Inhibition of Key Glycolytic Enzyme Hexokinase 2 Ameliorates Psoriasiform Inflammation in vitro and in vivo

References

• Damiani G, Bragazzi NL, Karimkhani Aksut C, et al. The global, regional, and national burden of psoriasis: results and insights from the global burden of disease 2019 study. Front Med. 2021;8:743180. doi:10.3389/fmed.2021.743180
   PubMed Web of Science ®Google Scholar
• Buja A, Miatton A, Cozzolino C, et al. The prevalent comorbidome at the onset of psoriasis diagnosis. Dermatol Ther. 2023;13(9):2093–2105. doi:10.1007/s13555-023-00986-0
   Web of Science ®Google Scholar
• Nestle FO, Kaplan DH, Barker J. Psoriasis. N Engl J Med. 2009;361(5):496–509. doi:10.1056/NEJMra0804595
   PubMed Web of Science ®Google Scholar
• Larsen MH, Strumse YS, Andersen MH, et al. Associations between disease education, self-management support, and health literacy in psoriasis. J Dermatolog Treat. 2021;32(6):603–609. doi:10.1080/09546634.2019.1688233
   PubMed Web of Science ®Google Scholar
• Ogawa E, Sato Y, Minagawa A, et al. Pathogenesis of psoriasis and development of treatment. J Dermatol. 2018;45(3):264–272. doi:10.1111/1346-8138.14139
   PubMed Web of Science ®Google Scholar
• Yang BY, Cheng YG, Liu Y, et al. Datura metel L. Ameliorates imiquimod-induced psoriasis-like dermatitis and inhibits inflammatory cytokines production through TLR7/8-MyD88-NF-kappaB-NLRP3 inflammasome pathway. Molecules. 2019;24. doi:10.3390/molecules24112157
   Web of Science ®Google Scholar
• Pasquali L, Srivastava A, Meisgen F, et al. The keratinocyte transcriptome in psoriasis: pathways related to immune responses, cell cycle and keratinization. Acta Derm Venereol. 2019;99(2):196–205. doi:10.2340/00015555-3066
   PubMed Web of Science ®Google Scholar
• Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science. 2009;324(5930):1029–1033. doi:10.1126/science.1160809
   PubMed Web of Science ®Google Scholar
• Lunt SY, Vander Heiden MG. Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu Rev Cell Dev Biol. 2011;27(1):441–464. doi:10.1146/annurev-cellbio-092910-154237
   PubMed Web of Science ®Google Scholar
• Kang H, Li X, Zhou Q, et al. Exploration of candidate biomarkers for human psoriasis based on gas chromatography-mass spectrometry serum metabolomics. Br J Dermatol. 2017;176(3):713–722. doi:10.1111/bjd.15008
   PubMed Web of Science ®Google Scholar
• Hamanaka RB, Mutlu GM. PFKFB3, a direct target of p63, is required for proliferation and inhibits differentiation in epidermal keratinocytes. J Invest Dermatol. 2017;137(6):1267–1276. doi:10.1016/j.jid.2016.12.020
   PubMed Web of Science ®Google Scholar
• Zhang Z, Zi Z, Lee EE, et al. Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis. Nat Med. 2018;24(5):617–627. doi:10.1038/s41591-018-0003-0
   PubMed Web of Science ®Google Scholar
• Liu YZ, Xu MY, Dai XY, et al. Pyruvate kinase M2 mediates glycolysis contributes to psoriasis by promoting keratinocyte proliferation. Front Pharmacol. 2021;12:765790. doi:10.3389/fphar.2021.765790
   PubMed Web of Science ®Google Scholar
• Hao L, Mao Y, Park J, et al. 2’-Hydroxycinnamaldehyde ameliorates imiquimod-induced psoriasiform inflammation by targeting PKM2-STAT3 signaling in mice. Exp Mol Med. 2021;53(5):875–884. doi:10.1038/s12276-021-00620-z
   PubMed Web of Science ®Google Scholar
• Wilson JE. Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function. J Exp Biol. 2003;206(12):2049–2057. doi:10.1242/jeb.00241
   PubMed Web of Science ®Google Scholar
• Mathupala SP, Ko YH, Pedersen PL. Hexokinase II: cancer’s double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria. Oncogene. 2006;25(34):4777–4786. doi:10.1038/sj.onc.1209603
   PubMed Web of Science ®Google Scholar
• Ciscato F, Ferrone L, Masgras I, et al. Hexokinase 2 in cancer: a prima donna playing multiple characters. Int J Mol Sci. 2021;22(9):4716. doi:10.3390/ijms22094716
   PubMed Web of Science ®Google Scholar
• Yang L, Yan X, Chen J, et al. Hexokinase 2 discerns a novel circulating tumor cell population associated with poor prognosis in lung cancer patients. Proc Natl Acad Sci U S A. 2021;118. doi:10.1073/pnas.2012228118
   Web of Science ®Google Scholar
• Hughes MM, O’Neill LAJ. Metabolic regulation of NLRP 3. Immunol Rev. 2018;281(1):88–98. doi:10.1111/imr.12608
   PubMed Web of Science ®Google Scholar
• Rabeony H, Petit-Paris I, Garnier J, et al. Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1alpha, TNFalpha and oncostatin M. PLoS One. 2014;9(7):e101937. doi:10.1371/journal.pone.0101937
   PubMed Web of Science ®Google Scholar
• Zhou X, Chen Y, Cui L, et al. Advances in the pathogenesis of psoriasis: from keratinocyte perspective. Cell Death Dis. 2022;13(1):81. doi:10.1038/s41419-022-04523-3
   PubMed Web of Science ®Google Scholar
• Mohd Noor AA, Azlan M, Mohd Redzwan N. Orchestrated cytokines mediated by biologics in psoriasis and its mechanisms of action. Biomedicines. 2022;10(2):498. doi:10.3390/biomedicines10020498
   PubMed Web of Science ®Google Scholar
• Kutwin M, Migdalska-Sek M, Brzezianska-Lasota E, et al. An analysis of IL-10, IL-17A, IL-17RA, IL-23A and IL-23R expression and their correlation with clinical course in patients with psoriasis. J Clin Med. 2021;10(24):5834. doi:10.3390/jcm10245834
   PubMed Web of Science ®Google Scholar
• Tian D, Lai Y. The relapse of psoriasis: mechanisms and mysteries. JID Innov. 2022;2(3):100116. doi:10.1016/j.xjidi.2022.100116
   PubMedGoogle Scholar
• Gao J, Chen F, Fang H, et al. Daphnetin inhibits proliferation and inflammatory response in human HaCaT keratinocytes and ameliorates imiquimod-induced psoriasis-like skin lesion in mice. Biol Res. 2020;53(1):48. doi:10.1186/s40659-020-00316-0
   PubMed Web of Science ®Google Scholar
• Cibrian D, de la Fuente H, Sanchez-Madrid F. Metabolic pathways that control skin homeostasis and inflammation. Trends Mol Med. 2020;26(11):975–986. doi:10.1016/j.molmed.2020.04.004
   PubMed Web of Science ®Google Scholar
• Wickersham M, Wachtel S, Wong Fok Lung T, et al. Metabolic stress drives keratinocyte defenses against Staphylococcus aureus infection. Cell Rep. 2017;18(11):2742–2751. doi:10.1016/j.celrep.2017.02.055
   PubMed Web of Science ®Google Scholar
• Garcia SN, Guedes RC, Marques MM. Unlocking the potential of HK2 in cancer metabolism and therapeutics. Curr Med Chem. 2019;26(41):7285–7322. doi:10.2174/0929867326666181213092652
   PubMed Web of Science ®Google Scholar
• Hodeib AA, Neinaa YME, Zakaria SS, et al. Glucose transporter-1 (GLUT-1) expression in psoriasis: correlation with disease severity. Int J Dermatol. 2018;57(8):943–951. doi:10.1111/ijd.14037
   PubMed Web of Science ®Google Scholar
• Guilloteau K, Paris I, Pedretti N, et al. Skin inflammation induced by the synergistic action of IL-17A, IL-22, oncostatin M, IL-1alpha, and TNF-alpha recapitulates some features of psoriasis. J Immunol. 2010;184(9):5263–5270. doi:10.4049/jimmunol.0902464
   PubMed Web of Science ®Google Scholar
• Duan Q, Wang G, Wang M, et al. LncRNA RP6-65G23.1 accelerates proliferation and inhibits apoptosis via p-ERK1/2/p-AKT signaling pathway on keratinocytes. J Cell Biochem. 2020;121(11):4580–4589. doi:10.1002/jcb.29685
   PubMed Web of Science ®Google Scholar
• Chen C, Yang Z, Yin X, et al. CircEIF5 contributes to hyperproliferation and inflammation of keratinocytes in psoriasis via p-NFkappaB and p-STAT3 signalling pathway. Exp Dermatol. 2022;31(8):1145–1153. doi:10.1111/exd.14565
   PubMed Web of Science ®Google Scholar
• Pajak B, Siwiak E, Soltyka M, et al. 2-Deoxy-d-glucose and its analogs: from diagnostic to therapeutic agents. Int J Mol Sci. 2019;21(1):234. doi:10.3390/ijms21010234
   PubMed Web of Science ®Google Scholar
• Zhang Q, Zhang Y, Zhang P, et al. Hexokinase II inhibitor, 3-BrPA induced autophagy by stimulating ROS formation in human breast cancer cells. Genes Cancer. 2014;5(3–4):100–112. doi:10.18632/genesandcancer.9
   PubMedGoogle Scholar
• Ortiz-Lopez LI, Choudhary V, Bollag WB. Updated perspectives on keratinocytes and psoriasis: keratinocytes are more than innocent bystanders. Psoriasis. 2022;12:73–87. doi:10.2147/PTT.S327310
   PubMed Web of Science ®Google Scholar
• Ferrari D, Casciano F, Secchiero P, et al. Purinergic signaling and inflammasome activation in psoriasis pathogenesis. Int J Mol Sci. 2021;22(17):9449. doi:10.3390/ijms22179449
   PubMed Web of Science ®Google Scholar
• Moorchung N, Kulaar JS, Chatterjee M, et al. Role of NF -κB in the pathogenesis of psoriasis elucidated by its staining in skin biopsy specimens. Int J Dermatol. 2014;53(5):570–574. doi:10.1111/ijd.12050
   PubMed Web of Science ®Google Scholar
• Kelley N, Jeltema D, Duan Y, et al. The NLRP3 inflammasome: an overview of mechanisms of activation and regulation. Int J Mol Sci. 2019;20(13):3328. doi:10.3390/ijms20133328
   PubMed Web of Science ®Google Scholar
• Ciazynska M, Olejniczak-Staruch I, Sobolewska-Sztychny D, et al. The role of NLRP1, NLRP3, and AIM2 inflammasomes in psoriasis: review. Int J Mol Sci. 2021;22(11):5898. doi:10.3390/ijms22115898
   PubMed Web of Science ®Google Scholar
• Tsuji G, Hashimoto-Hachiya A, Yen VH, et al. Metformin inhibits IL-1beta secretion via impairment of NLRP3 inflammasome in keratinocytes: implications for preventing the development of psoriasis. Cell Death Discov. 2020;6(1):11. doi:10.1038/s41420-020-0245-8
   PubMed Web of Science ®Google Scholar
• Ma Jewski N, Nogueira V, Bhaskar P, et al. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol Cell. 2004;16(5):819–830. doi:10.1016/j.molcel.2004.11.014
   PubMed Web of Science ®Google Scholar
• Moon JS, Hisata S, Park MA, et al. mTORC1-induced HK1-dependent glycolysis regulates NLRP3 inflammasome activation. Cell Rep. 2015;12(1):102–115. doi:10.1016/j.celrep.2015.05.046
   PubMed Web of Science ®Google Scholar
• Hahn-Windgassen A, Nogueira V, Chen CC, et al. Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. J Biol Chem. 2005;280(37):32081–32089. doi:10.1074/jbc.M502876200
   PubMed Web of Science ®Google Scholar