Evaluating the Efficacy and Safety of EZC Pak, a 5-Day Combination Echinacea-Zinc-Vitamin C Dose Pack with or without Vitamin D, in the Management of Outpatient Upper Respiratory Infections

References

• O’Neill, J. Tackling drug-resistant infections globally: final report and recommendations; 2016. Available from https://apo.org.au/node/63983. Accessed March 22, 2023.
   Google Scholar
• World Health Organization. Antimicrobial resistance. World Health Organization; 2023. Available from http://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance. Accessed March 22, 2023.
   Google Scholar
• Sanchez JD. Paho/WHO: antimicrobial resistance. Pan American Health Organization / World Health Organization; 2015. Available from https://www3.paho.org/hq/index.php?option=com_content&view=article&id=11129%3Aamr-antimicrobial-resistance-intro&Itemid=41534&lang=en#gsc.tab=0. Accessed March 22, 2023.
   Google Scholar
• Heikkinen T, Järvinen A. The common cold. Lancet. 2003;361(9351):51–59. doi:10.1016/s0140-6736(03)
   PubMed Web of Science ®Google Scholar
• Russell CD, Fairfield CJ, Drake TM, et al. Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study. Lancet Microb. 2021;2(8):e354–65. doi:10.1016/S2666-5247(21)00090-2
   PubMedGoogle Scholar
• Langford BJ, So M, Raybardhan S, et al. Bacterial co-infection and secondary infection in patients with COVID-19: a living rapid review and meta-analysis. Clin Microbiol Infect. 2020;26(12):1622–1629. doi:10.1016/j.cmi.2020.07.016
   PubMed Web of Science ®Google Scholar
• Hu Y, Lewandowski EM, Tan H, et al. Naturally occurring mutations of SARS-COV-2 main protease confer drug resistance to Nirmatrelvir. bioRxiv. 2022;2022:6.
   Google Scholar
• Sedova M, Jaroszewski L, Iyer M, Godzik A. Monitoring for SARS-COV-2 drug resistance mutations in broad viral populations. bioRxiv. 2022;2022:5.
   Google Scholar
• FDA. Pfizer reports additional data on paxlovid™ supporting upcoming new drug application submission to U.S. FDA. Pfizer; 2022. Available from: https://www.pfizer.com/news/press-release/press-release-detail/pfizer-reports-additional-data-paxlovidtm-supporting. Accessed March 22, 2023.
   Google Scholar
• Melchart D, Linde K, Worku F, Bauer R, Wagner H. Immunomodulation with echinacea — a systematic review of controlled clinical trials. Phytomedicine. 1994;1(3):245–254. doi:10.1016/s0944-7113(11)80072-3
   PubMedGoogle Scholar
• Barnes J, Anderson LA, Gibbons S, Phillipson JD. echinacea species (echinacea angustifolia (DC.) hell., echinacea pallida (Nutt.) Nutt, echinacea purpurea (L.) moench): a review of their chemistry, pharmacology and clinical properties. J Pharm Pharmacol. 2005;57(8):929–954. doi:10.1211/0022357056127
   PubMed Web of Science ®Google Scholar
• Barrett B. Medicinal properties of echinacea: a critical review. Phytomedicine. 2003;10(1):66–86. doi:10.1078/094471103321648692
   PubMed Web of Science ®Google Scholar
• Gupta M, Sharma D, Sharma A, Kumari V, Goshain OP. A review on purple cone flower (Echinacea purpurea L. Moench). J Pharm Res. 2012;5(8):4076–4081
   Google Scholar
• Mahady GB, Qato DM, Gyllenhaal C, Chadwick L, Fong HHS. Echinacea: recommendations for its use in prophylaxis and treatment of respiratory tract infections. Nutr Clin Care. 2001;4(4):199–208. doi:10.1046/j.1523-5408.2001.00143.x
   Google Scholar
• Melchart D, Linde K, Fischer P, Kaesmayr J. Echinacea for preventing and treating the common cold. Cochrane Database Syst Rev. 1999. doi:10.1002/14651858.cd000530
   Google Scholar
• Shah SA, Sander S, White CM, Rinaldi M, Coleman CI. Evaluation of echinacea for the prevention and treatment of the common cold: a meta-analysis. Lancet Infect Dis. 2007;7(7):473–480. doi:10.1016/s1473-3099(07)70160-3
   PubMed Web of Science ®Google Scholar
• Woelkart K, Linde K, Bauer R. Echinacea for preventing and treating the common cold. Planta Med. 2008;74(6):633–637. doi:10.1055/s-2007-993766
   PubMed Web of Science ®Google Scholar
• Petrus EJ, Lawson KA, Bucci LR, Blum K. Randomized, double-masked, placebo-controlled clinical study of the effectiveness of zinc acetate lozenges on common cold symptoms in allergy-tested subjects. Curr Ther Res. 1998;59(9):595–607. doi:10.1016/s0011-393x(98)85058-3
   PubMed Web of Science ®Google Scholar
• Prasad AS, Beck FWJ, Bao B, Snell D, Fitzgerald JT. Duration and severity of symptoms and levels of plasma interleukin-1 receptor antagonist, soluble tumor necrosis factor receptor, and adhesion molecules in patients with common cold treated with zinc acetate. J Infect Dis. 2008;197(6):795–802. doi:10.1086/528803
   PubMed Web of Science ®Google Scholar
• Eby J. Zinc ion availability-The determinant of efficacy in zinc lozenge treatment of common colds. J Antimicrob Chemother. 1997;40(4):483–493. doi:10.1093/oxfordjournals.jac.a020864
   PubMed Web of Science ®Google Scholar
• Hemilä H, Petrus EJ, Fitzgerald JT, Prasad A. Zinc acetate lozenges for treating the common cold: an individual patient data meta-analysis. Br J Clin Pharmacol. 2016;82(5):1393–1398. doi:10.1111/bcp.13057
   PubMed Web of Science ®Google Scholar
• Hemilä H. Vitamin C and common cold incidence: a review of studies with subjects under heavy physical stress. Int J Sports Med. 1996;17(05):379–383. doi:10.1055/s-2007-972864
   PubMedGoogle Scholar
• Hemilä H. Vitamin C supplementation and the common cold-was Linus Pauling right or wrong? Int J Vitam Nutr Res. 1997;67:329–335.
   PubMed Web of Science ®Google Scholar
• Hemilä H, Chalker E. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2013;2013(1):CD000980. doi:10.1002/14651858.CD000980.pub4
   PubMedGoogle Scholar
• Murdoch DR, Slow S, Chambers ST, et al. Effect of vitamin D3 supplementation on upper respiratory tract infections in healthy adults. JAMA. 2012;308(13):1333. doi:10.1001/jama.2012.12505
   PubMed Web of Science ®Google Scholar
• Jolliffe DA, Holt H, Greenig M, et al. Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: Phase 3 randomised controlled trial (CORONAVIT). BMJ. 2022;e071230. doi:10.1136/bmj-2022-071230
   PubMedGoogle Scholar
• Laaksi I, Ruohola JP, Mattila V, Auvinen A, Ylikomi T, Pihlajamäki H. Vitamin D supplementation for the prevention of acute respiratory tract infection: a randomized, double‐blinded trial among Young Finnish men. J Infect Dis. 2010;202(5):809–814. doi:10.1086/654881
   PubMed Web of Science ®Google Scholar
• Charan J, Goyal JP, Saxena D, Yadav P. Vitamin D for prevention of respiratory tract infections: a systematic review and meta-analysis. J Pharmacol Pharmacother. 2012;3(4):300–303. doi:10.4103/0976-500x.103685
   PubMedGoogle Scholar
• Jolliffe DA, Camargo CA, Sluyter JD, et al. Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials. Lancet Diabetes Endocrinol. 2021;9(5):276–292. doi:10.1016/s2213-8587(21)
   PubMed Web of Science ®Google Scholar
• National Heart, Lung, and Blood Institute PETAL Clinical Trials Network. Early high-dose vitamin D3 for critically ill, vitamin D–deficient patients. N Engl J Med. 2019;381(26):2529–2540. doi:10.1056/nejmoa1911124
   PubMed Web of Science ®Google Scholar
• Ogunwole SU. Population under age 18 declined last decade. Census.gov; 2022. Available from: https://www.census.gov/library/stories/2021/08/united-states-adult-population-grew-faster-than-nations-total-population-from-2010-to-2020.html. Accessed March 22, 2023.
   Google Scholar
• Avendaño Carvajal L, Perret Pérez C. Epidemiology of respiratory infections. In: Bertrand P, Sánchez I editors. Pediatric Respiratory Diseases. Cham: Springer; 2020. doi:10.1007/978-3-030-26961-6_28
   Google Scholar
• Mossink JP. Zinc as nutritional intervention and prevention measure for COVID–19 disease. BMJ Nutr Prev Health. 2020;3:111–117. doi:10.1136/bmjnph-2020-000095
   PubMedGoogle Scholar
• Ginde AA, Mansbach JM, Camargo CA Jr. Association between serum 25 hydroxyvitamin D level and upper respiratory tract infection in the third national health and nutrition examination survey. Arch Intern Med. 2009;169(4):384–390. doi:10.1001/archinternmed.2008.560
   PubMed Web of Science ®Google Scholar
• Katz J, Yue S, Xue W. Increased risk for COVID-19 in patients with vitamin D deficiency. Nutrition. 2021;84:111106. doi:10.1016/j.nut.2020.111106
   PubMed Web of Science ®Google Scholar
• Martineau AR, Cantorna MT. Vitamin D for COVID-19: where are we now? Nat Rev Immunol. 2022;22:529–530. doi:10.1038/s41577-022-00765-6
   PubMed Web of Science ®Google Scholar