The Efficacy and Safety of Oral and Topical Spironolactone in Androgenetic Alopecia Treatment: A Systematic Review

References

• Nestor MS, Ablon G, Gade A, Han H, Fischer DL. Treatment options for androgenetic alopecia: efficacy, side effects, compliance, financial considerations, and ethics. J Cosmet Dermatol. 2021;20(12):3759–3781. doi:10.1111/jocd.14537
   PubMed Web of Science ®Google Scholar
• Gupta AK, Mays RR, Dotzert MS, Versteeg SG, Shear NH, Piguet V. Efficacy of non-surgical treatments for androgenetic alopecia: a systematic review and network meta-analysis. J Eur Acad Dermatol Venereol. 2018;32(12):2112–2125. doi:10.1111/jdv.15081
   PubMed Web of Science ®Google Scholar
• Adil A, Godwin M. The effectiveness of treatments for androgenetic alopecia: a systematic review and meta-analysis. J Am Acad Dermatol. 2017;77(1):136–141.e135. doi:10.1016/j.jaad.2017.02.054
   PubMed Web of Science ®Google Scholar
• Abdel-Raouf H, Aly UF, Medhat W, Ahmed SS, Abdel-Aziz RTA. A novel topical combination of minoxidil and spironolactone for androgenetic alopecia: clinical, histopathological, and physicochemical study. Dermatol Ther. 2021;34(1):e14678. doi:10.1111/dth.14678
   PubMed Web of Science ®Google Scholar
• Gowda BHJ, Ahmed MG, Sahebkar A, Riadi Y, Shukla R, Kesharwani P. Stimuli-responsive microneedles as a transdermal drug delivery system: a demand-supply strategy. Biomacromolecules. 2022;23(4):1519–1544. doi:10.1021/acs.biomac.1c01691
   PubMed Web of Science ®Google Scholar
• Ioannides D, Lazaridou E. Female pattern hair loss. Curr Probl Dermatol. 2015;47:45–54.
   PubMedGoogle Scholar
• Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097. doi:10.1371/journal.pmed.1000097
   PubMed Web of Science ®Google Scholar
• Higgins JP, Altman DG, Gøtzsche PC, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928. doi:10.1136/bmj.d5928
   PubMed Web of Science ®Google Scholar
• Zeng X, Zhang Y, Kwong JS, et al. The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline: a systematic review. J Evid Based Med. 2015;8(1):2–10. doi:10.1111/jebm.12141
   PubMedGoogle Scholar
• Ammar AM, Elshahid AR, Abdel-Dayem HA, Mohamed AA, Elsaie ML. Dermoscopic evaluation of the efficacy of combination of topical spironolactone 5% and minoxidil 5% solutions in the treatment of androgenetic alopecia: a cross sectional-comparative study. J Cosmet Dermatol. 2022;2022:1.
   Google Scholar
• Burns LJ, De Souza B, Flynn E, Hagigeorges D, Senna MM. Spironolactone for treatment of female pattern hair loss. J Am Acad Dermatol. 2020;83(1):276–278. doi:10.1016/j.jaad.2020.03.087
   PubMed Web of Science ®Google Scholar
• Famenini S, Slaught C, Duan L, Goh C. Demographics of women with female pattern hair loss and the effectiveness of spironolactone therapy. J Am Acad Dermatol. 2015;73(4):705–706. doi:10.1016/j.jaad.2015.06.063
   PubMed Web of Science ®Google Scholar
• Liang X, Chang Y, Wu H, et al. Efficacy and safety of 5% minoxidil alone, minoxidil plus oral spironolactone, and minoxidil plus microneedling on female pattern hair loss: a prospective, single-center, parallel-group, evaluator blinded, randomized trial. Front Med. 2022;9:1. doi:10.3389/fmed.2022.905140
   Web of Science ®Google Scholar
• Sinclair R, Wewerinke M, Jolley D. Treatment of female pattern hair loss with oral antiandrogens. Br J Dermatol. 2005;152(3):466–473. doi:10.1111/j.1365-2133.2005.06218.x
   PubMed Web of Science ®Google Scholar
• Sinclair RD. Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone. Int J Dermatol. 2018;57(1):104–109. doi:10.1111/ijd.13838
   PubMed Web of Science ®Google Scholar
• Carone L, Oxberry SG, Twycross R, Charlesworth S, Mihalyo M, Wilcock A. Spironolactone. J Pain Symptom Manage. 2017;53(2):288–292. doi:10.1016/j.jpainsymman.2016.12.320
   PubMed Web of Science ®Google Scholar
• Searle TN, Al-Niaimi F, Ali FR. Spironolactone in dermatology: uses in acne and beyond. Clin Exp Dermatol. 2020;45(8):986–993. doi:10.1111/ced.14340
   PubMed Web of Science ®Google Scholar
• Sinclair R, Patel M, Dawson TL Jr, et al. Hair loss in women: medical and cosmetic approaches to increase scalp hair fullness. Br J Dermatol. 2011;165(Suppl 3):12–18. doi:10.1111/j.1365-2133.2011.10630.x
   PubMed Web of Science ®Google Scholar
• Fabbrocini G, Cantelli M, Masarà A, Annunziata MC, Marasca C, Cacciapuoti S. Female pattern hair loss: a clinical, pathophysiologic, and therapeutic review. Int J Womens Dermatol. 2018;4(4):203–211. doi:10.1016/j.ijwd.2018.05.001
   PubMedGoogle Scholar
• Hoedemaker C, van Egmond S, Sinclair R. Treatment of female pattern hair loss with a combination of spironolactone and minoxidil. Australas J Dermatol. 2007;48(1):43–45. doi:10.1111/j.1440-0960.2007.00332.x
   PubMed Web of Science ®Google Scholar
• Olamiju B, Craiglow BG. Combination oral minoxidil and spironolactone for the treatment of androgenetic alopecia in adolescent girls. J Am Acad Dermatol. 2021;84(6):1689–1691. doi:10.1016/j.jaad.2020.10.097
   PubMed Web of Science ®Google Scholar
• Aguilar Medina DA, Cazarín J, Magaña M. Spironolactone in dermatology. Dermatol Ther. 2022;35(5):e15321. doi:10.1111/dth.15321
   PubMed Web of Science ®Google Scholar
• c26hx RBR. Oral minoxidil and spironolactone versus topical minoxidil for female pattern hair loss; 2017. Available from: https://trialsearchwhoint/Trial2aspx?TrialID=RBR-6c26hx. Accessed March 6, 2023.
   Google Scholar
• Irct20211210053343N. Comparison of the effect of minoxidil and spironolactone with minoxidil and finasteride in the treatment of Androgenic Alopecia; 2021. Available from: https://trialsearchwhoint/Trial2aspx?TrialID=IRCT20211210053343N1. Accessed March 6, 2023.
   Google Scholar
• Tctr. Efficacy and safety of oral spironolactone combined with 3% topical minoxidil for the treatment of female pattern hair loss in premenopausal women: a randomized, double- blind, placebo-controlled study; 2022. Available from: https://trialsearchwhoint/Trial2aspx?TrialID=TCTR20220613005. Accessed March 6, 2023.
   Google Scholar
• Soliman AM, Hussein SM, El-Alim SHA, et al. Assessment of the efficacy of topical antiandrogen; spironolactone in patients with androgenetic alopecia by dermoscopy. J Pak Assoc Dermatol. 2022;32(3):493–501.
   Google Scholar