar
• Korda M, Blunn G, Goodship A, Hua J. Use of mesenchymal stem cells to enhance bone formation around revision hip replacements. J Orthop Res 2008;26:880-5
   PubMed Web of Science ®Google Scholar
• Korda M, Blunn G, Phipps K, et al. Can mesenchymal stem cells survive under normal impaction force in revision total hip replacements? Tissue Eng 2006;12:625-30
   PubMedGoogle Scholar
• Korda M, Hua J, Little NJ, et al. The effect of mesenchymal stromal cells on the osseoinduction of impaction grafts. Tissue Eng Part A 2010;16:675-83
   PubMed Web of Science ®Google Scholar
• Aulakh TS, Jayasekera N, Kuiper JH, Richardson JB. Long-term clinical outcomes following the use of synthetic hydroxyapatite and bone graft in impaction in revision hip arthroplasty. Biomaterials 2009;30:1732-8
   PubMed Web of Science ®Google Scholar
• Vulcano E, Murena L, Falvo DA, et al. Bone marrow aspirate and bone allograft to treat acetabular bone defects in revision total hip arthroplasty: preliminary report. Eur Rev Med Pharmacol Sci 2013;17:2240-9
   PubMed Web of Science ®Google Scholar
• Di Bella C, Aldini NN, Lucarelli E, et al. Osteogenic protein-1 associated with mesenchymal stem cells promote bone allograft integration. Tissue Eng Part A 2010;16:2967-76
   PubMed Web of Science ®Google Scholar
• Liu G, Sun J, Li Y, et al. Evaluation of partially demineralized osteoporotic cancellous bone matrix combined with human bone marrow stromal cells for tissue engineering: an in vitro and in vivo study. Calcif Tissue Int 2008;83:176-85
   PubMed Web of Science ®Google Scholar
• Tsiridis E, Bhalla A, Ali Z, et al. Enhancing the osteoinductive properties of hydroxyapatite by the addition of human mesenchymal stem cells, and recombinant human osteogenic protein-1 (BMP-7) in vitro. Injury 2006;37(Suppl 3):S25-32
   PubMed Web of Science ®Google Scholar
• Cornejo A, Sahar DE, Stephenson SM, et al. Effect of adipose tissue-derived osteogenic and endothelial cells on bone allograft osteogenesis and vascularization in critical-sized calvarial defects. Tissue Eng Part A 2012;18:1552-61
   PubMed Web of Science ®Google Scholar
• Lu Z, Wang G, Dunstan CR, Zreiqat H. Short-term exposure to tumor necrosis factor-alpha enables human osteoblasts to direct adipose tissue-derived mesenchymal stem cells into osteogenic differentiation. Stem Cells Dev 2012;21:2420-9
   PubMed Web of Science ®Google Scholar
• Lu Z, Wang G, Dunstan CR, et al. Activation and promotion of adipose stem cells by tumour necrosis factor-alpha preconditioning for bone regeneration. J Cell Physiol 2013;228:1737-44
   PubMed Web of Science ®Google Scholar
• Rada T, Santos TC, Marques AP, et al. Osteogenic differentiation of two distinct subpopulations of human adipose-derived stem cells: an in vitro and in vivo study. J Tissue Eng Regen Med 2012;6:1-11
   PubMed Web of Science ®Google Scholar
• Rada T, Reis RL, Gomes ME. Distinct stem cells subpopulations isolated from human adipose tissue exhibit different chondrogenic and osteogenic differentiation potential. Stem Cell Rev 2011;7:64-76
   PubMed Web of Science ®Google Scholar
• Xiao J, Yang X, Jing W, et al. Adipogenic and osteogenic differentiation of Lin(-)CD271(+)Sca-1(+) adipose-derived stem cells. Mol Cell Biochem 2013;377:107-19
   PubMed Web of Science ®Google Scholar
• Park BH, Zhou L, Jang KY, et al. Enhancement of tibial regeneration in a rat model by adipose-derived stromal cells in a PLGA scaffold. Bone 2012;51:313-23
   PubMed Web of Science ®Google Scholar
• Carvalho PP, Leonor IB, Smith BJ, et al. Undifferentiated human adipose-derived stromal/stem cells loaded onto wet-spun starch-polycaprolactone scaffolds enhance bone regeneration: nude mice calvarial defect in vivo study. J Biomed Mater Res A 2013; Epub ahead of print
   PubMedGoogle Scholar
• Arrigoni E, de Girolamo L, Di Giancamillo A, et al. Adipose-derived stem cells and rabbit bone regeneration: histomorphometric, immunohistochemical and mechanical characterization. J Orthop Sci 2013;18:331-9
   PubMed Web of Science ®Google Scholar
• Yang P, Huang X, Wang C, et al. Repair of bone defects using a new biomimetic construction fabricated by adipose-derived stem cells, collagen I, and porous beta-tricalcium phosphate scaffolds. Exp Biol Med (Maywood) 2013;238:1331-43
   PubMed Web of Science ®Google Scholar
• Kim HP, Ji YH, Rhee SC, et al. Enhancement of bone regeneration using osteogenic-induced adipose-derived stem cells combined with demineralized bone matrix in a rat critically-sized calvarial defect model. Curr Stem Cell Res Ther 2012;7:165-72
   PubMed Web of Science ®Google Scholar
• Choi JW, Park EJ, Shin HS, et al. In vivo differentiation of undifferentiated human adipose tissue-derived mesenchymal stem cells in critical-sized calvarial bone defects. Ann Plast Surg 2014;72(2):225-33
   PubMed Web of Science ®Google Scholar
• Liu G, Zhang Y, Liu B, et al. Bone regeneration in a canine cranial model using allogeneic adipose derived stem cells and coral scaffold. Biomaterials 2013;34:2655-64
   PubMed Web of Science ®Google Scholar
• Pourebrahim N, Hashemibeni B, Shahnaseri S, et al. A comparison of tissue-engineered bone from adipose-derived stem cell with autogenous bone repair in maxillary alveolar cleft model in dogs. Int J Oral Maxillofac Surg 2013;42:562-8
   PubMed Web of Science ®Google Scholar
• Hao W, Dong J, Jiang M, et al. Enhanced bone formation in large segmental radial defects by combining adipose-derived stem cells expressing bone morphogenetic protein 2 with nHA/RHLC/PLA scaffold. Int Orthop 2010;34:1341-9
   PubMed Web of Science ®Google Scholar
• Lin CY, Chang YH, Li KC, et al. The use of ASCs engineered to express BMP2 or TGF-beta3 within scaffold constructs to promote calvarial bone repair. Biomaterials 2013;34:9401-12
   PubMed Web of Science ®Google Scholar
• Sandor GK, Tuovinen VJ, Wolff J, et al. Adipose stem cell tissue-engineered construct used to treat large anterior mandibular defect: a case report and review of the clinical application of good manufacturing practice-level adipose stem cells for bone regeneration. J Oral Maxillofac Surg 2013;71:938-50
   PubMed Web of Science ®Google Scholar
• Wolff J, Sandor GK, Miettinen A, et al. GMP-level adipose stem cells combined with computer-aided manufacturing to reconstruct mandibular ameloblastoma resection defects: experience with three cases. Ann Maxillofac Surg 2013;3:114-25
   Google Scholar
• Mueller SM, Glowacki J. Age-related decline in the osteogenic potential of human bone marrow cells cultured in three-dimensional collagen sponges. J Cell Biochem 2001;82:583-90
   PubMed Web of Science ®Google Scholar
• Kim DW, Staples M, Shinozuka K, et al. Wharton’s Jelly-derived mesenchymal stem cells: phenotypic characterization and optimizing their therapeutic potential for clinical applications. Int J Mol Sci 2013;14:11692-712
   PubMed Web of Science ®Google Scholar
• Zhang ZY, Teoh SH, Hui JH, et al. The potential of human fetal mesenchymal stem cells for off-the-shelf bone tissue engineering application. Biomaterials 2012;33:2656-72
   PubMed Web of Science ®Google Scholar
• Gauthaman K, Venugopal JR, Yee FC, et al. Osteogenic differentiation of human Wharton’s jelly stem cells on nanofibrous substrates in vitro. Tissue Eng Part A 2011;17:71-81
   PubMed Web of Science ®Google Scholar
• Thein-Han W, Xu HH. Collagen-calcium phosphate cement scaffolds seeded with umbilical cord stem cells for bone tissue engineering. Tissue Eng Part A 2011;17:2943-54
   PubMed Web of Science ®Google Scholar
• Chen W, Zhou H, Weir MD, et al. Umbilical cord stem cells released from alginate-fibrin microbeads inside macroporous and biofunctionalized calcium phosphate cement for bone regeneration. Acta Biomater 2012;8:2297-306
   PubMed Web of Science ®Google Scholar
• Xu HH, Zhao L, Weir MD. Stem cell-calcium phosphate constructs for bone engineering. J Dent Res 2010;89:1482-8
   PubMed Web of Science ®Google Scholar
• Wang L, Ott L, Seshareddy K, et al. Musculoskeletal tissue engineering with human umbilical cord mesenchymal stromal cells. Regen Med 2011;6:95-109
   PubMed Web of Science ®Google Scholar
• Wen Y, Jiang B, Cui J, et al. Superior osteogenic capacity of different mesenchymal stem cells for bone tissue engineering. Oral Surg Oral Med Oral Pathol Oral Radiol 2013;116:e324-32
   Web of Science ®Google Scholar
• Zhang ZY, Teoh SH, Chong MS, et al. Superior osteogenic capacity for bone tissue engineering of fetal compared with perinatal and adult mesenchymal stem cells. Stem Cells 2009;27:126-37
   PubMed Web of Science ®Google Scholar
• Chen W, Liu J, Manuchehrabadi N, et al. Umbilical cord and bone marrow mesenchymal stem cell seeding on macroporous calcium phosphate for bone regeneration in rat cranial defects. Biomaterials 2013;34:9917-25
   PubMed Web of Science ®Google Scholar
• Sarugaser R, Ennis J, Stanford WL, Davies JE. Isolation, propagation, and characterization of human umbilical cord perivascular cells (HUCPVCs). Methods Mol Biol 2009;482:269-79
   PubMedGoogle Scholar
• Pipino C, Shangaris P, Resca E, et al. Placenta as a reservoir of stem cells: an underutilized resource? Br Med Bull 2013;105:43-68
   PubMed Web of Science ®Google Scholar
• In ’t Anker PS, Scherjon SA, Kleijburg-van der Keur C, et al. Isolation of mesenchymal stem cells of fetal or maternal origin from human placenta. Stem Cells 2004;22:1338-45
   PubMed Web of Science ®Google Scholar
• Campagnoli C, Roberts IA, Kumar S, et al. Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow. Blood 2001;98:2396-402
   PubMed Web of Science ®Google Scholar
• Guillot PV, Gotherstrom C, Chan J, et al. Human first-trimester fetal MSC express pluripotency markers and grow faster and have longer telomeres than adult MSC. Stem Cells 2007;25:646-54
   PubMed Web of Science ®Google Scholar
• Fu WL, Zhang JY, Fu X, et al. Comparative study of the biological characteristics of mesenchymal stem cells from bone marrow and peripheral blood of rats. Tissue Eng Part A 2012;18:1793-803
   PubMed Web of Science ®Google Scholar
• Moog R. Mobilization and harvesting of peripheral blood stem cells. Curr Stem Cell Res Ther 2006;1:189-201
   PubMedGoogle Scholar
• Wan C, He Q, Li G. Allogenic peripheral blood derived mesenchymal stem cells (MSCs) enhance bone regeneration in rabbit ulna critical-sized bone defect model. J Orthop Res 2006;24:610-18
   PubMed Web of Science ®Google Scholar
• Seebach C, Henrich D, Wilhelm K, et al. Endothelial progenitor cells improve directly and indirectly early vascularization of mesenchymal stem cell-driven bone regeneration in a critical bone defect in rats. Cell Transplant 2012;21:1667-77
   PubMed Web of Science ®Google Scholar
• Chen JL, Hunt P, McElvain M, et al. Osteoblast precursor cells are found in CD34+ cells from human bone marrow. Stem Cells 1997;15:368-77
   PubMed Web of Science ®Google Scholar
• Matsumoto T, Kawamoto A, Kuroda R, et al. Therapeutic potential of vasculogenesis and osteogenesis promoted by peripheral blood CD34-positive cells for functional bone healing. Am J Pathol 2006;169:1440-57
   PubMed Web of Science ®Google Scholar
• Mifune Y, Matsumoto T, Kawamoto A, et al. Local delivery of granulocyte colony stimulating factor-mobilized CD34-positive progenitor cells using bioscaffold for modality of unhealing bone fracture. Stem Cells 2008;26:1395-405
   PubMed Web of Science ®Google Scholar
• Kuznetsov SA, Mankani MH, Gronthos S, et al. Circulating skeletal stem cells. J Cell Biol 2001;153:1133-40
   PubMed Web of Science ®Google Scholar
• Roufosse CA, Direkze NC, Otto WR, Wright NA. Circulating mesenchymal stem cells. Int J Biochem Cell Biol 2004;36:585-97
   PubMed Web of Science ®Google Scholar
• Saw KY, Jee CSY. From ‘blade runner’ to ‘stem-cell player’ and beyond. Bone Joint 360 2013;2:6-11
   Google Scholar
• van Gastel N, Torrekens S, Roberts SJ, et al. Engineering vascularized bone: osteogenic and proangiogenic potential of murine periosteal cells. Stem Cells 2012;30:2460-71
   PubMed Web of Science ®Google Scholar
• Chen D, Shen H, Shao J, et al. Superior mineralization and neovascularization capacity of adult human metaphyseal periosteum-derived cells for skeletal tissue engineering applications. Int J Mol Med 2011;27:707-13
   PubMed Web of Science ®Google Scholar
• Mattioli-Belmonte M, Ferretti C, Gentile P, et al. Periosteal derived cells and bone tissue regenerative medicine. Ital J Anat Embryol 2011;116:115
   Google Scholar
• Gamie Z, Tran GT, Vyzas G, et al. Stem cells combined with bone graft substitutes in skeletal tissue engineering. Expert Opin Biol Ther 2012;12:713-29
   PubMed Web of Science ®Google Scholar
• Yoshimura H, Muneta T, Nimura A, et al. Comparison of rat mesenchymal stem cells derived from bone marrow, synovium, periosteum, adipose tissue, and muscle. Cell Tissue Res 2007;327:449-62
   PubMed Web of Science ®Google Scholar
• Stanko P, Kaiserova K, Altanerova V, Altaner C. Comparison of human mesenchymal stem cells derived from dental pulp, bone marrow, adipose tissue, and umbilical cord tissue by gene expression. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2013; Epub ahead of print
   PubMed Web of Science ®Google Scholar
• Zhang W, Walboomers XF, van Osch GJ, et al. Hard tissue formation in a porous HA/TCP ceramic scaffold loaded with stromal cells derived from dental pulp and bone marrow. Tissue Eng Part A 2008;14:285-94
   PubMed Web of Science ®Google Scholar
• Akkouch A, Zhang Z, Rouabhia M. Engineering bone tissue using human dental pulp stem cells and an osteogenic collagen-hydroxyapatite-poly (L-lactide-co-{varepsilon}-caprolactone) scaffold. J Biomater Appl 2014;28:922-36
   PubMed Web of Science ®Google Scholar
• Morad G, Kheiri L, Khojasteh A. Dental pulp stem cells for in vivo bone regeneration: a systematic review of literature. Arch Oral Biol 2013;58:1818-27
   PubMed Web of Science ®Google Scholar
• Annibali S, Cicconetti A, Cristalli MP, et al. A comparative morphometric analysis of biodegradable scaffolds as carriers for dental pulp and periosteal stem cells in a model of bone regeneration. J Craniofac Surg 2013;24:866-71
   PubMed Web of Science ®Google Scholar
• Zheng Y, Liu Y, Zhang CM, et al. Stem cells from deciduous tooth repair mandibular defect in swine. J Dent Res 2009;88:249-54
   PubMed Web of Science ®Google Scholar
• Liu HC, E LL, Wang DS, et al. Reconstruction of alveolar bone defects using bone morphogenetic protein 2 mediated rabbit dental pulp stem cells seeded on nano-hydroxyapatite/collagen/poly(L-lactide). Tissue Eng Part A 2011;17:2417-33
   PubMed Web of Science ®Google Scholar
• Ge S, Zhao N, Wang L, et al. Bone repair by periodontal ligament stem cellseeded nanohydroxyapatite-chitosan scaffold. Int J Nanomedicine 2012;7:5405-14
   PubMed Web of Science ®Google Scholar
• Tour G, Wendel M, Moll G, Tcacencu I. Bone repair using periodontal ligament progenitor cell-seeded constructs. J Dent Res 2012;91:789-94
   PubMed Web of Science ®Google Scholar
• Mitrano TI, Grob MS, Carrion F, et al. Culture and characterization of mesenchymal stem cells from human gingival tissue. J Periodontol 2010;81:917-25
   PubMed Web of Science ®Google Scholar
• Tomar GB, Srivastava RK, Gupta N, et al. Human gingiva-derived mesenchymal stem cells are superior to bone marrow-derived mesenchymal stem cells for cell therapy in regenerative medicine. Biochem Biophys Res Commun 2010;393:377-83
   PubMed Web of Science ®Google Scholar
• Yang H, Gao LN, An Y, et al. Comparison of mesenchymal stem cells derived from gingival tissue and periodontal ligament in different incubation conditions. Biomaterials 2013;34:7033-47
   PubMed Web of Science ®Google Scholar
• Wang F, Yu M, Yan X, et al. Gingiva-derived mesenchymal stem cell-mediated therapeutic approach for bone tissue regeneration. Stem Cells Dev 2011;20:2093-102
   PubMed Web of Science ®Google Scholar
• Chen W, Zhou H, Weir MD, et al. Human embryonic stem cell-derived mesenchymal stem cell seeding on calcium phosphate cement-chitosan-RGD scaffold for bone repair. Tissue Eng Part A 2013;19:915-27
   PubMed Web of Science ®Google Scholar
• Marolt D, Campos IM, Bhumiratana S, et al. Engineering bone tissue from human embryonic stem cells. Proc Natl Acad Sci USA 2012;109:8705-9
   PubMed Web of Science ®Google Scholar
• Yeo D, Kiparissides A, Cha JM, et al. Improving embryonic stem cell expansion through the combination of perfusion and bioprocess model design. PLoS One 2013;8:e81728
   PubMedGoogle Scholar
• Kuznetsov SA, Cherman N, Robey PG. In vivo bone formation by progeny of human embryonic stem cells. Stem Cells Dev 2011;20(2):269-87
   PubMed Web of Science ®Google Scholar
• Tang M, Chen W, Weir MD, et al. Human embryonic stem cell encapsulation in alginate microbeads in macroporous calcium phosphate cement for bone tissue engineering. Acta Biomater 2012;8:3436-45
   PubMed Web of Science ®Google Scholar
• Deville S, Saiz E, Nalla RK, Tomsia AP. Freezing as a path to build complex composites. Science 2006;311:515-18
   PubMed Web of Science ®Google Scholar
• Foppiano S, Marshall SJ, Marshall GW, et al. The influence of novel bioactive glasses on in vitro osteoblast behavior. J Biomed Mater Res A 2004;71:242-9
   PubMedGoogle Scholar
• Ginebra MP, Driessens FC, Planell JA. Effect of the particle size on the micro and nanostructural features of a calcium phosphate cement: a kinetic analysis. Biomaterials 2004;25:3453-62
   PubMed Web of Science ®Google Scholar
• Hwang NS, Varghese S, Lee HJ, et al. Biomaterials directed in vivo osteogenic differentiation of mesenchymal cells derived from human embryonic stem cells. Tissue Eng Part A 2013;19:1723-32
   Google Scholar
• Kuhn LT, Liu Y, Boyd NL, et al. Developmental-like bone regeneration by human embryonic stem cell-derived mesenchymal cells. Tissue Eng Part A 2014;20(1-2):365-77
   PubMed Web of Science ®Google Scholar
• Krawetz RJ, Taiani JT, Wu YE, et al. Collagen I scaffolds cross-linked with beta-glycerol phosphate induce osteogenic differentiation of embryonic stem cells in vitro and regulate their tumorigenic potential in vivo. Tissue Eng Part A 2012;18:1014-24
   PubMed Web of Science ®Google Scholar
• Handschel J, Naujoks C, Depprich R, et al. Embryonic stem cells in scaffold-free three-dimensional cell culture: osteogenic differentiation and bone generation. Head Face Med 2011;7:12
   PubMedGoogle Scholar
• Marcos-Campos I, Marolt D, Petridis P, et al. Bone scaffold architecture modulates the development of mineralized bone matrix by human embryonic stem cells. Biomaterials 2012;33:8329-42
   PubMed Web of Science ®Google Scholar
• Both SK, van Apeldoorn AA, Jukes JM, et al. Differential bone-forming capacity of osteogenic cells from either embryonic stem cells or bone marrow-derived mesenchymal stem cells. J Tissue Eng Regen Med 2011;5:180-90
   PubMed Web of Science ®Google Scholar
• Teng S, Liu C, Krettek C, Jagodzinski M. The application of induced pluripotent stem cells for bone regeneration: current progress and prospects. Tissue Eng Part B Rev 2013; Epub ahead of print
   PubMed Web of Science ®Google Scholar
• Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-76
   PubMed Web of Science ®Google Scholar
• Sun N, Longaker MT, Wu JC. Human iPS cell-based therapy: considerations before clinical applications. Cell Cycle 2010;9:880-5
   PubMed Web of Science ®Google Scholar
• Miura K, Okada Y, Aoi T, et al. Variation in the safety of induced pluripotent stem cell lines. Nat Biotechnol 2009;27:743-5
   PubMed Web of Science ®Google Scholar
• Zhou T, Benda C, Dunzinger S, et al. Generation of human induced pluripotent stem cells from urine samples. Nat Protoc 2012;7:2080-9
   PubMed Web of Science ®Google Scholar
• Tashiro K, Inamura M, Kawabata K, et al. Efficient adipocyte and osteoblast differentiation from mouse induced pluripotent stem cells by adenoviral transduction. Stem Cells 2009;27:1802-11
   PubMed Web of Science ®Google Scholar
• Ye JH, Xu YJ, Gao J, et al. Critical-size calvarial bone defects healing in a mouse model with silk scaffolds and SATB2-modified iPSCs. Biomaterials 2011;32:5065-76
   PubMed Web of Science ®Google Scholar
• Levi B, Hyun JS, Montoro DT, et al. In vivo directed differentiation of pluripotent stem cells for skeletal regeneration. Proc Natl Acad Sci USA 2012;109:20379-84
   PubMed Web of Science ®Google Scholar
• Ramos-Mejia V, Munoz-Lopez M, Garcia-Perez JL, Menendez P. iPSC lines that do not silence the expression of the ectopic reprogramming factors may display enhanced propensity to genomic instability. Cell Res 2010;20:1092-5
   PubMed Web of Science ®Google Scholar
• Zhao D, Cui D, Wang B, et al. Treatment of early stage osteonecrosis of the femoral head with autologous implantation of bone marrow-derived and cultured mesenchymal stem cells. Bone 2012;50:325-30
   PubMed Web of Science ®Google Scholar