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Meeting Highlights

American Society of Clinical Oncology 41st Annual Meeting

Pages 1117-1127 | Published online: 24 Nov 2005

Bibliography

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  • ••ASCO plenary paper; a large randomisedtrial confirming a change in the standard of care.
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  • HUSSEIN MA, BERENSON JR, NIESVIZKY R et ell.: Phase I trial of a humanized anti-CD40 monoclonal antibody (SGN-40) in the treatment of multiple myeloma. J. Clin. Oncol. (2005) 23(16S part 1):580s. [abstract #6581].
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  • FISCHKOFF SA, HERSH E, WEBER J et al.: Durable and long-term progression-free survival observed in a Phase II study of MDX-010 alone or in combination with dacarbazine (DTIC) in metastatic melanoma. J. Clin. Oncol. (2005) 23(16S part 1):516s. [abstract #7525].
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  • •ASCO plenary paper providing insights into the mechanism of imatinib resistance.
  • DEMATTEO RP, ANTONESCU CR, CHADARAM Vet al.: Adjuvant imatinib mesylate in patients with primary high risk gastrointestinal stromal tumor (GIST): safety results from the US Intergroup Phase II trial ACOSOG Z9000. J. Clin. Oncol. (2005) 23(16S part 1):818s. [abstract #9009].
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  • •Promising activity in an uncommon disease for which there is no effective systemic therapy.
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  • SAWYERS CL, SHAH NP, KANTARJIAN HM et al.: A Phase I study of BMS-354825 in patients with imatnib-resistant and intolerant accelerated and blast phase chronic myeloid leukemia (CML): results from CA180002. J. Clin. Oncol. (2005) 23(16S part 1):565s. [abstract #6520].
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  • •This paper shows that most mutations associated with imatinib-resistant disease are overcome with this agent.
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  • •Promising single-agent results in cancer that needs better systemic therapy.
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  • •ASCO plenary paper; likely to change the standard of care for advanced pancreatic cancer, as this is the first agent to add to the benefit of gemcitabine.
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  • ••May become the first agent to improvesurvival in a randomised trial in metastatic renal cell cancer.
  • EISEN T, AHMAD T, GORE ME et ell.: Phase I trial of BAY 43–9006 (sorafenib) combined with dacarbazine (DTIC) in metastatic melanoma patients. J. Clin. Oncol (2005) 23(16S part 1):712s. [abstract #7508].
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  • •Promising single-agent results in a cancer that needs better systemic therapy.
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  • •ASCO plenary paper; benefit of this small molecule antiangiogenesis agent did not quite reach statistical significance.
  • MOSCHOS SJ, EDINGTON HD, RAO UN et al.: High dose interferon-a2b: toxicity, response, and predictive markers in a neoadjuvant trial for regional lymph node metastatic melanoma. J. Clin. Oncol (2005) 23(16S part 1):714s. [abstract #7517].
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  • •First vaccine trial to suggest a survival benefit in prostate cancer, but study size and other results raise questions about the validity of the observation.
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  • THOMPSON P, FISHMAN M, SEIGNE J et al: Phase II study of B7-1 gene-modified autologous tumor cell vaccine and subcutaneous IL-2 for patients with stage IV renal cell carcinoma. J. Clin. Oncol (2005) 23(16S part 1):378s. [abstract #4502].
  • IBRAHIM RA, ACHTAR MS, HERRIN VE et al.: Autologous PBMCs pulsed with HPV16 E6 as an immunotherapeutic agent for patients with advanced cervical cancer. J. Clin. Oncol (2005) 23(16S part 1):167s. [abstract #2508].
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  • KIRKWOOD JM, BEDIKIAN AY, MILLWARD MJ et al.: Long-term survival results of a randomized multinational Phase III trial of dacarbazine (DTIC) with or without Bc1-2 antisense (oblimersen sodium) in patients with advanced malignant melanoma. J. Clin. Oncol (2005) 23(16S part 1):711s. [abstract #7506].
  • BLUMENSCHEIN GR, KHURI F, GATZEMEIER U et al.: A randomized Phase III trial comparing bexarotene/ carboplatin/paclitaxel versus carboplatin/ paclitaxel in chemotherapy-naive patients with advanced or metastatic non-small cell lung cancer. J. Clin. Oncol (2005) 23(16S part 2):1094s. [abstract #7001].
  • •Retinoids fail again in a large US randomised trial in lung cancer.
  • JASSEM J, ZATLOUKAL P, RAMLAU R et al.: A randomized Phase III trial comparing bexarotene/cisplatin/vinorelbine versus cisplatin/vinorelbine in chemotherapy-naive patients with advanced or metastatic non-small cell lung cancer. Clin. Oncol (2005) 23(16S part 2):1095s. [abstract #7024].
  • •Retinoids fail again in a large European randomised trial in lung cancer.
  • RICHTIG E, SOYER HP, POSCH M et al.: Prospective, randomized, multicenter, double-blind placebo-controlled trial comparing adjuvant combination therapy of interferon alfa and isotretinoin with adjuvant therapy of interferon alfa in patients with primary melanoma in stage IIA and JIB AJCC/UICC 1988. J. Clin. Oncol (2005) 23(16S part 1):713s. [abstract #7515].
  • LIST AF, DEWALD G, BENNETT Jet al.: Hematologic and cytogenetic response to lenalidomide (CC-5013) in patients with transfusion-dependent myelodysplastic syndrome (MDS) and chromosome 5q31.1 deletion: results of the multicenter MDS-003 study. J. Clin. Oncol (2005) 23(16S part 1):2s. [abstract #5].
  • ••ASCO plenary paper; agent will probably beapproved as treatment for myelodysplasia.
  • RAJKUMAR SV, DINGLI D, NOWAKOWSKI G et al.: Thaldiomide and dexamethasone in newly diagnosed mulitple myeloma: long-term results in patients not undergoing upfront autologous stem cell transplantation. J. Clin. Oncol (2005) 23(16S part 1):593s. [abstract #6632].
  • MILLER KC, CZUCZMAN MS, DIMICELI Let al.: Antileukemia effects of novel immunomodulatory agent lenalinomide with or without rituximab inpatients with relapsed or refractory chronic lymphocytic leukemia. Encouraging preliminary results of ongoing Phase II clinical study. J. Clin. Oncol (2005) 23(16S part 1):574s. [abstract #6557].
  • LUDWIG H, DRACH J, TOTHOVA E et al.: Thalidomide-dexamethasone versus melphalan-prednisolone as first line treatment in elderly patients with multiple myeloma. j Clin. Oncol. (2005) 23(16S part 1):569s. [abstract #6537].
  • KNISELY JPS, BERKEY BA, CHAKRAVARTI A et ell.: RTOG 0118: a Phase III study of conventional radiation therapy alone versus conventional radiation therapy plus thalidomide for multiple brain metastases. J. Clin. Oncol (2005) 23(16S part 1):114s. [abstract #1500].
  • PUDUVALLI VK, GIGLIO P, GROVES MD et al.: Phase II trial of thalidomide in combination with irinotecan in adults with recurrent glioblastoma multiforme. j Clin. Oncol (2005) 23(16S part 1):120s. [abstract #1524].
  • RICHARDSON PG, SONNEVELD P, SCHUSTER MW et al.: Safety and efficacy of bortezomib in high-risk and elderly patients with relapsed myeloma. Clin. Oncol (2005) 23(16S part 1):568s. [abstract #6533].
  • GOY A, BERNSTEIN S, KAHL B et al.: Bortezomib in patients with relapsed or refractory mantle cell lymphoma: preliminary results of the PINNACLE study. J. Clin. Oncol (2005) 23(16S part 1):575s. [abstract #6563].
  • FANUCCHI MP, FOSSELLA F, FIDIAS P et al.: Bortezombib ± docetaxel in previously treated patients with advanced non-small cell lung cancer: a Phase II study. J. Clin. Oncol (2005) 23(16S part 1):629s. [abstract #7034].
  • KOCHHAR R, KHURANA BEJJANKI HR, CALDITO G, FORT C: Statins to reduce breast cancer risk: a case control study in US female veterans. Clin. Oncol (2005) 23(16S part 1):7s. [abstract #514].
  • KHURANA V KOCCHAR R, JEJJANKI HR, CALDITO G, FORT C: Statins reduce the incidence of lung cancer: a study of half a million US veterans. Clin. Oncol (2005) 23(16S part 1):107s. [abstract #1006].
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