Adipose-Derived Stem Cell Exosomes Alleviate Psoriasis Serum Exosomes-Induced Inflammation by Regulating Autophagy and Redox Status in Keratinocytes

References

• Chhabra S, Dogra S, Sharma K, Raychaudhuri SK, Raychaudhuri SP. Recent update on immunopathogenesis of psoriasis. Indian J Dermatol. 2022;67(4):360–373. doi:10.4103/ijd.ijd_569_22
   PubMed Web of Science ®Google Scholar
• Takeshita J, Grewal S, Langan SM, et al. Psoriasis and comorbid diseases: epidemiology. J Am Acad Dermatol. 2017;76(3):377–390. doi:10.1016/j.jaad.2016.07.064
   PubMed Web of Science ®Google Scholar
• Gelfand JM, Feldman SR, Stern RS, Thomas J, Rolstad T, Margolis DJ. Determinants of quality of life in patients with psoriasis: a study from the US population. J Am Acad Dermatol. 2004;51(5):704–708. doi:10.1016/j.jaad.2004.04.014
   PubMed Web of Science ®Google Scholar
• Plenkowska J, Gabig-Ciminska M, Mozolewski P. Oxidative stress as an important contributor to the pathogenesis of psoriasis. Int J Mol Sci. 2020;21(17):6206.
   PubMed Web of Science ®Google Scholar
• Arthur JS, Darragh J. Signaling downstream of p38 in psoriasis. J Invest Dermatol. 2006;126(8):1689–1691. doi:10.1038/sj.jid.5700280
   PubMed Web of Science ®Google Scholar
• Goldminz AM, Au SC, Kim N, Gottlieb AB, Lizzul PF. NF-kappaB: an essential transcription factor in psoriasis. J Dermatol Sci. 2013;69(2):89–94. doi:10.1016/j.jdermsci.2012.11.002
   PubMed Web of Science ®Google Scholar
• Klionsky DJ, Petroni G, Amaravadi RK, et al. Autophagy in major human diseases. EMBO J. 2021;40(19):e108863. doi:10.15252/embj.2021108863
   PubMed Web of Science ®Google Scholar
• Klapan K, Frangez Z, Markov N, Yousefi S, Simon D, Simon HU. Evidence for lysosomal dysfunction within the epidermis in psoriasis and atopic dermatitis. J Invest Dermatol. 2021;141(12):2838–2848 e4. doi:10.1016/j.jid.2021.05.016
   PubMed Web of Science ®Google Scholar
• Orciani M, Campanati A, Salvolini E, et al. The mesenchymal stem cell profile in psoriasis. Br J Dermatol. 2011;165(3):585–592. doi:10.1111/j.1365-2133.2011.10438.x
   PubMed Web of Science ®Google Scholar
• Campanati A, Orciani M, Consales V, et al. Characterization and profiling of immunomodulatory genes in resident mesenchymal stem cells reflect the Th1-Th17/Th2 imbalance of psoriasis. Arch Dermatol Res. 2014;306(10):915–920. doi:10.1007/s00403-014-1493-3
   PubMed Web of Science ®Google Scholar
• Campanati A, Orciani M, Lazzarini R, et al. TNF-α inhibitors reduce the pathological Th1 -Th17 /Th2 imbalance in cutaneous mesenchymal stem cells of psoriasis patients. Exp Dermatol. 2017;26(4):319–324. doi:10.1111/exd.13139
   PubMed Web of Science ®Google Scholar
• Villarroya-Beltri C, Baixauli F, Gutierrez-Vazquez C, Sanchez-Madrid F, Mittelbrunn M. Sorting it out: regulation of exosome loading. Semin Cancer Biol. 2014;28:3–13. doi:10.1016/j.semcancer.2014.04.009
   PubMed Web of Science ®Google Scholar
• Robbins PD, Morelli AE. Regulation of immune responses by extracellular vesicles. Nat Rev Immunol. 2014;14(3):195–208. doi:10.1038/nri3622
   PubMed Web of Science ®Google Scholar
• Fruhbeis C, Frohlich D, Kuo WP, et al. Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication. PLoS Biol. 2013;11(7):e1001604. doi:10.1371/journal.pbio.1001604
   PubMed Web of Science ®Google Scholar
• Al-Nedawi K, Meehan B, Rak J. Microvesicles: messengers and mediators of tumor progression. Cell Cycle. 2009;8(13):2014–2018. doi:10.4161/cc.8.13.8988
   PubMed Web of Science ®Google Scholar
• Bellingham SA, Guo BB, Coleman BM, Hill AF. Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases? Front Physiol. 2012;3:124. doi:10.3389/fphys.2012.00124
   PubMed Web of Science ®Google Scholar
• Hawkes JE, Chan TC, Krueger JG. Psoriasis pathogenesis and the development of novel targeted immune therapies. J Allergy Clin Immunol. 2017;140(3):645–653. doi:10.1016/j.jaci.2017.07.004
   PubMed Web of Science ®Google Scholar
• Bellinato F, Gisondi P, Girolomoni G. Latest advances for the treatment of chronic plaque psoriasis with biologics and oral small molecules. Biologics. 2021;15:247–253. doi:10.2147/BTT.S290309
   PubMed Web of Science ®Google Scholar
• Wu JJ, Kearns DG, Lin TC, et al. Characterization of non-responders to interleukin-17 inhibitors in moderate to severe psoriasis patients enrolled in the Corrona((R)) Psoriasis Registry. J Eur Acad Dermatol Venereol. 2021;35(8):e531–e533. doi:10.1111/jdv.17270
   PubMed Web of Science ®Google Scholar
• FitzGerald O, Ogdie A, Chandran V, et al. Psoriatic arthritis. Nat Rev Dis Primers. 2021;7(1):59. doi:10.1038/s41572-021-00293-y
   PubMed Web of Science ®Google Scholar
• Valle-Prieto A, Conget PA. Human mesenchymal stem cells efficiently manage oxidative stress. Stem Cells Dev. 2010;19(12):1885–1893. doi:10.1089/scd.2010.0093
   PubMed Web of Science ®Google Scholar
• Nauta AJ, Fibbe WE. Immunomodulatory properties of mesenchymal stromal cells. Blood. 2007;110(10):3499–3506. doi:10.1182/blood-2007-02-069716
   PubMed Web of Science ®Google Scholar
• Galipeau J, Sensebe L. Mesenchymal stromal cells: clinical challenges and therapeutic opportunities. Cell Stem Cell. 2018;22(6):824–833. doi:10.1016/j.stem.2018.05.004
   PubMed Web of Science ®Google Scholar
• Timmers L, Lim SK, Arslan F, et al. Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium. Stem Cell Res. 2007;1(2):129–137. doi:10.1016/j.scr.2008.02.002
   PubMed Web of Science ®Google Scholar
• Witwer KW, Van Balkom BWM, Bruno S, et al. Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications. J Extracell Vesicles. 2019;8(1):1609206. doi:10.1080/20013078.2019.1609206
   PubMed Web of Science ®Google Scholar
• Shao S, Fang H, Zhang J, et al. Neutrophil exosomes enhance the skin autoinflammation in generalized pustular psoriasis via activating keratinocytes. FASEB J. 2019;33(6):6813–6828. doi:10.1096/fj.201802090RR
   PubMed Web of Science ®Google Scholar
• Jiang M, Fang H, Shao S, et al. Keratinocyte exosomes activate neutrophils and enhance skin inflammation in psoriasis. FASEB J. 2019;33(12):13241–13253. doi:10.1096/fj.201900642R
   PubMed Web of Science ®Google Scholar
• Lv J, Zhou D, Wang Y, et al. Effects of luteolin on treatment of psoriasis by repressing HSP90. Int Immunopharmacol. 2020;79:106070. doi:10.1016/j.intimp.2019.106070
   PubMed Web of Science ®Google Scholar
• Cheung KL, Jarrett R, Subramaniam S, et al. Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a. J Exp Med. 2016;213(11):2399–2412. doi:10.1084/jem.20160258
   PubMed Web of Science ®Google Scholar
• Asefi M, Vaisi-Raygani A, Khodarahmi R, et al. Methylentetrahydrofolatereductase (rs1801133) polymorphism and psoriasis: contribution to oxidative stress, lipid peroxidation and correlation with vascular adhesion protein 1, preliminary report. J Eur Acad Dermatol Venereol. 2014;28(9):1192–1198. doi:10.1111/jdv.12262
   PubMed Web of Science ®Google Scholar
• Guarneri F, Sapienza D, Papaianni V, et al. Association between genetic polymorphisms of glutathione S-transferase M1/T1 and psoriasis in a population from the area of the strict of messina (Southern Italy). Free Radic Res. 2020;54(1):57–63. doi:10.1080/10715762.2019.1698738
   PubMed Web of Science ®Google Scholar
• Husni ME, Wilson Tang WH, Lucke M, Chandrasekharan UM, Brennan DM, Hazen SL. Correlation of high-density lipoprotein-associated paraoxonase 1 activity with systemic inflammation, disease activity, and cardiovascular risk factors in psoriatic disease. Arthritis Rheumatol. 2018;70(8):1240–1250. doi:10.1002/art.40499
   PubMed Web of Science ®Google Scholar
• El-Rifaie AA, Sabry D, Doss RW, Kamal MA, Abd El Hassib DM. Heme oxygenase and iron status in exosomes of psoriasis patients. Arch Dermatol Res. 2018;310(8):651–656. doi:10.1007/s00403-018-1852-6
   PubMed Web of Science ®Google Scholar
• Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature. 2008;451(7182):1069–1075. doi:10.1038/nature06639
   PubMed Web of Science ®Google Scholar
• Choi AM, Ryter SW, Levine B. Autophagy in human health and disease. N Engl J Med. 2013;368(7):651–662. doi:10.1056/NEJMra1205406
   PubMed Web of Science ®Google Scholar
• Douroudis K, Kingo K, Traks T, et al. Polymorphisms in the ATG16L1 gene are associated with psoriasis vulgaris. Acta Derm Venereol. 2012;92(1):85–87. doi:10.2340/00015555-1183
   PubMed Web of Science ®Google Scholar
• Lee HM, Shin DM, Yuk JM, et al. Autophagy negatively regulates keratinocyte inflammatory responses via scaffolding protein p62/SQSTM1. J Immunol. 2011;186(2):1248–1258. doi:10.4049/jimmunol.1001954
   PubMed Web of Science ®Google Scholar
• Zhang Y, Yan J, Li Z, Zheng J, Sun Q. Exosomes derived from human umbilical cord mesenchymal stem cells alleviate psoriasis-like skin inflammation. J Interferon Cytokine Res. 2022;42(1):8–18. doi:10.1089/jir.2021.0146
   PubMed Web of Science ®Google Scholar
• Zhang B, Lai RC, Sim WK, Choo ABH, Lane EB, Lim SK. Topical application of mesenchymal stem cell exosomes alleviates the imiquimod induced psoriasis-like inflammation. Int J Mol Sci. 2021;22(2). doi:10.3390/ijms22020720
   Web of Science ®Google Scholar
• Shen K, Jia Y, Wang X, et al. Exosomes from adipose-derived stem cells alleviate the inflammation and oxidative stress via regulating Nrf2/HO-1 axis in macrophages. Free Radic Biol Med. 2021;165:54–66. doi:10.1016/j.freeradbiomed.2021.01.023
   PubMed Web of Science ®Google Scholar
• Xu P, Xin Y, Zhang Z, et al. Extracellular vesicles from adipose-derived stem cells ameliorate ultraviolet B-induced skin photoaging by attenuating reactive oxygen species production and inflammation. Stem Cell Res Ther. 2020;11(1):264. doi:10.1186/s13287-020-01777-6
   PubMed Web of Science ®Google Scholar
• Zhang W, Liu R, Chen Y, Wang M, Du J. Crosstalk between oxidative stress and exosomes. Oxid Med Cell Longev. 2022;2022:3553617. doi:10.1155/2022/3553617
   PubMed Web of Science ®Google Scholar
• Mendt M, Rezvani K, Shpall E. Mesenchymal stem cell-derived exosomes for clinical use. Bone Marrow Transplant. 2019;54(Suppl 2):789–792. doi:10.1038/s41409-019-0616-z
   PubMed Web of Science ®Google Scholar
• Mazini L, Rochette L, Amine M, Malka G. Regenerative Capacity of Adipose Derived Stem Cells (ADSCs), Comparison with Mesenchymal Stem Cells (MSCs). Int J Mol Sci. 2019;20(10). doi:10.3390/ijms20102523
   PubMed Web of Science ®Google Scholar