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Clinical, Cosmetic and Investigational Dermatology Volume 16, 2023 - Issue
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RAPID COMMUNICATION

Efficacy and Safety of Secukinumab in Elderly Patients with Moderate to Severe Plaque-Type Psoriasis: Post-Hoc Analysis of the SUPREME Study

Marina Talamonti1 Dermatology, University of Rome Tor Vergata, Rome, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-3070-4071View further author information
ORCID Icon,
Filomena Russo2 Department of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria alle Scotte Hospital, Siena, ItalyORCID Iconhttps://orcid.org/0000-0003-2780-7720View further author information
ORCID Icon,
Giovanna Malara3 Dermatology Unit, Hospital “Bianchi Melacrino Morelli”, Reggio, Calabria, Italy;4 Department of Dermatology, Papardo Hospital, Messina, ItalyView further author information
,
Katharina Hansel5 Section of Dermatology, Department of Medicine and Surgery, University of Perugia, Perugia, ItalyView further author information
,
Manuela Papini6 Dermatologic Clinic of Terni, Department of Medicine and Surgery, University of Perugia, Perugia, ItalyORCID Iconhttps://orcid.org/0000-0003-4679-4080View further author information
ORCID Icon,
Angelo Cattaneo7 U.O. Dermatologia, Fondazione IRCCS Ca’ Granda - Ospedale Maggiore Policlinico, Milano, ItalyView further author information
,
Aurora Parodi8 Di.S.Sal. Section of Dermatology, Ospedale Policlinico San Martino, University of Genova, Genova GE, 16132, ItalyView further author information
,
Andrea Chiricozzi9 UOC di Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli - IRCCS, Rome, Italy;10 Dermatologia, Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, ItalyORCID Iconhttps://orcid.org/0000-0002-6739-0387View further author information
ORCID Icon,
Piergiorgio Malagoli11 Psocare Unit, I.R.C.C.S Policlinico San Donato, Milano, ItalyView further author information
,
Federico Bardazzi12 Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyView further author information
,
Valeria Brazzelli13 Dermatology, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, ItalyView further author information
,
Paolo Dapavo14 Department of Biomedical Science and Human Oncology, Second Dermatologic Clinic, University of Torino, Torino, ItalyView further author information
,
Paolo Gisondi15 Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, ItalyORCID Iconhttps://orcid.org/0000-0002-1777-9001View further author information
ORCID Icon,
Cristina Zane16 Dermatology Department, ASST Spedali Civili di Brescia, University of Brescia, Brescia, ItalyView further author information
,
Concetta Potenza17 Dermatology Unit “Daniele Innocenzi”, Department of Medico-Surgical Sciences and Biotechnologies, Faculty of Pharmacy and Medicine, Sapienza University of Rome – Polo Pontino, Latina, ItalyView further author information
,
Franca Cantoresi18 Dermatology Unit, Department of Medicine, University of Roma, Roma, ItalyView further author information
,
Maria Concetta Fargnoli19 Dermatology, Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, ItalyORCID Iconhttps://orcid.org/0000-0002-7249-2556View further author information
ORCID Icon,
Sara Trevisini20 Department of Dermatology, University of Trieste, Trieste, ItalyView further author information
,
Pina Brianti21 Dermatology and Cosmetology Unit - San Raffaele Hospital, Milan, ItalyView further author information
,
Leonardo Pescitelli22 Department of Health Sciences, Dermatology Clinic, University of Firenze, Firenze, ItalyView further author information
,
Giovanni Gigante23 Novartis Farma SpA, Origgio, ItalyView further author information
,
Marta Bartezaghi23 Novartis Farma SpA, Origgio, ItalyView further author information
,
Luisa Caputo23 Novartis Farma SpA, Origgio, ItalyView further author information
,
Elisabetta Aloisi23 Novartis Farma SpA, Origgio, ItalyView further author information
&
Antonio Costanzo24 Unit of Dermatology, IRCCS Humanitas Research Hospital, Milano, Italy;25 Department of Biomedical Sciences, Humanitas University, Milano, ItalyView further author information
 show all
Pages 847-852 | Received 13 Dec 2022, Accepted 21 Mar 2023, Published online: 01 Apr 2023

References

  • Griffiths CEM, Armstrong AW, Gudjonsson JE, et al. Psoriasis. Lancet. 2021;397(10281):1301–1315. doi:10.1016/S0140-6736(20)32549-6
  • Michalek IM, Loring B, John SM. A systematic review of worldwide epidemiology of psoriasis. J Eur Acad Dermatol Venereol. 2017;31:205–212. doi:10.1111/jdv.13854
  • Iskandar IYK, Parisi R, Griffiths CEM, et al. Systematic review examining changes over time and variation in the incidence and prevalence of psoriasis by age and gender. Br J Dermatol. 2021;184:243–258. doi:10.1111/bjd.19169
  • van Winden MEC, Haar ELM, Groenewoud HMM, et al. Disease and treatment characteristics in geriatric psoriasis: a patient survey comparing age groups. Acta Derm Venereol. 2020;100(14):adv00215. doi:10.2340/00015555-3569
  • Megna M, Camela E, Cinelli E, Fabbrocini G. Real-life efficacy and safety of secukinumab in elderly patients with psoriasis over a 2-year period. Clin Exp Dermatol. 2020;45:848–852. doi:10.1111/ced.14258
  • Bakirtzi K, Sotiriou E, Papadimitriou I, et al. Elderly patients with psoriasis: long-term efficacy and safety of modern treatments. J Dermatol Treat. 2022;33:1339–1342. doi:10.1080/09546634.2020.1809623
  • Balato N, Patruno C, Napolitano M, et al. Managing moderate-to-severe psoriasis in the elderly. Drugs Aging. 2014;31(4):233–238. doi:10.1007/s40266-014-0156-6
  • Phan C, Sigal M-L, Estève E, et al. Psoriasis in the elderly: epidemiological and clinical aspects, and evaluation of patients with very late onset psoriasis. J Eur Acad Dermatol Venereol. 2016;30:78–82. doi:10.1111/jdv.12850
  • Sbidian E, Chaimani A, Afach S, et al. Systematic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis. Cochrane Database Syst Rev. 2020. doi:10.1002/14651858.CD011535.pub3
  • Costanzo A, Bianchi L, Flori ML, et al. Secukinumab shows high efficacy irrespective of HLA-Cw6 status in patients with moderate-to-severe plaque-type psoriasis: SUPREME study. Br J Dermatol. 2018;179:1072–1080. doi:10.1111/bjd.16705
  • Costanzo A, Russo F, Galluzzo M, et al. Secukinumab exhibits sustained and stable response in patients with moderate-to-severe psoriasis: results from the SUPREME study. Acta Derm Venereol. 2021;101:adv00576. doi:10.2340/00015555-3816
  • Körber A, Papavassilis C, Bhosekar V, Reinhardt M. Efficacy and safety of secukinumab in elderly subjects with moderate to severe plaque psoriasis: a pooled analysis of phase III studies. Drugs Aging. 2018;35(2):135–144. doi:10.1007/s40266-018-0520-z
  • Phan C, Beneton N, Dalaunay J, et al. Effectiveness and safety of anti-interleukin-17 therapies in elderly patients with psoriasis. Acta Derm Venereol. 2020;100:adv00316. doi:10.2340/00015555-3678
  • van Winden MEC, Haar ELM, Groenewoud JMM, Kerkhof PCM, Jong EMGJ, Lubeek SFK. Quality of life, treatment goals, preferences and satisfaction in older patients with psoriasis: a patient survey comparing age groups. Br J Dermatol. 2021;184(4):759–762. doi:10.1111/bjd.19665

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