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International Journal of Chronic Obstructive Pulmonary Disease Volume 14, 2019 - Issue
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Short Report

Sputum Streptococcus pneumoniae is reduced in COPD following treatment with benralizumab

Leena George1 Department of Respiratory Sciences, Institute for Lung Health, National Institute for Health Research Biomedical Research Centre, University of Leicester, Leicester, UK
,
Adam Wright1 Department of Respiratory Sciences, Institute for Lung Health, National Institute for Health Research Biomedical Research Centre, University of Leicester, Leicester, UK
,
Vijay Mistry1 Department of Respiratory Sciences, Institute for Lung Health, National Institute for Health Research Biomedical Research Centre, University of Leicester, Leicester, UK
,
Amanda Sutcliffe1 Department of Respiratory Sciences, Institute for Lung Health, National Institute for Health Research Biomedical Research Centre, University of Leicester, Leicester, UK
,
Latifa Chachi1 Department of Respiratory Sciences, Institute for Lung Health, National Institute for Health Research Biomedical Research Centre, University of Leicester, Leicester, UK
,
Koirobi Haldar1 Department of Respiratory Sciences, Institute for Lung Health, National Institute for Health Research Biomedical Research Centre, University of Leicester, Leicester, UK
,
Mohammadali Yavari Ramsheh1 Department of Respiratory Sciences, Institute for Lung Health, National Institute for Health Research Biomedical Research Centre, University of Leicester, Leicester, UK
,
Matthew Richardson1 Department of Respiratory Sciences, Institute for Lung Health, National Institute for Health Research Biomedical Research Centre, University of Leicester, Leicester, UK
,
René van der Merwe2 Clinical Respiratory Management, MedImmune Ltd., Cambridge, UK
,
Ubaldo Martin3 Global Medical Affairs, AstraZeneca, Gaithersburg, MD, USA
,
Paul Newbold3 Global Medical Affairs, AstraZeneca, Gaithersburg, MD, USA
&
Christopher E Brightling1 Department of Respiratory Sciences, Institute for Lung Health, National Institute for Health Research Biomedical Research Centre, University of Leicester, Leicester, UKCorrespondence[email protected]
 show all
Pages 1177-1185 | Published online: 05 Jun 2019

References

  • George L, Brightling CE. Eosinophilic airway inflammation: role in asthma and chronic obstructive pulmonary disease. Ther Adv Chronic Dis. 2016;7:34–51. doi:10.1177/204062231560925126770668
  • Singh D, Kolsum U, Brightling CE, et al. Eosinophilic inflammation in COPD: prevalence and clinical characteristics. Eur Respir J. 2014;44:1697–1700. doi:10.1183/09031936.0016241425323230
  • Brightling CE, Monteiro W, Ward R, et al. Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial. Lancet. 2000;356:1480–1485. doi:10.1016/S0140-6736(00)02872-511081531
  • Bafadhel M, McKenna S, Terry S, et al. Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial. Am J Respir Crit Care Med. 2012;186:48–55. doi:10.1164/rccm.201108-1553OC22447964
  • Brightling CE, Bleecker ER, Panettieri RA Jr, et al. Benralizumab for chronic obstructive pulmonary disease and sputum eosinophilia: a randomised, double-blind, placebo-controlled, phase 2a study. Lancet Respir Med. 2014;2:891–901. doi:10.1016/S2213-2600(14)70187-025208464
  • Pavord ID, Chanez P, Criner GJ, et al. Mepolizumab for eosinophilic chronic obstructive pulmonary disease. N Engl J Med. 2017;377:1613–1629. doi:10.1056/NEJMoa170820828893134
  • Wang Z, Bafadhel M, Haldar K, et al. Lung microbiome dynamics in COPD exacerbations. Eur Respir J. 2016;47:1082–1092. doi:10.1183/13993003.01406-201526917613
  • Eltboli O, Bafadhel M, Hollins F, et al. COPD exacerbation severity and frequency is associated with impaired efferocytosis of eosinophils. BMC Pulm Med. 2014;14:112. doi:10.1186/1471-2466-14-11225007795
  • Yazdanbakhsh M, Eckmann CM, Bot AA, et al. Bactericidal action of eosinophils from normal human blood. Infect Immun. 1986;53:192–198.3522428
  • Ahrén IL, Eriksson E, Egesten A, et al. Nontypeable haemophilus influenza activates human eosinophils through beta-glucan receptors. Am J Respir Cell Mol Biol. 2003;29:598–605. doi:10.1165/rcmb.2002-0138OC12689921

References

  • Greiner O, Day PJ, Bosshard PP, et al. Quantitative detection of Streptococcus pneumoniae in nasopharyngeal secretions by real-time PCR. J Clin Microbiol 2001;39(9):3129–3134.
  • Greiner O, Day PJ, Altwegg M, et al. Quantitative detection of Moraxella catarrhalis in nasopharyngeal secretions by real-time PCR. J Clin Microbiol. 2003;41(4):1386–1390.12682118
  • Price EP, Sarovich DS, Nosworthy E, et al. Haemophilus influenzae: using comparative genomics to accurately identify a highly recombinogenic human pathogen. BMC Genomics. 2015;16(1):641.26311542
  • Nadkarni MA, Martin FE, Jacques NA, et al. Determination of bacterial load by real-time PCR using a broad-range (universal) probe and primers set. Microbiology. 2002;148(1):257–266.11782518

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