Autophagy Inhibits Inflammation via Down-Regulation of p38 MAPK/mTOR Signaling Cascade in Endothelial Cells

References

• Liu J, Kuang F, Kroemer G, Klionsky DJ, Kang R, Tang D. Autophagy-dependent ferroptosis: machinery and regulation. Cell Chem Biol. 2020;27(4):420–435. doi:10.1016/j.chembiol.2020.02.005
   PubMed Web of Science ®Google Scholar
• Hazari Y, Bravo-San Pedro JM, Hetz C, Galluzzi L, Kroemer G. Autophagy in hepatic adaptation to stress. J Hepatol. 2020;72(1):183–196. doi:10.1016/j.jhep.2019.08.026
   PubMed Web of Science ®Google Scholar
• Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell. 2008;132(1):27–42. doi:10.1016/j.cell.2007.12.018
   PubMed Web of Science ®Google Scholar
• Galluzzi L, Pietrocola F, Levine B, Kroemer G. Metabolic control of autophagy. Cell. 2014;159(6):1263–1276. doi:10.1016/j.cell.2014.11.006
   PubMed Web of Science ®Google Scholar
• Netea-Maier RT, Plantinga TS, van de Veerdonk FL, Smit JW, Netea MG. Modulation of inflammation by autophagy: consequences for human disease. Autophagy. 2016;12(2):245–260. doi:10.1080/15548627.2015.1071759
   PubMed Web of Science ®Google Scholar
• Wu DJ, Adamopoulos IE. Autophagy and autoimmunity. Clin Immunol. 2017;176:55–62. doi:10.1016/j.clim.2017.01.007
   PubMed Web of Science ®Google Scholar
• Li XM, Jung KE, Yim SH, et al. Autophagy suppresses toll-like receptor 3-mediated inflammatory reaction in human epidermal keratinocytes. Biomed Res Int. 2020;2020:4584626. doi:10.1155/2020/4584626
   PubMed Web of Science ®Google Scholar
• Cao Y, Chen J, Ren G, Zhang Y, Tan X, Yang L. Punicalagin prevents inflammation in LPS-Induced RAW264.7 macrophages by Inhibiting FoxO3a/autophagy signaling pathway. Nutrients. 2019;11(11):2794. doi:10.3390/nu11112794
   PubMed Web of Science ®Google Scholar
• Green DR, Galluzzi L, Kroemer G. Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science. 2011;333(6046):1109–1112. doi:10.1126/science.1201940
   PubMed Web of Science ®Google Scholar
• Levine B, Mizushima N, Virgin HW. Autophagy in immunity and inflammation. Nature. 2011;469(7330):323–335. doi:10.1038/nature09782
   PubMed Web of Science ®Google Scholar
• Zhang Q, Kang R, Zeh HJ, et al. DAMPs and autophagy: cellular adaptation to injury and unscheduled cell death. Autophagy. 2013;9(4):451–458. doi:10.4161/auto.23691
   PubMed Web of Science ®Google Scholar
• Yang Z, Klionsky DJ. Eaten alive: a history of macroautophagy. Nat Cell Biol. 2010;12(9):814–822. doi:10.1038/ncb0910-814
   PubMed Web of Science ®Google Scholar
• Yang Z, Klionsky DJ. Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol. 2010;22(2):124–131. doi:10.1016/j.ceb.2009.11.014
   PubMed Web of Science ®Google Scholar
• Ko JH, Yoon S-O, Lee HJ, Oh JY. Rapamycin regulates macrophage activation by inhibiting NLRP3 inflammasome-p38 MAPK-NFκB pathways in autophagy- and p62-dependent manners. Oncotarget. 2017;8(25):40817–40831. doi:10.18632/oncotarget.17256
   PubMedGoogle Scholar
• Sui X, Kong N, Ye L, et al. p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic. Cancer Lett. 2014;344(2):174–179. doi:10.1016/j.canlet.2013.11.019
   PubMed Web of Science ®Google Scholar
• Vicic M, Kaštelan M, Brajac I, et al. Current concepts of psoriasis immunopathogenesis. Int J Mol Sci. 2021;22(21):11574. doi:10.3390/ijms222111574
   PubMed Web of Science ®Google Scholar
• Aryanian Z, Jafaripour I, Kohneshin E, et al. Echocardiographic and electrocardiographic assessments in patients with psoriasis. Caspian J Intern Med. 2021;12(2):162–166. doi:10.22088/cjim.12.2.162
   PubMed Web of Science ®Google Scholar
• Locker F, Vidali S, Holub BS, et al. Lack of galanin receptor 3 alleviates psoriasis by altering vascularization, immune cell infiltration, and cytokine expression. J Invest Dermatol. 2018;138(1):199–207. doi:10.1016/j.jid.2017.08.015
   PubMed Web of Science ®Google Scholar
• Rubina KA, Yu Sysoeva V, Zagorujko EI, et al. Increased expression of uPA, uPAR, and PAI-1 in psoriatic skin and in basal cell carcinomas. Arch Dermatol Res. 2017;309(6):433–442. doi:10.1007/s00403-017-1738-z
   PubMed Web of Science ®Google Scholar
• Barrera M-J, Aguilera S, Castro I, et al. Tofacitinib counteracts IL-6 overexpression induced by deficient autophagy: implications in Sjögren’s syndrome. Rheumatology. 2021;60(4):1951–1962. doi:10.1093/rheumatology/keaa670
   PubMed Web of Science ®Google Scholar
• Zhou L, Wang J, Liang J, et al. Psoriatic mesenchymal stem cells stimulate the angiogenesis of human umbilical vein endothelial cells in vitro. Microvasc Res. 2021;136:104151. doi:10.1016/j.mvr.2021.104151
   PubMed Web of Science ®Google Scholar
• Hou R, Yin G, Peng A, et al. DNA methylation of dermal MSCs in psoriasis: identification of epigenetically dysregulated genes. J Dermatol Sci. 2013;72(2):103–109. doi:10.1016/j.jdermsci.2013.07.002
   PubMed Web of Science ®Google Scholar
• Zhou L, Niu X, Liang J, et al. Efficient differentiation of vascular endothelial cells from dermal-derived mesenchymal stem cells induced by endothelial cell lines conditioned medium. Acta Histochem. 2018;120(8):734–740. doi:10.1016/j.acthis.2018.08.004
   PubMed Web of Science ®Google Scholar
• Yang B, Renlei J, Xueshan L, et al. Activation of autophagy relieves linoleic acid-induced inflammation in large yellow croaker (Larimichthys crocea). Front Immunol. 2021;12:649385. doi:10.3389/fimmu.2021.649385
   PubMed Web of Science ®Google Scholar
• Hamada M, Kameyama H, Iwai S, Yura Y. Induction of autophagy by sphingosine kinase 1 inhibitor PF-543 in head and neck squamous cell carcinoma cells. Cell Death Discov. 2017;3:17047. doi:10.1038/cddiscovery.2017.47
   PubMed Web of Science ®Google Scholar
• Liu Y, Fan D. Ginsenoside Rg5 induces G2/M phase arrest, apoptosis and autophagy via regulating ROS-mediated MAPK pathways against human gastric cancer. Biochem Pharmacol. 2019;68:285–304. doi:10.1016/j.bcp.2019.07.008
   Google Scholar
• He Y, She H, Zhang T, et al. p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1. J Cell Biol. 2018;217(1):315–328. doi:10.1083/jcb.201701049
   PubMed Web of Science ®Google Scholar
• Wang C, Wang H, Zhang D, et al. Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy. Nat Commun. 2018;9(1):3492. doi:10.1038/s41467-018-05449-1
   PubMed Web of Science ®Google Scholar
• Mercurio L, Failla CM, Capriotti L, et al. Interleukin (IL)-17/IL-36 axis participates to the crosstalk between endothelial cells and keratinocytes during inflammatory skin responses. PLoS One. 2020;15(4):e0222969. doi:10.1371/journal.pone.0222969
   PubMed Web of Science ®Google Scholar
• Alba BK, Greaney JL, Ferguson SB, Alexander LM. Endothelial function is impaired in the cutaneous microcirculation of adults with psoriasis through reductions in nitric oxide-dependent vasodilation. Am J Physiol Heart Circ Physiol. 2018;314(2):H343–H349. doi:10.1152/ajpheart.00446.2017
   PubMed Web of Science ®Google Scholar
• Harden JL, Lewis SM, Pierson KC, et al. CARD14 expression in dermal endothelial cells in psoriasis. PLoS One. 2014;9(11):e111255. doi:10.1371/journal.pone.0111255
   PubMed Web of Science ®Google Scholar
• Yufeng X, Rong J, Wang Y. Roles of Annexin A protein family in autophagy regulation and therapy. Biomed Pharmacother. 2020;130:110591. doi:10.1016/j.biopha.2020.110591
   PubMed Web of Science ®Google Scholar
• Krysko DV, Berghe TV, Parthoens E, et al. Methods for distinguishing apoptotic from necrotic cells and measuring their clearance. Methods Enzymol. 2008;442:307–341.
   PubMed Web of Science ®Google Scholar
• Deretic V, Saitoh T, Akira S. Autophagy in infection, inflammation and immunity. Nat Rev Immunol. 2013;13(10):722–737. doi:10.1038/nri3532
   PubMed Web of Science ®Google Scholar
• Harris J, Hartman M, Roche C, et al. Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation. J Biol Chem. 2011;286(11):9587–9597. doi:10.1074/jbc.M110.202911
   PubMed Web of Science ®Google Scholar
• Deretic V, Levine B. Autophagy balances inflammation in innate immunity. Autophagy. 2018;14(2):243–251. doi:10.1080/15548627.2017.1402992
   PubMed Web of Science ®Google Scholar
• Lv H, Liu X, Chen W, et al. Yangxue jiedu fang ameliorates psoriasis by regulating vascular regression via Survivin/PI3K/Akt pathway. J Immunol Res. 2021;2021:4678087. doi:10.1155/2021/4678087
   PubMed Web of Science ®Google Scholar
• Pan S-T, Qin Y, Zhou Z-W, et al. Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells. Drug Des Devel Ther. 2015;9:1601–1626. doi:10.2147/DDDT.S76057
   PubMed Web of Science ®Google Scholar
• Zhao Y, Huina W, Xing X, et al. CD13 induces autophagy to promote hepatocellular carcinoma cell chemoresistance through the P38/ Hsp27/CREB/ATG7 pathway. J Pharmacol Exp Ther. 2020;374(3):512–520. doi:10.1124/jpet.120.265637
   PubMed Web of Science ®Google Scholar
• Webber JL, Tooze SA. New insights into the function of Atg9. FEBS Lett. 2010;584(7):1319–1326. doi:10.1016/j.febslet.2010.01.020
   PubMed Web of Science ®Google Scholar
• Williams A, Sarkar S, Cuddon P, et al. Novel targets for Huntington’s disease in an mTOR-independent autophagy pathway. Nat Chem Biol. 2008;4(5):295–305. doi:10.1038/nchembio.79
   PubMed Web of Science ®Google Scholar
• Ganley IG, Lam DH, Wang J, Ding X, Chen S, Jiang X. ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem. 2009;284(18):12297–12305. doi:10.1074/jbc.M900573200
   PubMed Web of Science ®Google Scholar
• Unno R, Kawabata T, Taguchi K, et al. Deregulated MTOR (mechanistic target of rapamycin kinase) is responsible for autophagy defects exacerbating kidney stone development. Autophagy. 2020;16(4):709–723. doi:10.1080/15548627.2019.1635382
   PubMed Web of Science ®Google Scholar
• Saito H, Godo S, Sato S, et al. Important role of endothelial Caveolin-1 in the protective role of endothelium-dependent hyperpolarization against nitric oxide-mediated nitrative stress in microcirculation in mice. J Cardiovasc Pharmacol. 2018;71(2):113–126. doi:10.1097/FJC.0000000000000552
   PubMed Web of Science ®Google Scholar
• Karbach S, Wenzel P, Waisman A, Munzel T, Daiber A. eNOS uncoupling in cardiovascular diseases--The role of oxidative stress and inflammation. Curr Pharm Des. 2014;20(22):3579–3594. doi:10.2174/13816128113196660748
   PubMed Web of Science ®Google Scholar
• Karbach S, Croxford AL, Oelze M, et al. Interleukin 17 drives vascular inflammation, endothelial dysfunction, and arterial hypertension in psoriasis-like skin disease. Arterioscler Thromb Vasc Biol. 2014;34(12):2658–2668. doi:10.1161/ATVBAHA.114.304108
   PubMed Web of Science ®Google Scholar
• Pestana CR, Oishi JC, Salistre-Araújo HS, et al. Inhibition of autophagy by chloroquine stimulates nitric oxide production and protects endothelial function during serum deprivation. Cell Physiol Biochem. 2015;37(3):1168–1177. doi:10.1159/000430240
   PubMedGoogle Scholar