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Review

The structure and evolution of eye banking: a review on eye banks’ historical, present, and future contribution to corneal transplantation

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Pages 23-40 | Published online: 06 Jun 2017

References

  • Pascolini D, Mariotti SP. Global estimates of visual impairment: 2010. Br J Ophthalmol. 2012;96(5):614–618.
  • Gain P, Jullienne R, He Z, et al. Global survey of corneal transplantation and eye banking. JAMA Ophthalmol. 2016;134(2):167–173.
  • Eye Bank Association of America. 2015 Eye Banking Statistical Report. Washington, DC: EBAA; 2016. Available from: http://restoresight.org/wp-content/uploads/2016/03/2015-Statistical-Report.pdf. Accessed August 8, 2016.
  • Eye Bank Association of America. 2009 Eye Banking Statistical Report. Washington, DC: EBAA; 2009. Available from: http://www.corneas.org/repository/images/pressimages/EBAA%202009%20Statistical%20Report%20-%20Final.pdf. Accessed August 8, 2016.
  • Chu W. The past twenty-five years in eye banking. Cornea. 2000; 19(5):754–765.
  • Zirm EK. Eine erfolgreiche totale keratoplastik (A successful total keratoplasty). 1906. Refract Corneal Surg. 1989;5(4):258–261.
  • Armitage WJ, Tullo AB, Larkin DF. The first successful full-thickness corneal transplant: a commentary on Eduard Zirm’s landmark paper of 1906. Br J Ophthalmol. 2006;90(10):1222–1223.
  • Elschnig A, Vorisek EA. Keratoplasty. Arch Ophthalmol. 1930; 4(2):165–173.
  • Espandar L, Carlson AN. Lamellar keratoplasty: a literature review. J Ophthalmol. 2013;2013:894319.
  • EBAA. History of Corneal Transplantation, Eye Banking and the EBAA. Washington, DC: EBAA; 2012. Available from: http://www.restoresight.org/wp-content/uploads/2012/02/History-Corneal-Transplants-Eye-Banking-and-the-EBAA.pdf. Accessed August 8, 2016.
  • Coster DJ. History of corneal transplantation in Australia. Clin Exp Ophthalmol. 2015;43(3):268–276.
  • Narayan RP. Development of tissue bank. Indian J Plast Surg. 2012;45(2):396–402.
  • Strong DM. The US Navy Tissue Bank: 50 years on the cutting edge. Cell Tissue Bank. 2000;1(1):9–16.
  • Jones GL, Ponzin D, Pels E, Maas H, Tullo AB, Claerhout I. European eye bank association. Dev Ophthalmol. 2009;43:15–21.
  • Eye Bank of Canada. Can Fam Physician. 1967;13(9):75.
  • EBAANZ. National Guidelines. Eye Bank Association of Australia and New Zealand [homepage on the Internet]. 2017. Available from: http://www.ebaanz.org/wp-content/uploads/2016/03/EBAANZ-NATIONAL-GUIDELINES-2016-For-the-care-and-handling-of-HTO-FINAL.pdf. Accessed March 8, 2017.
  • Eye Bank Association of America. 2015 Eye Banking Medical Standards. Washington, DC: EBAA; 2016. Available from: http://restoresight.org/wp-content/uploads/2016/03/2015-Statistical-Report.pdf. Accessed August 10, 2016.
  • Eye Bank Association of America. Constitution and Bylaws. Washington, DC: EBAA; 2015. Available from: http://restoresight.org/wp-content/uploads/2015/05/Bylaws-Final.pdf. Accessed December 19, 2016.
  • FDA. Human tissue intended for transplantation—final rule. Fed Regis. 1997;62(145):40429–40447.
  • Department of Veterans Affairs. Payment for inpatient and outpatient health care professional services at non-departmental facilities and other medical charges associated with non-VA outpatient care. Fed Regist. 2010;75(242):78901–78915.
  • Food and Drug Administration (FDA). Draft guidance for industry: use of nucleic acid tests to reduce the risk of transmission of West Nile virus from donors of human cells, tissues, and cellular and tissue-based products. 2013; ID: FDA-2013-D-1143-0002. Available from: https://www.regulations.gov/document?D=FDA-2013-D-1143-0002. Accessed August 8, 2016.
  • Greenwald MA, Kuehnert MJ, Fishman JA. Infectious disease transmission during organ and tissue transplantation. Emerg Infect Dis. 2012;18(8):e1.
  • Corcoran KP. Letter to the FDA regarding “Draft guidance for industry: use of nucleic acid tests to reduce the risk of transmission of West Nile virus from donors of human cells, tissues, and cellular and tissue-based products”. January 21, 2014. Available from: http://restoresight.org/wp-content/uploads/2014/01/EBAA-Final-Comments-Draft-Guidance-Use-of-Nucleic-Acid-Tests-To-Reduce-the-Risk-of-Transmission-of-West-Nile-Virus-From-Donors-of-HCT-Ps.pdf. Accessed November 1, 2016.
  • Glasser DB. Serologic testing of cornea donors. Cornea. 1998;17(2):123–128.
  • Aiken-O’Neill P. Letter to FDA regarding “Draft guidance for industry: preventive measures to reduce the possible risk of transmission of Creutzfeldt-Jacob disease (CJD) and variant Creutzfeldt-Jakob disease (vCJD) by human cells, tissues, and cellular and tissue-based products”. 2002. Available from: http://www.fda.gov/ohrms/dockets/dailys/02/Dec02/122402/80043a70.pdf. Accessed August 8, 2016.
  • Heck E, Petty C, Palestine A, et al. ELISA HIV testing and viral culture in the screening of corneal tissue for transplant from medical examiner cases. Cornea. 1989;8(2):77–80.
  • Armstrong SA, Gangam N, Chipman ML, Rootman DS. The prevalence of positive hepatitis B, hepatitis C, and HIV serology in cornea donors prescreened by medical and social history in Ontario, Canada. Cornea. 1997;16(5):512–516.
  • Heck E, Brown A, Cavanagh HD. Nucleic acid testing and tissue safety: an eye bank’s five-year review of HIV and hepatitis testing for donor corneas. Cornea. 2013;32(4):503–505.
  • Caron MJ, Wilson R. Review of the risk of HIV infection through corneal transplantation in the United States. J Am Optom Assoc. 1994;65(3):173–178.
  • Simonds RJ, Holmberg SD, Hurwitz RL, et al. Transmission of human immunodeficiency virus type 1 from a seronegative organ and tissue donor. New Engl J Med. 1992;326(11):726–732.
  • Hoft RH, Pflugfelder SC, Forster RK, Ullman S, Polack FM, Schiff ER. Clinical evidence for hepatitis B transmission resulting from corneal transplantation. Cornea. 1997;16(2):132–137.
  • Houff SA, Burton RC, Wilson RW, et al. Human-to-human transmission of rabies virus by corneal transplant. New Engl J Med. 1979;300(11):603–604.
  • Cleator GM, Klapper PE, Dennett C, et al. Corneal donor infection by herpes simplex virus: herpes simplex virus DNA in donor corneas. Cornea. 1994;13(4):294–304.
  • Available from: https://www.fda.gov/downloads/biologicsbloodvaccines/guidancecomplianceregulatoryinformation/guidances/tissue/ucm488582.pdf. Accessed March 8, 2017.
  • Food and Drug Administration, HHS. Suitability determination for donors of human cellular and tissue-based products-proposed rule. Fed Regist. 1999;64(189)52696–52723.
  • Randolph ME. An experimental study of the possibility of transmitting syphilis by a corneal graft. Trans Am Ophthalmol Soc. 1949;47:683–691.
  • Macsai MS, Norris SJ. OptiSol corneal storage medium and transmission of Treponema pallidum. Cornea. 1995;14(6):595–600.
  • Pels E, Beele H, Claerhout I. Eye bank issues: II. Preservation techniques: warm versus cold storage. Int Ophthalmol. 2008;28(3):155–163.
  • Varner AC, Rich LF, Crow BL, MacRae S. Survival of streptococcus in optisol-GS medium. J Refract Surg. 1995;11(3):207–209.
  • Aldave AJ, DeMatteo J, Glasser DB, et al. Report of the Eye Bank Association of America medical advisory board subcommittee on fungal infection after corneal transplantation. Cornea. 2013;32(2):149–154.
  • Wilhelmus KR, Hassan SS. The prognostic role of donor corneoscleral rim cultures in corneal transplantation. Ophthalmology. 2007;114(3):440–445.
  • Hassan SS, Wilhelmus KR, Dahl P, et al; Medical Review Subcommittee of the Eye Bank Association of America. Infectious disease risk factors of corneal graft donors. Arch Ophthalmol. 2008;126(2):235–239.
  • Antonios SR, Cameron JA, Badr IA, Habash NR, Cotter JB. Contamination of donor cornea: postpenetrating keratoplasty endophthalmitis. Cornea. 1991;10(3):217–220.
  • Gandhi SS, Lamberts DW, Perry HD. Donor to host transmission of disease via corneal transplantation. Surv Ophthalmol. 1981;25(5):306–311.
  • Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992;101(6):1644–1655.
  • Chaurasia S, Muralidhar R, Garg P, Gopinathan U. Donor corneal button-related endophthalmitis after penetrating keratoplasty. Clin Exp Ophthalmol. 2010;38(1):75–76.
  • Khodadoust AA, Franklin RM. Transfer of bacterial infections by donor cornea in penetrating keratoplasty. Am J Ophthalmol. 1979;87(2):130–132.
  • Acharya M, Mathur U, Dave A. Evaluation of corneas from donors with septicemia for use in corneal transplant. Cornea. Epub 2016 Oct 14.
  • Mathur U, Acharya M, Garg J, Sapra N, Chauhan L. Risk of transmission of infection to host from septicaemic donor corneas. Int J Eye Bank. 2015;3(3):1–5.
  • Nagaraja H, Anandula V, Kugar T, Shivanna Y, Shetty R. Evaluation of corneas from donors with septicemia for use in corneal transplant. Cornea. 2016;35(8):1132–1135.
  • EEBA. European Eye Bank Association Statement on Pre-Processing Microbiology Testing in Eye Banks; 2009. Available from: http://www.europeaneyebanks.org/files/Statement_on_pre-processing_microbiology_testing_in_eye_banksFinalGJ.pdf. Accessed November 1, 2016.
  • Hata B. The development of glioma in the eye to which the cornea of patient, who suffered from glioma was transplanted. Acta Soc Ophthalmol Jpn. 1939;43:1763–1767.
  • Li JY. Donors with melanoma history: the risk to ocular tissue recipients. Int J Eye Bank. 2016;4(1):1–4.
  • McGeorge AJ, Vote BJ, Elliot DA, Polkinghorne PJ. Papillary adenocarcinoma of the iris transmitted by corneal transplantation. Arch Ophthalmol. 2002;120(10):1379–1383.
  • Floren I. Transmission of malignancy by corneal transplantation. Paper presented at: 15th Conference for European Eye Bank Association; January 22, 2003; Brussels, Belgium.
  • Holland E. Conjunctival-limbal melanoma after a keratolimbal allograft. Paper presented at: Cornea Society Fall Educational Symposium; October 14, 2016; Chicago, IL.
  • Li JY. EBAA major guidance and standards changes. Int J Eye Bank. 2016;4(2):1–3.
  • Miller AK, Young JW, Wilson DJ, Dunlap J, Chamberlain W. Transmission of donor-derived breast carcinoma as a recurrent mass in a keratolimbal allograft. 2017. doi: 10.1097/ICO.0000000000001185.
  • Prusiner SB. Prions. Proc Natl Acad Sci USA. 1998;95(23):13363–13383.
  • Duffy P, Wolf J, Collins G, DeVoe AG, Streeten B, Cowen D. Letter: possible person-to-person transmission of Creutzfeldt-Jakob disease. New Engl J Med. 1974;290(12):692–693.
  • Melles GR, Wijdh RH, Nieuwendaal CP. A technique to excise the descemet membrane from a recipient cornea (descemetorhexis). Cornea. 2004;23(3):286–288.
  • Terry MA, Ousley PJ. Deep lamellar endothelial keratoplasty in the first United States patients: early clinical results. Cornea. 2001;20(3):239–243.
  • Yong KL, Nguyen HV, Cajucom-Uy HY, et al. Cost minimization analysis of precut cornea grafts in descemet stripping automated endothelial keratoplasty. Medicine (Baltimore). 2016;95(8):e2887.
  • Li JY, Mannis MJ. Eye banking and the changing trends in contemporary corneal surgery. Int Ophthalmol Clin. 2010;50(3):101–112.
  • Kitzmann AS, Goins KM, Reed C, Padnick-Silver L, Macsai MS, Sutphin JE. Eye bank survey of surgeons using precut donor tissue for descemet stripping automated endothelial keratoplasty. Cornea. 2008;27(6):634–639.
  • Guerra FP, Anshu A, Price MO, Giebel AW, Price FW. Descemet’s membrane endothelial keratoplasty: prospective study of 1-year visual outcomes, graft survival, and endothelial cell loss. Ophthalmology. 2011;118(12):2368–2373.
  • Ham L, Dapena I, van Luijk C, van der Wees J, Melles GR. Descemet membrane endothelial keratoplasty (DMEK) for Fuchs endothelial dystrophy: review of the first 50 consecutive cases. Eye (Lond). 2009;23(10):1990–1998.
  • Rose L, Briceño CA, Stark WJ, Gloria DG, Jun AS. Assessment of eye bank-prepared posterior lamellar corneal tissue for endothelial keratoplasty. Ophthalmology. 2008;115(2):279–286.
  • Doughman DJ, Rogers CC. Eye banking in the 21st century: how far have we come? Are we prepared for what’s ahead? Int J Eye Bank. 2012;1(1):1–15.
  • Katzman LR, Hoover CK, Khalifa YM, Jeng BH. Assessment of the accuracy and cut-failure rates of eye bank-cut corneas for use in endothelial keratoplasty: a comparison of outcomes between 2010 and 2013. Cornea. 2015;34(11):1365–1368.
  • Price MO, Baig KM, Brubaker JW, Price FW Jr. Randomized, prospective comparison of precut vs surgeon-dissected grafts for descemet stripping automated endothelial keratoplasty. Am J Ophthalmol. 2008;146(1):36–41.
  • Terry MA. Endothelial keratoplasty: a comparison of complication rates and endothelial survival between precut tissue and surgeon-cut tissue by a single DSAEK surgeon. Trans Am Ophthalmol Soc. 2009;107:184–191.
  • Prabhu SS, Kaakeh R, Sugar A, Smith DG, Shtein RM. Comparative cost-effectiveness analysis of descemet stripping automated endothelial keratoplasty versus penetrating keratoplasty in the United States. Am J Ophthalmol. 2013;155(1):45–53. e1.
  • Melles GR, Ong TS, Ververs B, van der Wees J. Descemet membrane endothelial keratoplasty (DMEK). Cornea. 2006;25(8):987–990.
  • Agarwal A, Dua HS, Narang P, et al. Pre-Descemet’s endothelial keratoplasty (PDEK). Brit J Ophthalmol. 2014;98(9):1181–1185.
  • Boynton GE, Woodward MA. Eye-bank preparation of endothelial tissue. Curr Opin Ophthalmol. 2014;25(4):319–324.
  • Lie JT, Birbal R, Ham L, van der Wees J, Melles GR. Donor tissue preparation for Descemet membrane endothelial keratoplasty. J Cataract Refract Surg. 2008;34(9):1578–1583.
  • Jardine GJ, Holiman JD, Galloway JD, Stoeger CG, Chamberlain WD. Eye bank-prepared femtosecond laser-assisted automated Descemet membrane endothelial grafts. Cornea. 2015;34(7):838–843.
  • Ruzza A, Parekh M, Salvalaio G, et al. Bubble technique for Descemet membrane endothelial keratoplasty tissue preparation in an eye bank: air or liquid? Acta Ophthalmol. 2015;93(2):e129–e134.
  • Yoeruek E, Bayyoud T, Hofmann J, Szurman P, Bartz-Schmidt KU. Comparison of pneumatic dissection and forceps dissection in Descemet membrane endothelial keratoplasty: histological and ultrastructural findings. Cornea. 2012;31(8):920–925.
  • Vianna LM, Stoeger CG, Galloway JD, et al. Risk factors for eye bank preparation failure of Descemet membrane endothelial keratoplasty tissue. Am J Ophthalmol. 2015;159(5):829–834. e2.
  • Greiner MA, Rixen JJ, Wagoner MD, et al. Diabetes mellitus increases risk of unsuccessful graft preparation in Descemet membrane endothelial keratoplasty: a multicenter study. Cornea. 2014;33(11):1129–1133.
  • Heindl LM, Riss S, Bachmann BO, Laaser K, Kruse FE, Cursiefen C. Split cornea transplantation for 2 recipients: a new strategy to reduce corneal tissue cost and shortage. Ophthalmology. 2011;118(2):294–301.
  • Lam FC, Baydoun L, Dirisamer M, Lie J, Dapena I, Melles GR. Hemi-Descemet membrane endothelial keratoplasty transplantation: a potential method for increasing the pool of endothelial graft tissue. JAMA Ophthalmol. 2014;132(12):1469–1473.
  • Palioura S, Colby K. Outcomes of Descemet stripping endothelial keratoplasty using eye bank-prepared preloaded grafts. Cornea. 2017;36(1):21–25.
  • Shah SU, Gritz DC. Application of the femtosecond laser LASIK microkeratome in eye banking. Curr Opin Ophthalmol. 2012;23(4):257–263.
  • Juhasz T, Loesel FH, Kurtz RM, Horvath C, Bille JF, Mourou G. Corneal refractive surgery with femtosecond lasers. IEEE J Sel Top Quantum Electron. 1999;5(4):902–910.
  • Kezirian GM, Stonecipher KG. Comparison of the IntraLase femtosecond laser and mechanical keratomes for laser in situ keratomileusis. J Cataract Refract Surg. 2004;30(4):804–811.
  • Liu HH, Hu Y, Cui HP. Femtosecond laser in refractive and cataract surgeries. Int J Ophthalmol. 2015;8(2):419–426.
  • Bahar I, Kaiserman I, McAllum P, Rootman D. Femtosecond laser-assisted penetrating keratoplasty: stability evaluation of different wound configurations. Cornea. 2008;27(2):209–211.
  • Jones YJ, Goins KM, Sutphin JE, Mullins R, Skeie JM. Comparison of the femtosecond laser (IntraLase) versus manual microkeratome (Moria ALTK) in dissection of the donor in endothelial keratoplasty: initial study in eye bank eyes. Cornea. 2008;27(1):88–93.
  • Vetter JM, Butsch C, Faust M, et al. Irregularity of the posterior corneal surface after curved interface femtosecond laser-assisted versus microkeratome-assisted descemet stripping automated endothelial keratoplasty. Cornea. 2013;32(2):118–124.
  • Tomida D, Yamaguchi T, Ogawa A, et al. Effects of corneal irregular astigmatism on visual acuity after conventional and femtosecond laser-assisted Descemet’s stripping automated endothelial keratoplasty. Jpn J Ophthalmol. 2015;59(4):216–222.
  • Trinh L, Saubaméa B, Auclin F, et al. Femtosecond and excimer laser-assisted endothelial keratoplasty (FELEK): a new technique of endothelial transplantation. J Fr Ophtalmol. 2014;37(3):211–219.
  • Bethke W. Can you afford to do femtosecond cataract? Rev Ophthalmol. 2011. Available from: https://www.reviewofophthalmology.com/article/can-you-afford-to-do-femtosecond-cataract. Accessed November 1, 2016.
  • Espana EM, Di Pascuale M, Grueterich M, Solomon A, Tseng SC. Keratolimbal allograft in corneal reconstruction. Eye (Lond). 2004;18(4):406–417.
  • Farid M, Lee N. Ocular surface reconstruction with keratolimbal allograft for the treatment of severe or recurrent symblepharon. Cornea. 2015;34(6):632–636.
  • Croasdale CR, Schwartz GS, Malling JV, Holland EJ. Keratolimbal allograft: recommendations for tissue procurement and preparation by eye banks, and standard surgical technique. Cornea. 1999;18(1):52–58.
  • Mason SL, Stewart RM, Sheridan CM, et al. Yield and viability of human limbal stem cells from fresh and stored tissue. Invest Ophthalmol Vis Sci. 2016;57(8):3708–3713.
  • Lawrence SD, Netland PA. Gamma-irradiated cornea allograft for glaucoma surgery. J Glaucoma. 2013;22(5):355–357.
  • Smith MF, Doyle JW, Ticrney JW Jr. A comparison of glaucoma drainage implant tube coverage. J Glaucoma. 2002;11(2):143–147.
  • Al-Torbak AA, Al-Shahwan S, Al-Jadaan I, Al-Hommadi A, Edward DP. Endophthalmitis associated with the Ahmed glaucoma valve implant. Br J Ophthalmol. 2005;89(4):454–458.
  • Ekici F, Moster MR, Cvintal V, Hu WD, Waisbourd M. Tube shunt coverage with gamma-irradiated cornea allograft (VisionGraft). Clin Ophthalmol. 2015;9:751–755.
  • Rumelt S, Rehany U. A donor corneal patch graft for an incompetent scleral flap following trabeculectomy. Ophthalmic Surg Lasers. 1996;27(10):878–880.
  • Nolan KW, Lucas J, Abbasian J. The use of irradiated corneal patch grafts in pediatric Ahmed drainage implant surgery. J AAPOS. 2015;19(5):445–449.
  • Daoud YJ, Smith R, Smith T, Akpek EK, Ward DE, Stark WJ. The intraoperative impression and postoperative outcomes of gamma-irradiated corneas in corneal and glaucoma patch surgery. Cornea. 2011;30(12):1387–1391.
  • Holiman J, Li Y, Stoeger C, Huang D. The effects of a novel sterilization process on donor cornea clarity. 2014. Available from: http://visiongift.org/downloads/EBAA%202014%20Clarity%20Final_Version%202.pdf. Accessed November 1, 2016.
  • Gupta A, Jain S, Jain T, Gupta K. Awareness and perception regarding eye donation in students of a nursing college in Bangalore. Indian J Community Med. 2009;34(2):122–125.
  • Tandon R, Verma K, Vanathi M, Pandey RM, Vajpayee RB. Factors affecting eye donation from postmortem cases in a tertiary care hospital. Cornea. 2004;23(6):597–601.
  • Dandona R, Dandona L, Naduvilath TJ, McCarty CA, Rao GN. Awareness of eye donation in an urban population in India. Aust NZ J Ophthalmol. 1999;27(3–4):166–169.
  • Siminoff LA, Arnold RM, Caplan AL, Virnig BA, Seltzer DL. Public policy governing organ and tissue procurement in the United States. Results from the National Organ and Tissue Procurement Study. Ann Intern Med. 1995;123(1):10–17.
  • Pineda R. Corneal transplantation in the developing world: lessons learned and meeting the challenge. Cornea. 2015;34(Suppl 10):S35–S40.
  • Rao GN, Gopinathan U. Eye banking: an introduction. Community Eye Health. 2009;22(71):46–47.
  • de Araujo AL, Gomes JÁ. Corneal stem cells and tissue engineering: current advances and future perspectives. World J Stem Cells. 2015;7(5):806–814.
  • Ramaesh K, Dhillon B. Ex vivo expansion of corneal limbal epithelial/stem cells for corneal surface reconstruction. Eur J Ophthalmol. 2003;13(6):515–524.
  • Mimura T, Yamagami S, Amano S. Corneal endothelial regeneration and tissue engineering. Prog Retin Eye Res. 2013;35:1–17.
  • Mimura T, Yamagami S, Yokoo S, et al. Cultured human corneal endothelial cell transplantation with a collagen sheet in a rabbit model. Invest Ophthalmol Vis Sci. 2004;45(9):2992–2997.
  • Honda N, Mimura T, Usui T, Amano S. Descemet stripping automated endothelial keratoplasty using cultured corneal endothelial cells in a rabbit model. Arch Ophthalmol. 2009;127(10):1321–1326.
  • Lai JY, Chen KH, Hsiue GH. Tissue-engineered human corneal endothelial cell sheet transplantation in a rabbit model using functional biomaterials. Transplantation. 2007;84(10):1222–1232.
  • Di lorio E, Ferrari S, Fasolo A, Böhm E, Ponzin D, Barbaro V. Techniques for culture and assessment of limbal stem cell grafts. Ocul Surf. 2010;8(3):146–153.
  • Fasolo A, Pedrotti E, Passilongo M, et al. Safety outcomes and long-term effectiveness of ex vivo autologous cultured limbal epithelial transplantation for limbal stem cell deficiency. Br J Ophthalmol. Epub 2016 Aug 19.
  • James SE, Rowe A, Ilari L, Daya S, Martin R. The potential for eye bank limbal rings to generate cultured corneal epithelial allografts. Cornea. 2001;20(5):488–494.
  • Atala A, Kasper FK, Mikos AG. Engineering complex tissues. Sci Transl Med. 2012;4(160):160rv12.
  • Vázquez N, Chacón M, Meana Á, et al. Keratin-chitosan membranes as scaffold for tissue engineering of human cornea. Histol Histopathol. 2015;30(7):813–821.
  • Griffith M, Osborne R, Munger R, et al. Functional human corneal equivalents constructed from cell lines. Science. 1999;286(5447):2169–2172.
  • Griffith M, Jackson WB, Lagali N, Merrett K, Li F, Fagerholm P. Artificial corneas: a regenerative medicine approach. Eye (Lond). 2009;23(10):1985–1989.
  • Guo X, Hutcheon AE, Melotti SA, Zieske JD, Trinkaus-Randall V, Ruberti JW. Morphologic characterization of organized extracellular matrix deposition by ascorbic acid-stimulated human corneal fibroblasts. Invest Ophthalmol Vis Sci. 2007;48(9):4050–4060.
  • Fagerholm P, Lagali NS, Merrett K, et al. A biosynthetic alternative to human donor tissue for inducing corneal regeneration: 24-month follow-up of a phase 1 clinical study. Sci Transl Med. 2010; 2(46):46ra61.
  • Mason C, Manzotti E. Regenerative medicine cell therapies: numbers of units manufactured and patients treated between 1988 and 2010. Regen Med. 2010;5(3):307–313.
  • Yam GH, Yusoff NZ, Goh TW, et al. Decellularization of human stromal refractive lenticules for corneal tissue engineering. Sci Rep. 2016;6:26339.
  • Sekundo W, Kunert KS, Blum M. Small incision corneal refractive surgery using the small incision lenticule extraction (SMILE) procedure for the correction of myopia and myopic astigmatism: results of a 6 month prospective study. Br J Ophthalmol. 2011;95(3):335–339.
  • Sun L, Yao P, Li M, Shen Y, Zhao J, Zhou X. The safety and predictability of implanting autologous lenticule obtained by SMILE for hyperopia. J Refract Surg. 2015;31(6):374–379.
  • Ganesh S, Brar S. Femtosecond intrastromal lenticular implantation combined with accelerated collagen cross-linking for the treatment of keratoconus – initial clinical result in 6 eyes. Cornea. 2015; 34(10):1331–1339.
  • Angunawela RI, Riau AK, Chaurasia SS, Tan DT, Mehta JS. Refractive lenticule re-implantation after myopic ReLEx: a feasibility study of stromal restoration after refractive surgery in a rabbit model. Invest Ophthalmol Vis Sci. 2012;53(8):4975–4985.
  • Ganesh S, Brar S, Rao PA. Cryopreservation of extracted corneal lenticules after small incision lenticule extraction for potential use in human subjects. Cornea. 2014;33(12):1355–1362.