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REVIEW

The Impact of the COVID-19 Pandemic on Respiratory Syncytial Virus Infection: A Narrative Review

ORCID Icon, , , ORCID Icon & ORCID Icon
Pages 661-675 | Received 06 Nov 2022, Accepted 12 Jan 2023, Published online: 30 Jan 2023

References

  • Nam HH, Ison MG. Respiratory syncytial virus infection in adults. BMJ. 2019;366:l5021. doi:10.1136/bmj.l5021
  • Tin Tin Htar M, Yerramalla MS, Moisi JC, Swerdlow DL. The burden of respiratory syncytial virus in adults: a systematic review and meta-analysis. Epidemiol Infect. 2020;148:e48. doi:10.1017/S0950268820000400
  • Gomez GB, Mahe C, Chaves SS. Uncertain effects of the pandemic on respiratory viruses. Science. 2021;372(6546):1043–1044. doi:10.1126/science.abh3986
  • Haynes AK, Manangan AP, Iwane MK, et al. Respiratory syncytial virus circulation in seven countries with Global Disease Detection Regional Centers. J Infect Dis. 2013;208(Suppl 3):S246–54. doi:10.1093/infdis/jit515
  • Coutinho Baldoto Gava Chakr V. Which should we fear more in preschoolers and infants: SARS-CoV-2 or respiratory syncytial virus? Postgrad Med J. 2022;98(1161):e7. doi:10.1136/postgradmedj-2021-141012
  • World Health Organization. Considerations for Implementing and Adjusting Public Health and Social Measures in the Context of COVID-19: Interim Guidance, 14 June 2021. 2021. Available from: https://apps.who.int/iris/handle/10665/341811. Accessed January 18, 2023.
  • Achangwa C, Park H, Ryu S, Lee MS. Collateral Impact of Public Health and Social Measures on Respiratory Virus Activity during the COVID-19 Pandemic 2020-2021. Viruses. 2022;14(5):May. doi:10.3390/v14051071
  • Weinberger Opek M, Yeshayahu Y, Glatman-Freedman A, Kaufman Z, Sorek N, Brosh-Nissimov T. Delayed respiratory syncytial virus epidemic in children after relaxation of COVID-19 physical distancing measures, Ashdod, Israel, 2021. Euro Surveill. 2021;26(29). doi:10.2807/1560-7917.ES.2021.26.29.2100706
  • Williams TC, Sinha I, Barr IG, Zambon M. Transmission of paediatric respiratory syncytial virus and influenza in the wake of the COVID-19 pandemic. Euro Surveill. 2021;26(29). doi:10.2807/1560-7917.ES.2021.26.29.2100186
  • Fourgeaud J, Toubiana J, Chappuy H, et al. Impact of public health measures on the post-COVID-19 respiratory syncytial virus epidemics in France. Eur J Clin Microbiol Infect Dis. 2021;40(11):2389–2395. doi:10.1007/s10096-021-04323-1
  • Kim S, Williams TC, Viboud C, Campbell H, Chen J, Spiro DJ. RSV genomic diversity and the development of a globally effective RSV intervention. Vaccine. 2021;39(21):2811–2820. doi:10.1016/j.vaccine.2021.03.096
  • Mosscrop LG, Williams TC, Tregoning JS. Respiratory syncytial virus after the SARS-CoV-2 pandemic - what next? Nat Rev Immunol. 2022;22(10):589–590. doi:10.1038/s41577-022-00764-7
  • Giannekas M. MapChart. Available from: https://www.mapchart.net/.
  • Uhteg K, Amadi A, Forman M, Mostafa HH. Circulation of Non-SARS-CoV-2 Respiratory Pathogens and Coinfection with SARS-CoV-2 Amid the COVID-19 Pandemic. Open Forum Infect Dis. 2022;9(3):ofab618. doi:10.1093/ofid/ofab618
  • Yuan H, Yeung A, Yang W. Interactions among common non-SARS-CoV-2 respiratory viruses and influence of the COVID-19 pandemic on their circulation in New York City. Influenza Other Respir Viruses. 2022;16(4):653–661. doi:10.1111/irv.12976
  • Halabi KC, Saiman L, Zachariah P. The Epidemiology of Respiratory Syncytial Virus in New York City during the Coronavirus Disease-2019 Pandemic Compared with Previous Years. J Pediatr. 2022;242:242–244 e1. doi:10.1016/j.jpeds.2021.10.057
  • Nolen LD, Seeman S, Bruden D, et al. Impact of Social Distancing and Travel Restrictions on Non–Coronavirus Disease 2019 (Non–COVID-19) Respiratory Hospital Admissions in Young Children in Rural Alaska. Clin Infect Dis. 2020;72(12):2196–2198. doi:10.1093/cid/ciaa1328
  • Groves HE, Piche-Renaud PP, Peci A, et al. The impact of the COVID-19 pandemic on influenza, respiratory syncytial virus, and other seasonal respiratory virus circulation in Canada: a population-based study. Lancet Reg Health Am. 2021;1:100015. doi:10.1016/j.lana.2021.100015
  • Doroshenko A, Lee N, MacDonald C, Zelyas N, Asadi L, Kanji JN. Decline of Influenza and Respiratory Viruses With COVID-19 Public Health Measures: Alberta, Canada. Mayo Clin Proc. 2021;96(12):3042–3052. doi:10.1016/j.mayocp.2021.09.004
  • Varela FH, Scotta MC, Polese-Bonatto M, et al. Absence of detection of RSV and influenza during the COVID-19 pandemic in a Brazilian cohort: likely role of lower transmission in the community. J Glob Health. 2021;11:05007. doi:10.7189/jogh.11.05007
  • Quandelacy TM, Adams LE, Munoz J, et al. Reduced spread of influenza and other respiratory viral infections during the COVID-19 pandemic in southern Puerto Rico. PLoS One. 2022;17(4):e0266095. doi:10.1371/journal.pone.0266095
  • Redlberger-Fritz M, Kundi M, Aberle SW, Puchhammer-Stockl E. Significant impact of nationwide SARS-CoV-2 lockdown measures on the circulation of other respiratory virus infections in Austria. J Clin Virol. 2021;137:104795. doi:10.1016/j.jcv.2021.104795
  • Bardsley M, Morbey RA, Hughes HE, et al. Epidemiology of respiratory syncytial virus in children younger than 5 years in England during the COVID-19 pandemic, measured by laboratory, clinical, and syndromic surveillance: a retrospective observational study. Lancet Infect Dis. 2014;1:548. doi:10.1016/S1473-3099(22)00525-4
  • Van Brusselen D, De Troeyer K, Ter Haar E, et al. Bronchiolitis in COVID-19 times: a nearly absent disease? Eur J Pediatr. 2021;180(6):1969–1973. doi:10.1007/s00431-021-03968-6
  • Vittucci AC, Piccioni L, Coltella L, et al. The Disappearance of Respiratory Viruses in Children during the COVID-19 Pandemic. Int J Environ Res Public Health. 2021;18(18):9550. doi:10.3390/ijerph18189550
  • Nenna R, Matera L, Pierangeli A, et al. First COVID-19 lockdown resulted in most respiratory viruses disappearing among hospitalised children, with the exception of rhinoviruses. Acta Paediatr. 2022;111(7):1399–1403. doi:10.1111/apa.16326
  • Coma E, Vila J, Mendez-Boo L, et al. Respiratory Syncytial Virus Infections in Young Children Presenting to Primary Care in Catalonia During the COVID-19 Pandemic. J Pediatric Infect Dis Soc. 2022;11(2):69–72. doi:10.1093/jpids/piab121
  • Reyes Dominguez AI, Pavlovic Nesic S, Urquia Marti L, Reyes Suarez D, Garcia-Munoz Rodrigo F. Effects of public health measures during the SARS-CoV-2 pandemic on the winter respiratory syncytial virus epidemic: an interrupted time series analysis. Paediatr Perinat Epidemiol. 2022;36(3):329–336. doi:10.1111/ppe.12829
  • Torres-Fernandez D, Casellas A, Mellado MJ, Calvo C, Bassat Q. Acute bronchiolitis and respiratory syncytial virus seasonal transmission during the COVID-19 pandemic in Spain: a national perspective from the pediatric Spanish Society (AEP). J Clin Virol. 2021;145:105027. doi:10.1016/j.jcv.2021.105027
  • Delestrain C, Danis K, Hau I, et al. Impact of COVID-19 social distancing on viral infection in France: a delayed outbreak of RSV. Pediatr Pulmonol. 2021;56(12):3669–3673. doi:10.1002/ppul.25644
  • Stamm P, Sagoschen I, Weise K, et al. Influenza and RSV incidence during COVID-19 pandemic-an observational study from in-hospital point-of-care testing. Med Microbiol Immunol. 2021;210(5–6):277–282. doi:10.1007/s00430-021-00720-7
  • Engels G, Sack J, Weissbrich B, et al. Very Low Incidence of SARS-CoV-2, Influenza and RSV but High Incidence of Rhino-, Adeno- and Endemic Coronaviruses in Children With Acute Respiratory Infection in Primary Care Pediatric Practices During the Second and Third Wave of the SARS-CoV-2 Pandemic. Pediatr Infect Dis J. 2022;41(4):e146–e148. doi:10.1097/INF.0000000000003460
  • Kuitunen I, Artama M, Makela L, Backman K, Heiskanen-Kosma T, Renko M. Effect of Social Distancing Due to the COVID-19 Pandemic on the Incidence of Viral Respiratory Tract Infections in Children in Finland During Early 2020. Pediatr Infect Dis J. 2020;39(12):e423–e427. doi:10.1097/INF.0000000000002845
  • Kuitunen I, Renko M. Lessons to learn from the current pandemic for future non-pharmaceutical interventions against the respiratory syncytial virus - nationwide register-study in Finland. Infect Dis. 2021;53(6):476–478. doi:10.1080/23744235.2021.1894351
  • Yeoh DK, Foley DA, Minney-Smith CA, et al. Impact of Coronavirus Disease 2019 Public Health Measures on Detections of Influenza and Respiratory Syncytial Virus in Children During the 2020 Australian Winter. Clin Infect Dis. 2021;72(12):2199–2202. doi:10.1093/cid/ciaa1475
  • El-Heneidy A, Ware RS, Robson JM, Cherian SG, Lambert SB, Grimwood K. Respiratory virus detection during the COVID-19 pandemic in Queensland, Australia. Aust N Z J Public Health. 2022;46(1):10–15. doi:10.1111/1753-6405.13168
  • Abo YN, Clifford V, Lee LY, et al. COVID-19 public health measures and respiratory viruses in children in Melbourne. J Paediatr Child Health. 2021;57(12):1886–1892. doi:10.1111/jpc.15601
  • Britton PN, Hu N, Saravanos G, et al. COVID-19 public health measures and respiratory syncytial virus. Lancet Child Adolesc Health. 2020;4(11):e42–e43. doi:10.1016/S2352-4642(20)30307-2
  • Tempia S, Walaza S, Bhiman JN, et al. Decline of influenza and respiratory syncytial virus detection in facility-based surveillance during the COVID-19 pandemic, South Africa, January to October 2020. Euro Surveill. 2021;26(29). doi:10.2807/1560-7917.ES.2021.26.29.2001600
  • Trenholme A, Webb R, Lawrence S, et al. COVID-19 and Infant Hospitalizations for Seasonal Respiratory Virus Infections, New Zealand, 2020. Emerg Infect Dis. 2021;27(2):641–643. doi:10.3201/eid2702.204041
  • Huang QS, Wood T, Jelley L, et al. Impact of the COVID-19 non pharmaceutical interventions on influenza and other respiratory viral infections in New Zealand. Nat Commun. 2021;12(1):1001. doi:10.1038/s41467-021-21157-9
  • Maruo Y, Ishikawa S, Oura K, et al. The impact of the coronavirus disease 2019 pandemic on pediatric hospitalization in Kitami, Japan. Pediatr Int. 2022;64(1):e14937. doi:10.1111/ped.14937
  • Wagatsuma K, Koolhof IS, Shobugawa Y, Saito R. Decreased human respiratory syncytial virus activity during the COVID-19 pandemic in Japan: an ecological time-series analysis. BMC Infect Dis. 2021;21(1):734. doi:10.1186/s12879-021-06461-5
  • Kim JH, Roh YH, Ahn JG, et al. Respiratory syncytial virus and influenza epidemics disappearance in Korea during the 2020-2021 season of COVID-19. Int J Infect Dis. 2021;110:29–35. doi:10.1016/j.ijid.2021.07.005
  • Park S, Michelow IC, Choe YJ. Shifting Patterns of Respiratory Virus Activity Following Social Distancing Measures for Coronavirus Disease 2019 in South Korea. J Infect Dis. 2021;224(11):1900–1906. doi:10.1093/infdis/jiab231
  • Lee CY, Wu TH, Fang YP, et al. Delayed respiratory syncytial virus outbreak in 2020 in Taiwan was correlated with two novel RSV-A genotype ON1 variants. Influenza Other Respi Viruses. 2022;16(3):511–520. doi:10.1111/irv.12951
  • Chiu SS, Cowling BJ, Peiris JSM, Chan ELY, Wong WHS, Lee KP. Effects of Non pharmaceutical COVID-19 Interventions on Pediatric Hospitalizations for Other Respiratory Virus Infections, Hong Kong. Emerg Infect Dis. 2022;28(1):62–68. doi:10.3201/eid2801.211099
  • Bhardwaj S, Choudhary ML, Jadhav S, et al. A retrospective analysis of respiratory virus transmission before and during the COVID-19 pandemic in Pune the western region of India. Front Public Health. 2022;10:936634. doi:10.3389/fpubh.2022.936634
  • Rana MS, Usman M, Alam MM, et al. Impact of COVID-19 preventive measures on other infectious and non-infectious respiratory diseases in Pakistan. J Infect. 2021;82(5):e31–e32. doi:10.1016/j.jinf.2021.01.018
  • Letafati A, Aghamirmohammadali FS, Rahimi-Foroushani A, Hasani SA, Mokhtari-Azad T, Yavarian J. No human respiratory syncytial virus but SARS-CoV-2 found in children under 5 years old referred to Children Medical Center in 2021, Tehran, Iran. J Med Virol. 2022;94(7):3096–3100. doi:10.1002/jmv.27685
  • Zhu Y, Li W, Yang B, et al. Epidemiological and virological characteristics of respiratory tract infections in children during COVID-19 outbreak. BMC Pediatr. 2021;21(1):195. doi:10.1186/s12887-021-02654-8
  • Du X, Wu G, Zhu Y, Zhang S. Exploring the epidemiological changes of common respiratory viruses since the COVID-19 pandemic: a hospital study in Hangzhou, China. Arch Virol. 2021;166(11):3085–3092. doi:10.1007/s00705-021-05214-8
  • Li L, Wang H, Liu A, et al. Comparison of 11 respiratory pathogens among hospitalized children before and during the COVID-19 epidemic in Shenzhen, China. Virol J. 2021;18(1):202. doi:10.1186/s12985-021-01669-y
  • Ye Q, Liu H. Impact of non-pharmaceutical interventions during the COVID-19 pandemic on common childhood respiratory viruses - An epidemiological study based on hospital data. Microbes Infect. 2022;24(1):104911. doi:10.1016/j.micinf.2021.104911
  • Liu P, Xu M, Lu L, et al. The changing pattern of common respiratory and enteric viruses among outpatient children in Shanghai, China: two years of the COVID-19 pandemic. J Med Virol. 2022;94(10):4696–4703. doi:10.1002/jmv.27896
  • Leuzinger K, Roloff T, Gosert R, et al. Epidemiology of SARS-CoV-2 Emergence Amidst Community-Acquired Respiratory Viruses. medRxiv. 2020. doi:10.1101/2020.07.07.20148163
  • Nenna R, Matera L, Licari A, et al. An Italian Multicenter Study on the Epidemiology of Respiratory Syncytial Virus During SARS-CoV-2 Pandemic in Hospitalized Children. Front Pediatr. 2022;10:930281. doi:10.3389/fped.2022.930281
  • Kim D, Quinn J, Pinsky B, Shah NH, Brown I. Rates of Co-infection Between SARS-CoV-2 and Other Respiratory Pathogens. JAMA. 2020;323(20):2085–2086. doi:10.1001/jama.2020.6266
  • Baker RE, Park SW, Yang W, Vecchi GA, Metcalf CJE, Grenfell BT. The impact of COVID-19 non pharmaceutical interventions on the future dynamics of endemic infections. Proce National Acad Sci. 2020;117(48):30547–30553. doi:10.1073/pnas.2013182117
  • Li Y, Wang X, Msosa T, de Wit F, Murdock J, Nair H. The impact of the 2009 influenza pandemic on the seasonality of human respiratory syncytial virus: a systematic analysis. Influenza Other Respir Viruses. 2021;15(6):804–812. doi:10.1111/irv.12884
  • Madaniyazi L, Seposo X, Ng CFS, et al. Respiratory Syncytial Virus Outbreaks Are Predicted after the COVID-19 Pandemic in Tokyo, Japan. Jpn J Infect Dis. 2022;75(2):209–211. doi:10.7883/yoken.JJID.2021.312
  • Baker RE, Park SW, Yang W, Vecchi GA, Metcalf CJE, Grenfell BT. The impact of COVID-19 non pharmaceutical interventions on the future dynamics of endemic infections. Proc Natl Acad Sci U S A. 2020;117(48):30547–30553. doi:10.1073/pnas.2013182117
  • Cooney HC, Fleming C, Scheffer IE. Respiratory syncytial virus epidemic during the COVID-19 pandemic. J Paediatr Child Health. 2022;58(1):215–216. doi:10.1111/jpc.15847
  • Perez A, Lively JY, Curns A, et al. Respiratory Virus Surveillance Among Children with Acute Respiratory Illnesses - New Vaccine Surveillance Network, United States, 2016-2021. MMWR Morb Mortal Wkly Rep. 2022;71(40):1253–1259. doi:10.15585/mmwr.mm7140a1
  • Foley DA, Phuong LK, Peplinski J, et al. Examining the interseasonal resurgence of respiratory syncytial virus in Western Australia. Arch Dis Child. 2022;107(3):e7. doi:10.1136/archdischild-2021-322507
  • Foley DA, Yeoh DK, Minney-Smith CA, et al. The Interseasonal Resurgence of Respiratory Syncytial Virus in Australian Children Following the Reduction of Coronavirus Disease 2019-Related Public Health Measures. Clin Infect Dis. 2021;73(9):e2829–e2830. doi:10.1093/cid/ciaa1906
  • Agha R, Avner JR. Delayed Seasonal RSV Surge Observed During the COVID-19 Pandemic. Pediatrics. 2021;148(3). doi:10.1542/peds.2021-052089
  • von Hammerstein AL, Aebi C, Barbey F, et al. Interseasonal RSV infections in Switzerland - rapid establishment of a clinician-led national reporting system (RSV EpiCH). Swiss Med Wkly. 2021;151:w30057. doi:10.4414/SMW.2021.w30057
  • Cai W, Durrwald R, Biere B, et al. Determination of respiratory syncytial virus epidemic seasons by using 95% confidence interval of positivity rates, 2011-2021, Germany. Influenza Other Respir Viruses. 2022;16(5):854–857. doi:10.1111/irv.12996
  • Loconsole D, Centrone F, Rizzo C, et al. Out-of-Season Epidemic of Respiratory Syncytial Virus during the COVID-19 Pandemic: the High Burden of Child Hospitalization in an Academic Hospital in Southern Italy in 2021. Children. 2022;9(6):Jun. doi:10.3390/children9060848
  • Kuitunen I, Artama M, Haapanen M, Renko M. Respiratory virus circulation in children after relaxation of COVID-19 restrictions in fall 2021-A nationwide register study in Finland. J Med Virol. 2022;94(9):4528–4532. doi:10.1002/jmv.27857
  • Moro G, Mamo C. 2021 EIP abstract book. Cogent Med. 2021;8(1):2002558. doi:10.1080/2331205X.2021.2002558
  • Sberna G, Lalle E, Valli MB, Bordi L, Garbuglia AR, Amendola A. Changes in the Circulation of Common Respiratory Pathogens among Hospitalized Patients with Influenza-like Illnesses in the Lazio Region (Italy) during Fall Season of the Past Three Years. Int J Environ Res Public Health. 2022;19(10):5962. doi:10.3390/ijerph19105962
  • Ujiie M, Tsuzuki S, Nakamoto T, Iwamoto N. Resurgence of Respiratory Syncytial Virus I nfections during COVID-19 Pandemic, Tokyo, Japan. Emerg Infect Dis. 2021;27(11):2969–2970. doi:10.3201/eid2711.211565
  • Mohebi L, Karami H, Mirsalehi N, et al. A delayed resurgence of respiratory syncytial virus (RSV) during the COVID-19 pandemic: an unpredictable outbreak in a small proportion of children in the Southwest of Iran, April 2022. J Med Virol. 2022;94(12):5802–5807. doi:10.1002/jmv.28065
  • Billard M-N, van de Ven PM, Baraldi B, Kragten-Tabatabaie L, Bont LJ, Wildenbeest JG. International changes in respiratory syncytial virus (RSV) epidemiology during the COVID-19 pandemic: association with school closures. Influenza Other Respi Viruses. 2022;16(5):926–936. doi:10.1111/irv.12998
  • Binns E, Koenraads M, Hristeva L, et al. Influenza and respiratory syncytial virus during the COVID-19 pandemic: time for a new paradigm? Pediatr Pulmonol. 2022;57(1):38–42. doi:10.1002/ppul.25719
  • Casalegno J, Javouhey E, Ploin D, et al. Delayed Start of the Respiratory Syncytial Virus Epidemic at the End of the 20/21 Northern Hemisphere Winter Season, Lyon, France. medRxiv. 2021. doi:10.1101/2021.03.12.21253446
  • van Summeren J, Meijer A, Aspelund G, et al. Low levels of respiratory syncytial virus activity in Europe during the 2020/21 season: what can we expect in the coming summer and autumn/winter? Euro Surveill. 2021;26(29). doi:10.2807/1560-7917.ES.2021.26.29.2100639
  • Di Mattia G, Nenna R, Mancino E, et al. During the COVID-19 pandemic where has respiratory syncytial virus gone? Pediatr Pulmonol. 2021;56(10):3106–3109. doi:10.1002/ppul.25582
  • Cohen R, Ashman M, Taha MK, et al. Pediatric Infectious Disease Group (GPIP) position paper on the immune debt of the COVID-19 pandemic in childhood, how can we fill the immunity gap? Infect Dis Now. 2021;51(5):418–423. doi:10.1016/j.idnow.2021.05.004
  • Reicherz F, Xu RY, Abu-Raya B, et al. Waning immunity against respiratory syncytial virus during the COVID-19 pandemic. J Infect Dis. 2022;226(12):2064–2068. doi:10.1093/infdis/jiac192
  • Hatter L, Eathorne A, Hills T, Bruce P, Beasley R. Respiratory syncytial virus: paying the immunity debt with interest. Lancet Child Adolesc Health. 2021;5(12):e44–e45. doi:10.1016/S2352-4642(21)00333-3
  • Emanuels A, Heimonen J, O’Hanlon J, et al. Remote household observation for noninfluenza respiratory viral illness. Clin Infect Dis. 2021;73(11):e4411–e4418. doi:10.1093/cid/ciaa1719
  • Pappa S, Haidopoulou K, Zarras C, et al. Early initiation of the respiratory syncytial virus season in 2021-2022, Greece. J Med Virol. 2022;94(7):3453–3456. doi:10.1002/jmv.27671
  • Eden JS, Sikazwe C, Xie R, et al. Off-season RSV epidemics in Australia after easing of COVID-19 restrictions. Nat Commun. 2022;13(1):2884. doi:10.1038/s41467-022-30485-3
  • Baier C, Huang J, Reumann K, et al. Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients. Antimicrob Resist Infect Control. 2022;11(1):88. doi:10.1186/s13756-022-01120-z
  • Kahanowitch R, Gaviria S, Aguilar H, et al. How did respiratory syncytial virus and other pediatric respiratory viruses change during the COVID-19 pandemic? Pediatr Pulmonol. 2022;57(10):2542–2545. doi:10.1002/ppul.26053
  • Kuchar E, Zaleski A, Wronowski M, et al. Children were less frequently infected with SARS-CoV-2 than adults during 2020 COVID-19 pandemic in Warsaw, Poland. Eur J Clin Microbiol Infect Dis. 2021;40(3):541–547. doi:10.1007/s10096-020-04038-9
  • Swets MC, Russell CD, Harrison EM, et al. SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses. Lancet. 2022;399(10334):1463–1464. doi:10.1016/S0140-6736(22)00383-X
  • Cong B, Deng S, Wang X, Li Y. The role of respiratory co-infection with influenza or respiratory syncytial virus in the clinical severity of COVID-19 patients: a systematic review and meta-analysis. J Glob Health. 2022;12:05040. doi:10.7189/jogh.12.05040
  • Alvares PA. SARS-CoV-2 and Respiratory Syncytial Virus Coinfection in Hospitalized Pediatric Patients. Pediatr Infect Dis J. 2021;40(4):e164–e166. doi:10.1097/INF.0000000000003057
  • Hashemi SA, Safamanesh S, Ghasemzadeh-Moghaddam H, Ghafouri M, Azimian A. High prevalence of SARS-CoV-2 and influenza A virus (H1N1) coinfection in dead patients in Northeastern Iran. J Med Virol. 2021;93(2):1008–1012. doi:10.1002/jmv.26364
  • Hedberg P, Johansson N, Ternhag A, Abdel-Halim L, Hedlund J, Naucler P. Bacterial co-infections in community-acquired pneumonia caused by SARS-CoV-2, influenza virus and respiratory syncytial virus. BMC Infect Dis. 2022;22(1):108. doi:10.1186/s12879-022-07089-9
  • Borchers AT, Chang C, Gershwin ME, Gershwin LJ. Respiratory syncytial virus--a comprehensive review. Clin Rev Allergy Immunol. 2013;45(3):331–379. doi:10.1007/s12016-013-8368-9
  • Walsh EE, Peterson DR, Falsey AR. Risk factors for severe respiratory syncytial virus infection in elderly persons. J Infect Dis. 2004;189(2):233–238. doi:10.1086/380907
  • Manzoni P, Figueras-Aloy J, Simoes EAF, et al. Defining the Incidence and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Children with Chronic Diseases. Infect Dis Ther. 2017;6(3):383–411. doi:10.1007/s40121-017-0160-3
  • Miller JM, Binnicker MJ, Campbell S, et al. A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious Diseases Society of America and the American Society for Microbiology. Clin Infect Dis. 2018;67(6):e1–e94. doi:10.1093/cid/ciy381
  • Kim SH, AlMutawa F. Tracheal Aspirate and Bronchoalveolar Lavage as Potential Specimen Types for COVID-19 Testing Using the Cepheid Xpert Xpress SARS-CoV-2/Flu/RSV. Microbiol Spectr. 2022;10(3):e0039922. doi:10.1128/spectrum.00399-22
  • Teirlinck AC, Broberg EK, Stuwitz Berg A, et al. Recommendations for respiratory syncytial virus surveillance at the national level. Eur Respir J. 2021;58(3):2003766. doi:10.1183/13993003.03766-2020
  • Mostafa HH, Carroll KC, Hicken R, et al. Multicenter Evaluation of the Cepheid Xpert Xpress SARS-CoV-2/Flu/RSV Test. J Clin Microbiol. 2021;59(3):e02955–20. doi:10.1128/JCM.02955-20
  • Wolters F, Grunberg M, Huber M, et al. European multicenter evaluation of Xpert(R) Xpress SARS-CoV-2/Flu/RSV test. J Med Virol. 2021;93(10):5798–5804. doi:10.1002/jmv.27111
  • Leung EC, Chow VC, Lee MK, Tang KP, Li DK, Lai RW. Evaluation of the Xpert Xpress SARS-CoV-2/Flu/RSV Assay for Simultaneous Detection of SARS-CoV-2, Influenza A and B Viruses, and Respiratory Syncytial Virus in Nasopharyngeal Specimens. J Clin Microbiol. 2021;59(4). doi:10.1128/jcm.02965-20
  • Quinton M, Geahr M, Gluck L, Jarrett J, Mostafa HH. Evaluation of the respiratory NeuMoDx Flu A-B/RSV/SARS-CoV-2 Vantage and Alinity m Resp-4-Plex assays. J Clin Virol. 2022;150-151:105164. doi:10.1016/j.jcv.2022.105164
  • Yun J, Park JH, Kim N, et al. Evaluation of Three Multiplex Real-time Reverse Transcription PCR Assays for Simultaneous Detection of SARS-CoV-2, Influenza A/B, and Respiratory Syncytial Virus in Nasopharyngeal Swabs. J Korean Med Sci. 2021;36(48):e328. doi:10.3346/jkms.2021.36.e328
  • Phan T, Tran NYK, Gottlieb T, Siarakas S, McKew G. Evaluation of the influenza and respiratory syncytial virus (RSV) targets in the AusDiagnostics SARS-CoV-2, Influenza and RSV 8-well assay: sample pooling increases testing throughput. Pathology. 2022;54(4):466–471. doi:10.1016/j.pathol.2022.02.002
  • Larkin HD. First Nonprescription COVID-19 Test That Also Detects Flu and RSV. JAMA. 2022;328(1):11. doi:10.1001/jama.2022.11031
  • Kim TY, Kim JY, Shim HJ, et al. Comparison of the PowerChek SARS-CoV-2, Influenza A&B, RSV Multiplex Real-time PCR Kit and BioFire Respiratory Panel 2.1 for simultaneous detection of SARS-CoV-2, influenza A and B, and respiratory syncytial virus. J Virol Methods. 2021;298:114304. doi:10.1016/j.jviromet.2021.114304
  • Beaird OE, Freifeld A, Ison MG, et al. Current practices for treatment of respiratory syncytial virus and other non-influenza respiratory viruses in high-risk patient populations: a survey of institutions in the Midwestern Respiratory Virus Collaborative. Transpl Infect Dis. 2016;18(2):210–215. doi:10.1111/tid.12510
  • Hirsch HH, Martino R, Ward KN, Boeckh M, Einsele H, Ljungman P. Fourth European Conference on Infections in Leukaemia (ECIL-4): guidelines for diagnosis and treatment of human respiratory syncytial virus, parainfluenza virus, metapneumovirus, rhinovirus, and coronavirus. Clin Infect Dis. 2013;56(2):258–266. doi:10.1093/cid/cis844
  • Ventre K, Randolph A. Ribavirin for respiratory syncytial virus infection of the lower respiratory tract in infants and young children. Cochrane Database Syst Rev. 2004;(4):CD000181. doi:10.1002/14651858.CD000181.pub2
  • Gorcea CM, Tholouli E, Turner A, et al. Effective use of oral ribavirin for respiratory syncytial viral infections in allogeneic haematopoietic stem cell transplant recipients. J Hosp Infect. 2017;95(2):214–217. doi:10.1016/j.jhin.2016.11.012
  • Shah JN, Chemaly RF. Management of RSV infections in adult recipients of hematopoietic stem cell transplantation. Blood. 2011;117(10):2755–2763. doi:10.1182/blood-2010-08-263400
  • Sinclair SM, Jones JK, Miller RK, Greene MF, Kwo PY, Maddrey WC. The Ribavirin Pregnancy Registry: an Interim Analysis of Potential Teratogenicity at the Mid-Point of Enrollment. Drug Saf. 2017;40(12):1205–1218. doi:10.1007/s40264-017-0566-6
  • Ottolini MG, Porter DD, Hemming VG, Zimmerman MN, Schwab NM, Prince GA. Effectiveness of RSVIG prophylaxis and therapy of respiratory syncytial virus in an immunosuppressed animal model. Bone Marrow Transplant. 1999;24(1):41–45. doi:10.1038/sj.bmt.1701813
  • American Academy of Pediatrics Committee on Infectious D, American Academy of Pediatrics Bronchiolitis Guidelines C. Updated guidance for palivizumab prophylaxis among infants and young children at increased risk of hospitalization for respiratory syncytial virus infection. Pediatrics. 2014;134(2):e620–38. doi:10.1542/peds.2014-1666
  • Villanueva DH, Arcega V, Rao M. Review of respiratory syncytial virus infection among older adults and transplant recipients. Ther Adv Infect Dis. 2022;9:20499361221091413. doi:10.1177/20499361221091413
  • Boeckh M, Berrey MM, Bowden RA, Crawford SW, Balsley J, Phase CL. 1 evaluation of the respiratory syncytial virus-specific monoclonal antibody palivizumab in recipients of hematopoietic stem cell transplants. J Infect Dis. 2001;184(3):350–354. doi:10.1086/322043
  • Permpalung N, Mahoney MV, McCoy C, et al. Clinical characteristics and treatment outcomes among respiratory syncytial virus (RSV)-infected hematologic malignancy and hematopoietic stem cell transplant recipients receiving palivizumab. Leuk Lymphoma. 2019;60(1):85–91. doi:10.1080/10428194.2018.1468896
  • American Academy of Pediatrics. Updated Guidance: use of Palivizumab Prophylaxis to Prevent Hospitalization From Severe Respiratory Syncytial Virus Infection During the 2022-2023 RSV Season. Available from: https://www.aap.org/en/pages/2019-novel-coronavirus-covid-19-infections/clinical-guidance/interim-guidance-for-use-of-palivizumab-prophylaxis-to-prevent-hospitalization/. Accessed January 18, 2023.
  • Taylor RS. Respiratory syncytial virus and palivizumab prophylaxis in the COVID-19 era. CMAJ. 2021;193(15):E523. doi:10.1503/cmaj.78240
  • Tripp RA, Stambas J. Intervention Strategies for Seasonal and Emerging Respiratory Viruses with Drugs and Vaccines Targeting Viral Surface Glycoproteins. Viruses. 2021;13(4):Apr. doi:10.3390/v13040625
  • Lambkin-Williams R, DeVincenzo JP. A COVID-19 human viral challenge model. Learning from experience. Influenza Other Respir Viruses. 2020;14(6):747–756. doi:10.1111/irv.12797
  • Zhen W, Manji R, Smith E, Wuitschick J, Lucic D, Berry GJ. Evaluation of the Alinity m Resp-4-Plex Assay for the Detection of Severe Acute Respiratory Syndrome Coronavirus 2, Influenza A Virus, Influenza B Virus, and Respiratory Syncytial Virus. Microbiol Spectr. 2022;10(1):e0109021. doi:10.1128/spectrum.01090-21
  • Cheng A, Riedel S, Arnaout R, Kirby JE. Verification of the Abbott Alinity m Resp-4-Plex assay for detection of SARS-CoV-2, influenza A/B, and respiratory syncytial virus. Diagn Microbiol Infect Dis. 2022;102(2):115575. doi:10.1016/j.diagmicrobio.2021.115575
  • Sahajpal NS, Mondal AK, Ananth S, et al. Clinical validation of a multiplex PCR-based detection assay using saliva or nasopharyngeal samples for SARS-Cov-2, influenza A and B. Sci Rep. 2022;12(1):3480. doi:10.1038/s41598-022-07152-0
  • Prevention CfDCa. Table 4. Multiplex Assays Authorized for Simultaneous Detection of Influenza Viruses and SARS-CoV-2 by FDA. Accessed October 10, 2022. Available from: https://www.cdc.gov/flu/professionals/diagnosis/table-flu-covid19-detection.html.
  • Administration USFaD. In vitro diagnostics EUAs - Molecular Diagnostic Tests for SARS-CoV-2. Available from: https://www.fda.gov/medical-devices/coronavirus-disease-2019-covid-19-emergency-use-authorizations-medical-devices/in-vitro-diagnostics-euas-molecular-diagnostic-tests-sars-cov-2#individual-molecular. Accessed Oct 10, 2022.
  • Lim HJ, Park JE, Park MY, et al. Assay System for Simultaneous Detection of SARS-CoV-2 and Other Respiratory Viruses. Diagnostics. 2021;11(6):548. doi:10.3390/diagnostics11061084
  • Neopane P, Nypaver J, Shrestha R, Beqaj S. Performance Evaluation of TaqMan SARS-CoV-2, Flu A/B, RSV RT-PCR Multiplex Assay for the Detection of Respiratory Viruses. Infect Drug Resist. 2022;15:5411–5423. doi:10.2147/IDR.S373748
  • Mboumba Bouassa RS, Tonen-Wolyec S, Veyer D, Pere H, Belec L. Analytical performances of the AMPLIQUICK(R) Respiratory Triplex assay for simultaneous detection and differentiation of SARS-CoV-2, influenza A/B and respiratory syncytial viruses in respiratory specimens. PLoS One. 2022;17(1):e0262258. doi:10.1371/journal.pone.0262258
  • Chung HY, Jian MJ, Chang CK, et al. Multicenter study evaluating one multiplex RT-PCR assay to detect SARS-CoV-2, influenza A/B, and respiratory syncytial virus using the LabTurbo AIO open platform: epidemiological features, automated sample-to-result, and high-throughput testing. Aging. 2021;13(23):24931–24942. doi:10.18632/aging.203761