Current status of animal-to-human transplantation

Bibliography

• JABOULAY M: De reins au ph du coude par soutures arterielles et veineuses. Lyon Med. (1906) 107:575–577.
   Google Scholar
• ULLMAN E: Tissue and organ transplantation. Ann. Surg-. (1914) 60:195–219.
   PubMedGoogle Scholar
• CASCALHO M, PLATT JL: Xenotransplantation and other means of organ replacement. Nat. Rev. Immunol. (2001) 1:154–160.
   PubMed Web of Science ®Google Scholar
• CASCALHO M, PLATT JL: The immunological barrier to xenotransplantation. Immunity (2001) 14:437–446.
   PubMed Web of Science ®Google Scholar
• ••This paper reviews the immunologicalbarriers to xenotransplantation.
   Google Scholar
• KHALPEY Z, KOCH CA, PLATT JL: Xenograft transplantation. Anesethesiol. Clin. North Am. (2004) 22:871–875.
   PubMedGoogle Scholar
• WILLIAMS JM, HOLZKNECHT ZE, PLUMMER TB, UN SS, BRUNN GJ, PLATT JL: Acute vascular rejection and accommodation: divergent outcomes of the humoral response to organ transplantation. Transplantation (2004) 78:1471–1478.
   PubMed Web of Science ®Google Scholar
• SAADI S, TAKAHASHI T, HOLZKNECHT RA, PLATT JL: Pathways to acute humoral rejection. Am. J. Pathol. (2004) 164:1073–1080.
   PubMed Web of Science ®Google Scholar
• OGATA K, PLATT JL: Cardiac xenotransplantation: future and limitations. Cardiology (2004) 101:144–155.
   PubMed Web of Science ®Google Scholar
• PLATT JL, VERCELLOTTI GM, LINDMAN BJ, OEGEMA TR JR, BACH FH, DALMASSO AP: Release of heparan sulfate from endothelial cells. Implications for pathogenesis of hyperacute rejection. J. Exp. Med. (1990) 171:1363–1368.
   Google Scholar
• HOLZKNECHT ZE, KUYPERS KL, PLUMMER TB et al.: Apoptosis and cellular activation in the pathogenesis of acute vascular rejection. Circ. Res. (2002) 91:1135–1141.
   PubMed Web of Science ®Google Scholar
• SAADI S, HOLZKNECHT RA, PATTE CP, STERN DM, PLATT JL: Complement-mediated regulation of tissue factor activity in endothelium. J. Exp. Med. (1995) 182:1807–1814.
   PubMed Web of Science ®Google Scholar
• SAADI S, HOLZKNECHT RA, PATTE CP, PLATT JL: Endothelial cell activation by pore forming structures: pivotal role for IL-la. Circulation (2000) 101:1867–1873.
   PubMed Web of Science ®Google Scholar
• MCGREGOR CG, TEOTIA SS, BYRNE GW et al.: Cardiac xenotransplantation: progress toward the clinic. Transplantation (2004) 78:1569–1575.
   PubMed Web of Science ®Google Scholar
• PLATT JL, VERCELLOTTI GM, DALMASSO AP et al.: Transplantation of discordant xenografts: a review of progress. Immunol. Today (1990) 11:450–456.
   PubMedGoogle Scholar
• ••This paper provides the first suggestionthat genetic engineering and accommodation might be applied in xenotransplantation.
   Google Scholar
• KOCH CA, KHALPEY ZI, PLATT JL: Accommodation: preventing injury in transplantation and disease. J. Immunol. (2004) 172:5143–5148.
   PubMed Web of Science ®Google Scholar
• GOOD AH, COOPER DK, MALCOLM AJ et aL: Identification of carbohydrate structures that bind human antiporcine antibodies: implications for discordant xenografting in humans. Transplant. Proc. (1992) 24:559–562.
   PubMed Web of Science ®Google Scholar
• ••This paper first mentions Gala1-3Galas a potential target of rejection in xenotransplantation.
   Google Scholar
• UN SS, KOOYMAN DL, DANIELS LJ et al.: The role of natural anti-Gala1-3Gal antibodies in hyperacute rejection of pig-to-baboon cardiac xenotransplants. Transpl. Immunol. (1997) 5:212–218.
   PubMed Web of Science ®Google Scholar
• UN SS, HANAWAY MJ, GONZALEZ-STAWINSKI GV et al.: The role of anti-Gala1-3Gal antibodies in acute vascular rejection and accommodation of xenografts. Transplantation (2000) 70: 1667-1674.
   Google Scholar
• SACHS DH, SABLINSKI T: Tolerance across discordant xenogeneic barriers. Xenotransplantation (1995) 2:234–239.
   Google Scholar
• SABLINSKI T, EMERY DW, MONROY R et al.: Long-term discordant xenogeneic (porcine-to-primate) bone marrow engraftment in a monkey treated with porcine-specific growth factors. Transplantation (1999) 67:972–977.
   PubMed Web of Science ®Google Scholar
• BRACY JL, SACHS DH, IACOMINI J: Inhibition of xenoreactive natural antibody production by retroviral gene therapy. Science (1998) 281:1845–1847.
   PubMed Web of Science ®Google Scholar
• MCCURRY KR, KOOYMAN DL, ALVARADO CG et al.: Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury. Nat. Med. (1995) 1:423–427.
   PubMed Web of Science ®Google Scholar
• ••This paper reports the first transplants using genetically engineered pigs as a source of organs.
   Google Scholar
• COZZI E, YANNOUTSOS N, LANGFORD GA, PINO-CHAVEZ G, WALLWORK J, WHITE DJG: Effect of transgenic expression of human decay-accelerating factor on the inhibition of hyperacute rejection of pig organs. In: Xenotransplantation: The Transplantation of Organs and Tissues Between Species. 2nd ed. Cooper DKC, Kemp E, Platt JL, -White DJG (Eds), Springer, Berlin, Germany (1997):665–682.
   Google Scholar
• COZZI E, BHATTI F, SCHMOECKEL M et al.: Long-term survival of nonhuman primates receiving life-supporting transgenic porcine kidney xenografts. Transplantation (2000) 70:15–21.
   PubMed Web of Science ®Google Scholar
• LAI L, KOLBER-SIMONDS D, PARK KW et al.: Production of a-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science (2002) 295:1089–1092.
   PubMed Web of Science ®Google Scholar
• PHELPS CJ, KOIKE C, VAUGHT TD et al.: Production of alpha 1,3-galactosyltransferase-deficient pigs. Science (2003) 299:411–414.
   PubMed Web of Science ®Google Scholar
• MIYATA Y, PLATT J: Xeno: still stuck without alphaGal. Nat. Biotechnol. (2003) 21:359–360.
   PubMed Web of Science ®Google Scholar
• KUWAKI K, TSENG YI,, DOR FJ et al.: Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat. Med. (2005) 11:29–31.
   Google Scholar
• ••This paper reports the first use ofGala1-3Gal-deficient pigs as a source of cardiac xenografts.
   Google Scholar
• YAMADA K, YAZAWA K, SHIMIZU A et al.: Marked prolongation of porcine renal xenograft survival in baboons through the use of alphal,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. Nat. Med. (2005) 11:32–34.
   PubMed Web of Science ®Google Scholar
• ••This paper reports the first use ofGala1-3Gal-deficient pigs as a source of renal xenografts.
   Google Scholar
• MCGREGOR CG, DAVIES WR, 01 K et al.: Cardiac xenotransplantation: recent preclinical progress with 3-month median survival. J. Thorac. Cardiovasc. Surg. (2005) 130:e844 e841.
   Google Scholar
• ••This paper reports the outstandingoutcome of xenografts that express Gala1-3Gal and no evidence of spontaneous, uncontrollable coagulation independent of rejection.
   Google Scholar
• CHEN G, QIAN H, STARZL T et al.: Induced anti-non-Gal antibodies lead to acute humoral xenograft rejection in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as kidney donors. Nat. Med. (2005) (In Press).
   Google Scholar
• ••This paper cautions that eliminatingGala1-3Gal, the main target in pigs of the human antibody response, may not improve the outcome of xenografts.
   Google Scholar
• LIN SS, WEIDNER BC, BYRNE GW et al.: The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants. J. Clin. Invest. (1998) 101:1745–1756.
   PubMed Web of Science ®Google Scholar
• BUHLER L, BASKER M, ALWAYN IP et al.: Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates. Transplantation (2000) 70:1323–1331.
   PubMed Web of Science ®Google Scholar
• COWAN PJ, AMINIAN A. BARLOW H et al.: Renal xenografts from triple-transgenic pigs are not hyperacutely rejected but cause coagulopathy in non-immunosuppressed baboons. Transplantation (2000) 69:2504–2515.
   Google Scholar
• KUWAKI K, KNOSALLA C, DOR FJ et al.: Suppression of natural and elicited antibodies in pig-to-baboon heart transplantation using a human anti-human CD154 mAb-based regimen. Am. J. Transplant. (2004) 4:363–372.
   PubMed Web of Science ®Google Scholar
• MAZZUCATO M, DE MARCO L, PRADELLA P, MASOTTI A, PARETI Fl: Porcine von Willebrand factor binding to human platelet GPIb induces transmembrane calcium influx. Thromb. Haemost. (1996) 75:655–660.
   PubMed Web of Science ®Google Scholar
• LAWSON JH, PLATT JL: Molecular barriers to xenotransplantation. Transp/antation (1996) 62:303–310.
   PubMed Web of Science ®Google Scholar
• LAWSON JH, DANIELS L, PLATT JL: The evaluation of thrombomodulin activity in porcine to human xenotransplantation. Transplant. Proc. (1997) 29:884–885.
   PubMed Web of Science ®Google Scholar
• CHEN D, WEBER M, MCVEY JH et al.: Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium. Am. J. Transplant. (2004) 4:1958–1963.
   PubMed Web of Science ®Google Scholar
• DWYER KM, ROBSON SC, NANDURKAR HH et aL: Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and
   Google Scholar
• •• transplantation. J. Clin. Invest. (2004) 113:1440–1446.
   Google Scholar
• MENDICINO M, LIU M, GHANEKAR A et al.: Targeted deletion of Fg1-2/fibroleukin in the donor modulates immunologic response and acute vascular rejection in cardiac xenografts. Circulation (2005) 112:248–256.
   PubMed Web of Science ®Google Scholar
• COWAN PJ, AMINIAN A, BARLOW H et al.: Protective effects of recombinant human antithrombin III in pig-to-primate renal xenotransplantation. Am. J. Transplant. (2002) 2:520–525.
   PubMed Web of Science ®Google Scholar
• BYRNE GW, SCHIRMER JM, FASS DN et aL: Warfarin or low-molecular-weight heparin therapy does not prolong pig-to-primate cardiac xenograft function. Am. J. Transplant. (2005) 5:1011–1020.
   PubMed Web of Science ®Google Scholar
• PATIENCE C, TAKEUCHI Y, WEISS RA:Infection of human cells by an endogenous retrovirus of pigs. Nat. Med. (1997) 3:282–286.
   PubMed Web of Science ®Google Scholar
• PATIENCE C, PATTON GS, TAKEUCHI Yet al.: No evidence of pig DNA or retroviral infection in patients with short-term extracorporeal connection to pig kidneys. Lancet (1998) 352:699–701.
   Google Scholar
• PARADIS K, LANGFORD G, LONG Z et al.: Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissue. Science (1999) 285:1236–1241.
   PubMed Web of Science ®Google Scholar
• OGLE BM, BUTTERS KB, PLUMMER TB et al.: Spontaneous fusion of cells between species yields transdifferentiation and retroviral in vivo. FASEB J. (2004) 18:548-550. This paper provides the first evidence of transfer of the endogenous retrovirus of pigs from swine to human cells in vivo.
   Google Scholar
• OGLE BM, CASCALHO M, PLATT JL: Biological implications of cell fusion. Nat. Rev. MoL Cell Biol. (2005) 6:567–575.
   PubMed Web of Science ®Google Scholar
• DALMASSO AP, VERCELLOTTI GM, FISCHEL RJ, BOLMAN RM, BACH FH, PLATT JL: Mechanism of complement activation in the hyperacute rejection of porcine organs transplanted into primate recipients. Am. J. PathoL (1992) 140:1157–1166.
   PubMed Web of Science ®Google Scholar
• YAMADA K, SACHS DH, DERSIMONIAN H: Human anti-porcine xenogeneic T cell response. Evidence for allelic specificity of mixed leukocyte reaction and for both direct and indirect pathways of recognition. J. Immunol. (1995) 155:5249–5256.
   Google Scholar
• DORLING A, LOMBARDI G, BINNS R,LECHLER RI: Detection of primary direct and indirect human anti-porcine T cell responses using a porcine dendritic cell population. Eur. J. ImmunoL (1996) 26:1378–1387.
   PubMed Web of Science ®Google Scholar
• INVERARDI L, SAMAJA M, MOTTERLINI R, MANGILI F, BENDER JR, PARDI R: Early recognition of a discordant xenogeneic organ by human circulating lymphocytes./ ImmunoL (1992) 149:1416–1423.
   PubMed Web of Science ®Google Scholar
• AL-MOHANNA F, COLLISON K, PART-JAR R et al.: Activation of naive xenogeneic but not allogeneic endothelial cells by human naive neutrophils: a potential occult barrier to xenotransplantation. Am. J. PathoL (1997) 151:111–120.
   PubMed Web of Science ®Google Scholar
• BLAKELY ML, VAN DER WERE WJ, BERNDT MC, DALMASSO AP, BACH FH, HANCOCK WW: Activation of intragraft endothelial and mononuclear cells during discordant xenograft rejection. Transplantation (1994) 58:1059–1066.
   PubMed Web of Science ®Google Scholar
• BUSTOS M, SAADI S, PLATT JL: Platelet-mediated activation of endothelial cells: implications for the pathogenesis of transplant rejection. Transplantation (2001) 72:509–515.
   PubMed Web of Science ®Google Scholar