References
- World Health OrganizationThe top 10 causes of death2017 http://www.who.int/mediacentre/factsheets/fs310/en/Accessed April 2018
- SeemungalTADonaldsonGCPaulEABestallJCJeffriesDJWedzichaJAEffect of exacerbation on quality of life in patients with chronic obstructive pulmonary diseaseAm J Respir Crit Care Med19981575 Pt 11418142210.1164/ajrccm.157.5.97090329603117
- Global Initiative for Chronic Obstructive Lung Diseaseglobal strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease 2018 reportGlobal initiative for chronic obstructive lung disease2018
- FrithPAThompsonPJRatnavadivelRGlycopyrronium once-daily significantly improves lung function and health status when combined with salmeterol/fluticasone in patients with COPD: the GLISTEN study, a randomised controlled trialThorax201570651952710.1136/thoraxjnl-2014-20667025841237
- LipsonDABarnacleHBirkRFULFIL trial: once-daily triple therapy for patients with chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2017196443844610.1164/rccm.201703-0449OC28375647
- SilerTMKerwinETombsLFahyWANayaITriple therapy of umeclidinium + inhaled corticosteroids/long-acting beta2 agonists for patients with COPD: pooled results of randomized placebo-controlled trialsPulm Ther20162435810.1007/s41030-016-0012-4
- SinghDPapiACorradiMSingle inhaler triple therapy versus inhaled corticosteroid plus long-acting beta2-agonist therapy for chronic obstructive pulmonary disease (TRILOGY): a double-blind, parallel group, randomised controlled trialLancet20163881004896397310.1016/S0140-6736(16)31354-X27598678
- LipsonDABarnhartFBrealeyNOnce-daily single-inhaler triple versus dual therapy in patients with COPDN Engl J Med2018378181671168010.1056/NEJMc171158329668352
- PavordIDChanezPCrinerGJMepolizumab for eosino-philic chronic obstructive pulmonary diseaseN Engl J Med2017377171613162910.1056/NEJMoa170820828893134
- AgustiABelEThomasMTreatable traits: toward precision medicine of chronic airway diseasesEur Respir J201647241041910.1183/13993003.01359-201526828055
- LeighRPizzichiniMMMorrisMMMaltaisFHargreaveFEPizzichiniEStable COPD: predicting benefit from high-dose inhaled corticosteroid treatmentEur Respir J200627596497110.1183/09031936.06.0007210516446316
- BrightlingCEMonteiroWWardRSputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trialLancet200035692401480148510.1016/S0140-6736(00)02872-511081531
- SinghDKolsumUBrightlingCEEosinophilic inflammation in COPD: prevalence and clinical characteristicsEur Respir J20144461697170010.1183/09031936.0000381425323230
- BafadhelMMcKennaSTerrySAcute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkersAm J Respir Crit Care Med2011184666267110.1164/rccm.201104-0597OC21680942
- SivaRGreenRHBrightlingCEEosinophilic airway inflammation and exacerbations of COPD: a randomised controlled trialEur Respir J200729590691310.1183/09031936.0014630617301099
- KreindlerJLWatkinsMLLettisSTal-SingerRLocantoreNEffect of inhaled corticosteroids on blood eosinophil count in steroid-naive patients with COPDBMJ Open Respir Res201631e00015110.1136/bmjresp-2016-000151
- PascoeSLocantoreNDransfieldMTBarnesNCPavordIDBlood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomised controlled trialsLancet Respir Med20153643544210.1016/S2213-2600(15)00106-X25878028
- KolsumUDameraGPhamT-HPulmonary inflammation in patients with chronic obstructive pulmonary disease with higher blood eosinophil countsJ Allergy Clin Immunol2017140411811184.e118710.1016/j.jaci.2017.04.02728506852
- KimVLCoombsNAStaplesKJImpact and associations of eosinophilic inflammation in COPD: analysis of the AERIS cohortEur Respir J2017504170085310.1183/13993003.00711-201729025891
- LandisSSurukiRMaskellJBonarKHiltonEComptonCDemographic and clinical characteristics of COPD patients at different blood eosinophil levels in the UK clinical practice research datalinkCopd201815217718410.1080/15412555.2018.144127529558236
- WellsJMWashkoGRHanMKPulmonary arterial enlargement and acute exacerbations of COPDN Engl J Med20123671091392110.1056/NEJMoa120383022938715
- KimJKLeeSHLeeBHFactors associated with exacerbation in mild- to-moderate COPD patientsInt J Chron Obstruct Pulmon Dis2016111327133310.2147/COPD.S10558327366060
- BarnesPJInflammatory mechanisms in patients with chronic obstructive pulmonary diseaseJ Allergy Clin Immunol20161381162710.1016/j.jaci.2016.05.01127373322
- SeguelaPEIriartXAcarPMontaudonMRoudautRThamboJBEosinophilic cardiac disease: molecular, clinical and imaging aspectsArch Cardiovasc Dis2015108425826810.1016/j.acvd.2015.01.00625858537
- GeorgeLBrightlingCEEosinophilic airway inflammation: role in asthma and chronic obstructive pulmonary diseaseTher Adv Chronic Dis201671345110.1177/204062231560925126770668
- Vedel-KroghSNielsenSFLangePVestboJNordestgaardBGBlood eosinophils and exacerbations in chronic obstructive pulmonary disease. The Copenhagen general population studyAm J Respir Crit Care Med2016193996597410.1164/rccm.201509-1869OC26641631
- ZeigerRSTranTNButlerRKRelationship of blood eosinophil count to exacerbations in chronic obstructive pulmonary diseaseJ Allergy Clin Immunol Pract201863e945:94495410.1016/j.jaip.2017.10.004
- HastieATMartinezFJCurtisJLAssociation of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohortLancet Respir Med201751295696710.1016/S2213-2600(17)30234-529146301
- PavordIDKornSHowarthPMepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trialLancet2012380984265165910.1016/S0140-6736(12)60988-X22901886
- BjermerLLemiereCMasperoJWeissSZangrilliJGerminaroMReslizumab for inadequately controlled asthma with elevated blood eosinophil levels: a randomized phase 3 studyChest2016150478979810.1016/j.chest.2016.03.03227056586
- CoumouHWesterhofGAde NijsSBAmelinkMBelEHDiagnosing persistent blood eosinophilia in asthma with single blood eosinophil or exhaled nitric oxide levelRespir Med2018141818610.1016/j.rmed.2018.06.02530053977
- PasqualeMKSunSXSongFHartnettHJStemkowskiSAImpact of exacerbations on health care cost and resource utilization in chronic obstructive pulmonary disease patients with chronic bronchitis from a predominantly medicare populationInt J Chron Obstruct Pulmon Dis2012775776410.2147/COPD.S3699723152680
- PunekarYSShuklaAMullerovaHCOPD management costs according to the frequency of COPD exacerbations in UK primary careInt J Chron Obstruct Pulmon Dis20149657310.2147/COPD.S6017924426781
- CasanovaCCelliBRde-TorresJPPrevalence of persistent blood eosinophilia: relation to outcomes in patients with COPDEur Respir J201750510.1183/13993003.00711-2017
- OshagbemiOABurdenAMBraekenDCWStability of blood eosinophils in patients with chronic obstructive pulmonary disease and in control subjects, and the impact of sex, age, smoking, and baseline countsAm J Respir Crit Care Med2017195101402140410.1164/rccm.201701-0150WS28165763
- LandisSHSurukiRHiltonEComptonCGalweyNWStability of blood eosinophil count in patients with COPD in the UK clinical practice research datalinkCopd201714438238810.1080/15412555.2017.131382728569614