Quaternary Ammonium Compounds and Contact Dermatitis: A Review and Considerations During the COVID-19 Pandemic

References

• United States Environmental Protection Agency. List N. disinfectants for use against SARS-CoV-2; 2022. Available from: https://www.epa.gov/pesticide-registration/list-n-disinfectants-coronavirus-covid-19. Accessed July 27, 2022.
   Google Scholar
• Bures F. Quaternary ammonium compounds: simple in structure, complex in application. Top Curr Chem. 2019;377(3):14. doi:10.1007/s41061-019-0239-2
   PubMed Web of Science ®Google Scholar
• McKeen L. 1 - Introduction to Food Irradiation and Medical Sterilization. In: McKeen L, editor. The Effect of Sterilization on Plastics and Elastomers. 3rd ed. William Andrew Publishing; 2012:1–40.
   Google Scholar
• Ioannou CJ, Hanlon GW, Denyer SP. Action of disinfectant quaternary ammonium compounds against staphylococcus aureus. Antimicrob Agents Chemother. 2007;51(1):296–306. doi:10.1128/aac.00375-06
   PubMed Web of Science ®Google Scholar
• Shutty BG, Scheinman PL. occupationally induced allergic contact dermatitis to aerosolized quaternary ammonium compounds. Dermatitis. 2017;28(6):369. doi:10.1097/DER.0000000000000326
   PubMed Web of Science ®Google Scholar
• Osimitz TG, Droege W. Quaternary ammonium compounds: perspectives on benefits, hazards, and risk. Toxicol Res Applicat. 2021;5:23978473211049085. doi:10.1177/23978473211049085
   Google Scholar
• Perrenoud D, Bircher A, Hunziker T, et al. Frequency of sensitization to 13 common preservatives in Switzerland. Swiss contact dermatitis research group. Contact Dermatitis. 1994;30(5):276–279. doi:10.1111/j.1600-0536.1994.tb00597.x
   PubMed Web of Science ®Google Scholar
• Warshaw EM, Ahmed RL, Belsito DV, et al. Contact dermatitis of the hands: cross-sectional analyses of North American Contact Dermatitis Group Data, 1994-2004. J Am Acad Dermatol. 2007;57(2):301–314. doi:10.1016/j.jaad.2007.04.016
   PubMed Web of Science ®Google Scholar
• Hamann CR, Duprat G, Dagrosa AT, Mann JA. “Desktop Dermatitis”: a case series of 7 patients with forearm contact dermatitis from frequent surface cleaning. Dermatitis. 2021;32(6):e104–e107. doi:10.1097/DER.0000000000000766
   PubMed Web of Science ®Google Scholar
• Dear K, Palmer A, Nixon R. Contact allergy and allergic contact dermatitis from benzalkonium chloride in a tertiary dermatology center in Melbourne, Australia. Contact Dermatitis. 2021;85:146–153. doi:10.1111/cod.13826
   Web of Science ®Google Scholar
• Stanford D, Georgouras K. Allergic contact dermatitis from benzalkonium chloride in plaster of Paris. Contact Dermatitis. 1996;35(6):371–372. doi:10.1111/j.1600-0536.1996.tb02427.x
   PubMed Web of Science ®Google Scholar
• Wong DA, Watson AB. Allergic contact dermatitis due to benzalkonium chloride in plaster of Paris. Australas J Dermatol. 2001;42(1):33–35. doi:10.1046/j.1440-0960.2001.00469.x
   PubMedGoogle Scholar
• Zhang AJ, Boyd AH, Schlarbaum JP, Warshaw EM. Allergic contact dermatitis secondary to the use of a bandage impregnated with benzalkonium chloride. Contact Dermatitis. 2018;79(6):387–388. doi:10.1111/cod.13091
   PubMed Web of Science ®Google Scholar
• Amin KA, Belsito DV. The aetiology of eyelid dermatitis: a 10-year retrospective analysis. Contact Dermatitis. 2006;55(5):280–285. doi:10.1111/j.1600-0536.2006.00927.x
   PubMed Web of Science ®Google Scholar
• Orsini D, D’Arino A, Pigliacelli F, Assorgi C, Latini A, Cristaudo A. Allergic contact dermatitis to dorzolamide and benzalkonium chloride. Postepy Dermatol Alergol. 2018;35(5):538–539. doi:10.5114/ada.2018.73859
   PubMed Web of Science ®Google Scholar
• Suchi ST, Gupta A, Srinivasan R. Contact allergic dermatitis and periocular depigmentation after using olapatidine eye drops. Indian J Ophthalmol. 2008;56(5):439–440. doi:10.4103/0301-4738.42431
   PubMed Web of Science ®Google Scholar
• Tartari F, Vincenzi C, Di Altobrando A, Bruni F, Neri I. Allergic contact dermatitis to benzalkonium chloride with erythema multiforme-like reaction in a child. Contact Dermatitis. 2020;82(6):397–399. doi:10.1111/cod.13481
   PubMed Web of Science ®Google Scholar
• Saw NK, Hindmarsh JR. Acute irritant reaction to an antiseptic bath emollient. Postgrad Med J. 2005;81(952):131–132. doi:10.1136/pgmj.2003.018564
   PubMed Web of Science ®Google Scholar
• Afzelius H, Thulin H. Allergic reactions to benzalkonium chloride. Contact Dermatitis. 1979;5(1):60. doi:10.1111/j.1600-0536.1979.tb05546.x
   PubMed Web of Science ®Google Scholar
• Ulicki M, Dendooven E, Aerts O. Triple relevant sensitization to didecyldimethylammonium chloride, benzalkonium chloride, and polyhexamethylene biguanide in a hospital cleaner. Contact Dermatitis. 2022;86(6):546–547. doi:10.1111/cod.14062
   PubMed Web of Science ®Google Scholar
• Isaac J, Scheinman PL. Benzalkonium chloride: an irritant and sensitizer. Dermatitis. 2017;28(6):346–352. doi:10.1097/DER.0000000000000316
   PubMed Web of Science ®Google Scholar
• Geier J, Lessmann H, Cevik N, Fuchs T, Buhl T. Patch testing with didecyldimethylammonium chloride. Contact Dermatitis. 2016;74(6):374–376. doi:10.1111/cod.12539
   PubMed Web of Science ®Google Scholar
• Geier J, Lessmann H, Krautheim A, Fuchs T. Airborne allergic contact dermatitis caused by didecyldimethylammonium chloride in a geriatric nurse. Contact Dermatitis. 2013;68(2):123–125. doi:10.1111/cod.12013
   PubMed Web of Science ®Google Scholar
• Ruiz Oropeza A, Fischer Friis U, Duus Johansen J. Occupational contact urticaria caused by didecyl dimethyl ammonium chloride. Contact Dermatitis. 2011;64(5):297–298. doi:10.1111/j.1600-0536.2011.01882.x
   PubMed Web of Science ®Google Scholar
• Dibo M, Brasch J. Occupational allergic contact dermatitis from N, N-bis(3-aminopropyl)dodecylamine and dimethyldidecylammonium chloride in 2 hospital staff. Contact Dermatitis. 2001;45(1):40. doi:10.1034/j.1600-0536.2001.045001040.x
   PubMed Web of Science ®Google Scholar
• Mowitz M, Ponten A. Foot dermatitis caused by didecyldimethylammonium chloride in a shoe refresher spray. Contact Dermatitis. 2015;73(6):374–376. doi:10.1111/cod.12456
   PubMed Web of Science ®Google Scholar
• Sharma VK, Bhatia R, Yadav CP. Clinical profile and allergens in pigmented cosmetic dermatitis and allergic contact dermatitis to cosmetics in India. Dermatitis. 2018;29(5):264–269. doi:10.1097/DER.0000000000000407
   PubMed Web of Science ®Google Scholar
• Lee JY, Wang BJ. Contact dermatitis caused by cetrimide in antiseptics. Contact Dermatitis. 1995;33(3):168–171. doi:10.1111/j.1600-0536.1995.tb00539.x
   PubMed Web of Science ®Google Scholar
• Engebretsen KA, Hald M, Johansen JD, Thyssen JP. Allergic contact dermatitis caused by an antiseptic containing cetrimide. Contact Dermatitis. 2015;72(1):60–61. doi:10.1111/cod.12303
   PubMed Web of Science ®Google Scholar
• Garg T, Agarwal S, Chander R, Singh A, Yadav P. Patch testing in patients with suspected cosmetic dermatitis: a retrospective study. J Cosmet Dermatol. 2018;17(1):95–100. doi:10.1111/jocd.12359
   PubMed Web of Science ®Google Scholar
• Inman JK. Cetrimide allergy presenting as suspected non-accidental injury. Br Med J. 1982;284(6313):385. doi:10.1136/bmj.284.6313.385
   PubMedGoogle Scholar
• Staniforth P. Allergy to benzalkonium chloride in plaster of Paris after sensitisation to cetrimide. A case report. J Bone Joint Surg Br. 1980;62-B(4):500–501. doi:10.1302/0301-620X.62B4.7430233
   PubMedGoogle Scholar
• Ponten A, Hamnerius N, Bruze M, et al. Occupational allergic contact dermatitis caused by sterile non-latex protective gloves: clinical investigation and chemical analyses. Contact Dermatitis. 2013;68(2):103–110. doi:10.1111/cod.12010
   PubMed Web of Science ®Google Scholar
• Hansen A, Buse AS, Wilke A, Skudlik C, John SM, Brans R. Sensitization to 1,3-diphenylguanidine: an underestimated problem in physicians and nurses using surgical gloves? Contact Dermatitis. 2021;84(3):207–208. doi:10.1111/cod.13713
   PubMed Web of Science ®Google Scholar
• Hirata Y, Yanagi T, Yamaguchi Y, et al. Ulcerative contact dermatitis caused by benzethonium chloride. Contact Dermatitis. 2017;76(3):188–190. doi:10.1111/cod.12682
   PubMed Web of Science ®Google Scholar
• Merchel Piovesan Pereira B, Tagkopoulos I. Benzalkonium chlorides: uses, regulatory status, and microbial resistance. Appl Environ Microbiol. 2019;85:13.
   Web of Science ®Google Scholar
• Kundsin RB, Walter CW. Investigations on adsorption of benzalkonium chloride U.S.P. by skin, gloves, and sponges. AMA Arch Surg. 1957;75(6):1036–1042. doi:10.1001/archsurg.1957.01280180168027
   PubMedGoogle Scholar
• Mehdawi IM, Young A. 10 - Antibacterial composite restorative materials for dental applications. In: Barnes L, Cooper IR, editors. Biomaterials and Medical Device - Associated Infections. Woodhead Publishing; 2015:199–221.
   Google Scholar
• Wentworth AB, Yiannias JA, Davis MD, Killian JM. Benzalkonium chloride: a known irritant and novel allergen. Dermatitis. 2016;27(1):14–20. doi:10.1097/DER.0000000000000160
   PubMed Web of Science ®Google Scholar
• Yamamoto M, Matsumura R, Hirata Y, Nagamune H. A comparative study of skin irritation caused by novel bis-quaternary ammonium compounds and commonly used antiseptics by using cell culture methods. Toxicol In Vitro. 2019;54:75–81. doi:10.1016/j.tiv.2018.09.009
   PubMed Web of Science ®Google Scholar
• Hann S, Hughes TM, Stone NM. Flexural allergic contact dermatitis to benzalkonium chloride in antiseptic bath oil. Br J Dermatol. 2007;157(4):795–798. doi:10.1111/j.1365-2133.2007.08134.x
   PubMed Web of Science ®Google Scholar
• Loo WJ, Alexandroff A, Burrows NP. Irritant dermatitis due to prolonged contact with Oilatum Plus. Br J Dermatol. 2003;148(1):171–172. doi:10.1046/j.1365-2133.2003.50891.x
   PubMed Web of Science ®Google Scholar
• Nettis E, Colanardi MC, Soccio AL, Ferrannini A, Tursi A. Occupational irritant and allergic contact dermatitis among healthcare workers. Contact Dermatitis. 2002;46(2):101–107. doi:10.1034/j.1600-0536.2002.460208.x
   PubMed Web of Science ®Google Scholar
• Uter W, Lessmann H, Geier J, Schnuch A. Is the irritant benzalkonium chloride a contact allergen? A contribution to the ongoing debate from a clinical perspective. Contact Dermatitis. 2008;58(6):359–363. doi:10.1111/j.1600-0536.2008.01327.x
   PubMed Web of Science ®Google Scholar
• Lee SS, Hong DK, Jeong NJ, et al. Multicenter study of preservative sensitivity in patients with suspected cosmetic contact dermatitis in Korea. J Dermatol. 2012;39(8):677–681. doi:10.1111/j.1346-8138.2012.01551.x
   PubMed Web of Science ®Google Scholar
• Cusano F, Luciano S. Contact allergy to benzalkonium chloride and glutaraldehyde in a dental nurse. Contact Dermatitis. 1993;28(2):127. doi:10.1111/j.1600-0536.1993.tb03369.x
   PubMed Web of Science ®Google Scholar
• Placucci F, Benini A, Guerra L, Tosti A. Occupational allergic contact dermatitis from disinfectant wipes used in dentistry. Contact Dermatitis. 1996;35(5):306. doi:10.1111/j.1600-0536.1996.tb02397.x
   PubMed Web of Science ®Google Scholar
• Benjamin B, Chris F, Salvador G, Melissa G, Susan N. Visual and confocal microscopic interpretation of patch tests to benzethonium chloride and benzalkonium chloride. Skin Res Technol. 2012;18(3):272–277. doi:10.1111/j.1600-0846.2011.00577.x
   PubMed Web of Science ®Google Scholar
• Dao H Jr, Fricker C, Nedorost ST. Sensitization prevalence for benzalkonium chloride and benzethonium chloride. Dermatitis. 2012;23(4):162–166. doi:10.1097/DER.0b013e318260d78d
   PubMed Web of Science ®Google Scholar
• Dong W, Green J, Korza G, Setlow P. Killing of spores of Bacillus species by cetyltrimethylammonium bromide. J Appl Microbiol. 2019;126(5):1391–1401. doi:10.1111/jam.14242
   PubMed Web of Science ®Google Scholar
• Jairoun AA, Al-Hemyari SS, Shahwan M, Zyoud Se H. Analysis and Quantification of Alkyl (C12-22) trimethyl ammonium chloride content in cosmetics: regulatory compliance gap analysis. Cosmetics. 2021;8(4):103. doi:10.3390/cosmetics8040103
   Google Scholar
• Becker LC, Bergfeld WF, Belsito DV, et al. Safety assessment of trimoniums as used in cosmetics. Int J Toxicol. 2012;31(6 Suppl):296S–341S. doi:10.1177/1091581812467378
   PubMedGoogle Scholar
• Terol A, Gómez-Mingot M, Maestre SE, Prats S, Luis Todolí J, Paredes E. Simple and rapid analytical method for the simultaneous determination of cetrimonium chloride and alkyl alcohols in hair conditioners. Int J Cosmet Sci. 2010;32(1):65–72. doi:10.1111/j.1468-2494.2009.00553.x
   PubMedGoogle Scholar
• Sauerova P, Pilgrova T, Pekar M, Hubalek Kalbacova M. Hyaluronic acid in complexes with surfactants: the efficient tool for reduction of the cytotoxic effect of surfactants on human cell types. Int J Biol Macromol. 2017;103:1276–1284. doi:10.1016/j.ijbiomac.2017.05.173
   PubMed Web of Science ®Google Scholar
• Bigliardi PL, Herron MJ, Nelson RD, Dahl MV. Effects of detergents on proliferation and metabolism of human keratinocytes. Exp Dermatol. 1994;3(2):89–94. doi:10.1111/j.1600-0625.1994.tb00053.x
   PubMedGoogle Scholar
• Sanchez L, Mitjans M, Infante MR, Vinardell MP. Assessment of the potential skin irritation of lysine-derivative anionic surfactants using mouse fibroblasts and human keratinocytes as an alternative to animal testing. Pharm Res. 2004;21(9):1637–1641. doi:10.1023/b:pham.0000041459.63362.6f
   PubMed Web of Science ®Google Scholar
• Kataria V, Pandhi D, Bhattacharya SN. A cross-sectional study to analyze the clinical subtype, contact sensitization and impact of disease severity on quality of life and cost of illness in patients of hand eczema. Indian J Dermatol Venereol Leprol. 2020;86(6):663–668. doi:10.4103/ijdvl.IJDVL_333_18
   PubMed Web of Science ®Google Scholar
• DeLima Associates. Consumer product information database; 2022. Available from: https://www.whatsinproducts.com. Accessed December 11, 2022.
   Google Scholar
• Commision Regulation (EU) No 866/2014. Amending Annexes III, V and VI to Regulation (EC) No 1223/2009 of the European Parliament and the Council on cosmetic products; 2014.
   Google Scholar
• Walsh SE, Maillard JY, Russell AD, Catrenich CE, Charbonneau DL, Bartolo RG. Activity and mechanisms of action of selected biocidal agents on Gram-positive and -negative bacteria. J Appl Microbiol. 2003;94(2):240–247. doi:10.1046/j.1365-2672.2003.01825.x
   PubMed Web of Science ®Google Scholar
• Shane HL, Lukomska E, Kashon ML, Anderson SE. Topical application of the quaternary ammonium compound didecyldimethylammonium chloride activates type 2 innate lymphoid cells and initiates a mixed-type allergic response. Toxicol Sci. 2019;168(2):508–518. doi:10.1093/toxsci/kfz002
   PubMed Web of Science ®Google Scholar
• Shane HL, Lukomska E, Stefaniak AB, Anderson SE. Divergent hypersensitivity responses following topical application of the quaternary ammonium compound, didecyldimethylammonium bromide. J Immunotoxicol. 2017;14(1):204–214. doi:10.1080/1547691X.2017.1397826
   PubMed Web of Science ®Google Scholar
• Dejobert Y, Martin P, Piette F, Thomas P, Bergoend H. Contact dermatitis from didecyldimethylammonium chloride and bis-(aminopropyl)-lauryl amine in a detergent-disinfectant used in hospital. Contact Dermatitis. 1997;37(2):95–96. doi:10.1111/j.1600-0536.1997.tb00050.x
   PubMed Web of Science ®Google Scholar
• Aronson JK. Cetrimonium bromide and cetrimide. In: Meyler’s Side Effects of Drugs. 6th. Elsevier; 2016:224.
   Google Scholar
• Kumar P, Paulose R. Patch testing in suspected allergic contact dermatitis to cosmetics. Dermatol Res Pract. 2014;2014:695387. doi:10.1155/2014/695387
   PubMedGoogle Scholar
• Haidar Z. An adverse reaction to a topical antiseptic (cetrimide). Br J Oral Surg. 1978;16(1):86–91. doi:10.1016/s0007-117x(78)80061-4
   PubMedGoogle Scholar
• Tomar J, Jain VK, Aggarwal K, Dayal S, Gupta S. Contact allergies to cosmetics: testing with 52 cosmetic ingredients and personal products. J Dermatol. 2005;32(12):951–955. doi:10.1111/j.1346-8138.2005.tb00880.x
   PubMed Web of Science ®Google Scholar
• August PJ. Cutaneous necrosis due to cetrimide application. Br Med J. 1975;1(5949):70. doi:10.1136/bmj.1.5949.70
   PubMedGoogle Scholar
• Gathwala G, Agarwal N, Das K. Skin necrosis due to cetrimide application in a neonate. Indian J Pediatr. 2006;73(10):948. doi:10.1007/BF02859296
   PubMedGoogle Scholar
• Becker LC. Quaternium-15. Int J Toxicol. 2017;36(5_suppl2):52S. doi:10.1177/1091581817717643
   PubMedGoogle Scholar
• Cahill J, Nixon R. Allergic contact dermatitis to quaternium 15 in a moisturizing lotion. Australas J Dermatol. 2005;46(4):284–285. doi:10.1111/j.1440-0960.2005.00210.x
   PubMedGoogle Scholar
• Sreenivasan PK, Haraszthy VI, Zambon JJ. Antimicrobial efficacy of 0.05% cetylpyridinium chloride mouthrinses. Lett Appl Microbiol. 2013;56(1):14–20. doi:10.1111/lam.12008
   PubMed Web of Science ®Google Scholar
• Tomino M, Nagano K, Hayashi T, Kuroki K, Kawai T. Antimicrobial efficacy of gutta-percha supplemented with cetylpyridinium chloride. J Oral Sci. 2016;58(2):277–282. doi:10.2334/josnusd.15-0620
   PubMed Web of Science ®Google Scholar
• Shima K, Tanizaki H, Endo Y, et al. Immediate hypersensitivity caused by cetylpyridinium chloride in a throat spray. Contact Dermatitis. 2015;73(4):248–249. doi:10.1111/cod.12418
   PubMed Web of Science ®Google Scholar
• Castelain M, Castelain PY. Allergic contact dermatitis from cetyl pyridinium chloride in latex gloves. Contact Dermatitis. 1993;28(2):118. doi:10.1111/j.1600-0536.1993.tb03360.x
   PubMed Web of Science ®Google Scholar
• Steinkjer B. Contact dermatitis from cetyl pyridinium chloride in latex surgical gloves. Contact Dermatitis. 1998;39(1):29–30. doi:10.1111/j.1600-0536.1998.tb05808.x
   PubMed Web of Science ®Google Scholar
• Liebert MA. 3 Final report on the safety assessment of benzethonium chloride and methylbenzethonium chloride. J Am Coll Toxicol. 1985;4(5):65–106. doi:10.3109/10915818509078687
   Google Scholar
• Landeck L, Gonzalez E, Baden L, Neumann K, Schalock P. Positive concomitant test reactions to allergens in the standard patch test series. Int J Dermatol. 2010;49(5):517–519. doi:10.1111/j.1365-4632.2010.04309.x
   PubMed Web of Science ®Google Scholar
• The American Contact Dermatitis Society. Contact allergen management program (CAMP). Available from: https://www.contactderm.org/resources/acds-camp. Accessed December 11, 2022.
   Google Scholar
• Ijaz MK, Whitehead K, Srinivasan V, et al. Microbicidal actives with virucidal efficacy against SARS-CoV-2. Am J Infect Control. 2020;48(8):972–973. doi:10.1016/j.ajic.2020.05.015
   PubMed Web of Science ®Google Scholar
• Chin AWH, Chu JTS, Perera MRA, et al. Stability of SARS-CoV-2 in different environmental conditions. Lancet Microbe. 2020;1(1):e10. doi:10.1016/S2666-5247(20)30003-3
   PubMedGoogle Scholar
• Ogilvie BH, Solis-Leal A, Lopez JB, Poole BD, Robison RA, Berges BK. Alcohol-free hand sanitizer and other quaternary ammonium disinfectants quickly and effectively inactivate SARS-CoV-2. J Hosp Infect. 2020;108:142–145. doi:10.1016/j.jhin.2020.11.023
   PubMed Web of Science ®Google Scholar
• Ferreira JM. The quat advantage: quaternary ammonium chloride and its advantages in healthcare facilities. PDI Res Dev. 2015;2015:1–5.
   Google Scholar
• Kadivar S, Belsito DV. Occupational dermatitis in health care workers evaluated for suspected allergic contact dermatitis. Dermatitis. 2015;26(4):177–183. doi:10.1097/DER.0000000000000124
   PubMed Web of Science ®Google Scholar
• De Quintana Sancho A, Raton JA, Eizaguirre X. Occupational allergic contact dermatitis caused by N, N-didecyl-N-methyl-poly(oxyethyl) ammonium propionate in a dental assistant. Contact Dermatitis. 2014;70(6):379–380. doi:10.1111/cod.12174
   PubMed Web of Science ®Google Scholar
• Bernstein JA, Stauder T, Bernstein DI, Bernstein IL. A combined respiratory and cutaneous hypersensitivity syndrome induced by work exposure to quaternary amines. J Allergy Clin Immunol. 1994;94(2 Pt 1):257–259. doi:10.1016/0091-6749(94)90048-5
   PubMed Web of Science ®Google Scholar