208
Views
1
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

TET2 Promotes Keloid Hyperplasia by Regulating 5hmC Modification in the TGFβ Promoter Region

& ORCID Icon
Pages 1063-1070 | Received 22 Feb 2023, Accepted 12 Apr 2023, Published online: 21 Apr 2023

References

  • Limandjaja GC, Niessen FB, Scheper RJ, Gibbs S. The keloid disorder: heterogeneity, histopathology, mechanisms and models. Front Cell Dev Biol. 2020;8:360. doi:10.3389/fcell.2020.00360
  • Rippa AL, Kalabusheva EP, Vorotelyak EA. Regeneration of dermis: scarring and cells involved. Cells. 2019;8(6):607. doi:10.3390/cells8060607
  • Berman B, Maderal A, Keloids RB. Hypertrophic scars: pathophysiology, classification, and treatment. Dermatol Surg. 2017;43(Suppl 1):S3–s18. doi:10.1097/DSS.0000000000000819
  • Har-Shai Y, Brown W, Labbé D, et al. Intralesional cryosurgery for the treatment of hypertrophic scars and keloids following aesthetic surgery: the results of a prospective observational study. Int J Low Extrem Wounds. 2008;7(3):169–175. doi:10.1177/1534734608322813
  • Martin P, Nunan R. Cellular and molecular mechanisms of repair in acute and chronic wound healing. Br J Dermatol. 2015;173(2):370–378. doi:10.1111/bjd.13954
  • Ito S, Shen L, Dai Q, et al. Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science. 2011;333(6047):1300–1303. doi:10.1126/science.1210597
  • Blaschke K, Ebata KT, Karimi MM, et al. Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells. Nature. 2013;500(7461):222–226. doi:10.1038/nature12362
  • Seritrakul P, Gross JM. Tet-mediated DNA hydroxymethylation regulates retinal neurogenesis by modulating cell-extrinsic signaling pathways. PLoS Genet. 2017;13(9):e1006987–e1006987. doi:10.1371/journal.pgen.1006987
  • Sardina JL, Collombet S, Tian TV, et al. Transcription factors drive Tet2-mediated enhancer demethylation to reprogram cell fate. Cell Stem Cell. 2018;23(5):727–741.e729. doi:10.1016/j.stem.2018.08.016
  • Rodríguez-Aguilera JR, Ecsedi S, Goldsmith C, et al. Genome-wide 5-hydroxymethylcytosine (5hmC) emerges at early stage of in vitro differentiation of a putative hepatocyte progenitor. Sci Rep. 2020;10(1):7822. doi:10.1038/s41598-020-64700-2
  • Lichtman MK, Otero-Vinas M, Falanga V. Transforming growth factor beta (TGF-β) isoforms in wound healing and fibrosis. Wound Repair Regen. 2016;24(2):215–222. doi:10.1111/wrr.12398
  • Nong Q, Li S, Wu Y, LncRNA LD. COL1A2-AS1 inhibits the scar fibroblasts proliferation via regulating miR-21/Smad7 pathway. Biochem Biophys Res Commun. 2018;495(1):319–324. doi:10.1016/j.bbrc.2017.11.027
  • Zhang Y-F, Wang Q, Luo J, Yang S, Wang J-L, Li H-Y. Knockdown of elF3a inhibits collagen synthesis in renal fibroblasts via Inhibition of transforming growth factor-β1/Smad signaling pathway. Int J Clin Exp Pathol. 2015;8(8):8983–8989.
  • Luan P, Jian W, Xu X, et al. NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPARγ. Nat Commun. 2019;10(1):2882. doi:10.1038/s41467-019-10784-y
  • Association WM. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2013;310(20):2191–2194. doi:10.1001/jama.2013.281053
  • Zhang Z, Jin Y, Zhang W, et al. Values of 5mC, 5hmC, and TET2 for identifying the presence and progression of breast precancerous lesion. J Clin Lab Anal. 2020;34(5):e23162–e23162.
  • Chen B, Lei Y, Wang H, et al. Repression of the expression of TET2 by ZEB1 contributes to invasion and growth in glioma cells. Mol Med Rep. 2017;15(5):2625–2632. doi:10.3892/mmr.2017.6288
  • Melamed P, Yosefzon Y, David C, Tsukerman A, Pnueli L. Tet enzymes, variants, and differential effects on function. Front Cell Dev Biol. 2018;6:22. doi:10.3389/fcell.2018.00022
  • Ren Y, Song Z, Rieser J, et al. USP15 represses hepatocellular carcinoma progression by regulation of pathways of cell proliferation and cell migration: a system biology analysis. Cancers. 2023;15(5):1371. doi:10.3390/cancers15051371
  • Murphy-Marshman H, Quensel K, Shi-Wen X, et al. Antioxidants and NOX1/NOX4 inhibition blocks TGFβ1-induced CCN2 and α-SMA expression in dermal and gingival fibroblasts. PLoS One. 2017;12(10):e0186740. doi:10.1371/journal.pone.0186740