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REVIEW

Medical Applications of Hydrogels in Skin Infections: A Review

ORCID Icon, , , , &
Pages 391-401 | Received 10 Nov 2022, Accepted 29 Dec 2022, Published online: 23 Jan 2023

References

  • Khan MUA, Razak SIA, Haider S, Mannan HA, Hussain J, Hasan A. Sodium alginate-f-GO composite hydrogels for tissue regeneration and antitumor applications. Int J Biol Macromol. 2022;208:475–485. doi:10.1016/j.ijbiomac.2022.03.091
  • Khan MUA, Yaqoob Z, Ansari MNM, et al. Chitosan/poly vinyl alcohol/graphene oxide based pH-responsive composite hydrogel films: drug release, anti-microbial and cell viability studies. Polymers. 2021;13(18):3124. doi:10.3390/polym13183124
  • Peppas NA, Bures P, Leobandung W, Ichikawa HE. Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm. 2000;50(1):27–46. doi:10.1016/S0939-6411(00)00090-4
  • Caló E, Khutoryanskiy VV. Biomedical applications of hydrogels: a review of patents and commercial products - ScienceDirect. Eur Polym J. 2015;65:252–267. doi:10.1016/j.eurpolymj.2014.11.024
  • Hubbell JA. Hydrogel systems for barriers and local drug delivery in the control of wound healing. J Control Release. 1996;39(2–3):305–313. doi:10.1016/0168-3659(95)00162-X
  • Khan MUA, Razaq SIA, Mehboob H, Rehman S, Al-Arjan WS, Amin R. Antibacterial and hemocompatible pH-responsive hydrogel for skin wound healing application: in vitro drug release. Polymers. 2021;13(21):3703. doi:10.3390/polym13213703
  • Khan MUA, Iqbal I, Ansari MNM, et al. Development of antibacterial, degradable and pH-responsive chitosan/guar gum/polyvinyl alcohol blended hydrogels for wound dressing. Molecules. 2021;26(19):5937. doi:10.3390/molecules26195937
  • Rizwan M, Yahya R, Hassan A, et al. pH sensitive hydrogels in drug delivery: brief history, properties, swelling, and release mechanism, material selection and applications. Polymers. 2017;9(4):137.
  • Koga T, Tomimori K, Higashi N. Transparent, high-strength, and shape memory hydrogels from thermo-responsive amino acid-derived vinyl polymer networks. Macromol Rapid Commun. 2020;41(7):e1900650. doi:10.1002/marc.201900650
  • Fisher DR, Fidel J, Maitz CA. Direct interstitial treatment of solid tumors using an injectable yttrium-90-polymer composite. Cancer Biother Radiopharm. 2020;35(1):1–9. doi:10.1089/cbr.2019.2947
  • Raman R, Hua T, Gwynne D, et al. Light-degradable hydrogels as dynamic triggers for gastrointestinal applications. Sci Adv. 2020;6(3):eaay0065. doi:10.1126/sciadv.aay0065
  • Chaves LL, Silveri A, Vieira ACC, et al. pH-responsive chitosan based hydrogels affect the release of dapsone: design, set-up, and physicochemical characterization. Int J Biol Macromol. 2019;133:1268–1279. doi:10.1016/j.ijbiomac.2019.04.178
  • Bisht A, Hemrajani C, Rathore C, et al. Hydrogel composite containing azelaic acid and tea tree essential oil as a therapeutic strategy for Propionibacterium and testosterone-induced acne. Drug Deliv Transl Res. 2022;12(10):2501–2517. doi:10.1007/s13346-021-01092-4
  • Frade ML, de Annunzio SR, Calixto GMF, Victorelli FD, Chorilli M, Fontana CR. Assessment of chitosan-based hydrogel and photodynamic inactivation against Propionibacterium acnes. Molecules. 2018;23(2):473. doi:10.3390/molecules23020473
  • Williams HC, Dellavalle RP, Garner S. Acne vulgaris. Lancet. 2012;379(9813):361–372. doi:10.1016/S0140-6736(11)60321-8
  • Kurokawa I, Danby FW, Ju Q, et al. New developments in our understanding of acne pathogenesis and treatment. Exp Dermatol. 2010;18(10):821–832.
  • O’Neill A, Gallo R. Host-microbiome interactions and recent progress into understanding the biology of acne vulgaris. Microbiome. 2018;6. doi:10.1186/s40168-018-0558-5
  • Blaskovich M, Elliott AG, Kavanagh AM, Ramu S, Cooper MA. In vitro antimicrobial activity of acne drugs against skin-associated bacteria. Sci Rep. 2019;9(1). doi:10.1038/s41598-019-50746-4
  • Pazyar N, Yaghoobi R, Bagherani N, Kazerouni A. A review of applications of tea tree oil in dermatology. Int J Dermatol. 2013;52(7):784–790. doi:10.1111/j.1365-4632.2012.05654.x
  • Sevimli Dikicier B. Topical treatment of acne vulgaris: efficiency, side effects, and adherence rate. J Int Med Res. 2019;47(7):2987–2992. doi:10.1177/0300060519847367
  • Bowen AC, Antoine M, Hay RJ, et al. The global epidemiology of impetigo: a systematic review of the population prevalence of impetigo and pyoderma. PLoS One. 2015;10(8):e0136789. doi:10.1371/journal.pone.0136789
  • Romani L, Steer AC, Whitfeld MJ, Kaldor JM. Prevalence of scabies and impetigo worldwide: a systematic review. Lancet Infect Dis. 2015;15(8):960–967. doi:10.1016/S1473-3099(15)00132-2
  • Salarian AA, Mollamahale YB, Hami Z, Soltani-Rezaee-Rad M. Cephalexin nanoparticles: synthesis, cytotoxicity and their synergistic antibacterial study in combination with silver nanoparticles. Mater Chem Phys. 2017;198:125–130. doi:10.1016/j.matchemphys.2017.05.059
  • Poulikakos P, Falagas ME. Aminoglycoside therapy in infectious diseases. Expert Opin Pharmacother. 2013;14(12):1585–1597. doi:10.1517/14656566.2013.806486
  • Brown J, Shriner DL, Schwartz RA, Janniger CK. Impetigo: an update. Int J Dermatol. 2010;42(4):251–255. doi:10.1046/j.1365-4362.2003.01647.x
  • Salatin S, Lotfipour F, Jelvehgari M. Preparation and characterization of a novel thermosensitive and bioadhesive cephalexin nanohydrogel: a promising platform for topical antibacterial delivery. Expert Opin Drug Deliv. 2020;17(6):1–13. doi:10.1080/17425247.2020.1764530
  • Augustin M, Goepel L, Jacobi A, Bosse B, Mueller S, Hopp M. (2017). Efficacy and tolerability of liposomal polyvinylpyrrolidone-iodine hydrogel for the localized treatment of chronic infective, inflammatory, dermatoses: an uncontrolled pilot study. Clin Cosmet Investig Dermatol, 10 373–384. doi: 10.2147/CCID.S141887
  • Aggarwal N, Goindi S. Preparation and evaluation of antifungal efficacy of griseofulvin loaded deformable membrane vesicles in optimized Guinea pig model of Microsporum canis--dermatophytosis. Int J Pharm. 2012;437(1–2):277–287. doi:10.1016/j.ijpharm.2012.08.015
  • Kumar N, Goindi S. Statistically designed nonionic surfactant vesicles for dermal delivery of itraconazole: characterization and in vivo evaluation using a standardized Tinea pedis infection model. Int J Pharm. 2014;472(1–2):224–240. doi:10.1016/j.ijpharm.2014.06.030
  • Jain S, Jain S, Khare P, Gulbake A, Bansal D, Jain S K. (2010). Design and development of solid lipid nanoparticles for topical delivery of an anti-fungal agent. Drug Deliv, 17(6), 443–51. doi: 10.3109/10717544.2010.483252
  • Looker KJ, Magaret AS, May MT, et al. Global and Regional Estimates of Prevalent and Incident Herpes Simplex Virus Type 1 Infections in 2012. PLoS One. 2015;10(10):e0140765. doi:10.1371/journal.pone.0140765
  • Looker KJ, Magaret AS, Turner K, Vickerman P, Gottlieb SL, Newman LM. Global estimates of prevalent and incident herpes simplex virus type 2 infections in 2012. PLoS One. 2015;10:e114989.
  • Sahoo S, Pani N Ranjan, Sahoo S Kumar. (2016). Effect of microemulsion in topical sertaconazole hydrogel: in vitro and in vivo study. Drug Deliv, 23(1), 338–45. doi: 10.3109/10717544.2014.914601
  • Sharma G, Thakur K, Setia A, et al. Fabrication of Acyclovir-loaded flexible membrane vesicles (FMVs): evidence of preclinical efficacy of antiviral activity in murine model of cutaneous HSV-1 infection. Drug Deliv Transl Res. 2017;7(5):683–694. doi:10.1007/s13346-017-0417-0
  • Piotr O, Emilia T, Marianna G, et al. Tannic acid modified silver nanoparticles show antiviral activity in herpes simplex virus type 2 infection. PLoS One. 2014;9(8):e104113. doi:10.1371/journal.pone.0104113
  • Nguyen HP, Franz E, Stiegel KR, Hsu S, Tyring SK. Treatment of molluscum contagiosum in adult, pediatric, and immunodeficient populations. J Cutan Med Surg. 2014;18(5):1–8.
  • Al-Subaie M M, Hosny K M, El-Say K Mohamed, Ahmed T A, Aljaeid B M. (2015). Utilization of nanotechnology to enhance percutaneous absorption of acyclovir in the treatment of herpes simplex viral infections. Int J Nanomedicine, 10 3973–85. doi: 10.2147/IJN.S83962
  • Jessica FMD, Carl-Fredrik WMD. EMLA cream provides rapid pain relief for the curettage of molluscum contagiosum in children with atopic dermatitis without causing serious application‐site reactions. Pediatr Dermatol. 2010;15(4):309–312.
  • Gagliano-Jucá T, Castelli MR, Mendes GD, Arruda A, Nucci GD. Pharmacokinetic and pharmacodynamic evaluation of a nanotechnological topical formulation of lidocaine/prilocaine (Nanorap) in healthy volunteers. Ther Drug Monit. 2015;37(3):362. doi:10.1097/FTD.0000000000000156
  • Stasko N, Mchale K, Hollenbach SJ, Martin M, Doxey R. Nitric oxide-releasing macromolecule exhibits broad-spectrum anti-fungal activity and utility as a topical treatment for superficial fungal infections. Antimicrob Agents Chemother. 2018;62(7):e01026–e01017.
  • Szymańska E, Orłowski P, Winnicka K, Tomaszewska E, Bąska P, Celichowski G, Grobelny J, Basa A, Krzyżowska M. (2018). Multifunctional Tannic Acid/Silver Nanoparticle-Based Mucoadhesive Hydrogel for Improved Local Treatment of HSV Infection: In Vitro and In Vivo Studies. Int J Mol Sci, 19(2). doi: 10.3390/ijms19020387
  • Jebran AF, Schleicher U, Steiner R, et al. Rapid healing of cutaneous leishmaniasis by high-frequency electrocauterization and hydrogel wound care with or without DAC N-055: a randomized controlled phase iia trial in Kabul. PLoS Negl Trop Dis. 2014;8(2):e2694. doi:10.1371/journal.pntd.0002694
  • Tyring SK, Rosen T, Berman B, Stasko N, Maeda-Chubachi T, Phase A. 2 controlled study of SB206, a topical nitric oxide-releasing drug for extragenital wart treatment. J Drugs Dermatol. 2018;17(10):1100–1105.
  • Mila-Kierzenkowska C, Woźniak A, Krzyżyńska-Malinowska E, Kałużna L, Owcarz M. Comparative efficacy of topical pertmehrin, crotamiton and sulfur ointment in treatment of scabies. J Arthropod Borne Dis. 2017;11(1):1–9.
  • Hada E, Derda M, Cholewiński M. Evaluation of the effectiveness of tea tree oil in treatment of Acanthamoeba infection. Parasitol Res. 2017;116(3):997–1001. doi:10.1007/s00436-017-5377-2
  • Chen L, Alrobaian M, Afzal O, et al. Crotamiton-loaded tea tree oil containing phospholipid-based microemulsion hydrogel for scabies treatment: in vitro, in vivo evaluation, and dermatokinetic studies. Drug Deliv. 2021;28(1):1972–1981. doi:10.1080/10717544.2021.1979131
  • Gobbato A A, Babadópulos T, Gobbato C A, Moreno R A, Gagliano-Jucá T, De Nucci G. (2016). Tolerability of 2.5% Lidocaine/Prilocaine Hydrogel in Children Undergoing Cryotherapy for Molluscum Contagiosum. Pediatr Dermatol, 33(3), e214–5. doi: 10.1111/pde.12842
  • Hebert A A. Siegfried E C, Durham T, de León E N, Reams T, Messersmith E, Maeda-Chubachi T. (2020)Efficacy and tolerability of an investigational nitric oxidereleasing topical gel in patients with molluscum contagiosum: A randomized clinical trial. J Am Acad Dermatol;)Efficacy and tolerability of an investigational nitric oxidereleasing topical gel in patients with molluscum contagiosum: A randomized clinical trial. J Am Acad Dermatol;82(4):887–894. doi:10.1016/j.jaad.2019.09.064
  • Smith LA, Serrano DR, Mauger M, Bolás-Fernández F, Dea-Ayuela MA, Lalatsa A. Orally bioavailable and effective buparvaquone lipid-based nanomedicines for visceral leishmaniasis. Mol Pharm. 2018;15(7):2570–2583. doi:10.1021/acs.molpharmaceut.8b00097
  • Venkatesh G, Majid M, Mansor SM, Nair NK, Croft SL, Navaratnam V. In vitro and in vivo evaluation of self-microemulsifying drug delivery system of buparvaquone. Drug Dev Ind Pharm. 2010;36(6):735. doi:10.3109/03639040903460446
  • Lalatsa A, Statts L, Adriana de Jesus J, et al. Topical buparvaquone nano-enabled hydrogels for cutaneous leishmaniasis. Int J Pharm. 2020;588:119734. doi:10.1016/j.ijpharm.2020.119734
  • Crump A. Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to Surprise and exceed expectations. J Antibiot. 2017;70(5):495–505. doi:10.1038/ja.2017.11
  • Romero AI, Cid AG, Minetti NE, et al. Sustained-release hydrogels of ivermectin as alternative systems to improve the treatment of cutaneous leishmaniasis. Ther Deliv. 2020;11(12):779–790. doi:10.4155/tde-2020-0090
  • Oliveira MJA, Villegas GME, Motta FD, et al. Influence of gamma radiation on Amphotericin B incorporated in PVP hydrogel as an alternative treatment for cutaneous leishmaniosis. Acta Trop. 2021;215:105805. doi:10.1016/j.actatropica.2020.105805
  • Sharma G, Dhankar G, Thakur K, Raza K, Katare O P. (2016). Benzyl Benzoate-Loaded Microemulsion for Topical Applications: Enhanced Dermatokinetic Profile and Better Delivery Promises. AAPS PharmSciTech, 17(5), 1221–31. 10.1208/s12249-015-0464-0
  • Scollard DM. Infection with Mycobacterium lepromatosis. Am J Trop Med Hyg. 2016;95(3):500–501. doi:10.4269/ajtmh.16-0473