Greater eosinophil counts at first COPD hospitalization are associated with more readmissions and fewer deaths

References

• VestboJHurdSSAgustíAGGlobal strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summaryAm J Respir Crit Care Med2013187434736522878278
   PubMed Web of Science ®Google Scholar
• CruzAAGlobal Surveillance, Prevention and Control of Chronic Respiratory Diseases: A Comprehensive ApproachSwitzerlandWorld Health Organization2007
   Google Scholar
• Information (CIHI) CI for HAll-Cause Readmission to Acute Care and Return to the Emergency DepartmentOttawaCIHI2012
   Google Scholar
• DorseyKGradyJDesairNCenters Medicare Medicaid Services20152015 Condition-Specific Measures Updates and Specifications Report Hospital-Level 30-Day Risk-Standardized Readmission Measures Available from: https://www.qualitynet.org/dcs/BlobServer?blobkey=id&blobnocache=true&blobwhere=1228890435217&blobheader=multipart%2Foctetstream&blobheadername1=Content-Disposition&blobheadervalue1=attachment%3Bfilename%3DRdmn_AMIHFPNCOPDSTK_Msr_UpdtRpt.pdf&blobcol=urldata&blobtable=MungoBlobsAccessed January 7, 2019
   Google Scholar
• SpivackSBBernheimSMFormanHPDryeEEKrumholzHMHospital cardiovascular outcome measures in federal pay-for-reporting and pay-for-performance programs: a brief overview of current effortsCirc Cardiovasc Qual Outcomes20147562763325205787
   PubMed Web of Science ®Google Scholar
• PoderTGKouakouCRCBouchardPACost-effectiveness of FreeO2 in patients with chronic obstructive pulmonary disease hospitalised for acute exacerbations: analysis of a pilot study in QuebecBMJ Open201881e018835
   Web of Science ®Google Scholar
• VanasseACourteauJCouillardSBeauchesneM-FLarivéePPredicting one-year mortality after a “first” hospitalization for chronic obstructive pulmonary disease: an eight-variable assessment score toolCOPD201714549049728745528
   PubMedGoogle Scholar
• MayhewDDevosNLambertCLongitudinal profiling of the lung microbiome in the AERIS study demonstrates repeatability of bacterial and eosinophilic COPD exacerbationsThorax201873542243029386298
   PubMed Web of Science ®Google Scholar
• RocaJVargasCCanoIChronic obstructive pulmonary disease heterogeneity: challenges for health risk assessment, stratification and managementJ Transl Med201412Suppl 2S325472887
   PubMed Web of Science ®Google Scholar
• AgustiACalverleyPMCelliBCharacterisation of COPD heterogeneity in the ECLIPSE cohortRespir Res201011112220831787
   PubMed Web of Science ®Google Scholar
• SethiSMurphyTFInfection in the pathogenesis and course of chronic obstructive pulmonary diseaseN Engl J Med2008359222355236519038881
   PubMed Web of Science ®Google Scholar
• BélangerMCouillardSCourteauJEosinophil counts in first COPD hospitalizations: a comparison of health service utilizationInt J Chron Obstruct Pulmon Dis2018133045305430319252
   PubMed Web of Science ®Google Scholar
• BafadhelMPavordIDRussellREKEosinophils in COPD: just another biomarker?Lancet Respir Med20175974775928601554
   PubMed Web of Science ®Google Scholar
• BafadhelMMckennaSTerrySAcute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkersAm J Respir Crit Care Med2011184666267121680942
   PubMed Web of Science ®Google Scholar
• BafadhelMDaviesLCalverleyPMAaronSDBrightlingCEPavordIDBlood eosinophil guided prednisolone therapy for exacerbations of COPD: a further analysisEur Respir J201444378979124925917
   PubMed Web of Science ®Google Scholar
• PascoeSLocantoreNDransfieldMTBarnesNCPavordIDBlood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomised controlled trialsLancet Respir Med20153643544225878028
   PubMed Web of Science ®Google Scholar
• SiddiquiSHGuasconiAVestboJBlood eosinophils: a bio-marker of response to extrafine beclomethasone/formoterol in chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2015192452352526051430
   PubMed Web of Science ®Google Scholar
• PavordIDLettisSLocantoreNBlood eosinophils and inhaled corticosteroid/long-acting β-2 agonist efficacy in COPDThorax201671211812526585525
   PubMed Web of Science ®Google Scholar
• BafadhelMGreeningNJHarvey-DunstanTCBlood eosinophils and outcomes in severe hospitalized exacerbations of COPDChest2016150232032826851799
   PubMed Web of Science ®Google Scholar
• BafadhelMPetersonSde BlasMAPredictors of exacerbation risk and response to budesonide in patients with chronic obstructive pulmonary disease: a post-hoc analysis of three randomised trialsLancet Respir Med20186211712629331313
   PubMed Web of Science ®Google Scholar
• CouillardSLarivéePCourteauJVanasseAEosinophils in COPD exacerbations are associated with increased readmissionsChest2017151236637327746201
   PubMed Web of Science ®Google Scholar
• Vedel-KroghSNielsenSFLangePVestboJNordestgaardBGBlood eosinophils and exacerbations in chronic obstructive pulmonary disease. The Copenhagen General Population StudyAm J Respir Crit Care Med2016193996597426641631
   PubMed Web of Science ®Google Scholar
• PrinsHJDuijkersRLutterRBlood eosinophilia as a marker of early and late treatment failure in severe acute exacerbations of COPDRespir Med201713111812428947018
   PubMed Web of Science ®Google Scholar
• DumanDAksoyEAgcaMCErratum: The utility of inflammatory markers to predict readmissions and mortality in COPD cases with or without eosinophilia [corrigendum]Int J Chron Obstruct Pulmon Dis20161141727013872
   PubMed Web of Science ®Google Scholar
• PoderTGCarrierNBélangerMEosinophil counts in first COPD hospitalizations: a 1-year cost analysis in Quebec, CanadaInt J Chron Obstruct Pulmon Dis2018133065307630349220
   PubMed Web of Science ®Google Scholar
• ChungLPWinshipPPhungSLakeFWatererGFive-year outcome in COPD patients after their first episode of acute exacerbation treated with non-invasive ventilationRespirology20101571084109120573056
   PubMed Web of Science ®Google Scholar
• SuissaSDell’AnielloSErnstPLong-term natural history of chronic obstructive pulmonary disease: severe exacerbations and mortalityThorax2012671195796322684094
   PubMed Web of Science ®Google Scholar
• HoTWTsaiYJRuanSYIn-hospital and one-year mortality and their predictors in patients hospitalized for first-ever chronic obstructive pulmonary disease exacerbations: a nationwide population-based studyPLoS One2014912e11486625490399
   PubMed Web of Science ®Google Scholar
• CoxDRMillerHDThe Theory of Stochastic ProcessesLondonMethuen Co Ltd1965
   Google Scholar
• D’HooreWBouckaertATilquinCPractical considerations on the use of the Charlson comorbidity index with administrative data basesJ Clin Epidemiol19964912142914338991959
   PubMed Web of Science ®Google Scholar
• JacksonCHflexsurv: A Platform for Parametric Survival Modeling in RJ Stat Softw2016708133
   Web of Science ®Google Scholar
• JacksonCHMulti-state models for panel data: the msm package for RJ Stat Softw201138828
   Web of Science ®Google Scholar
• GreenRHBrightlingCEWoltmannGParkerDWardlawAJPavordIDAnalysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroidsThorax2002571087587912324674
   PubMed Web of Science ®Google Scholar
• CastroMZangrilliJWechslerMEReslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trialsLancet Respir Med20153535536625736990
   PubMed Web of Science ®Google Scholar
• HillasGPerlikosFTzanakisNAcute exacerbation of COPD: is it the “stroke of the lungs”?Int J Chron Obstruct Pulmon Dis201611157927471380
   PubMed Web of Science ®Google Scholar
• WoodruffPGAgustiARocheNSinghDMartinezFJCurrent concepts in targeting chronic obstructive pulmonary disease pharmacotherapy: making progress towards personalised managementLancet201538599791789179825943943
   PubMed Web of Science ®Google Scholar
• NathooFSDeanCBSpatial multistate transitional models for longitudinal event dataBiometrics200864127127917425639
   PubMed Web of Science ®Google Scholar
• SaltürkCKarakurtZAdiguzelNDoes eosinophilic COPD exacerbation have a better patient outcome than non-eosinophilic in the intensive care unit?Int J Chron Obstruct Pulmon Dis201510183726392758
   PubMed Web of Science ®Google Scholar
• HollandMAlkhalilMChandromouliSJanjuaABaboresMEosinopenia as a marker of mortality and length of stay in patients admitted with exacerbations of chronic obstructive pulmonary diseaseRespirology201015116516719947999
   PubMed Web of Science ®Google Scholar
• SteerJGibsonJBourkeSCThe DECAF Score: predicting hospital mortality in exacerbations of chronic obstructive pulmonary diseaseThorax2012671197097622895999
   PubMed Web of Science ®Google Scholar
• AgustiABelEThomasMTreatable traits: toward precision medicine of chronic airway diseasesEur Respir J201647241041926828055
   PubMed Web of Science ®Google Scholar
• BarnesNCSharmaRLettisSCalverleyPMBlood eosinophils as a marker of response to inhaled corticosteroids in COPDEur Respir J20164751374138226917606
   PubMed Web of Science ®Google Scholar
• PascoeSPavordIHindsDLocantoreNBarnesNThe association between blood eosinophils and risk and treatment outcome in COPD is not dichotomisedLancet Respir Med201865e1829627194
   PubMed Web of Science ®Google Scholar
• HuangYJSethiSMurphyTNariyaSBousheyHALynchSVAirway microbiome dynamics in exacerbations of chronic obstructive pulmonary diseaseJ Clin Microbiol20145282813282324850358
   PubMed Web of Science ®Google Scholar
• MillaresLFerrariRGallegoMBronchial microbiome of severe COPD patients colonised by Pseudomonas aeruginosaEur J Clin Microbiol Infect Dis20143371101111124449346
   PubMed Web of Science ®Google Scholar