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ORIGINAL RESEARCH

Construction and Identification of an NLR-Associated Prognostic Signature Revealing the Heterogeneous Immune Response in Skin Cutaneous Melanoma

ORCID Icon, , , , , , & show all
Pages 1623-1639 | Received 28 Mar 2023, Accepted 31 May 2023, Published online: 26 Jun 2023

References

  • Lv H, Liu X, Zeng X, et al. Comprehensive analysis of cuproptosis-related genes in immune infiltration and prognosis in melanoma. Front Pharmacol. 2022;13:930041. doi:10.3389/fphar.2022.930041
  • Banach K, Kowalska J, Rzepka Z, Beberok A, Rok J, Wrzesniok D. The role of uva radiation in ketoprofen-mediated braf-mutant amelanotic melanoma cells death - a study at the cellular and molecular level. Toxicol in Vitro. 2021;72:105108. doi:10.1016/j.tiv.2021.105108
  • Zhang W, Xie X, Huang Z, et al. The integration of single-cell sequencing, TCGA, and geo data analysis revealed that prrt3-as1 is a biomarker and therapeutic target of skcm. Front Immunol. 2022;13:919145. doi:10.3389/fimmu.2022.919145
  • Singh M, Vianden C, Cantwell MJ, et al. Intratumoral cd40 activation and checkpoint blockade induces t cell-mediated eradication of melanoma in the brain. Nat Commun. 2017;8(1):1447. doi:10.1038/s41467-017-01572-7
  • Wilmanski JM, Petnicki-Ocwieja T, Kobayashi KS. Nlr proteins: integral members of innate immunity and mediators of inflammatory diseases. J Leukoc Biol. 2008;83(1):13–30. doi:10.1189/jlb.0607402
  • Kim YK, Shin JS, Nahm MH. Nod-like receptors in infection, immunity, and diseases. Yonsei Med J. 2016;57(1):5–14. doi:10.3349/ymj.2016.57.1.5
  • Velloso FJ, Trombetta-Lima M, Anschau V, Sogayar MC, Correa RG. Nod-like receptors: major players (and targets) in the interface between innate immunity and cancer. Biosci Rep. 2019;39:4. doi:10.1042/BSR20181709
  • Zheng C. The emerging roles of nod-like receptors in antiviral innate immune signaling pathways. Int J Biol Macromol. 2021;169:407–413. doi:10.1016/j.ijbiomac.2020.12.127
  • Cui J, Chen Y, Wang HY, Wang RF. Mechanisms and pathways of innate immune activation and regulation in health and cancer. Hum Vaccin Immunother. 2014;10(11):3270–3285. doi:10.4161/21645515.2014.979640
  • Bai L, Li W, Zheng W, Xu D, Chen N, Cui J. Promising targets based on pattern recognition receptors for cancer immunotherapy. Pharmacol Res. 2020;159:105017. doi:10.1016/j.phrs.2020.105017
  • Saxena M, Yeretssian G. Nod-like receptors: master regulators of inflammation and cancer. Front Immunol. 2014;5:327. doi:10.3389/fimmu.2014.00327
  • Goutagny N, Estornes Y, Hasan U, Lebecque S, Caux C. Targeting pattern recognition receptors in cancer immunotherapy. Target Oncol. 2012;7(1):29–54. doi:10.1007/s11523-012-0213-1
  • Zhong Y, Kinio A, Saleh M. Functions of nod-like receptors in human diseases. Front Immunol. 2013;4:333. doi:10.3389/fimmu.2013.00333
  • Zhai Z, Liu W, Kaur M, et al. Nlrp1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma. Oncogene. 2017;36(27):3820–3830. doi:10.1038/onc.2017.26
  • Verma D, Bivik C, Farahani E, et al. Inflammasome polymorphisms confer susceptibility to sporadic malignant melanoma. Pigment Cell Melanoma Res. 2012;25(4):506–513. doi:10.1111/j.1755-148X.2012.01008.x
  • Auslander N, Zhang G, Lee JS, et al. Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma. Nat Med. 2018;24(10):1545–1549. doi:10.1038/s41591-018-0157-9
  • Yoshihara K, Shahmoradgoli M, Martinez E, et al. Inferring tumour purity and stromal and immune cell admixture from expression data. Nat Commun. 2013;4:2612. doi:10.1038/ncomms3612
  • Wang H, Xia L, Yao CC, et al. Nlrp4 negatively regulates type i interferon response and influences the outcome in anti-programmed cell death protein (pd)-1/pd-ligand 1 therapy. Cancer Sci. 2022;113(3):838–851. doi:10.1111/cas.15243
  • Ozbayer C, Kurt H, Bayramoglu A, et al. The role of nod1/card4 and nod2/card15 genetic variations in lung cancer risk. Inflamm Res. 2015;64(10):775–779. doi:10.1007/s00011-015-0859-0
  • Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proil-beta. Mol Cell. 2002;10(2):417–426. doi:10.1016/s1097-2765(02)00599-3
  • Chen G, Shaw MH, Kim YG, Nunez G. Nod-like receptors: role in innate immunity and inflammatory disease. Annu Rev Pathol. 2009;4:365–398. doi:10.1146/annurev.pathol.4.110807.092239
  • Da SCJ, Miranda Y, Austin-Brown N, et al. Nod1-dependent control of tumor growth. Proc Natl Acad Sci USA. 2006;103(6):1840–1845. doi:10.1073/pnas.0509228103
  • Lener MR, Oszutowska D, Castaneda J, et al. Prevalence of the nod2 3020insc mutation in aggregations of breast and lung cancer. Breast Cancer Res Treat. 2006;95(2):141–145. doi:10.1007/s10549-005-9057-z
  • Wang Z, Hou H, Zhang H, Duan X, Li L, Meng L. Effect of muc16 mutations on tumor mutation burden and its potential prognostic significance for cutaneous melanoma. Am J Transl Res. 2022;14(2):849–862.
  • Komohara Y, Fujiwara Y, Ohnishi K, Takeya M. Tumor-associated macrophages: potential therapeutic targets for anti-cancer therapy. Adv Drug Deliv Rev. 2016;99(Pt B):180–185. doi:10.1016/j.addr.2015.11.009
  • Partecke LI, Gunther C, Hagemann S, et al. Induction of m2-macrophages by tumour cells and tumour growth promotion by m2-macrophages: a quid pro quo in pancreatic cancer. Pancreatology. 2013;13(5):508–516. doi:10.1016/j.pan.2013.06.010
  • He X, Xu C. Immune checkpoint signaling and cancer immunotherapy. Cell Res. 2020;30(8):660–669. doi:10.1038/s41422-020-0343-4
  • Samstein RM, Lee CH, Shoushtari AN, et al. Tumor mutational load predicts survival after immunotherapy across multiple cancer types. Nat Genet. 2019;51(2):202–206. doi:10.1038/s41588-018-0312-8
  • Song LB, Luan JC, Zhang QJ, et al. The identification and validation of a robust immune-associated gene signature in cutaneous melanoma. J Immunol Res. 2021;2021:6686284. doi:10.1155/2021/6686284
  • Mei Y, Chen MM, Liang H, Ma L. A four-gene signature predicts survival and anti-ctla4 immunotherapeutic responses based on immune classification of melanoma. Commun Biol. 2021;4(1):383. doi:10.1038/s42003-021-01911-x
  • Udden S, Peng L, Gan JL, et al. Nod2 suppresses colorectal tumorigenesis via downregulation of the tlr pathways. Cell Rep. 2017;19(13):2756–2770. doi:10.1016/j.celrep.2017.05.084
  • Couturier-Maillard A, Secher T, Rehman A, et al. Nod2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. J Clin Invest. 2013;123(2):700–711. doi:10.1172/JCI62236
  • Wright CM, Savarimuthu FS, Tan ME, et al. Ms4a1 dysregulation in asbestos-related lung squamous cell carcinoma is due to cd20 stromal lymphocyte expression. PLoS One. 2012;7(4):e34943. doi:10.1371/journal.pone.0034943
  • Hammouda MB, Ford AE, Liu Y, Zhang JY. The jnk signaling pathway in inflammatory skin disorders and cancer. Cells. 2020;9(4). doi:10.3390/cells9040857
  • Gao Y, Wang Y, Wang X, et al. Mir-335-5p suppresses gastric cancer progression by targeting mapk10. Cancer Cell Int. 2021;21(1):71. doi:10.1186/s12935-020-01684-z
  • Qiao B, Wang Q, Zhao Y, Wu J. Mir-205-3p functions as a tumor suppressor in ovarian carcinoma. Reprod Sci. 2020;27(1):380–388. doi:10.1007/s43032-019-00047-y
  • Nie S, Ni N, Chen N, et al. Development of a necroptosis-related gene signature and the immune landscape in ovarian cancer. J Ovarian Res. 2023;16(1):82. doi:10.1186/s13048-023-01155-9
  • Lian W, Zheng X. Identification and validation of tme-related signatures to predict prognosis and response to anti-tumor therapies in skin cutaneous melanoma. Funct Integr Genomics. 2023;23(2):153. doi:10.1007/s10142-023-01051-x
  • Marzano AV, Trevisan V, Gattorno M, Ceccherini I, De Simone C, Crosti C. Pyogenic arthritis, pyoderma gangrenosum, acne, and hidradenitis suppurativa (papash): a new autoinflammatory syndrome associated with a novel mutation of the pstpip1 gene. JAMA Dermatol. 2013;149(6):762–764. doi:10.1001/jamadermatol.2013.2907
  • Zhao Z, Zhong X, Wu T, et al. Identification of a nfkbia polymorphism associated with lower nfkbia protein levels and poor survival outcomes in patients with glioblastoma multiforme. Int J Mol Med. 2014;34(5):1233–1240. doi:10.3892/ijmm.2014.1932
  • Zou J, Xia H, Zhang C, et al. Casp8 acts through a20 to inhibit pd-l1 expression: the mechanism and its implication in immunotherapy. Cancer Sci. 2021;112(7):2664–2678. doi:10.1111/cas.14932
  • Danquah M. Embelin and its derivatives: design, synthesis, and potential delivery systems for cancer therapy. Pharmaceuticals. 2022;15(9). doi:10.3390/ph15091131
  • Ahmad I, Dera AA, Irfan S, et al. Bv6 enhances apoptosis in lung cancer cells by ameliorating caspase expressions through attenuation of xiap, ciap-1, and ciap-2 proteins. J Cancer Res Ther. 2022;18(6):1651–1657. doi:10.4103/jcrt.JCRT_1281_20
  • Miles MA, Caruso S, Baxter AA, Poon I, Hawkins CJ. Smac mimetics can provoke lytic cell death that is neither apoptotic nor necroptotic. Apoptosis. 2020;25(7–8):500–518. doi:10.1007/s10495-020-01610-8
  • Cremona M, Vandenberg CJ, Farrelly AM, et al. BRCA mutations lead to xiap overexpression and sensitise ovarian cancer to inhibitor of apoptosis (iap) family inhibitors. Br J Cancer. 2022;127(3):488–499. doi:10.1038/s41416-022-01823-5
  • Ye F, Cai Z, Wang B, et al. Tgf-beta antagonizes ifn-gamma-mediated adaptive immune evasion via activation of the akt-smad3-shp1 axis in lung adenocarcinoma. Cancer Res. 2023. doi:10.1158/0008-5472.CAN-22-3009
  • Boutilier AJ, Elsawa SF. Macrophage polarization states in the tumor microenvironment. Int J Mol Sci. 2021;22(13). doi:10.3390/ijms22136995