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CASE SERIES

Real-World Case Studies Showing the Effective Use of Azelaic Acid in the Treatment, and During the Maintenance Phase, of Adult Female Acne Patients

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Pages 515-527 | Received 29 Nov 2022, Accepted 01 Feb 2023, Published online: 24 Feb 2023

References

  • Albuquerque RGR, Rocha MAD, Bagatin E, Tufik S, Andersen ML. Could adult female acne be associated with modern life? Arch Res. 2014;306:683–688.
  • Ayer J, Burrows N. Acne: more than skin deep. Postgrad Med J. 2006;82:500–506. doi:10.1136/pgmj.2006.045377
  • Tuchayi SM, Makrantonaki E, Gancevicience R, Dessinioti C, Feldman S, Zouboulis CC. Acne vulgaris. Nat Rev Dis Primers. 2015;1:15029. doi:10.1038/nrdp.2015.29
  • Bagatin E, Proença Freitas TH, Rivitti-Machado MC, Medeiros Ribeiro B, Nunes S, Dias da Rocha MA. Adult female acne: a guide to clinical practice. An Bras Dermatol. 2019;94:62⁠–75. doi:10.1590/abd1806-4841.20198203
  • Vera N, Patel N, Cardwell LA, Saleem M, Feldman SR. Chemical pharmacotherapy options for managing adult acne. Exp Opin Pharmacother. 2017;18:263. doi:10.1080/14656566.2017.1282460
  • Baldwin H, Tan J. Effects of diet on acne and its response to treatment. Am J Clin Dermatol. 2021;22:55–65. doi:10.1007/s40257-020-00542-y
  • Nast A, Dréno B, Bettoli V. European evidence-based (S3) guideline for the treatment of acne - update 2016 - short version. J Eur Acad Dermatol Venereol. 2016;30(8):1261–1268. doi:10.1111/jdv.13776
  • Dréno B. Treatment of adult female acne: a new challenge. J Eur Acad Dermatol Venereol. 2015;29(Suppl. 5):14–19. doi:10.1111/jdv.13188
  • Lynn DD, Umari T, Dunnick CA, Dellavalle RP. The epidemiology of acne vulgaris in late adolescence. Adolesc Health Med Ther. 2016;7:13–25. doi:10.2147/AHMT.S55832
  • Vargas-Diez E, Hofmann M, Bravo B, Malgazhdarova G, Katkhanova OA, Yutskovskaya Y. Azelaic acid in the treatment of acne in adult females: case reports. Skin Pharmacol Physiol. 2014;27(Suppl. 1):18–25. doi:10.1159/000354889
  • Dumont-Wallon G, Dreno B. Specificity of acne in women older than 25 years. Presse Med. 2008;37(Pt. 1):585–591. doi:10.1016/j.lpm.2007.07.014
  • Holzmann R, Shakery K. Postadolescent acne in females. Skin Pharmacol Physiol. 2014;27(Suppl. 1):3–8. doi:10.1159/000354887
  • Karimkhani C, Dellavalle R, Coffeng LE, et al. Global skin disease morbidity and mortality: an update from the Global Burden of Disease Study 2013. JAMA Dermatol. 2017;153:406–412. doi:10.1001/jamadermatol.2016.5538
  • Gallitano SM, Berson DS. How acne bumps cause the blues: the influence of acne vulgaris on self-esteem. Int J Womens Dermatol. 2018;4:12–17. doi:10.1016/j.ijwd.2017.10.004
  • Dias da Rocha MA, Guadanhim LRS, Sanudo A, Bagatin E. Modulation of Toll Like Receptor-2 on sebaceous gland by the treatment of adult female acne. Dermatoendocrinol. 2017;9:e1361570. doi:10.1080/19381980.2017.1361570
  • Dréno B, Layton A, Zouboulis C, et al. Adult female acne: a new paradigm. J Eur Acad Dermatol Venereol. 2013;27:1063–1070. doi:10.1111/jdv.12061
  • Bhate K, Williams HC. Epidemiology of acne vulgaris. Br J Dermatol. 2013;168:474–485. doi:10.2147/CCID.S137794
  • Dreno B, Bagatin E, Blume-Peytavi U, Rocha M, Gollnick H. Female type of adult acne: physiological and psychological considerations and management. J Dtsch Dermatol Ges. 2018;16:1185–1194.
  • Dreno B, Bordet C, Seite S, Taieb C. Acne relapses: impact on quality of life and productivity. J Eur Acad Dermatol Venereol. 2019;33:937–943. doi:10.1111/jdv.15419
  • Nast A, Dreno B, Bettoli V, Degitz K, Erdmann R, Finlay AY. European evidence-based (S3) guidelines for the treatment of acne. J Eur Acad Dermatol Venereol. 2012;26:1–29. doi:10.1111/j.1468-3083.2011.04374.x
  • Bagatin E, Dias da Rocha MA, Proença Freitas TH, Sousa Costa C. Treatment challenges in adult female acne and future directions. Expert Rev Clin Pharmacol. 2021;14:687–701. doi:10.1080/17512433.2021.1917376
  • Katsambas A, Dessinioti C. Hormonal therapy for acne: why not as first line therapy? Facts and controversies. Clin Dermatol. 2010;28(1):17–23. doi:10.1016/j.clindermatol.2009.03.006
  • Lakshmi C. Hormonal Therapy in acne. Indian J Dermatol Venereol Leprol. 2013;79:322–337. doi:10.4103/0378-6323.110765
  • Rocha MA, Bagatin E. Adult-onset acne: prevalence, impact, and management challenges. Clin Cosmet Investig Dermatol. 2018;11:59–69. doi:10.2147/CCID.S137794
  • Zeichner J. New insights into azelaic acid. Practical dermatology; 2013:45–46. Available from: practicaldermatology.com/pdfs/pd0313_ClinicalFocus.pdf. Accessed February 21, 2023.
  • CCDS. Skinoren® 20% Cream v1.0. LEO Pharma; 2022.
  • Sieber MA, Hegel JK. Azelaic acid: properties and mode of action. Skin Pharmacol Physiol. 2014;27(Suppl. 1):9–17. doi:10.1159/000354888
  • Fluhr JW, Degitz K. Antibiotics, azelaic acid and benzoyl peroxide in topical acne therapy. J Dtsch Dermatol Ges. 2010;8:24–30. doi:10.1111/j.1610-0387.2009.07169.x
  • Williams C, Layton AM. Persistent acne in women: implications for the patient and for therapy. Am J Clin Dermatol. 2006;7:281–290. doi:10.2165/00128071-200607050-00002
  • Pappas A, Kendall AC, Brownbridge LC, Batchvarova N, Nicolaou A. Seasonal changes in epidermal ceramides are linked to impaired barrier function in acne patients. Exp Dermatol. 2018;27:833–836. doi:10.1111/exd.13499
  • Dias da Rocha MA, Bagatin E. Skin barrier and microbiome in acne. Arch Dermatol Res. 2018;310:181–185. doi:10.1007/s00403-017-1795-3
  • Rogers J, Harding C, Mayo A, Banks J, Rawlings A. Stratum corneum lipids: the effect of ageing and the seasons. Arch Dermatol Res. 1996;288(12):765–770. doi:10.1007/BF02505294
  • Gether L, Overgaard LK, Egeberg A, Thyssen JP. Incidence and prevalence of rosacea: a systematic review and meta-analysis. Br J Dermatol. 2018;179:282–289. doi:10.1111/bjd.16481
  • Ogbechie-Godec OA, Elbuluk N. Melasma: an up-to-date comprehensive review. Dermatol Ther. 2017;7:305–318. doi:10.1007/s13555-017-0194-1
  • Tan J, Thiboutot D, Gollnick H, et al. Development of an atrophic acne scar risk assessment tool. J Eur Acad Dermatol Venereol. 2017;31:1547–1554. doi:10.1111/jdv.14325
  • Breathnach AS, Robins E, Nazzaro-Porro M, Passi S, Picardo M. Hyperpigmentary disorders--mechanisms of action. Effect of azelaic acid on melanoma and other tumoral cells in culture. Acta Derm Venereol. 1989;143:62–66.
  • Kircik LH. Efficacy and safety of azelaic acid (AzA) gel 15% in the treatment of post-inflammatory hyperpigmentation and acne: a 16-week, baseline-controlled study. J Drugs Dermatol. 2011;10:586–590.
  • Katsambas AD, Stefanaki C, Cunliffe WJ. Guidelines for treating acne. Clin Dermatol. 2004;22:439–444. doi:10.1016/j.clindermatol.2004.03.002
  • Gollnick HP, Graupe K, Zaumseil RP. Comparison of combined azelaic acid cream plus oral minocycline with oral isotretinoin in severe acne. Eur J Dermatol. 2001;11:538–644.