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Review

Recent advances in the development of peptide nucleic acid as a gene-targeted drug

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Pages 337-348 | Published online: 03 Mar 2005

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  • •This paper reports on backbone-modified PNAs.
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  • •This was also the first paper that demonstrated PNA antisense in live animals.
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  • •This paper provides a comprehensive study of PNA antisense in cells and shows how inhibition of translation is highly context dependent.
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  • •This paper demonstrates that homopyrimidine PNAs can be effective antisense agents, indicating that triplex formation can improve therapeutic potential.
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  • ••The double-duplex invasion strategysignificantly extends PNA recognition of double-stranded DNA.
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