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Drug Evaluation

Adalimumab: an anti-TNF agent for the treatment of psoriatic arthritis

Pages 1491-1504 | Published online: 30 Nov 2005

Bibliography

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  • •A comprehensive review of traditional and newer therapies for the treatment of PsA.
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  • •Meta-analysis evaluating double-blind, placebo-controlled studies of various pharmacological agents in PsA.
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  • •This clinical trial was the first large-scale trial to demonstrate the efficacy and safety of etanercept in PsA.
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  • •Results demonstrating the efficacy of etanercept in PsA after 24 weeks of therapy.
  • MEASE PJ, KIVITZ AJ, BURGH FX et al.: Etanercept treatment of psoriatic arthritis: safety, efficacy, and effect on disease progression. Arthritis Rheum. (2004) 50:2264–2272.
  • •Pivotal trial evaluating the efficacy of etanercept in the management of PsA.
  • MEASE PJ, RUDERMAN EM, RITCHLIN C, ORY P, TSUJI W: Etanercept in psoriatic arthritis: sustained improvement in joint and skin disease and inhibition of radiographic progression at 2 years [abstract]. Ann. Rheum. Dis. (2004) 63\(Suppl. 1):99 (Abstract OP0136).
  • •This study demonstrates the long-term ability of etanercept to inhibit disease progression in patients with PsA.
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  • •This article describes results from the first large-scale trial of infliximab in patients with PsA.
  • ANTONI C, KRUEGER GG, DE VLAM K et al.: Infliximab improves signs and symptoms of psoriatic arthritis: results of the IMPACT 2 trial. Ann. Rheum. Dis. (2005) 64:1158–1164.
  • •An article describing the primary results of the IMPACT 2 trial, a large-scale trial of infliximab in PsA.
  • ANTONI CE, KAVANAUGH A, GLADMAN D et al.: The Infliximab Multinational Psoriatic Arthritis Controlled Trial (IMPACT): results of radiographic analyses after 1 year [abstract]. Ann. Rheum. Dis. (2005) 64(Suppl. III [3]):Abstract OP0156.
  • •This clinical trial demonstrated the ability of infliximab to inhibit disease progression long-term in patients with PsA.
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  • •This large-scale study of infliximab in PsA demonstrated inhibition of disease progression.
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  • •This article provides a comprehensive review of the mechanism of TNF-a therapy in PsA.
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  • •This article provides an in-depth review of the immunopathology of PsA, with specific focus on the role of TNF-a.
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  • •This experimental model provided important evidence of the central role of TNF in the acceleration of inflammation in inflammatory arthritis.
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  • •This experimental model provided important evidence of the central role of anti-TNF antibodies in decreasing inflammation in inflammatory arthritis.
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  • KAVANAUGH A, GREENWALD M, ZIZIC T et al.: Immune response is not affected by adalimumab therapy [abstract]. Ann. Rheum. Dis. (2003) 62\(Suppl. 1):169 (Poster THU0196).
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  • AWNI WM, CASCELLA P, OLEKA N et al.: Steady-state pharmacokinetics (PK) of adalimumab (Humiram, Abbott) following 40 mg subcutaneous (se) injection every other week (eow) in rheumatoid arthritis (RA) patients with and without methotrexate (MTX) background therapy [abstract]. Arthritis Rheum. (2003) 48(9)(Suppl.):S140 (Poster 255).
  • AWNI WM, CASCELLA P, OLEKA N et al.: Steady-state adalimumab (HumiraTm) pharmacokinetics (PK) following every other week (eow) dosing of 40 mg subcutaneous (se) injection, in rheumatoid arthritis (RA) patients treated with and without concomitant methotrexate (MTX) [abstract]. Rheumatology (2004) 43\(Suppl. 2):ii40 (Abstract 39).
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  • RITCHLIN C, ANADARAJAHA A, TOTTERMAN S et al.: Preliminary data from a study of adalimumab in the treatment of psoriatic arthritis [abstract]. Ann. Rheum. Dis. (2004) 63(Suppl. I):403 (Poster SAT0054).
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  • ••This placebo-controlled, double-blindstudy identifies adalimumab as an effective and well-tolerated treatment for patients with PsA who have failed NSAIDs. Adalimumab improved the signs and symptoms of PsA, as well as measures of disability, quality of life and disease progression.
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  • ••This subanalysis of ADEPT demonstratesthe efficacy of adalimumab in retarding disease progression up to 48 weeks.
  • MEASE PJ, GANGULY R, WANKE L, YU E, SINGH A: How much improvement in functional status is considered important by patients with active psoriatic arthritis: applying the Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT) group guidelines [abstract]. Ann. Rheum. Dis. (2004) 63\(Suppl. 1):Poster SAT0015.
  • GLADMAN DD, MEASE PJ, EMERY P, WELLBORNE F, COMBE B, WEINBERG MA: Adalimumab treatment effects on quality of life in patients with psoriatic arthritis: results from ADEPT. Ann. Rheum. Dis. (2005) 64(Suppl. III [3]):Abstract FRI0203.
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  • ••This placebo-controlled, double-blindstudy evaluates adalimumab in patients with PsA who have failed DMARDs. Adalimumab improved skin and joint symptoms, as well as measures of disability.
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  • WALLACE KL, LANGLEY R, BISSONNETTE R, MELLULI L, HOFFMAN R: Quality of life in patients with psoriatic arthritis treated with adalimumab: subanalysis of studies in moderate to severe psoriasis [abstract]. J. Am. Acad. Dermatol. (2005) 52(3 Suppl.):192 (Poster P2783).
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  • SCHIFF MH, KAVANAUGH AF, WEISMAN M et al.: Safety and efficacy of more than 4 years of adalimumab therapy in rheumatoid arthritis [abstract]. J. Am. Acad. Dermatol. (2005) 52(3 Suppl.):203 (Poster P2825).
  • SCHIFF MH, BURMESTER GR, KENT J et al.: Safety of adalimumab in long-term treatment of patients with rheumatoid arthritis [abstract]. J. Am. Acad. Dermatol. (2005) 52(3 Suppl.):203 (Poster P286).
  • WELLS AF, KUPPER H, FISCHKOFF S et al.: Injection-site reactions in adalimumab rheumatoid arthritis (RA) pivotal clinical trials [abstract]. Ann. Rheum. Dis. (2003) 62(Suppl. I):411 (Abstract AB0166).
  • MEASE P: TNF-a inhibitors in psoriatic arthritis. In: Psoriasis and Psoriatic Arthritis: An Integrated Approach. Gordon KB, Ruderman EM (Eds), Springer-Verlag, Heidelberg, Germany (2005):223–234.
  • SCHIFF M, VAN DE PUTTE LB, BREEDVELD FC et al.: Rates of infection in adalimumab rheumatoid arthritis clinical trials [abstract]. Ann. Rheum. Dis. (2003) 62(Suppl. I):184 (Poster THU0246).
  • SCHIFF MH, CHARTASH E, SPENCER-GREEN G: Malignancies in rheumatoid arthritis (RA) clinical trials with adalimumab (HUMIRA(D) [abstract]. Arthritis Rheum. (2003) 48(9 Suppl.):S700 (Abstract 1832).
  • STRAND V, CHARTASH E, SENGUPTA N et al.: Improvement in health-related quality of life, health utility, and fatigue in patients with active rheumatoid arthritis (RA) on adalimumab (HUMIRA(D) therapy [abstract]. Arthritis Rheum. (2003) 48(9)(Suppl.):S402 (Poster 991).
  • WALLACE KL, GORDON KB, LANGLEY M et al.: Dermatologic quality of life in patients with moderate to severe plaque psoriasis receiving 48 weeks of adalimumab therapy [abstract]. J. Am. Acad. Dermatol (2005) 52(3 Suppl.):180 (Poster P2734).
  • WALLACE KL, BISSONNETTE R, LEONARDI C et al.: Effects of adalimumab on health status as measured by EQ-5D in patients with moderate to severe plaque psoriasis [abstract]. J. Am. Acad. Dermatol (2005) 52(3 Suppl.):181 (Poster P2741).
  • WALLACE KL, LEONARDI C, KEMPERS S et al.: General physical and mental health status in patients with moderate to severe plaque psoriasis receiving 48 weeks of adalimumab therapy [abstract]. J. Am. Acad. Dermatol (2005) 52(3 Suppl.):185 (Poster P2757).
  • MEASE PJ, GLADMAN DD, KRUEGER GG: Prologue: Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA). Ann. Rheum. Dis. (2005) 64:1-2. Websites
  • http://www.psoriasis.org/news/stories/ 2001 /200104_npfsurvey.php National Psoriasis Foundation: Survey: what people with psoriasis are saying (2001).
  • http://www.emedicine.com/derm/ topic918.htm Voorhes AV Fadeyi DW: Psoriatic arthritis (2004).

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