Efficacy and safety of a novel, nebulized glycopyrrolate for the treatment of COPD: effect of baseline disease severity and age; pooled analysis of GOLDEN 3 and GOLDEN 4

References

• Global Initiative for Chronic Obstructive Lung Disease IncGlobal Initiative for Chronic Obstructive Lung Disease (GOLD). Global strategy for the diagnosis, management and prevention of COPD, 2018. [Guidelines]2018 Available from: http://goldcopd.org/Accessed July 26, 2018
   Google Scholar
• WheatonAGCunninghamTJFordESCroftJBCenters for Disease Control and Prevention (CDC). Employment and activity limitations among adults with chronic obstructive pulmonary disease – United States, 2013MMWR Morb Mortal Wkly Rep2015641128929525811677
   PubMed Web of Science ®Google Scholar
• MapelDWDalalAABlanchetteCMPetersenHFergusonGTSeverity of COPD at initial spirometry-confirmed diagnosis: data from medical charts and administrative claimsInt J Chron Obstruct Pulmon Dis2011657358122135490
   PubMed Web of Science ®Google Scholar
• Cabrera LópezCCasanova MacarioCMarín TrigoJMComparison of the 2017 and 2015 Global Initiative for Chronic Obstructive Lung Disease Reports. Impact on grouping and outcomesAm J Respir Crit Care Med2018197446346929099607
   PubMed Web of Science ®Google Scholar
• SharmaGGoodwinJEffect of aging on respiratory system physiology and immunologyClin Interv Aging20061325326018046878
   PubMed Web of Science ®Google Scholar
• TaffetGEDonohueJFAltmanPRConsiderations for managing chronic obstructive pulmonary disease in the elderlyClin Interv Aging20149233024376347
   PubMed Web of Science ®Google Scholar
• SchermerTHeijdraYZadelSFlow and volume responses after routine salbutamol reversibility testing in mild to very severe COPDRespir Med200710161355136217098407
   PubMed Web of Science ®Google Scholar
• VogelmeierCHedererBGlaabTTiotropium versus salmeterol for the prevention of exacerbations of COPDN Engl J Med2011364121093110321428765
   PubMed Web of Science ®Google Scholar
• DecramerMLChapmanKRDahlROnce-daily indacaterol versus tiotropium for patients with severe chronic obstructive pulmonary disease (INVIGORATE): a randomised, blinded, parallel-group studyLancet Respir Med20131752453324461613
   PubMed Web of Science ®Google Scholar
• AnthonisenNRLindgrenPGTashkinDPBronchodilator response in the lung health study over 11 yrsEur Respir J2005261455115994388
   PubMed Web of Science ®Google Scholar
• WieshammerSDreyhauptJDry powder inhalers: which factors determine the frequency of handling errors?Respiration2008751182517911976
   PubMed Web of Science ®Google Scholar
• AminANGanapathyVRoughleyASmallMConfidence in correct inhaler technique and its association with treatment adherence and health status among US patients with chronic obstructive pulmonary diseasePatient Prefer Adherence2017111205121228744110
   PubMed Web of Science ®Google Scholar
• BarbourKEHelmickCGBoringMBradyTJVital signs: prevalence of doctor-diagnosed arthritis and arthritis-attributable activity limitation – United States, 2013–2015MMWR Morb Mortal Wkly Rep201766924625328278145
   PubMed Web of Science ®Google Scholar
• MahlerDAWatermanLAWardJGiffordAHComparison of dry powder versus nebulized beta-agonist in patients with COPD who have suboptimal peak inspiratory flow rateJ Aerosol Med Pulm Drug Deliv201427210310923745526
   PubMed Web of Science ®Google Scholar
• FilukRDelivery system selection: clinical considerationsAm Health Drug Benefit20081Suppl 81317
   Google Scholar
• BarronsRPegramABorriesAInhaler device selection: special considerations in elderly patients with chronic obstructive pulmonary diseaseAm J Health Syst Pharm201168131221123221690428
   PubMed Web of Science ®Google Scholar
• GraySLWilliamsDMPulliamCCSirgoMABishopALDonohueJFCharacteristics predicting incorrect metered-dose inhaler technique in older subjectsArch Intern Med199615699849888624178
   PubMedGoogle Scholar
• LONHALA MAGNAIR (glycopyrrolate) inhalation solution [package insert]Marlborough, MASunovion Pharmaceuticals Inc.2018
   Google Scholar
• KerwinEDonohueJFGoodinTTosielloRWheelerAFergusonGTEfficacy and safety of glycopyrrolate/eFlow® CS (nebulized glycopyrrolate) in moderate-to-very-severe COPD: Results from the glycopyrrolate for obstructive lung disease via electronic nebulizer (GOLDEN) 3 and 4 randomized controlled trialsRespir Med201713223825028838685
   PubMed Web of Science ®Google Scholar
• FeldmanGMaltaisFKhindriSA randomized, blinded study to evaluate the efficacy and safety of umeclidinium 62.5 μg compared with tiotropium 18 μg in patients with COPDInt J Chron Obstruct Pulmon Dis20161171973027103795
   PubMed Web of Science ®Google Scholar
• FergusonGTKarpelJPClerisme-BeatyEGrönkeLVoßFBuhlREfficacy and safety of tiotropium + olodaterol maintenance treatment in patients with COPD in the TONADO® and OTEMTO® studies: a subgroup analysis by ageInt J Chron Obstruct Pulmon Dis2016112701271027843306
   PubMed Web of Science ®Google Scholar
• SinghDGagaMSchmidtOEffects of tiotropium + olodaterol versus tiotropium or placebo by COPD disease severity and previous treatment history in the OTEMTO® studiesRespir Res20161717327316465
   PubMed Web of Science ®Google Scholar
• FergusonGTFležarMKornSEfficacy of tiotropium + olodaterol in patients with chronic obstructive pulmonary disease by initial disease severity and treatment intensity: a post hoc analysisAdv Ther201532652353626112656
   PubMed Web of Science ®Google Scholar
• ChapmanKRBatemanEDChenHHuHFogelRBanerjiDQVA149 improves lung function, dyspnea, and health status independent of previously prescribed medications and COPD severity: A subgroup analysis from the SHINE and ILLUMINATE studiesChronic Obstr Pulm Dis201521486028848830
   PubMedGoogle Scholar
• AdeloyeDChuaSLeeCGlobal and regional estimates of COPD prevalence: Systematic review and meta-analysisJ Glob Health20155202041526755942
   PubMed Web of Science ®Google Scholar
• BurneyPSuissaSSorianoJBThe pharmacoepidemiology of COPD: recent advances and methodological discussionEur Respir J Suppl2003431s44s14582902
   PubMedGoogle Scholar
• FerrucciLGiallauriaFGuralnikJMEpidemiology of agingRadiol Clin North Am200846464365218922285
   PubMed Web of Science ®Google Scholar
• RauJLPractical problems with aerosol therapy in COPDRespir Care200651215817216441960
   PubMed Web of Science ®Google Scholar
• DhandRDolovichMChippsBMyersTRRestrepoRFarrarJRThe role of nebulized therapy in the management of COPD: evidence and recommendationsCOPD201291587222292598
   PubMedGoogle Scholar