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Expert Opinion on Biological Therapy Volume 5, 2005 - Issue 1
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Meeting Report

12th Annual Congress of the European Society of Gene Therapy

Martin L Read University of Birmingham, Molecular Neuroscience, Wolfson Research Laboratories, Division of Medical Sciences, Birmingham, B152TH, UK. [email protected]
,
Rachel Spice University of Birmingham, Molecular Neuroscience, Wolfson Research Laboratories, Division of Medical Sciences, Birmingham, B152TH, UK. [email protected]
,
Alan L Parker King’s College London, Department of Clinical Sciences, The Rayne Institute, 123 Coldharbour Lane, Denmark Hill, London, SE5 9NU, UK
,
Sohaib Mir University of Birmingham, Molecular Neuroscience, Wolfson Research Laboratories, Division of Medical Sciences, Birmingham, B152TH, UK. [email protected]
&
Ann Logan University of Birmingham, Molecular Neuroscience, Wolfson Research Laboratories, Division of Medical Sciences, Birmingham, B152TH, UK. [email protected]
Pages 137-141 | Published online: 20 Apr 2005

Bibliography

  • READ ML, STEVENSON M, FARROW PJ et al.: RNA-based therapeutic strategies for cancer. Expert Opin. Ther. Patents (2003) 13:627–638.
  • READ ML, FARROW PJ, SEYMOUR LW: Emerging developments in RNA therapeutics. Expert Opin. Ther. Targets (2003) 7:299–303.
  • WADHWA R, KAUL SC, MIYAGISHI M et al.: Know-how of RNA interference and its applications in research and therapy. Mutat. Res. (2004) 567:71–84.
  • UI-TEI K, NAITO Y, TAKAHASHI F et al.: Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference. Nucleic Acids Res. (2004) 32:936–948.
  • KAWASAKI H, TAIRA K: Induction of DNA methylation and gene silencing by short interfering RNAs in human cells. Nature (2004) 431:211–217.
  • ••This paper describes a novel approach togene silencing that uses siRNA targeting CpG islands in promoters.
  • KUWABARA T, HSIEH J, NAKASHIMA K et aL: A small modulatory dsRNA specifies the fate of adult neural stem cells. Cell (2004)116:779–793.
  • •This study reports on the gene activation effects of a short dsRNA that distinguish it from the cellular silencing effects of miRNA/siRNAs.
  • HE L, HANNON GJ: MicroRNAs: small RNAs with a big role in gene regulation. Nat. Rev. Genet. (2004) 5:522–531.
  • ••An excellent review describing microRNAsin mammalian systems.
  • JENKE AC, STEHLE IM, HERRMANN F et aL: Nuclear scaffold/ matrix attached region modules linked to a transcription unit are sufficient for replication and maintenance of a mammalian episome. Proc. Natl. Acad. Sci. USA (2004) 101:11322–11327.
  • READ ML, BREMNER KH, OUPICKY D et al.: Vectors based on reducible polycations facilitate intracellular release of nucleic acids./ Gene Med. (2003) 5:232–245.
  • SCACHERI PC, ROZENBLATT-ROSEN O, CAPLEN NJ et al.: Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells. Proc. Nail. Acad. Sci. USA (2004) 101:1892–1897.
  • ••This report highlights how siRNA caninduce nonspecific effects on protein levels. Websites
  • http://www.esgt.org European Society of Gene therapy website.
  • http:www.wiley.co.uk/genmedlclinical Journal of Gene Medicine, Gene Therapy Clinical Trials Worldwide website.
  • http://wok.mimas.ac.uk ISI Web of Knowledge homepage.
  • http://www.ic-vec.com IC-Vec website.
  • http://www.arktherapeutics.com Ark Therapeutics website.
  • http://www.advisorybodies.doh.gov.uk/ genetics/gtac Department of Health Gene Therapy Advisory Committee website.

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