232
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Prevalence of Statin Use and Predictors of Statin Initiation Among Patients with Alcohol-Related Cirrhosis - A Danish Nationwide Cohort Study

ORCID Icon, ORCID Icon & ORCID Icon
Pages 435-446 | Received 17 Dec 2022, Accepted 09 Mar 2023, Published online: 01 Apr 2023

References

  • Jepsen P, Vilstrup H, Sørensen HT. Alcoholic cirrhosis in Denmark - population-based incidence, prevalence, and hospitalization rates between 1988 and 2005: a descriptive cohort study. BMC Gastroenterol. 2008;8:3. doi:10.1186/1471-230x-8-3
  • Jepsen P, Ott P, Andersen PK, Sørensen HT, Vilstrup H. Clinical course of alcoholic liver cirrhosis: a Danish population-based cohort study. Hepatology. 2010;51(5):1675–1682. doi:10.1002/hep.23500
  • Liao JK, Laufs U. Pleiotropic effects of statins. Annu Rev Pharmacol Toxicol. 2005;45:89–118. doi:10.1146/annurev.pharmtox.45.120403.095748
  • Bays H, Cohen DE, Chalasani N, Harrison SA. The National Lipid Association’s Statin Safety Task F. An assessment by the Statin Liver Safety Task Force: 2014 update. J Clin Lipidol. 2014;8(3Suppl):S47–57. doi:10.1016/j.jacl.2014.02.011
  • Naci H, Brugts JJ, Fleurence R, Tsoi B, Toor H, Ades AE. Comparative benefits of statins in the primary and secondary prevention of major coronary events and all-cause mortality: a network meta-analysis of placebo-controlled and active-comparator trials. Eur J Prev Cardiol. 2013;20(4):641–657. doi:10.1177/2047487313480435
  • Abraldes JG, Villanueva C, Aracil C, et al. Addition of Simvastatin to Standard Therapy for the Prevention of Variceal Rebleeding Does Not Reduce Rebleeding but Increases Survival in Patients With Cirrhosis. Gastroenterology. 2016;150(5):1160–1170.e3. doi:10.1053/j.gastro.2016.01.004
  • Abraldes JG, Albillos A, Bañares R, et al. Simvastatin lowers portal pressure in patients with cirrhosis and portal hypertension: a randomized controlled trial. Gastroenterology. 2009;136(5):1651–1658. doi:10.1053/j.gastro.2009.01.043
  • Pollo-Flores P, Soldan M, Santos UC, et al. Three months of simvastatin therapy vs. placebo for severe portal hypertension in cirrhosis: a randomized controlled trial. Dig Liver Dis. 2015;47(11):957–963. doi:10.1016/j.dld.2015.07.156
  • Bishnu S, Ahammed SM, Sarkar A, et al. Effects of atorvastatin on portal hemodynamics and clinical outcomes in patients with cirrhosis with portal hypertension: a proof-of-concept study. Eur J Gastroenterol Hepatol. 2018;30(1):54–59. doi:10.1097/meg.0000000000001006
  • Kumar S, Grace ND, Qamar AA. Statin use in patients with cirrhosis: a retrospective cohort study. Dig Dis Sci. 2014;59(8):1958–1965. doi:10.1007/s10620-014-3179-2
  • Bang UC, Benfield T, Bendtsen F. Reduced risk of decompensation and death associated with use of statins in patients with alcoholic cirrhosis. A nationwide case-cohort study. Aliment Pharmacol Ther. 2017;46(7):673–680. doi:10.1111/apt.14243
  • Chang FM, Wang YP, Lang HC, et al. Statins decrease the risk of decompensation in hepatitis B virus- and hepatitis C virus-related cirrhosis: a population-based study. Hepatology. 2017;66(3):896–907. doi:10.1002/hep.29172
  • Mohanty A, Tate JP, Garcia-Tsao G. Statins Are Associated With a Decreased Risk of Decompensation and Death in Veterans With Hepatitis C-Related Compensated Cirrhosis. Gastroenterology. 2016;150(2):430–40.e1. doi:10.1053/j.gastro.2015.10.007
  • Henson JB, Patel YA, Muir AJ. Trends in statin utilisation in US adults with non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2021;54(11–12):1481–1489. doi:10.1111/apt.16646
  • Thomsen RW, Johnsen SP, Olesen AV, et al. Socioeconomic gradient in use of statins among Danish patients: population-based cross-sectional study. Br J Clin Pharmacol. 2005;60(5):534–542. doi:10.1111/j.1365-2125.2005.02494.x
  • Carlsson AC, Wändell P, Gasevic D, Sundquist J, Sundquist K. Neighborhood deprivation and warfarin, aspirin and statin prescription - A cohort study of men and women treated for atrial fibrillation in Swedish primary care. Int J Cardiol. 2015;187:547–552. doi:10.1016/j.ijcard.2015.04.005
  • Erickson SR, Bravo M, Tootoo J. Geosocial Factors Associated With Adherence to Statin Medications. Ann Pharmacother. 2020;54(12):1194–1202. doi:10.1177/1060028020934879
  • Aarnio E, Martikainen J, Winn AN, Huupponen R, Vahtera J, Korhonen MJ. Socioeconomic Inequalities in Statin Adherence Under Universal Coverage: does Sex Matter? Circ Cardiovasc Qual Outcomes. 2016;9(6):704–713. doi:10.1161/circoutcomes.116.002728
  • Jepsen P, Vilstrup H, Andersen PK, Sørensen HT. Socioeconomic status and survival of cirrhosis patients: a Danish nationwide cohort study. BMC Gastroenterol. 2009;9:35. doi:10.1186/1471-230x-9-35
  • Kildemoes HW, Sørensen HT, Hallas J. The Danish National Prescription Registry. Scand J Public Health. 2011;39(7 Suppl):38–41. doi:10.1177/1403494810394717
  • Pedersen CB, Gøtzsche H, Møller JO, Mortensen PB. The Danish Civil Registration System. A cohort of eight million persons. Dan Med Bull. 2006;53(4):441–449.
  • Randomised trial of cholesterol lowering in. 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet. 1994;344(8934):1383–1389.
  • Sundhedsstyrelsen. Viden om forbrug og bivirkninger ved behandling med statiner; 2012.
  • Hernán MA, Hsu J, Healy B, Second A. Chance to Get Causal Inference Right: a Classification of Data Science Tasks. CHANCE. 2019;32(1):42–49. doi:10.1080/09332480.2019.1579578
  • Wallach Kildemoes H, Toft Sørensen H, Hallas J. The Danish National Prescription Registry. Scand J Public Health. 2011;39(7_suppl):38–41. doi:10.1177/1403494810394717
  • Petersson F, Baadsgaard M, Thygesen LC. Danish registers on personal labour market affiliation. Scand J Public Health. 2011;39(7 Suppl):95–98. doi:10.1177/1403494811408483
  • Jensen VM, Rasmussen AW. Danish Education Registers. Scand J Public Health. 2011;39(7Suppl):91–94. doi:10.1177/1403494810394715
  • Vestberg K, Thulstrup AM, Sørensen HT, Ottesen P, Sabroe S, Vilstrup H. Data quality of administratively collected hospital discharge data for liver cirrhosis epidemiology. J Med Syst. 1997;21(1):11–20.
  • Mahmud N, Chapin S, Goldberg DS, Reddy KR, Taddei TH, Kaplan DE. Statin exposure is associated with reduced development of acute-on-chronic liver failure in a Veterans Affairs cohort. J Hepatol. 2022;76(5):1100–1108. doi:10.1016/j.jhep.2021.12.034
  • Carstensen B, Rønn PF, Jørgensen ME. Prevalence, incidence and mortality of type 1 and type 2 diabetes in Denmark 1996-2016. BMJ Open Diabetes Res Care. 2020;8(1):e001071. doi:10.1136/bmjdrc-2019-001071
  • Traub J, Reiss L, Aliwa B, Stadlbauer V. Malnutrition in Patients with Liver Cirrhosis. Nutrients. 2021;13(2):540. doi:10.3390/nu13020540
  • Askgaard G, Fleming KM, Crooks C, et al. Socioeconomic inequalities in the incidence of alcohol-related liver disease: a nationwide Danish study. Lancet Reg Health Eur. 2021;8:100172. doi:10.1016/j.lanepe.2021.100172
  • Forsberg P-O, Li X, Sundquist K. Neighborhood socioeconomic characteristics and statin medication in patients with myocardial infarction: a Swedish nationwide follow-up study. BMC Cardiovasc Disord. 2016;16(1):146. doi:10.1186/s12872-016-0319-y
  • Adedinsewo D, Taka N, Agasthi P, Sachdeva R, Rust G, Onwuanyi A. Prevalence and factors associated with statin use among a nationally representative sample of us adults: national health and nutrition examination survey, 2011-2012. Clin Cardiol. 2016;39(9):491–496. doi:10.1002/clc.22577
  • Thompson W, Jarbøl DE, Nielsen JB, Haastrup P, Pottegård A. Statin use and discontinuation in Danes age 70 and older: a nationwide drug utilisation study. Age Ageing. 2021;50(2):554–558. doi:10.1093/ageing/afaa160