Inhibition Effect of Physalis angulata Leaf Extract on Viability, Collagen Type I, and Tissue Inhibitor of Metalloproteinase 1 (TIMP-1) but Not Plasminogen Activator Inhibitor-1 (PAI-1) of Keloid Fibroblast Culture

References

• Young WG, Worsham MJ, Joseph CLM, Divine GW, Jones LRD. Incidence of keloid and risk factors following head and neck surgery. JAMA Facial Plast Surg. 2014;16(5):379–380.
   PubMed Web of Science ®Google Scholar
• Kassi K, Kouame K, Kouassi A, et al. Quality of life in black African patients with keloid scars. Dermatol Reports. 2020;12(2):28–31.
   Web of Science ®Google Scholar
• Andrews JP, Marttala J, Macarak E, Rosenbloom J, Uitto J. Keloids: the paradigm of skin fibrosis - Pathomechanisms and treatment. Matrix Biol. 2016;51:37–46.
   PubMed Web of Science ®Google Scholar
• Ashcroft KJ, Syed F, Bayat A. Site-specific keloid fibroblasts alter the behaviour of normal skin and normal scar fibroblasts through paracrine signalling. PLoS One. 2013;8(11):e75600.
   PubMedGoogle Scholar
• Liu Y, Li Y, Li N, et al. TGF-β1 promotes scar fibroblasts proliferation and transdifferentiation via up-regulating MicroRNA-21. Sci Reports. 2016;6:32231.
   PubMed Web of Science ®Google Scholar
• Wulandari E, Jusman SRIWA, Moenadjat Y, Jusuf AA, Sadikin M. Expressions of collagen I and III in hypoxic keloid tissue. Kobe J Med Sci. 2016;62(3):E58–69.
   PubMedGoogle Scholar
• Ulrich D, Ulrich F, Unglaub F, Piatkowski A, Pallua N. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in patients with different types of scars and keloids. J Plast Reconstr Aesthet Surg. 2010;63:1015–1021.
   PubMed Web of Science ®Google Scholar
• Ogawa R, Akita S, Akaishi S, et al. Diagnosis and Treatment of Keloids and Hypertrophic Scars—Japan Scar Workshop Consensus Document 2018. Burns Trauma. 2019;7:1–40.
   PubMed Web of Science ®Google Scholar
• Unahabhokha T, Sucontphunt A, Nimmannit U, Chanvorachote P, Yongsanguanchai N, Pongrakhananon V. Molecular signalings in keloid disease and current therapeutic approaches from natural based compounds. Pharm Biol. 2015;53(3):457–463.
   PubMed Web of Science ®Google Scholar
• Ahmadu AA, Omonigho U. Flavonoids from the leaves of Physalis angulata Linn. African J Pharm Res Dev. 2013;5(1):40–43.
   Google Scholar
• Cobaleda-Velasco M, Alanis-Bañuelos RE, Almaraz-Abarca N, et al. Phenolic profiles and antioxidant properties of Physalis angulata L. as quality indicators. J Pharm Pharmacogn Res. 2017;5(2):114–128.
   Web of Science ®Google Scholar
• Ramakrishnan KM, Babu M, Madhavi MSL. Response of keloid fibroblasts to vitamin D3 and quercetin treatment - In vitro study. Ann Burns Fire Disasters. 2015;28(3):187–191.
   PubMedGoogle Scholar
• Li H, Yang L, Zhang Y, Gao Z. Kaempferol inhibits fibroblast collagen synthesis, proliferation and activation in hypertrophic scar via targeting TGF-b receptor type I. Biomed Pharmacother. 2016;83:967–974.
   PubMed Web of Science ®Google Scholar
• Hseu YC, Wu CR, Chang HW, et al. Inhibitory effects of Physalis angulata on tumor metastasis and angiogenesis. J Ethnopharmacol. 2011;135(3):762–771.
   PubMed Web of Science ®Google Scholar
• Sharma JR, Lebeko M, Kidzeru EB, Khumalo NP, Bayat A. In vitro and ex vivo models for functional testing of therapeutic anti-scarring drug targets in keloids. Adv Wound Care. 2019;8(12):655–670.
   Web of Science ®Google Scholar
• Kurniawati Y, Suwarsa O, Agung A, Adi S. The Comparison of the Levels of Leukotriene B4, TGF-β1, Collagen in Keloid Fibroblasts and Normal Skin Fibroblast. Open Access Libr. 2016;3:e2801.
   Google Scholar
• Dohi T, Miyake K, Aoki M, et al. Tissue inhibitor of metalloproteinase-2 suppresses collagen synthesis in cultured keloid fibroblasts. Plast Reconstr Surg - Glob Open. 2015;3(9):1–11.
   PubMedGoogle Scholar
• Luo L, Li J, Liu H, et al. Adiponectin is involved in connective tissue growth factor-induced proliferation, migration and overproduction of the extracellular matrix in keloid fibroblasts. Int J Mol Sci. 2017;18(5):1–21.
   Web of Science ®Google Scholar
• Suarez E, Syed F, Alonso-Rasgado T, Bayat A. Identification of biomarkers involved in differential profiling of hypertrophic and keloid scars versus normal skin. Arch Dermatol Res. 2015;307(2):115–133.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Nie F, Kang C, et al. Increased periostin expression affects the proliferation, collagen synthesis, migration and invasion of keloid fibroblasts under hypoxic conditions. Int J Mol Med. 2014;34(1):253–261.
   PubMed Web of Science ®Google Scholar
• Feng F, Liu M, Pan L, et al. Biomechanical regulatory factors and therapeutic targets in keloid fibrosis. Front Pharmacol. 2022;13(May):1–12.
   Google Scholar
• Tang M, Bian W, Cheng L, et al. Ginsenoside Rg3 inhibits keloid fibroblast proliferation, angiogenesis and collagen synthesis in vitro via the TGF-β/Smad and ERK signaling pathways. Int J Mol Med. 2018;41:1487–1499.
   PubMed Web of Science ®Google Scholar
• Chairissy MD, Wulandari LR, Sujuti H. Pro-apoptotic and anti-proliferative effects of Physalis angulata leaf extract on retinoblastoma cells. Int J Ophthalmol. 2019;12(9):1402–1407.
   PubMed Web of Science ®Google Scholar
• Hidayat T, Priyandoko D, Perdana FS, Insan AM. Cytotoxicity effects of leaf extracts of Ciplukan (Physalis angulata; Solanaceae) on human blood and ovary cancer cell lines. J Phys: Conf Ser. 2019;1280(2):022009.
   Google Scholar
• Xiang D, Zou J, Zhu X, et al. Physalin D attenuates hepatic stellate cell activation and liver fibrosis by blocking TGF-β/Smad and YAP signaling. Phytomedicine. 2020;78:153294.
   PubMed Web of Science ®Google Scholar
• Liu Q, Chen J, Wang X, Yu L, Hu LH, Shen X. Withagulatin A inhibits hepatic stellate cell viability and procollagen I production through Akt and Smad signaling pathways. Acta Pharmacol Sin. 2010;31(8):944–952.
   PubMed Web of Science ®Google Scholar
• Zhang T, Wang XF, Wang ZC, et al. Current potential therapeutic strategies targeting the TGF-β/Smad signaling pathway to attenuate keloid and hypertrophic scar formation. Biomed Pharmacother. 2020;129(June):110287.
   PubMedGoogle Scholar
• Aoki M, Miyake K, Ogawa R, Dohi T, Akaishi S, Hyakusoku H. siRNA knockdown of tissue inhibitor of metalloproteinase-1 in keloid fibroblasts leads to degradation of collagen type I. J Invest Dermatol. 2014;134(3):818–826.
   PubMed Web of Science ®Google Scholar
• Wihastyoko HYL, Soeharto S, Widjajanto E, Handono K, Pardjianto B. Does papain enzyme improve collagen degradation? Syst Rev Pharm. 2021;12(3):676–684.
   Google Scholar
• Vieceli PS, Juiz PJL, Lauria PSS, et al. Physalis angulata reduces the progression of chronic experimental periodontitis by immunomodulatory mechanisms. J Ethnopharmacol. 2021;273:113986.
   PubMed Web of Science ®Google Scholar
• Wang Y, Long J, Wang X, Sun Y. Association of the plasminogen activator inhibitor-1 (PAI-1) Gene −675 4G/5G and −844 A/G promoter polymorphism with risk of keloid in a Chinese han population. Med Sci Monit. 2014;20:2069–2073.
   PubMed Web of Science ®Google Scholar
• Gong ZH, Ji JF, Yang J, et al. Association of plasminogen activator inhibitor-1 and vitamin D receptor expression with the risk of keloid disease in a Chinese population. Kaohsiung J Med Sci. 2017;33(1):24–29.
   PubMed Web of Science ®Google Scholar
• Syed F, Bagabir RA, Paus R, Bayat A. Ex vivo evaluation of antifibrotic compounds in skin scarring: EGCG and silencing of PAI-1 independently inhibit growth and induce keloid shrinkage. Lab Invest. 2013;93(8):946–960.
   PubMed Web of Science ®Google Scholar